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Protein

WD repeat-containing protein 97

Gene

WDR97

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiA6NE52.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 97Imported
Gene namesi
Name:WDR97Imported
Synonyms:KIAA1875
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:26959. WDR97.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16221622WD repeat-containing protein 97PRO_0000332994Add
BLAST

Proteomic databases

EPDiA6NE52.
PaxDbiA6NE52.
PRIDEiA6NE52.

PTM databases

iPTMnetiA6NE52.

Expressioni

Gene expression databases

BgeeiA6NE52.
CleanExiHS_KIAA1875.
ExpressionAtlasiA6NE52. baseline and differential.
GenevisibleiA6NE52. HS.

Organism-specific databases

HPAiHPA059409.

Interactioni

Protein-protein interaction databases

IntActiA6NE52. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliA6NE52.
SMRiA6NE52. Positions 307-362, 557-585.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati187 – 23347WD 1Add
BLAST
Repeati290 – 32940WD 2Add
BLAST
Repeati331 – 37040WD 3Add
BLAST
Repeati552 – 59241WD 4Add
BLAST
Repeati594 – 63340WD 5Add
BLAST
Repeati687 – 72640WD 6Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1094 – 111825Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1509 – 160597Pro-richAdd
BLAST

Sequence similaritiesi

Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IEN5. Eukaryota.
ENOG410ZARW. LUCA.
GeneTreeiENSGT00390000011787.
HOGENOMiHOG000113181.
InParanoidiA6NE52.
OMAiHSKASQL.
PhylomeDBiA6NE52.

Family and domain databases

Gene3Di2.130.10.10. 4 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NE52-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAEVWEAEG YNLVLDSDLY DADGYDVPDP GLLTEKNELT FTEPSQVLPF
60 70 80 90 100
LTSSQQWQSL TPRARARRLW LLLRTSLHEV VEKEKRAELR AARLTHGLEP
110 120 130 140 150
LRRLEVAAGL RSVAQDPVGG RFVVLDGAGR LHLHKEDGWA QETLLAPVRL
160 170 180 190 200
TGLVTVLGPL GAVGRFVGWG PAGLAILRPN LSLLWLSEQG VGRAPGWAPT
210 220 230 240 250
CCLPVPDLRL LLVAEMNSSL ALWQFRSGGR RLVLRGSALH PPPSPTGRLM
260 270 280 290 300
RLAVAPVPPH HVLRCFAAYG SAVLTFDLHA WTLVDVRRDL HKTTISDLAY
310 320 330 340 350
CEEVEAMVTA SRDSTVKVWE ADWQIRMVFV GHTGPVTAMT VLPNTTLVLS
360 370 380 390 400
ASQDGTLRTW DLQAAAQVGE VALGFWGQDK LSRRVGRLLA PVRPGWPVLS
410 420 430 440 450
LCASSMQLWR VRELYSPLAQ LPAKVLHVQV APALPAPAHQ SLPTRLVCAC
460 470 480 490 500
ADGSVYLLSA ATGRIVSSLL LEPEDCAAAV AYCLPREALW LLTRAGHLVR
510 520 530 540 550
ANAARCPMSV LHRVCPPPPP APQPCCLHLY SHLTDLEGAF SSWEIVRQHW
560 570 580 590 600
GELRCSSVAC AWKNKNRYLP VVGHTDGTLS VLEWLSSKTV FQTEAHSPGP
610 620 630 640 650
VVAIASTWNS IVSSGGDLTV KMWRVFPYAE ESLSLLRTFS CCYPAVALCA
660 670 680 690 700
LGRRVTAGFE DPDSATYGLV QFGLGDSPRL DHRPQDDPTD HITGLCCCPT
710 720 730 740 750
LKLYACSSLD CTVRIWTAEN RLLRLLQLNG APQALAFCSN SGDLVLALGS
760 770 780 790 800
RLCLVSHRLY LPTSYLVKKM CRKAPDVVDD PPLPLMSQES LTSAQLQRLT
810 820 830 840 850
NLHGAASLSE ALSLIHRRRA TSQHLVPKED LDAIVARDRD LQQLRLGLVV
860 870 880 890 900
PAAQPPPSWQ QRQEGFDNYL RLIYGSGLLG MQSGRGSQQW SAGTLRVERE
910 920 930 940 950
TRDVCAVPQA AHCLARAEVS TAAQTVPTAL SPQDLGALGQ HFSQSPRVTV
960 970 980 990 1000
PIPPTHRRVH SKASQLLARS SLSHYLGISL DLQLQLEQLR GRTTMALDLP
1010 1020 1030 1040 1050
SSHLQCRIPL LPKRWDKEPL SSLRGFFPAT VQPHKHCLRP ICFPGYVPNS
1060 1070 1080 1090 1100
AVLQQMWLNA EPGASQDALW LWRPRPSQTQ WQRKLLQWMG EKPGEEGEED
1110 1120 1130 1140 1150
KKEEEEEKED EELDWALASL SPHSNQQLDS WELEDQSAVD WTQEPRRRSC
1160 1170 1180 1190 1200
KVARTHPHPW HRHGSLLLDE HYGHLPKFLH FFIYQTWFKK LFPIFSLQAY
1210 1220 1230 1240 1250
PEAGTIEGLA SLLVALLEKT TWVDRVHILQ VLLRLLPNMS SDLQGQLQGL
1260 1270 1280 1290 1300
LVHLLNLDQP PSLQDQTQKK FVILALQLLL ACSLESRDVV LELMSYFLYS
1310 1320 1330 1340 1350
PVHCRPELKK LLHGLGLQDP EGFLFKEMMT WVQGPDLDSK AGLRTCCHQK
1360 1370 1380 1390 1400
LEDMIQELQE TPSQTSVVSG APTRASVIPS GTSWSASGIF GRLSQVSEVP
1410 1420 1430 1440 1450
LMVVSPAEPH SLAPELQAQR MLAPKRSWGT PQLRLRVLSE TLKSFCLEPE
1460 1470 1480 1490 1500
ARLHPAGPAQ LPGEPPPLEE TDWSHSQLLD LGPIDALNFF CEQLRAQQRS
1510 1520 1530 1540 1550
SLQEKAAHPH PPEPYTVAPV PDMVVPPPRE HWYHPILRLQ EAKPQRSARS
1560 1570 1580 1590 1600
AMRLRGPMRS RLCAGRTLDG PIRTLKLPLP RVEPQPFPLD WPMPPRPLPP
1610 1620
RLLQPALQRY FLPADADPDT YS
Note: No experimental confirmation available.
Length:1,622
Mass (Da):180,307
Last modified:May 20, 2008 - v2
Checksum:i3991010D04BFD01A
GO
Isoform 2 (identifier: A6NE52-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     809-837: SEALSLIHRRRATSQHLVPKEDLDAIVAR → RSHGGLLSPPGGPPFPLWVGAWRCGALWS
     838-1622: Missing.

