A6NDL7 (MT21E_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative methyltransferase-like protein 21E pseudogene
EC=2.1.1.-

Gene names

Name:	METTL21EP
Synonyms:	METTL21CP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Function	Protein-lysine methyltransferase By similarity.
Sequence similarities	Belongs to the methyltransferase superfamily. METTL21 family.
Caution	Could be the product of a pseudogene.

Ontologies

Keywords
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Putative methyltransferase-like protein 21E pseudogene		PRO_0000329291

Sequences

	Sequence		Length	Mass (Da)
	A6NDL7 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: E669135ACD7F6ACE	FASTA	271	31,188
	10 20 30 40 50 60 MIHFNLLETQ LTPLASFQEI MKKTSIYHLP SFHYLMDSEA QEDTREAYDD KQVVTEIMAR 70 80 90 100 110 120 CFIPTLITTT SWESFHFIGH EIRITEAMDC YGAVVWPSAL VLCYFLETNA KQYNMVDKNV 130 140 150 160 170 180 IEIGAGTGLV SIVASLLGAH VTATDLPELL GNLQYNISRN TKMKSKHLPQ VKELSWGVAL 190 200 210 220 230 240 DTNFPRSSNN FDYILAADVV YAHPFLEELL ITFDHLCKET TIILWAMKFR LEKENKFVDR 250 260 270 FKELFDLEEI SSFPSLNIKL YKAVKKNRRS V

References

[1]

"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL157769 Genomic DNA. No translation available.
IPI	IPI00186395.
UniGene	Hs.660773.
3D structure databases
ProteinModelPortal	A6NDL7.
ModBase	Search...
Proteomic databases
PRIDE	A6NDL7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
HGNC	HGNC:41948. METTL21EP.
neXtProt	NX_A6NDL7.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG107723.
InParanoid	A6NDL7.
OrthoDB	EOG4VT5Z3.
Gene expression databases
Genevestigator	A6NDL7.
Family and domain databases
InterPro	IPR019410. Nicotinamide_N-MeTfrase-like. [Graphical view]
Pfam	PF10294. Methyltransf_16. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MT21E_HUMAN

Accession

Primary (citable) accession number: A6NDL7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	January 15, 2008
Last modified:	May 1, 2013
This is version 39 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.