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A6NDL7

- MT21E_HUMAN

UniProt

A6NDL7 - MT21E_HUMAN

Protein

Putative methyltransferase-like protein 21E pseudogene

Gene

METTL21EP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Protein-lysine methyltransferase.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei96 – 961S-adenosyl-L-methionine; via amide nitrogenBy similarity
    Binding sitei145 – 1451S-adenosyl-L-methionineBy similarity
    Binding sitei176 – 1761S-adenosyl-L-methionine; via amide nitrogenBy similarity
    Binding sitei197 – 1971S-adenosyl-L-methionine; via carbonyl oxygenBy similarity

    GO - Molecular functioni

    1. methyltransferase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative methyltransferase-like protein 21E pseudogene (EC:2.1.1.-)
    Gene namesi
    Name:METTL21EP
    Synonyms:METTL21CP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:41948. METTL21EP.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 271271Putative methyltransferase-like protein 21E pseudogenePRO_0000329291Add
    BLAST

    Proteomic databases

    PRIDEiA6NDL7.

    Expressioni

    Gene expression databases

    GenevestigatoriA6NDL7.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NDL7.
    SMRiA6NDL7. Positions 62-266.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni124 – 1263S-adenosyl-L-methionine bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG107723.
    InParanoidiA6NDL7.
    PhylomeDBiA6NDL7.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR019410. Nicotinamide_N-MeTfrase-like.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF10294. Methyltransf_16. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6NDL7-1 [UniParc]FASTAAdd to Basket

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    MIHFNLLETQ LTPLASFQEI MKKTSIYHLP SFHYLMDSEA QEDTREAYDD    50
    KQVVTEIMAR CFIPTLITTT SWESFHFIGH EIRITEAMDC YGAVVWPSAL 100
    VLCYFLETNA KQYNMVDKNV IEIGAGTGLV SIVASLLGAH VTATDLPELL 150
    GNLQYNISRN TKMKSKHLPQ VKELSWGVAL DTNFPRSSNN FDYILAADVV 200
    YAHPFLEELL ITFDHLCKET TIILWAMKFR LEKENKFVDR FKELFDLEEI 250
    SSFPSLNIKL YKAVKKNRRS V 271
    Length:271
    Mass (Da):31,188
    Last modified:January 15, 2008 - v2
    Checksum:iE669135ACD7F6ACE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL157769 Genomic DNA. No translation available.
    UniGeneiHs.660773.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL157769 Genomic DNA. No translation available.
    UniGenei Hs.660773.

    3D structure databases

    ProteinModelPortali A6NDL7.
    SMRi A6NDL7. Positions 62-266.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi A6NDL7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC13P103535.
    HGNCi HGNC:41948. METTL21EP.
    neXtProti NX_A6NDL7.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG107723.
    InParanoidi A6NDL7.
    PhylomeDBi A6NDL7.

    Gene expression databases

    Genevestigatori A6NDL7.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR019410. Nicotinamide_N-MeTfrase-like.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF10294. Methyltransf_16. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiMT21E_HUMAN
    AccessioniPrimary (citable) accession number: A6NDL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3