ID   MADL2_HUMAN             Reviewed;         307 AA.
AC   A6NDP7;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 3.
DT   18-APR-2012, entry version 43.
DE   RecName: Full=Myeloid-associated differentiation marker-like protein 2;
GN   Name=MYADML2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC       (Potential).
CC   -!- SIMILARITY: Belongs to the MAL family.
CC   -!- SIMILARITY: Contains 2 MARVEL domains.
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DR   EMBL; AC145207; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC029306; -; NOT_ANNOTATED_CDS; mRNA.
DR   IPI; IPI00161380; -.
DR   RefSeq; NP_001138585.2; NM_001145113.2.
DR   UniGene; Hs.729645; -.
DR   ProteinModelPortal; A6NDP7; -.
DR   PRIDE; A6NDP7; -.
DR   Ensembl; ENST00000330655; ENSP00000327718; ENSG00000185105.
DR   Ensembl; ENST00000409745; ENSP00000386702; ENSG00000185105.
DR   GeneID; 255275; -.
DR   KEGG; hsa:255275; -.
DR   UCSC; uc010wvf.1; human.
DR   CTD; 255275; -.
DR   GeneCards; GC17M079897; -.
DR   HGNC; HGNC:34548; MYADML2.
DR   neXtProt; NX_A6NDP7; -.
DR   PharmGKB; PA164723246; -.
DR   eggNOG; NOG291197; -.
DR   GeneTree; ENSGT00390000010832; -.
DR   HOGENOM; HBG444560; -.
DR   HOVERGEN; HBG052545; -.
DR   InParanoid; A6NDP7; -.
DR   OMA; VATQWCV; -.
DR   OrthoDB; EOG4PK289; -.
DR   NextBio; 92535; -.
DR   Bgee; A6NDP7; -.
DR   Genevestigator; A6NDP7; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR008253; Marvel.
DR   InterPro; IPR021128; MARVEL-like_dom.
DR   Pfam; PF01284; MARVEL; 2.
DR   PROSITE; PS51225; MARVEL; 2.
PE   2: Evidence at transcript level;
KW   Complete proteome; Membrane; Reference proteome; Repeat;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    307       Myeloid-associated differentiation
FT                                marker-like protein 2.
FT                                /FTId=PRO_0000332206.
FT   TRANSMEM     53     73       Helical; (Potential).
FT   TRANSMEM     90    110       Helical; (Potential).
FT   TRANSMEM    129    149       Helical; (Potential).
FT   TRANSMEM    163    183       Helical; (Potential).
FT   TRANSMEM    198    218       Helical; (Potential).
FT   TRANSMEM    229    249       Helical; (Potential).
FT   TRANSMEM    278    298       Helical; (Potential).
FT   DOMAIN       17    154       MARVEL 1.
FT   DOMAIN      159    303       MARVEL 2.
FT   CONFLICT    116    116       S -> P (in Ref. 2; BC029306).
SQ   SEQUENCE   307 AA;  32967 MW;  814A830384894673 CRC64;
     MGSTMEPPGG AYLHLGAVTS PVGTARVLQL AFGCTTFSLV AHRGGFAGVQ GTFCMAAWGF
     CFAVSALVVA CEFTRLHGCL RLSWGNFTAA FAMLATLLCA TAAVLYPLYF ARRECSPEPA
     GCAARDFRLA ASVFAGLLFL AYAVEVALTR ARPGQVSSYM ATVSGLLKIV QAFVACIIFG
     ALVHDSRYGR YVATQWCVAV YSLCFLATVA VVALSVMGHT GGLGCPFDRL VVVYTFLAVL
     LYLSAAVIWP VFCFDPKYGE PKRPPNCARG SCPWDSQLVV AIFTYVNLLL YVVDLAYSQR
     IRFVPSL
//