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Protein

RCC1 domain-containing protein 1

Gene

RCCD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
RCC1 domain-containing protein 1
Gene namesi
Name:RCCD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:30457. RCCD1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671092.

Polymorphism and mutation databases

BioMutaiRCCD1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376RCC1 domain-containing protein 1PRO_0000337973Add
BLAST

Proteomic databases

EPDiA6NED2.
MaxQBiA6NED2.
PaxDbiA6NED2.
PRIDEiA6NED2.

PTM databases

iPTMnetiA6NED2.
PhosphoSiteiA6NED2.

Expressioni

Gene expression databases

BgeeiENSG00000166965.
CleanExiHS_RCCD1.
ExpressionAtlasiA6NED2. baseline and differential.
GenevisibleiA6NED2. HS.

Organism-specific databases

HPAiHPA039683.
HPA040776.

Interactioni

Protein-protein interaction databases

BioGridi124832. 20 interactions.
STRINGi9606.ENSP00000377801.

Structurei

3D structure databases

ProteinModelPortaliA6NED2.
SMRiA6NED2. Positions 119-370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati6 – 5651RCC1 1Add
BLAST
Repeati176 – 22752RCC1 2Add
BLAST
Repeati229 – 31789RCC1 3Add
BLAST
Repeati318 – 37154RCC1 4Add
BLAST

Sequence similaritiesi

Contains 4 RCC1 repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1426. Eukaryota.
COG5184. LUCA.
GeneTreeiENSGT00830000128260.
HOGENOMiHOG000154085.
HOVERGENiHBG061852.
InParanoidiA6NED2.
OMAiWASEGLL.
OrthoDBiEOG091G0MAE.
PhylomeDBiA6NED2.
TreeFamiTF329484.

Family and domain databases

Gene3Di2.130.10.30. 2 hits.
InterProiIPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PfamiPF00415. RCC1. 3 hits.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SUPFAMiSSF50985. SSF50985. 3 hits.
PROSITEiPS00626. RCC1_2. 2 hits.
PS50012. RCC1_3. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NED2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEERPGAWF GFGFCGFGQE LGSGRGRQVH SPSPLRAGVD ICRVSASWSY
60 70 80 90 100
TAFVTRGGRL ELSGSASGAA GRCKDAWASE GLLAVLRAGP GPEALLQVWA
110 120 130 140 150
AESALRGEPL WAQNVVPEAE GEDDPAGEAQ AGRLPLLPCA RAYVSPRAPF
160 170 180 190 200
YRPLAPELRA RQLELGAEHA LLLDAAGQVF SWGGGRHGQL GHGTLEAELE
210 220 230 240 250
PRLLEALQGL VMAEVAAGGW HSVCVSETGD IYIWGWNESG QLALPTRNLA
260 270 280 290 300
EDGETVAREA TELNEDGSQV KRTGGAEDGA PAPFIAVQPF PALLDLPMGS
310 320 330 340 350
DAVKASCGSR HTAVVTRTGE LYTWGWGKYG QLGHEDTTSL DRPRRVEYFV
360 370
DKQLQVKAVT CGPWNTYVYA VEKGKS
Length:376
Mass (Da):40,079
Last modified:July 24, 2007 - v1
Checksum:iF72566D12352BBAE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti133 – 18654RLPLL…WGGGR → GGAAGGLVRLRFLRLRAGAG LRTRAPGAQPQSAAGGRRHL PRERELELHRFRDP in AAI13827 (PubMed:15489334).CuratedAdd
BLAST

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81A → S.
Corresponds to variant rs4932380 [ dbSNP | Ensembl ].
VAR_043727

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068831 Genomic DNA. No translation available.
CH471101 Genomic DNA. Translation: EAX02130.1.
BC113826 mRNA. Translation: AAI13827.1.
BC140708 mRNA. Translation: AAI40709.1.
BC140709 mRNA. Translation: AAI40710.1.
CCDSiCCDS32333.1.
RefSeqiNP_001017919.1. NM_001017919.1.
NP_291022.2. NM_033544.2.
UniGeneiHs.655895.

Genome annotation databases

EnsembliENST00000394258; ENSP00000377801; ENSG00000166965.
ENST00000556618; ENSP00000451963; ENSG00000166965.
GeneIDi91433.
KEGGihsa:91433.
UCSCiuc002bqk.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068831 Genomic DNA. No translation available.
CH471101 Genomic DNA. Translation: EAX02130.1.
BC113826 mRNA. Translation: AAI13827.1.
BC140708 mRNA. Translation: AAI40709.1.
BC140709 mRNA. Translation: AAI40710.1.
CCDSiCCDS32333.1.
RefSeqiNP_001017919.1. NM_001017919.1.
NP_291022.2. NM_033544.2.
UniGeneiHs.655895.

3D structure databases

ProteinModelPortaliA6NED2.
SMRiA6NED2. Positions 119-370.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124832. 20 interactions.
STRINGi9606.ENSP00000377801.

PTM databases

iPTMnetiA6NED2.
PhosphoSiteiA6NED2.

Polymorphism and mutation databases

BioMutaiRCCD1.

Proteomic databases

EPDiA6NED2.
MaxQBiA6NED2.
PaxDbiA6NED2.
PRIDEiA6NED2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394258; ENSP00000377801; ENSG00000166965.
ENST00000556618; ENSP00000451963; ENSG00000166965.
GeneIDi91433.
KEGGihsa:91433.
UCSCiuc002bqk.4. human.

Organism-specific databases

CTDi91433.
GeneCardsiRCCD1.
HGNCiHGNC:30457. RCCD1.
HPAiHPA039683.
HPA040776.
neXtProtiNX_A6NED2.
PharmGKBiPA142671092.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1426. Eukaryota.
COG5184. LUCA.
GeneTreeiENSGT00830000128260.
HOGENOMiHOG000154085.
HOVERGENiHBG061852.
InParanoidiA6NED2.
OMAiWASEGLL.
OrthoDBiEOG091G0MAE.
PhylomeDBiA6NED2.
TreeFamiTF329484.

Miscellaneous databases

ChiTaRSiRCCD1. human.
GenomeRNAii91433.
PROiA6NED2.

Gene expression databases

BgeeiENSG00000166965.
CleanExiHS_RCCD1.
ExpressionAtlasiA6NED2. baseline and differential.
GenevisibleiA6NED2. HS.

Family and domain databases

Gene3Di2.130.10.30. 2 hits.
InterProiIPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PfamiPF00415. RCC1. 3 hits.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SUPFAMiSSF50985. SSF50985. 3 hits.
PROSITEiPS00626. RCC1_2. 2 hits.
PS50012. RCC1_3. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRCCD1_HUMAN
AccessioniPrimary (citable) accession number: A6NED2
Secondary accession number(s): B2RTP9, Q29RX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 24, 2007
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.