Note: No experimental confirmation available.
Show »
Length:837
Mass (Da):91,360
Checksum:i4AB02FFBFA80A027
GO

Sequence cautioni

The sequence BAB47504.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti430 – 4301V → L in BAB47504 (PubMed:11347906).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti149 – 1491R → G.1 Publication
Corresponds to variant rs4977196 [ dbSNP | Ensembl ].
VAR_043029
Natural varianti427 – 4271H → Q.
Corresponds to variant rs34324679 [ dbSNP | Ensembl ].
VAR_043030
Natural varianti537 – 5371E → G.1 Publication
Corresponds to variant rs13250446 [ dbSNP | Ensembl ].
VAR_043031

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei809 – 83729SEALS…AIVAR → RSHGGLLSPPGGPPFPLWVG AWRCGALWS in isoform 2. 1 PublicationVSP_033425Add
BLAST
Alternative sequencei838 – 1622785Missing in isoform 2. 1 PublicationVSP_033426Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058778 mRNA. Translation: BAB47504.1. Sequence problems.
AC104592 Genomic DNA. No translation available.
RefSeqiNP_001303238.1. NM_001316309.1. [A6NE52-1]
UniGeneiHs.98723.

Genome annotation databases

EnsembliENST00000323662; ENSP00000320648; ENSG00000179698. [A6NE52-1]
GeneIDi340390.
KEGGihsa:340390.
UCSCiuc064riy.1. human. [A6NE52-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058778 mRNA. Translation: BAB47504.1. Sequence problems.
AC104592 Genomic DNA. No translation available.
RefSeqiNP_001303238.1. NM_001316309.1. [A6NE52-1]
UniGeneiHs.98723.

3D structure databases

ProteinModelPortaliA6NE52.
SMRiA6NE52. Positions 307-362, 557-585.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA6NE52. 1 interaction.

PTM databases

iPTMnetiA6NE52.

Proteomic databases

EPDiA6NE52.
PaxDbiA6NE52.
PRIDEiA6NE52.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323662; ENSP00000320648; ENSG00000179698. [A6NE52-1]
GeneIDi340390.
KEGGihsa:340390.
UCSCiuc064riy.1. human. [A6NE52-1]

Organism-specific databases

CTDi340390.
GeneCardsiKIAA1875.
HGNCiHGNC:26959. WDR97.
HPAiHPA059409.
neXtProtiNX_A6NE52.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEN5. Eukaryota.
ENOG410ZARW. LUCA.
GeneTreeiENSGT00390000011787.
HOGENOMiHOG000113181.
InParanoidiA6NE52.
OMAiHSKASQL.
PhylomeDBiA6NE52.

Enzyme and pathway databases

SignaLinkiA6NE52.

Miscellaneous databases

PROiA6NE52.

Gene expression databases

BgeeiA6NE52.
CleanExiHS_KIAA1875.
ExpressionAtlasiA6NE52. baseline and differential.
GenevisibleiA6NE52. HS.

Family and domain databases

Gene3Di2.130.10.10. 4 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS GLY-149 AND GLY-537.
    Tissue: Brain.
  2. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiWDR97_HUMAN
AccessioniPrimary (citable) accession number: A6NE52
Secondary accession number(s): Q96JF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: June 8, 2016
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.