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Protein

Pleckstrin homology domain-containing family D member 1

Gene

PLEKHD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family D member 1
Short name:
PH domain-containing family D member 1
Gene namesi
Name:PLEKHD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20148. PLEKHD1.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175985.

Polymorphism and mutation databases

BioMutaiPLEKHD1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003491961 – 506Pleckstrin homology domain-containing family D member 1Add BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei503Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiA6NEE1.
PRIDEiA6NEE1.

PTM databases

iPTMnetiA6NEE1.
PhosphoSitePlusiA6NEE1.

Expressioni

Gene expression databases

BgeeiENSG00000175985.

Organism-specific databases

HPAiHPA051875.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000317175.

Structurei

3D structure databases

ProteinModelPortaliA6NEE1.
SMRiA6NEE1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 136PHPROSITE-ProRule annotationAdd BLAST109

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili146 – 391Sequence analysisAdd BLAST246

Sequence similaritiesi

Belongs to the PLEKHD1 family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE09. Eukaryota.
ENOG410YFD5. LUCA.
GeneTreeiENSGT00510000048833.
HOGENOMiHOG000060105.
HOVERGENiHBG108639.
InParanoidiA6NEE1.
OMAiHEDFHGN.
OrthoDBiEOG091G0NZC.
PhylomeDBiA6NEE1.
TreeFamiTF320494.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NEE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTSKSNSVS PSPSLEQADS DALDISTKVQ LYGVLWKRPF GRPSAKWSRR
60 70 80 90 100
FFIIKESFLL YYSESEKKSF ETNKYFNIHP KGVIPLGGCL VEPKEEPSMP
110 120 130 140 150
YAMKISHQDF HGNILLAAES EFEQTQWLEM LQESGKVTWK NAQLGEAMIK
160 170 180 190 200
SLEAQGLQLA KEKQEYLDKL MEETEELCLQ REQREELERL NQVLEAEKQQ
210 220 230 240 250
FEEVVQELRM EQEQIKRELE LTARCLKGVE QEKKELRHLT ESLQQTLEEL
260 270 280 290 300
SIEKKKTLEM LEENENHLQT LANQSEQPPP SGGLHSNLRQ IEEKMQQLLE
310 320 330 340 350
EKLLAEKRMK ENEERSRALE EEREFYSSQS QALQNSLQEL TAEKQQAERE
360 370 380 390 400
LKAEVKVRMD LERRLREAEG ALRSLEQGLN SKVRNKEKEE RMRADVSHLK
410 420 430 440 450
RFFEECIRNA ELEAKMPVIM KNSVYIHKAA TRRIKSCRFH RRRSSTSWND
460 470 480 490 500
MKPSQSFMTS QLDANNMEEL KEVAKRLSRD QRFRESIYHI MATQPGAPSA

LSRGGK
Length:506
Mass (Da):59,203
Last modified:February 22, 2012 - v3
Checksum:iF97AAE61E8840FC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133445 Genomic DNA. No translation available.
AL157996 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW80997.1.
BC146872 mRNA. Translation: AAI46873.1.
CCDSiCCDS53903.1.
RefSeqiNP_001154970.1. NM_001161498.1.
UniGeneiHs.509796.

Genome annotation databases

EnsembliENST00000322564; ENSP00000317175; ENSG00000175985.
GeneIDi400224.
KEGGihsa:400224.
UCSCiuc010ttf.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133445 Genomic DNA. No translation available.
AL157996 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW80997.1.
BC146872 mRNA. Translation: AAI46873.1.
CCDSiCCDS53903.1.
RefSeqiNP_001154970.1. NM_001161498.1.
UniGeneiHs.509796.

3D structure databases

ProteinModelPortaliA6NEE1.
SMRiA6NEE1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000317175.

PTM databases

iPTMnetiA6NEE1.
PhosphoSitePlusiA6NEE1.

Polymorphism and mutation databases

BioMutaiPLEKHD1.

Proteomic databases

PaxDbiA6NEE1.
PRIDEiA6NEE1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322564; ENSP00000317175; ENSG00000175985.
GeneIDi400224.
KEGGihsa:400224.
UCSCiuc010ttf.2. human.

Organism-specific databases

CTDi400224.
GeneCardsiPLEKHD1.
HGNCiHGNC:20148. PLEKHD1.
HPAiHPA051875.
neXtProtiNX_A6NEE1.
OpenTargetsiENSG00000175985.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE09. Eukaryota.
ENOG410YFD5. LUCA.
GeneTreeiENSGT00510000048833.
HOGENOMiHOG000060105.
HOVERGENiHBG108639.
InParanoidiA6NEE1.
OMAiHEDFHGN.
OrthoDBiEOG091G0NZC.
PhylomeDBiA6NEE1.
TreeFamiTF320494.

Miscellaneous databases

ChiTaRSiPLEKHD1. human.
GenomeRNAii400224.
PROiA6NEE1.

Gene expression databases

BgeeiENSG00000175985.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLHD1_HUMAN
AccessioniPrimary (citable) accession number: A6NEE1
Secondary accession number(s): B9EJC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: February 22, 2012
Last modified: November 2, 2016
This is version 66 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.