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Protein

Transmembrane protein 247

Gene

TMEM247

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 247
Gene namesi
Name:TMEM247
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:42967. TMEM247.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei167 – 18721HelicalSequence AnalysisAdd
BLAST
Transmembranei194 – 21421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiTMEM247.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Transmembrane protein 247PRO_0000328813Add
BLAST

Proteomic databases

PaxDbiA6NEH6.
PRIDEiA6NEH6.

PTM databases

PhosphoSiteiA6NEH6.

Expressioni

Gene expression databases

BgeeiA6NEH6.
GenevisibleiA6NEH6. HS.

Organism-specific databases

HPAiHPA049130.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000388684.

Structurei

3D structure databases

ProteinModelPortaliA6NEH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili121 – 15636Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41616.
GeneTreeiENSGT00390000002879.
HOGENOMiHOG000168313.
HOVERGENiHBG108691.
InParanoidiA6NEH6.
OMAiLFSKHYL.
OrthoDBiEOG7288SD.
PhylomeDBiA6NEH6.
TreeFamiTF337834.

Family and domain databases

InterProiIPR029200. TMEM247.
[Graphical view]
PfamiPF15444. TMEM247. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NEH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEDREMME ARGAGESCPT FPKMVPGDSK SEGKPRAYLE AESQKPDSSY
60 70 80 90 100
DYLEEMEACE DGGCQGPLKS LSPKSCRATK GQAGDGPKPA ELPPTPGTER
110 120 130 140 150
NPEMELEKVR MEFELTRLKY LHEKNQRQRQ HEVVMEQLQR ERQHEVVMEQ
160 170 180 190 200
LQQEAAPRLF SGGLQNFLLP QNQFAMFLYC FIFIHIIYVT KEMVFFLFAK
210
HYLFCIAAIL LCLIKTFWS
Length:219
Mass (Da):25,168
Last modified:April 8, 2008 - v2
Checksum:i83A376D61158E80E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018682 Genomic DNA. No translation available.
CCDSiCCDS56117.1.
RefSeqiNP_001138523.1. NM_001145051.2.
UniGeneiHs.733348.

Genome annotation databases

EnsembliENST00000434431; ENSP00000388684; ENSG00000187600.
GeneIDi388946.
KEGGihsa:388946.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018682 Genomic DNA. No translation available.
CCDSiCCDS56117.1.
RefSeqiNP_001138523.1. NM_001145051.2.
UniGeneiHs.733348.

3D structure databases

ProteinModelPortaliA6NEH6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000388684.

PTM databases

PhosphoSiteiA6NEH6.

Polymorphism and mutation databases

BioMutaiTMEM247.

Proteomic databases

PaxDbiA6NEH6.
PRIDEiA6NEH6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000434431; ENSP00000388684; ENSG00000187600.
GeneIDi388946.
KEGGihsa:388946.

Organism-specific databases

CTDi388946.
GeneCardsiGC02P046657.
HGNCiHGNC:42967. TMEM247.
HPAiHPA049130.
neXtProtiNX_A6NEH6.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG41616.
GeneTreeiENSGT00390000002879.
HOGENOMiHOG000168313.
HOVERGENiHBG108691.
InParanoidiA6NEH6.
OMAiLFSKHYL.
OrthoDBiEOG7288SD.
PhylomeDBiA6NEH6.
TreeFamiTF337834.

Miscellaneous databases

GenomeRNAii388946.
NextBioi102462.
PROiA6NEH6.

Gene expression databases

BgeeiA6NEH6.
GenevisibleiA6NEH6. HS.

Family and domain databases

InterProiIPR029200. TMEM247.
[Graphical view]
PfamiPF15444. TMEM247. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTM247_HUMAN
AccessioniPrimary (citable) accession number: A6NEH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: June 24, 2015
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.