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A6NDI0

- TR49B_HUMAN

UniProt

A6NDI0 - TR49B_HUMAN

Protein

Putative tripartite motif-containing protein 49B

Gene

TRIM49B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri15 – 5642RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri88 – 12942B box-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative tripartite motif-containing protein 49B
    Alternative name(s):
    RING finger protein 18B
    Gene namesi
    Name:TRIM49B
    Synonyms:RNF18B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:42955. TRIM49B.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 452452Putative tripartite motif-containing protein 49BPRO_0000328997Add
    BLAST

    Proteomic databases

    PaxDbiA6NDI0.
    PRIDEiA6NDI0.

    PTM databases

    PhosphoSiteiA6NDI0.

    Expressioni

    Gene expression databases

    BgeeiA6NDI0.
    GenevestigatoriA6NDI0.

    Interactioni

    Protein-protein interaction databases

    BioGridi129465. 1 interaction.
    STRINGi9606.ENSP00000330216.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NDI0.
    SMRiA6NDI0. Positions 9-55, 287-447.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini269 – 452184B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRIM/RBCC family.Curated
    Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri15 – 5642RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri88 – 12942B box-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG278898.
    HOGENOMiHOG000234135.
    HOVERGENiHBG108727.
    InParanoidiA6NDI0.
    KOiK12019.
    OMAiICPICMN.
    OrthoDBiEOG7MD4Q8.
    PhylomeDBiA6NDI0.
    TreeFamiTF338674.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProiIPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view]
    PRINTSiPR01407. BUTYPHLNCDUF.
    SMARTiSM00336. BBOX. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6NDI0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSGILQVFQ RELICPICMN YFIDPVTIDC GHSFCRPCFY LNWKDSPFLV    50
    QCSECTKSTG QINLKTNIHF KKMASLARKV SLWLFLSSEE QMCGTHRETK 100
    KMFCEVDRSL LCLLCSSSQE HRDHRHCPIE SAAEEHQEKL LQKMQSLWEK 150
    ACENHRNLNV ETTRTRCWKD YVNLRLEAIR AEYQKMPAFH HEEEKHNLEM 200
    LKKKGKDIFH RLHLSKAKMA HRREILRGMY EELNEMCHKP DVELLQAFGD 250
    ILHRSESVLL HMPQPLNPEL SAGPITGLRD RLNQFRVHIT LHHEEANSDI 300
    FLCEILRSMC IGCDHQDVPY FTATPRSFLA WGAQTFTSGK YYWEVHVGDS 350
    WNWAFGVCNM YWKEKNQNEK IDGEDGLFLL GCVKNDIQRS LFTTSPLLLQ 400
    YIPRPTSRVG LFLDCEAKTV SFVDVNQSSL IYTIPNCSFS PPLRPIFCCI 450
    HF 452
    Length:452
    Mass (Da):52,747
    Last modified:July 24, 2007 - v1
    Checksum:iF6A703FD7A1E10BE
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti398 – 3981L → M.
    Corresponds to variant rs2696914 [ dbSNP | Ensembl ].
    VAR_042601

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC084851 Genomic DNA. No translation available.
    JF968463 mRNA. No translation available.
    RefSeqiNP_001193555.1. NM_001206626.1.
    UniGeneiHs.448644.

    Genome annotation databases

    EnsembliENST00000332682; ENSP00000330216; ENSG00000182053.
    GeneIDi283116.
    KEGGihsa:283116.
    UCSCiuc021qix.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC084851 Genomic DNA. No translation available.
    JF968463 mRNA. No translation available.
    RefSeqi NP_001193555.1. NM_001206626.1.
    UniGenei Hs.448644.

    3D structure databases

    ProteinModelPortali A6NDI0.
    SMRi A6NDI0. Positions 9-55, 287-447.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129465. 1 interaction.
    STRINGi 9606.ENSP00000330216.

    PTM databases

    PhosphoSitei A6NDI0.

    Proteomic databases

    PaxDbi A6NDI0.
    PRIDEi A6NDI0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332682 ; ENSP00000330216 ; ENSG00000182053 .
    GeneIDi 283116.
    KEGGi hsa:283116.
    UCSCi uc021qix.1. human.

    Organism-specific databases

    CTDi 283116.
    GeneCardsi GC11P049050.
    HGNCi HGNC:42955. TRIM49B.
    neXtProti NX_A6NDI0.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG278898.
    HOGENOMi HOG000234135.
    HOVERGENi HBG108727.
    InParanoidi A6NDI0.
    KOi K12019.
    OMAi ICPICMN.
    OrthoDBi EOG7MD4Q8.
    PhylomeDBi A6NDI0.
    TreeFami TF338674.

    Miscellaneous databases

    GenomeRNAii 283116.
    NextBioi 93631.
    PROi A6NDI0.

    Gene expression databases

    Bgeei A6NDI0.
    Genevestigatori A6NDI0.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProi IPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view ]
    PRINTSi PR01407. BUTYPHLNCDUF.
    SMARTi SM00336. BBOX. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Identification of a genomic reservoir for new TRIM genes in primate genomes."
      Han K., Lou D.I., Sawyer S.L.
      PLoS Genet. 7:E1002388-E1002388(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 39-223.

    Entry informationi

    Entry nameiTR49B_HUMAN
    AccessioniPrimary (citable) accession number: A6NDI0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3