A6NEK1 (ARRD5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arrestin domain-containing protein 5

Gene names

Name:

ARRDC5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	342 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the arrestin family.
Caution	It is uncertain whether Met-1 or Met-15 is the initiator.
Sequence caution	The sequence EAW69191.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	signal transduction Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 342	342	Arrestin domain-containing protein 5		PRO_0000309620

Sequences

	Sequence		Length	Mass (Da)
	A6NEK1 [UniParc]. Last modified March 8, 2011. Version 2. Checksum: A009077E00D30F35	FASTA	342	38,383
	10 20 30 40 50 60 MGDREECLST PQPPMSVVKS IELVLPEDRI YLAGSSIKGQ VILTLNSTLV DPIVKVELVG 70 80 90 100 110 120 RGYVEWSEEA GASCDYSRNV ICNNKADYVH KTKTFPVEDN WLSAGSHTFD FHFNLPPRLP 130 140 150 160 170 180 STFTSKFGHV FYFVQASCMG REHILAKKRM YLLVQGTSTF HKETPFQNPL FVEAEEKVSY 190 200 210 220 230 240 NCCRQGTVCL QIQMERNTFT PGEKVVFTTE INNQTSKCIK TVVFALYAHI QYEGFTPSAE 250 260 270 280 290 300 RRSRLDSSEL LRQEANTPVT RFNTTKVVST FNLPLLLSVS SSTQDGEIMH TRYELVTTVH 310 320 330 340 LPWSLTSLKA KVPIIITSAS VDSAICQLSE DGVLPVNPDH QN

References

[1]

"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC027319 Genomic DNA. No translation available. CH471139 Genomic DNA. Translation: EAW69191.1. Different initiation.
IPI	IPI00643956.
RefSeq	NP_001073992.1. NM_001080523.1.
UniGene	Hs.574574.
3D structure databases
ProteinModelPortal	A6NEK1.
ModBase	Search...
PTM databases
PhosphoSite	A6NEK1.
Proteomic databases
PRIDE	A6NEK1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000381781; ENSP00000371200; ENSG00000205784.
GeneID	645432.
KEGG	hsa:645432.
UCSC	uc002mbm.1. human.
Organism-specific databases
CTD	645432.
GeneCards	GC19M004844.
HGNC	HGNC:31407. ARRDC5.
neXtProt	NX_A6NEK1.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG11761.
GeneTree	ENSGT00510000049183.
HOGENOM	HBG506062.
HOVERGEN	HBG080868.
InParanoid	A6NEK1.
OMA	ADYVHKT.
OrthoDB	EOG4J3WHC.
PhylomeDB	A6NEK1.
Gene expression databases
CleanEx	HS_ARRDC5.
Genevestigator	A6NEK1.
Family and domain databases
InterPro	IPR011021. Arrestin-like_N. IPR014752. Arrestin_C. IPR011022. Arrestin_C-like. IPR014756. Ig_E-set. [Graphical view]
Gene3D	G3DSA:2.60.40.640. Arrestin_C. 1 hit.
Pfam	PF02752. Arrestin_C. 1 hit. PF00339. Arrestin_N. 1 hit. [Graphical view]
SMART	SM01017. Arrestin_C. 1 hit. [Graphical view]
SUPFAM	SSF81296. Ig_E-set. 2 hits.
ProtoNet	Search...

Entry information

Entry name

ARRD5_HUMAN

Accession

Primary (citable) accession number: A6NEK1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	March 8, 2011
Last modified:	January 25, 2012
This is version 35 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.