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Protein

Transmembrane protein 247

Gene

TMEM247

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 247
Gene namesi
Name:TMEM247
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000187600.12.
HGNCiHGNC:42967. TMEM247.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187600.

Polymorphism and mutation databases

BioMutaiTMEM247.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003288131 – 219Transmembrane protein 247Add BLAST219

Proteomic databases

PaxDbiA6NEH6.
PRIDEiA6NEH6.

PTM databases

PhosphoSitePlusiA6NEH6.

Expressioni

Gene expression databases

BgeeiENSG00000187600.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000388684.

Structurei

3D structure databases

ProteinModelPortaliA6NEH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili121 – 156Sequence analysisAdd BLAST36

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J4VW. Eukaryota.
ENOG41113DE. LUCA.
GeneTreeiENSGT00390000002879.
HOGENOMiHOG000168313.
HOVERGENiHBG108691.
InParanoidiA6NEH6.
OMAiQNQFAMF.
OrthoDBiEOG091G0P0P.
PhylomeDBiA6NEH6.
TreeFamiTF337834.

Family and domain databases

InterProiView protein in InterPro
IPR029200. TMEM247.
PfamiView protein in Pfam
PF15444. TMEM247. 2 hits.

Sequencei

Sequence statusi: Complete.

A6NEH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEDREMME ARGAGESCPT FPKMVPGDSK SEGKPRAYLE AESQKPDSSY
60 70 80 90 100
DYLEEMEACE DGGCQGPLKS LSPKSCRATK GQAGDGPKPA ELPPTPGTER
110 120 130 140 150
NPEMELEKVR MEFELTRLKY LHEKNQRQRQ HEVVMEQLQR ERQHEVVMEQ
160 170 180 190 200
LQQEAAPRLF SGGLQNFLLP QNQFAMFLYC FIFIHIIYVT KEMVFFLFAK
210
HYLFCIAAIL LCLIKTFWS
Length:219
Mass (Da):25,168
Last modified:April 8, 2008 - v2
Checksum:i83A376D61158E80E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018682 Genomic DNA. No translation available.
CCDSiCCDS56117.1.
RefSeqiNP_001138523.1. NM_001145051.2.
UniGeneiHs.733348.

Genome annotation databases

EnsembliENST00000434431; ENSP00000388684; ENSG00000187600.
GeneIDi388946.
KEGGihsa:388946.
UCSCiuc061ivl.1. human.

Similar proteinsi

Entry informationi

Entry nameiTM247_HUMAN
AccessioniPrimary (citable) accession number: A6NEH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: September 27, 2017
This is version 68 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM