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Protein

Putative methyltransferase-like protein 21E pseudogene

Gene

METTL21EP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

Protein-lysine methyltransferase.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei96S-adenosyl-L-methionine; via amide nitrogenBy similarity1
Binding sitei145S-adenosyl-L-methionineBy similarity1
Binding sitei176S-adenosyl-L-methionine; via amide nitrogenBy similarity1
Binding sitei197S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Putative methyltransferase-like protein 21E pseudogene (EC:2.1.1.-)
Gene namesi
Name:METTL21EP
Synonyms:METTL21CP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:41948. METTL21EP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003292911 – 271Putative methyltransferase-like protein 21E pseudogeneAdd BLAST271

Proteomic databases

MaxQBiA6NDL7.
PRIDEiA6NDL7.

Structurei

3D structure databases

ProteinModelPortaliA6NDL7.
SMRiA6NDL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni124 – 126S-adenosyl-L-methionine bindingBy similarity3

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG107723.
InParanoidiA6NDL7.
PhylomeDBiA6NDL7.

Family and domain databases

InterProiView protein in InterPro
IPR019410. Methyltransf_16.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF10294. Methyltransf_16. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NDL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIHFNLLETQ LTPLASFQEI MKKTSIYHLP SFHYLMDSEA QEDTREAYDD
60 70 80 90 100
KQVVTEIMAR CFIPTLITTT SWESFHFIGH EIRITEAMDC YGAVVWPSAL
110 120 130 140 150
VLCYFLETNA KQYNMVDKNV IEIGAGTGLV SIVASLLGAH VTATDLPELL
160 170 180 190 200
GNLQYNISRN TKMKSKHLPQ VKELSWGVAL DTNFPRSSNN FDYILAADVV
210 220 230 240 250
YAHPFLEELL ITFDHLCKET TIILWAMKFR LEKENKFVDR FKELFDLEEI
260 270
SSFPSLNIKL YKAVKKNRRS V
Length:271
Mass (Da):31,188
Last modified:January 15, 2008 - v2
Checksum:iE669135ACD7F6ACE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157769 Genomic DNA. No translation available.
UniGeneiHs.660773.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMT21E_HUMAN
AccessioniPrimary (citable) accession number: A6NDL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: January 15, 2008
Last modified: May 10, 2017
This is version 59 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families