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Protein

Myeloid-associated differentiation marker-like protein 2

Gene

MYADML2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Myeloid-associated differentiation marker-like protein 2
Gene namesi
Name:MYADML2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:34548. MYADML2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei53 – 7321HelicalSequence analysisAdd
BLAST
Transmembranei90 – 11021HelicalSequence analysisAdd
BLAST
Transmembranei129 – 14921HelicalSequence analysisAdd
BLAST
Transmembranei163 – 18321HelicalSequence analysisAdd
BLAST
Transmembranei198 – 21821HelicalSequence analysisAdd
BLAST
Transmembranei229 – 24921HelicalSequence analysisAdd
BLAST
Transmembranei278 – 29821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164723246.

Polymorphism and mutation databases

BioMutaiMYADML2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Myeloid-associated differentiation marker-like protein 2PRO_0000332206Add
BLAST

Proteomic databases

PaxDbiA6NDP7.
PeptideAtlasiA6NDP7.
PRIDEiA6NDP7.

Expressioni

Gene expression databases

BgeeiA6NDP7.
GenevisibleiA6NDP7. HS.

Organism-specific databases

HPAiHPA041856.
HPA048476.

Structurei

3D structure databases

ProteinModelPortaliA6NDP7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 154138MARVEL 1PROSITE-ProRule annotationAdd
BLAST
Domaini159 – 303145MARVEL 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MAL family.Curated
Contains 2 MARVEL domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00390000010832.
HOGENOMiHOG000294158.
HOVERGENiHBG052545.
InParanoidiA6NDP7.
OMAiVATQWCV.
OrthoDBiEOG73JKVX.
PhylomeDBiA6NDP7.
TreeFamiTF331088.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 2 hits.
[Graphical view]
PROSITEiPS51225. MARVEL. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NDP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSTMEPPGG AYLHLGAVTS PVGTARVLQL AFGCTTFSLV AHRGGFAGVQ
60 70 80 90 100
GTFCMAAWGF CFAVSALVVA CEFTRLHGCL RLSWGNFTAA FAMLATLLCA
110 120 130 140 150
TAAVLYPLYF ARRECSPEPA GCAARDFRLA ASVFAGLLFL AYAVEVALTR
160 170 180 190 200
ARPGQVSSYM ATVSGLLKIV QAFVACIIFG ALVHDSRYGR YVATQWCVAV
210 220 230 240 250
YSLCFLATVA VVALSVMGHT GGLGCPFDRL VVVYTFLAVL LYLSAAVIWP
260 270 280 290 300
VFCFDPKYGE PKRPPNCARG SCPWDSQLVV AIFTYVNLLL YVVDLAYSQR

IRFVPSL
Length:307
Mass (Da):32,967
Last modified:November 24, 2009 - v3
Checksum:i814A830384894673
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti116 – 1161S → P in BC029306 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC145207 Genomic DNA. No translation available.
BC029306 mRNA. No translation available.
CCDSiCCDS45815.1.
RefSeqiNP_001138585.2. NM_001145113.2.
UniGeneiHs.729645.

Genome annotation databases

EnsembliENST00000330655; ENSP00000327718; ENSG00000185105.
ENST00000409745; ENSP00000386702; ENSG00000185105.
GeneIDi255275.
KEGGihsa:255275.
UCSCiuc010wvf.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC145207 Genomic DNA. No translation available.
BC029306 mRNA. No translation available.
CCDSiCCDS45815.1.
RefSeqiNP_001138585.2. NM_001145113.2.
UniGeneiHs.729645.

3D structure databases

ProteinModelPortaliA6NDP7.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiMYADML2.

Proteomic databases

PaxDbiA6NDP7.
PeptideAtlasiA6NDP7.
PRIDEiA6NDP7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330655; ENSP00000327718; ENSG00000185105.
ENST00000409745; ENSP00000386702; ENSG00000185105.
GeneIDi255275.
KEGGihsa:255275.
UCSCiuc010wvf.1. human.

Organism-specific databases

CTDi255275.
GeneCardsiMYADML2.
HGNCiHGNC:34548. MYADML2.
HPAiHPA041856.
HPA048476.
neXtProtiNX_A6NDP7.
PharmGKBiPA164723246.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00390000010832.
HOGENOMiHOG000294158.
HOVERGENiHBG052545.
InParanoidiA6NDP7.
OMAiVATQWCV.
OrthoDBiEOG73JKVX.
PhylomeDBiA6NDP7.
TreeFamiTF331088.

Miscellaneous databases

GenomeRNAii255275.
PROiA6NDP7.

Gene expression databases

BgeeiA6NDP7.
GenevisibleiA6NDP7. HS.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 2 hits.
[Graphical view]
PROSITEiPS51225. MARVEL. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Placenta.

Entry informationi

Entry nameiMADL2_HUMAN
AccessioniPrimary (citable) accession number: A6NDP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 24, 2009
Last modified: July 6, 2016
This is version 63 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.