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A6NDL7 (MT21E_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative methyltransferase-like protein 21E pseudogene

EC=2.1.1.-
Gene names
Name:METTL21EP
Synonyms:METTL21CP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Function

Protein-lysine methyltransferase By similarity.

Sequence similarities

Belongs to the methyltransferase superfamily. METTL21 family.

Caution

Could be the product of a pseudogene.

Ontologies

Keywords
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionmethyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 271271Putative methyltransferase-like protein 21E pseudogene
PRO_0000329291

Regions

Region124 – 1263S-adenosyl-L-methionine binding By similarity

Sites

Binding site961S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding site1451S-adenosyl-L-methionine By similarity
Binding site1761S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding site1971S-adenosyl-L-methionine; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
A6NDL7 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: E669135ACD7F6ACE

FASTA27131,188
        10         20         30         40         50         60 
MIHFNLLETQ LTPLASFQEI MKKTSIYHLP SFHYLMDSEA QEDTREAYDD KQVVTEIMAR 

        70         80         90        100        110        120 
CFIPTLITTT SWESFHFIGH EIRITEAMDC YGAVVWPSAL VLCYFLETNA KQYNMVDKNV 

       130        140        150        160        170        180 
IEIGAGTGLV SIVASLLGAH VTATDLPELL GNLQYNISRN TKMKSKHLPQ VKELSWGVAL 

       190        200        210        220        230        240 
DTNFPRSSNN FDYILAADVV YAHPFLEELL ITFDHLCKET TIILWAMKFR LEKENKFVDR 

       250        260        270 
FKELFDLEEI SSFPSLNIKL YKAVKKNRRS V 

« Hide

References

[1]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL157769 Genomic DNA. No translation available.
UniGeneHs.660773.

3D structure databases

ProteinModelPortalA6NDL7.
SMRA6NDL7. Positions 62-266.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEA6NDL7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC13P103535.
HGNCHGNC:41948. METTL21EP.
neXtProtNX_A6NDL7.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG107723.
InParanoidA6NDL7.
PhylomeDBA6NDL7.

Gene expression databases

GenevestigatorA6NDL7.

Family and domain databases

InterProIPR019410. Nicotinamide_N-MeTfrase-like.
[Graphical view]
PfamPF10294. Methyltransf_16. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMT21E_HUMAN
AccessionPrimary (citable) accession number: A6NDL7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: January 15, 2008
Last modified: April 16, 2014
This is version 47 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM