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A6NEL2 (ANR56_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ankyrin repeat domain-containing protein 56
Gene names
Name:ANKRD56
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length793 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 2 ANK repeats.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainANK repeat
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 793793Ankyrin repeat domain-containing protein 56
PRO_0000317240

Regions

Repeat630 – 65930ANK 1
Repeat669 – 69931ANK 2
Compositional bias121 – 1255Poly-Arg
Compositional bias134 – 274141Ala-rich
Compositional bias300 – 3045Poly-Gln

Natural variations

Natural variant1521D → G.
Corresponds to variant rs2703129 [ dbSNP | Ensembl ].
VAR_059126
Natural variant3771P → T.
Corresponds to variant rs2703130 [ dbSNP | Ensembl ].
VAR_048280

Sequences

Sequence LengthMass (Da)Tools
A6NEL2 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 8072B1D09C52F32F

FASTA79385,742
        10         20         30         40         50         60 
MARELSQEAL LDFLCQAGGR VTNAALLSHF KSFLRDPDAS PSQHQHRREL FKGFVNSVAA 

        70         80         90        100        110        120 
VRQDPDGTKY VVLKRRYRDL LGEEGLQRPR EPPAAAPSAG GAAPCSPRGA RRGEPPQQQP 

       130        140        150        160        170        180 
RRRRREKEPE EEPAGAAARA ADAACNGLPG SDSRRAPGKG GGSKGSPGQR PPVPAAAAAG 

       190        200        210        220        230        240 
AQARASCAAA KTQGRCCWEC LQNNLAVLPG ELGALPHSAT AEEKPARALP AQDDRGASRE 

       250        260        270        280        290        300 
REEGALAEPA PVPAVAHSPP ATVEAATSRA SPPALLPGPA PRGDRPELLT PSSLHYSTLQ 

       310        320        330        340        350        360 
QQQQRTREWV ARHPQVPEAR DQGPIRAWSV LPDNFLQLPL EPGSTEPNSE PPDPCLSSHS 

       370        380        390        400        410        420 
LFPVVPDESW ESWAGNPSLT VFRSIRCQLS LQDLDDFVDQ ESDGSEESSS GPKDSPGASE 

       430        440        450        460        470        480 
EGLQVVLGTP DRGKLRNPAG GLSVSRKEGS PSRSPQGLRN RGDGHISQQV PAGANGLAGH 

       490        500        510        520        530        540 
PLKPLPWPVP KLRRSLRRSS LAGRAKLSSS DEEYLDEGLL KRSRRPPRSR KPSKAGTAPS 

       550        560        570        580        590        600 
PRVDAGLSLK LAEVKAVVAE RGWRHSLWVP SGEGSAALAP HRTSEHKSSL VPLDAREHEW 

       610        620        630        640        650        660 
IVKLASGSWI QVWTLFWEDP QLALHKDFLT GYTALHWIAK HGDLRALQDL VSGAKKAGIV 

       670        680        690        700        710        720 
LDVNVRSSCG YTPLHLAAIH GHQGVIKLLV QRLASRVNVR DSSGKKPWQY LTSNTSGEIW 

       730        740        750        760        770        780 
QLLGAPRGKP IFPVYPLVGS SSPTRKAKSK EISRSVTRKT SFAALLKSQH NKWKLANQYE 

       790 
KFHSPREREE YSD 

« Hide

References

[1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed: 15815621] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC104687 Genomic DNA. No translation available.
BC137241 mRNA. Translation: AAI37242.1.
BC137255 mRNA. Translation: AAI37256.1.
IPIIPI00234154.
RefSeqNP_001025041.1. NM_001029870.1.
UniGeneHs.257292.

3D structure databases

ProteinModelPortalA6NEL2.
SMRA6NEL2. Positions 629-726.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6NEL2.

PTM databases

PhosphoSiteA6NEL2.

Proteomic databases

PRIDEA6NEL2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000334306; ENSP00000334879; ENSG00000186212.
GeneID345079.
KEGGhsa:345079.
NMPDRfig|9606.3.peg.24294.
UCSCuc003hki.1. human.

Organism-specific databases

CTD345079.
GeneCardsGC04M077816.
HGNCHGNC:32958. ANKRD56.
HPAHPA036809.
neXtProtNX_A6NEL2.
PharmGKBPA145149864.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG10681.
GeneTreeENSGT00530000063547.
HOGENOMHBG126596.
HOVERGENHBG094934.
InParanoidA6NEL2.
OMARTREWVA.
OrthoDBEOG408N97.
PhylomeDBA6NEL2.

Gene expression databases

BgeeA6NEL2.
CleanExHS_ANKRD56.
GenevestigatorA6NEL2.

Family and domain databases

InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
Gene3DG3DSA:1.25.40.20. ANK. 1 hit.
PfamPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMSSF48403. ANK. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio98826.

Entry information

Entry nameANR56_HUMAN
AccessionPrimary (citable) accession number: A6NEL2
Secondary accession number(s): B2RP29
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 24, 2007
Last modified: January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families