ID   MADL2_HUMAN             Reviewed;         307 AA.
AC   A6NDP7;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   16-DEC-2008, entry version 14.
DE   RecName: Full=Myeloid-associated differentiation marker-like protein 2;
GN   Name=MYADML2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC       (Potential).
CC   -!- SIMILARITY: Belongs to the MAL family.
CC   -!- SIMILARITY: Contains 2 MARVEL domains.
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DR   EMBL; AC137723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC029306; -; NOT_ANNOTATED_CDS; mRNA.
DR   UniGene; Hs.163451; -.
DR   PRIDE; A6NDP7; -.
DR   Ensembl; ENSG00000185105; Homo sapiens.
DR   GeneCards; GC17M077491; -.
DR   HGNC; HGNC:34548; MYADML2.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR008253; Marvel.
DR   Pfam; PF01284; MARVEL; 2.
DR   PROSITE; PS51225; MARVEL; 2.
PE   2: Evidence at transcript level;
KW   Membrane; Repeat; Transmembrane.
FT   CHAIN         1    307       Myeloid-associated differentiation
FT                                marker-like protein 2.
FT                                /FTId=PRO_0000332206.
FT   TRANSMEM     53     73       Potential.
FT   TRANSMEM     90    110       Potential.
FT   TRANSMEM    129    149       Potential.
FT   TRANSMEM    163    183       Potential.
FT   TRANSMEM    198    218       Potential.
FT   TRANSMEM    229    249       Potential.
FT   TRANSMEM    278    298       Potential.
FT   DOMAIN       17    154       MARVEL 1.
FT   DOMAIN      159    303       MARVEL 2.
FT   CONFLICT    116    116       S -> P (in Ref. 2; BC029306).
FT   CONFLICT    229    229       W -> R (in Ref. 2; BC029306).
SQ   SEQUENCE   307 AA;  32997 MW;  F7FC330534894226 CRC64;
     MGSTMEPPGG AYLHLGAVTS PVGTARVLQL AFGCTTFSLV AHRGGFAGVQ GTFCMAAWGF
     CFAVSALVVA CEFTRLHGCL RLSWGNFTAA FAMLATLLCA TAAVLYPLYF ARRECSPEPA
     GCAARDFRLA ASVFAGLLFL AYAVEVALTR ARPGQVSSYM ATVSGLLKIV QAFVACIIFG
     ALVHDSRYGR YVATQWCVAV YSLCFLATVA VVALSVMGHT GGLGCPFDWL VVVYTFLAVL
     LYLSAAVIWP VFCFDPKYGE PKRPPNCARG SCPWDSQLVV AIFTYVNLLL YVVDLAYSQR
     IRFVPSL
//