A6NEL2 (ANR56_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ankyrin repeat domain-containing protein 56

Gene names

Name:

ANKRD56

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	793 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 2 ANK repeats.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	ANK repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 793	793	Ankyrin repeat domain-containing protein 56		PRO_0000317240
Regions
	Repeat	630 – 659	30	ANK 1
	Repeat	669 – 699	31	ANK 2
	Compositional bias	121 – 125	5	Poly-Arg
	Compositional bias	134 – 274	141	Ala-rich
	Compositional bias	300 – 304	5	Poly-Gln
Natural variations
	Natural variant	152	1	D → G. Corresponds to variant rs2703129 [ dbSNP | Ensembl ].		VAR_059126
	Natural variant	377	1	P → T. Corresponds to variant rs2703130 [ dbSNP | Ensembl ].		VAR_048280

Sequences

	Sequence		Length	Mass (Da)
	A6NEL2 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 8072B1D09C52F32F	FASTA	793	85,742
	10 20 30 40 50 60 MARELSQEAL LDFLCQAGGR VTNAALLSHF KSFLRDPDAS PSQHQHRREL FKGFVNSVAA 70 80 90 100 110 120 VRQDPDGTKY VVLKRRYRDL LGEEGLQRPR EPPAAAPSAG GAAPCSPRGA RRGEPPQQQP 130 140 150 160 170 180 RRRRREKEPE EEPAGAAARA ADAACNGLPG SDSRRAPGKG GGSKGSPGQR PPVPAAAAAG 190 200 210 220 230 240 AQARASCAAA KTQGRCCWEC LQNNLAVLPG ELGALPHSAT AEEKPARALP AQDDRGASRE 250 260 270 280 290 300 REEGALAEPA PVPAVAHSPP ATVEAATSRA SPPALLPGPA PRGDRPELLT PSSLHYSTLQ 310 320 330 340 350 360 QQQQRTREWV ARHPQVPEAR DQGPIRAWSV LPDNFLQLPL EPGSTEPNSE PPDPCLSSHS 370 380 390 400 410 420 LFPVVPDESW ESWAGNPSLT VFRSIRCQLS LQDLDDFVDQ ESDGSEESSS GPKDSPGASE 430 440 450 460 470 480 EGLQVVLGTP DRGKLRNPAG GLSVSRKEGS PSRSPQGLRN RGDGHISQQV PAGANGLAGH 490 500 510 520 530 540 PLKPLPWPVP KLRRSLRRSS LAGRAKLSSS DEEYLDEGLL KRSRRPPRSR KPSKAGTAPS 550 560 570 580 590 600 PRVDAGLSLK LAEVKAVVAE RGWRHSLWVP SGEGSAALAP HRTSEHKSSL VPLDAREHEW 610 620 630 640 650 660 IVKLASGSWI QVWTLFWEDP QLALHKDFLT GYTALHWIAK HGDLRALQDL VSGAKKAGIV 670 680 690 700 710 720 LDVNVRSSCG YTPLHLAAIH GHQGVIKLLV QRLASRVNVR DSSGKKPWQY LTSNTSGEIW 730 740 750 760 770 780 QLLGAPRGKP IFPVYPLVGS SSPTRKAKSK EISRSVTRKT SFAALLKSQH NKWKLANQYE 790 KFHSPREREE YSD

References

[1]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC104687 Genomic DNA. No translation available. BC137241 mRNA. Translation: AAI37242.1. BC137255 mRNA. Translation: AAI37256.1.
IPI	IPI00234154.
RefSeq	NP_001025041.1. NM_001029870.1.
UniGene	Hs.257292.
3D structure databases
ProteinModelPortal	A6NEL2.
SMR	A6NEL2. Positions 629-726.
ModBase	Search...
Protein-protein interaction databases
STRING	A6NEL2.
PTM databases
PhosphoSite	A6NEL2.
Proteomic databases
PRIDE	A6NEL2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000334306; ENSP00000334879; ENSG00000186212.
GeneID	345079.
KEGG	hsa:345079.
NMPDR	fig|9606.3.peg.24294.
UCSC	uc003hki.1. human.
Organism-specific databases
CTD	345079.
GeneCards	GC04M077816.
HGNC	HGNC:32958. ANKRD56.
HPA	HPA036809.
neXtProt	NX_A6NEL2.
PharmGKB	PA145149864.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG10681.
GeneTree	ENSGT00530000063547.
HOGENOM	HBG126596.
HOVERGEN	HBG094934.
InParanoid	A6NEL2.
OMA	RTREWVA.
OrthoDB	EOG408N97.
PhylomeDB	A6NEL2.
Gene expression databases
Bgee	A6NEL2.
CleanEx	HS_ANKRD56.
Genevestigator	A6NEL2.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF12796. Ank_2. 1 hit. [Graphical view]
SMART	SM00248. ANK. 2 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	98826.

Entry information

Entry name

ANR56_HUMAN

Accession

Primary (citable) accession number: A6NEL2
Secondary accession number(s): B2RP29

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 24, 2007
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.