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Protein

TBC1 domain family member 3B

Gene

TBC1D3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).By similarity

Miscellaneous

TBC1D3 is encoded by a collection of very similar paralogs with multiple copies of each paralog, some human genomes encoding well over 50 copies depending on ethnic origin of the donor.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 3B
Gene namesi
Name:TBC1D3B
Synonyms:TBC1D3I
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:27011. TBC1D3B.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi414059.
OpenTargetsiENSG00000274808.
PharmGKBiPA142670833.

Polymorphism and mutation databases

BioMutaiTBC1D3B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003002641 – 549TBC1 domain family member 3BAdd BLAST549

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi318S-palmitoyl cysteineBy similarity1
Lipidationi325S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation.By similarity
Palmitoylation is required for membrane localization and protects TBC1D3 from ubiquitination.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Ubl conjugation

Proteomic databases

PaxDbiA6NDS4.
PRIDEiA6NDS4.

PTM databases

iPTMnetiA6NDS4.
PhosphoSitePlusiA6NDS4.

Expressioni

Gene expression databases

BgeeiENSG00000224226.
ExpressionAtlasiA6NDS4. baseline and differential.
GenevisibleiA6NDS4. HS.

Organism-specific databases

HPAiHPA046969.
HPA047745.
HPA052553.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiA6NDS4. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliA6NDS4.
SMRiA6NDS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini101 – 293Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST193

Phylogenomic databases

eggNOGiKOG1102. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00860000133698.
HOGENOMiHOG000293177.
HOVERGENiHBG061154.
InParanoidiA6NDS4.
KOiK20134.
OMAiCHSEKEG.
OrthoDBiEOG091G05BV.
TreeFamiTF318099.

Family and domain databases

InterProiView protein in InterPro
IPR000195. Rab-GTPase-TBC_dom.
PfamiView protein in Pfam
PF00566. RabGAP-TBC. 1 hit.
SMARTiView protein in SMART
SM00164. TBC. 1 hit.
SUPFAMiSSF47923. SSF47923. 1 hit.
PROSITEiView protein in PROSITE
PS50086. TBC_RABGAP. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NDS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVVEVAGSW WAQEREDIIM KYEKGHRAGL PEDKGPKPFR SYNNNVDHLG
60 70 80 90 100
IVHETELPPL TAREAKQIRR EISRKSKWVD MLGDWEKYKS SRKLIDRAYK
110 120 130 140 150
GMPMNIRGPM WSVLLNIEEM KLKNPGRYQI MKEKGKRSSE HIQRIDRDIS
160 170 180 190 200
GTLRKHMFFR DRYGTKQREL LHILLAYEEY NPEVGYCRDL SHIAALFLLY
210 220 230 240 250
LPEEDAFWAL VQLLASERHS LQGFHSPNGG TVQGLQDQQE HVVATSQSKT
260 270 280 290 300
MGHQDKKDLC GQCSPLGCLI RILIDGISLG LTLRLWDVYL VEGEQALMPI
310 320 330 340 350
TRIAFKVQQK RLTKTSRCGP WARFCNRFVD TWARDEDTVL KHLRASMKKL
360 370 380 390 400
TRKQGDLPPP AKPEQGSSAS RPVPASRGRK TLCKGDRQAP PGPPARFPRP
410 420 430 440 450
IWSASPPRAP RSSTPCPGGA VREDTYPVGT QGVPSPALAQ GGPQGSWRFL
460 470 480 490 500
QWNSMPRLPT DLDVEGPWFR HYDFRQSCWV RAISQEDQLA PCWQAEHPAE
510 520 530 540
RVRSAFAAPS TDSDQGTPFR ARDEQQCAPT SGPCLCGLHL ESSQFPPGF
Length:549
Mass (Da):62,320
Last modified:January 7, 2015 - v2
Checksum:i6AA476A73DAE152B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti201L → F in BAF84946 (PubMed:14702039).Curated1
Sequence conflicti379R → G in BAF84946 (PubMed:14702039).Curated1
Sequence conflicti527C → Y in BAF84946 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292257 mRNA. Translation: BAF84946.1.
AC243829 Genomic DNA. No translation available.
CCDSiCCDS42300.1.
RefSeqiNP_001001417.6. NM_001001417.6.
UniGeneiHs.105891.
Hs.454716.

Genome annotation databases

EnsembliENST00000611257; ENSP00000478473; ENSG00000274808.
GeneIDi414059.
KEGGihsa:414059.
UCSCiuc032fbj.2. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTBC3B_HUMAN
AccessioniPrimary (citable) accession number: A6NDS4
Secondary accession number(s): A8K892
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 7, 2015
Last modified: July 5, 2017
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot