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A6NDL7

- MT21E_HUMAN

UniProt

A6NDL7 - MT21E_HUMAN

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Protein

Putative methyltransferase-like protein 21E pseudogene

Gene
METTL21EP, METTL21CP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Protein uncertaini

Functioni

Protein-lysine methyltransferase By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei96 – 961S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding sitei145 – 1451S-adenosyl-L-methionine By similarity
Binding sitei176 – 1761S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding sitei197 – 1971S-adenosyl-L-methionine; via carbonyl oxygen By similarity

GO - Molecular functioni

  1. methyltransferase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Putative methyltransferase-like protein 21E pseudogene (EC:2.1.1.-)
Gene namesi
Synonyms:METTL21CP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:41948. METTL21EP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Putative methyltransferase-like protein 21E pseudogenePRO_0000329291Add
BLAST

Proteomic databases

PRIDEiA6NDL7.

Expressioni

Gene expression databases

GenevestigatoriA6NDL7.

Structurei

3D structure databases

ProteinModelPortaliA6NDL7.
SMRiA6NDL7. Positions 62-266.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni124 – 1263S-adenosyl-L-methionine binding By similarity

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG107723.
InParanoidiA6NDL7.
PhylomeDBiA6NDL7.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR019410. Nicotinamide_N-MeTfrase-like.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF10294. Methyltransf_16. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NDL7-1 [UniParc]FASTAAdd to Basket

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MIHFNLLETQ LTPLASFQEI MKKTSIYHLP SFHYLMDSEA QEDTREAYDD    50
KQVVTEIMAR CFIPTLITTT SWESFHFIGH EIRITEAMDC YGAVVWPSAL 100
VLCYFLETNA KQYNMVDKNV IEIGAGTGLV SIVASLLGAH VTATDLPELL 150
GNLQYNISRN TKMKSKHLPQ VKELSWGVAL DTNFPRSSNN FDYILAADVV 200
YAHPFLEELL ITFDHLCKET TIILWAMKFR LEKENKFVDR FKELFDLEEI 250
SSFPSLNIKL YKAVKKNRRS V 271
Length:271
Mass (Da):31,188
Last modified:January 15, 2008 - v2
Checksum:iE669135ACD7F6ACE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL157769 Genomic DNA. No translation available.
UniGeneiHs.660773.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL157769 Genomic DNA. No translation available.
UniGenei Hs.660773.

3D structure databases

ProteinModelPortali A6NDL7.
SMRi A6NDL7. Positions 62-266.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi A6NDL7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

GeneCardsi GC13P103535.
HGNCi HGNC:41948. METTL21EP.
neXtProti NX_A6NDL7.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG107723.
InParanoidi A6NDL7.
PhylomeDBi A6NDL7.

Gene expression databases

Genevestigatori A6NDL7.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR019410. Nicotinamide_N-MeTfrase-like.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF10294. Methyltransf_16. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiMT21E_HUMAN
AccessioniPrimary (citable) accession number: A6NDL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: January 15, 2008
Last modified: June 11, 2014
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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