Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative zinc finger protein 840

Gene

ZNF840P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri151 – 17323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri207 – 22923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri235 – 25723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri277 – 29923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri305 – 32723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri361 – 38323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri389 – 41123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri417 – 43923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri445 – 46723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri473 – 49523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri501 – 52323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri549 – 57123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri577 – 59923C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri605 – 62723C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri633 – 65523C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri661 – 68323C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri689 – 71123C2H2-type 18PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative zinc finger protein 840
Alternative name(s):
Zinc finger protein 840 pseudogene
Gene namesi
Name:ZNF840P
Synonyms:C20orf157, ZNF840
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:34344. ZNF840P.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 716716Putative zinc finger protein 840PRO_0000332148Add
BLAST

Proteomic databases

PRIDEiA6NDX5.

PTM databases

iPTMnetiA6NDX5.
PhosphoSiteiA6NDX5.

Structurei

3D structure databases

ProteinModelPortaliA6NDX5.
SMRiA6NDX5. Positions 124-716.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 11372KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 18 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri151 – 17323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri207 – 22923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri235 – 25723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri277 – 29923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri305 – 32723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri361 – 38323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri389 – 41123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri417 – 43923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri445 – 46723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri473 – 49523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri501 – 52323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri549 – 57123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri577 – 59923C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri605 – 62723C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri633 – 65523C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri661 – 68323C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri689 – 71123C2H2-type 18PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG018163.
InParanoidiA6NDX5.
PhylomeDBiA6NDX5.

Family and domain databases

Gene3Di3.30.160.60. 20 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NDX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLMGHGKVE MLLYAVPLLK APNCLSSSMQ LPHGGGRHQE LVRFRDVAVV
60 70 80 90 100
FSPEEWDHLT PEQRNLYKDV MLDNCKYLAS LGNWTYKAHV MSSLKQGKEP
110 120 130 140 150
WMMEREVTGD PCPACQPALA TFRALNESGN AFRQSFHHGE YRTHRTFVQH
160 170 180 190 200
YECDDCGMAF GHVSQLTGHQ KIHKVGETHE YGENTRGFRH RSSFTMLQRI
210 220 230 240 250
CTLYKHFECN QCGETFNRPS KVIQHQSMHS GLKPYKCDVC QKAFRFLSSL
260 270 280 290 300
SIHQRFHVGN RVNLTRHQKT HTQRKPFSCN FCGKTFHRFS EKTQHLLIHT
310 320 330 340 350
RKKYYTCNYC KKEFNPYSKF ILHQRTHTGE KPHKCDVCEK SFKSISNLNK
360 370 380 390 400
HQKTHTGEKP FSCNECKKTF AQRTDLARHQ QIHTGKKSFI CSSCKKTFVR
410 420 430 440 450
LSDLTQHKGT HTGERPYQCT TCEKAFKYRS NFTKHQKTHS IGRPFACNEC
460 470 480 490 500
GKTYRLNWEL NQHKKIHTGE KPYECGECGK RFNNNSNLNK HKKIHTGEKH
510 520 530 540 550
FVCNQCGKAF SLNSKLSRHQ RTHNKKENSS KSVSNLNKHQ KTHAGEKPFP
560 570 580 590 600
CNECKKAFAQ RMDLARHQQI HTGRKPFICS SCKKTFVRLS DLTQHKGTHT
610 620 630 640 650
GERPYQCTTC EKAFKYQSNF TKHQKTHSIG RPFTCNECGK TFRLNWKLNQ
660 670 680 690 700
HKKIHTGEKP YECGECGKCF NNNSNLSKHK KIHTGEKHFV CNQCGKAFSL
710
NSKLSRHQIT HNKKKP
Length:716
Mass (Da):83,235
Last modified:December 16, 2008 - v5
Checksum:i32A5D13B52610D4B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti181 – 1811Y → C.
Corresponds to variant rs3752261 [ dbSNP | Ensembl ].
VAR_048027

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031686 Genomic DNA. No translation available.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031686 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliA6NDX5.
SMRiA6NDX5. Positions 124-716.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiA6NDX5.
PhosphoSiteiA6NDX5.

Proteomic databases

PRIDEiA6NDX5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiZNF840P.
HGNCiHGNC:34344. ZNF840P.
neXtProtiNX_A6NDX5.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG018163.
InParanoidiA6NDX5.
PhylomeDBiA6NDX5.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Family and domain databases

Gene3Di3.30.160.60. 20 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiZN840_HUMAN
AccessioniPrimary (citable) accession number: A6NDX5
Secondary accession number(s): Q6KAL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 16, 2008
Last modified: January 20, 2016
This is version 70 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.