A6NDY0 (EPAB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Embryonic polyadenylate-binding protein 2
Short name=Embryonic poly(A)-binding protein 2
Short name=ePABP-2
Short name=ePABP2

Alternative name(s):
Embryonic poly(A)-binding protein type II
Poly(A)-binding protein nuclear-like 1

Gene names

Name:	PABPN1L
Synonyms:	EPABP2, PABPNL1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Binds the poly(A) tail of mRNA By similarity.
Subcellular location	Cytoplasm By similarity.
Tissue specificity	Expressed in various adult tissues. Ref.1
Sequence similarities	Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Ligand	RNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A6NDY0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A6NDY0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     190-190: Y → CCRKEPTSLGSAPQTAGAFEDTQAPGGHPSPTAASRAGPGSDHKGRTGPVENSHHGFHRIKGKTRF
     191-278: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: A6NDY0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     267-278: ARGKFSPWFSPY → TPAALTPLWARPLPWVVVSHVIK

Note: No experimental confirmation available.

Isoform 3 (identifier: A6NDY0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     154-154: V → LCLHRVCHQG...RSKPLVLHPG
     155-278: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Embryonic polyadenylate-binding protein 2		PRO_0000349172
Regions
	Domain	147 – 224	78	RRM
Natural variations
	Alternative sequence	154	1	V → LCLHRVCHQGLRAGRRGAGP EPLPGPGHQGAAEKNQLPWD QLHRPRGPSRTPRLQGGTLP PQRPPGQAPAQTTRAEPGPW KILTMVFTVLKGRPDFERGA GAWIRSKPLVLHPG in isoform 3.		VSP_035211
	Alternative sequence	155 – 278	124	Missing in isoform 3.		VSP_035212
	Alternative sequence	190	1	Y → CCRKEPTSLGSAPQTAGAFE DTQAPGGHPSPTAASRAGPG SDHKGRTGPVENSHHGFHRI KGKTRF in isoform 2.		VSP_035213
	Alternative sequence	191 – 278	88	Missing in isoform 2.		VSP_035214
	Alternative sequence	267 – 278	12	ARGKF…WFSPY → TPAALTPLWARPLPWVVVSH VIK in isoform 4.		VSP_040501

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 4662DAB7022CACD5	FASTA	278	30,386
	10 20 30 40 50 60 MWPFPSRSLF PPPTQAWLQT VSSDPEAQGW GAWNETKEIL GPEGGEGKEE KEEEEDAEED 70 80 90 100 110 120 QDGDAGFLLS LLEQENLAEC PLPDQELEAI KMKVCAMEQA EGTPRPPGVQ QQAEEEEGTA 130 140 150 160 170 180 AGQLLSPETV GCPLSGTPEE KVEADHRSVY VGNVDYGGSA EELEAHFSRC GEVHRVTILC 190 200 210 220 230 240 DKFSGHPKGY AYIEFATKGS VQAAVELDQS LFRGRVIKVL PKRTNFPGIS STDRGGLRGH 250 260 270 PGSRGAPFPH SGLQGRPRLR PQGQNRARGK FSPWFSPY
	Isoform 2 [UniParc]. Checksum: CFB6377FA13689F8	FASTA	255	27,382
	10 20 30 40 50 60 MWPFPSRSLF PPPTQAWLQT VSSDPEAQGW GAWNETKEIL GPEGGEGKEE KEEEEDAEED 70 80 90 100 110 120 QDGDAGFLLS LLEQENLAEC PLPDQELEAI KMKVCAMEQA EGTPRPPGVQ QQAEEEEGTA 130 140 150 160 170 180 AGQLLSPETV GCPLSGTPEE KVEADHRSVY VGNVDYGGSA EELEAHFSRC GEVHRVTILC 190 200 210 220 230 240 DKFSGHPKGC CRKEPTSLGS APQTAGAFED TQAPGGHPSP TAASRAGPGS DHKGRTGPVE 250 NSHHGFHRIK GKTRF
	Isoform 4 [UniParc]. Checksum: B7B2FE2E6A478128	FASTA	289	31,495
	10 20 30 40 50 60 MWPFPSRSLF PPPTQAWLQT VSSDPEAQGW GAWNETKEIL GPEGGEGKEE KEEEEDAEED 70 80 90 100 110 120 QDGDAGFLLS LLEQENLAEC PLPDQELEAI KMKVCAMEQA EGTPRPPGVQ QQAEEEEGTA 130 140 150 160 170 180 AGQLLSPETV GCPLSGTPEE KVEADHRSVY VGNVDYGGSA EELEAHFSRC GEVHRVTILC 190 200 210 220 230 240 DKFSGHPKGY AYIEFATKGS VQAAVELDQS LFRGRVIKVL PKRTNFPGIS STDRGGLRGH 250 260 270 280 PGSRGAPFPH SGLQGRPRLR PQGQNRTPAA LTPLWARPLP WVVVSHVIK
	Isoform 3 [UniParc]. Checksum: 481820E362076EB9	FASTA	267	29,017
	10 20 30 40 50 60 MWPFPSRSLF PPPTQAWLQT VSSDPEAQGW GAWNETKEIL GPEGGEGKEE KEEEEDAEED 70 80 90 100 110 120 QDGDAGFLLS LLEQENLAEC PLPDQELEAI KMKVCAMEQA EGTPRPPGVQ QQAEEEEGTA 130 140 150 160 170 180 AGQLLSPETV GCPLSGTPEE KVEADHRSVY VGNLCLHRVC HQGLRAGRRG AGPEPLPGPG 190 200 210 220 230 240 HQGAAEKNQL PWDQLHRPRG PSRTPRLQGG TLPPQRPPGQ APAQTTRAEP GPWKILTMVF 250 260 TVLKGRPDFE RGAGAWIRSK PLVLHPG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of the human ePAB and ePABP2 cDNAs and analysis of the expression patterns." Sakugawa N., Miyamoto T., Sato H., Ishikawa M., Horikawa M., Hayashi H., Ishikawa M., Sengoku K. J. Assist. Reprod. Genet. 25:215-221(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Ovary.
[2]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC092384 Genomic DNA. No translation available. BC130001 mRNA. Translation: AAI30002.1. BC130002 mRNA. Translation: AAI30003.1.
IPI	IPI00375983. IPI00854628. IPI00942797. IPI01021917.
RefSeq	NP_001073956.2. NM_001080487.2.
UniGene	Hs.730522.
3D structure databases
ProteinModelPortal	A6NDY0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000367609.
PTM databases
PhosphoSite	A6NDY0.
Proteomic databases
PaxDb	A6NDY0.
PRIDE	A6NDY0.
Protocols and materials databases
DNASU	390748.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000378358; ENSP00000367609; ENSG00000205022. ENST00000411789; ENSP00000405259; ENSG00000205022. ENST00000419291; ENSP00000408598; ENSG00000205022. ENST00000547152; ENSP00000449247; ENSG00000205022.
GeneID	390748.
KEGG	hsa:390748.
UCSC	uc002fmi.3. human. uc010vpd.2. human. uc010vpe.2. human.
Organism-specific databases
CTD	390748.
GeneCards	GC16M088928.
H-InvDB	HIX0059621.
HGNC	HGNC:37237. PABPN1L.
HPA	HPA043415.
neXtProt	NX_A6NDY0.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0724.
HOGENOM	HOG000208465.
HOVERGEN	HBG107480.
InParanoid	A6NDY0.
KO	K14396.
OMA	RCGEVHR.
Gene expression databases
ArrayExpress	A6NDY0.
Bgee	A6NDY0.
Genevestigator	A6NDY0.
Family and domain databases
Gene3D	3.30.70.330. 1 hit.
InterPro	IPR012677. Nucleotide-bd_a/b_plait. IPR000504. RRM_dom. [Graphical view]
Pfam	PF00076. RRM_1. 1 hit. [Graphical view]
SMART	SM00360. RRM. 1 hit. [Graphical view]
PROSITE	PS50102. RRM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	390748.
NextBio	104019.

Entry information

Entry name

EPAB2_HUMAN

Accession

Primary (citable) accession number: A6NDY0
Secondary accession number(s): A1L3B3, A2VDI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	July 24, 2007
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.