Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative tripartite motif-containing protein 49B

Gene

TRIM49B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri15 – 5642RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri88 – 12942B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative tripartite motif-containing protein 49B
Alternative name(s):
RING finger protein 18B
Gene namesi
Name:TRIM49B
Synonyms:RNF18B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:42955. TRIM49B.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Putative tripartite motif-containing protein 49BPRO_0000328997Add
BLAST

Proteomic databases

PaxDbiA6NDI0.
PRIDEiA6NDI0.

PTM databases

PhosphoSiteiA6NDI0.

Expressioni

Gene expression databases

BgeeiA6NDI0.
GenevestigatoriA6NDI0.

Interactioni

Protein-protein interaction databases

BioGridi129465. 1 interaction.
STRINGi9606.ENSP00000330216.

Structurei

3D structure databases

ProteinModelPortaliA6NDI0.
SMRiA6NDI0. Positions 9-55, 93-260, 287-447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini269 – 452184B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri15 – 5642RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri88 – 12942B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG278898.
GeneTreeiENSGT00770000120497.
HOGENOMiHOG000234135.
HOVERGENiHBG108727.
InParanoidiA6NDI0.
KOiK12019.
OMAiICPICMN.
OrthoDBiEOG7MD4Q8.
PhylomeDBiA6NDI0.
TreeFamiTF338674.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NDI0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSGILQVFQ RELICPICMN YFIDPVTIDC GHSFCRPCFY LNWKDSPFLV
60 70 80 90 100
QCSECTKSTG QINLKTNIHF KKMASLARKV SLWLFLSSEE QMCGTHRETK
110 120 130 140 150
KMFCEVDRSL LCLLCSSSQE HRDHRHCPIE SAAEEHQEKL LQKMQSLWEK
160 170 180 190 200
ACENHRNLNV ETTRTRCWKD YVNLRLEAIR AEYQKMPAFH HEEEKHNLEM
210 220 230 240 250
LKKKGKDIFH RLHLSKAKMA HRREILRGMY EELNEMCHKP DVELLQAFGD
260 270 280 290 300
ILHRSESVLL HMPQPLNPEL SAGPITGLRD RLNQFRVHIT LHHEEANSDI
310 320 330 340 350
FLCEILRSMC IGCDHQDVPY FTATPRSFLA WGAQTFTSGK YYWEVHVGDS
360 370 380 390 400
WNWAFGVCNM YWKEKNQNEK IDGEDGLFLL GCVKNDIQRS LFTTSPLLLQ
410 420 430 440 450
YIPRPTSRVG LFLDCEAKTV SFVDVNQSSL IYTIPNCSFS PPLRPIFCCI

HF
Length:452
Mass (Da):52,747
Last modified:July 24, 2007 - v1
Checksum:iF6A703FD7A1E10BE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti398 – 3981L → M.
Corresponds to variant rs2696914 [ dbSNP | Ensembl ].
VAR_042601

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084851 Genomic DNA. No translation available.
JF968463 mRNA. No translation available.
RefSeqiNP_001193555.1. NM_001206626.1.
UniGeneiHs.448644.

Genome annotation databases

EnsembliENST00000332682; ENSP00000330216; ENSG00000182053.
ENST00000622138; ENSP00000481457; ENSG00000182053.
GeneIDi283116.
KEGGihsa:283116.
UCSCiuc021qix.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084851 Genomic DNA. No translation available.
JF968463 mRNA. No translation available.
RefSeqiNP_001193555.1. NM_001206626.1.
UniGeneiHs.448644.

3D structure databases

ProteinModelPortaliA6NDI0.
SMRiA6NDI0. Positions 9-55, 93-260, 287-447.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129465. 1 interaction.
STRINGi9606.ENSP00000330216.

PTM databases

PhosphoSiteiA6NDI0.

Proteomic databases

PaxDbiA6NDI0.
PRIDEiA6NDI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332682; ENSP00000330216; ENSG00000182053.
ENST00000622138; ENSP00000481457; ENSG00000182053.
GeneIDi283116.
KEGGihsa:283116.
UCSCiuc021qix.1. human.

Organism-specific databases

CTDi283116.
GeneCardsiGC11P049050.
HGNCiHGNC:42955. TRIM49B.
neXtProtiNX_A6NDI0.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG278898.
GeneTreeiENSGT00770000120497.
HOGENOMiHOG000234135.
HOVERGENiHBG108727.
InParanoidiA6NDI0.
KOiK12019.
OMAiICPICMN.
OrthoDBiEOG7MD4Q8.
PhylomeDBiA6NDI0.
TreeFamiTF338674.

Miscellaneous databases

GenomeRNAii283116.
NextBioi93631.
PROiA6NDI0.

Gene expression databases

BgeeiA6NDI0.
GenevestigatoriA6NDI0.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Identification of a genomic reservoir for new TRIM genes in primate genomes."
    Han K., Lou D.I., Sawyer S.L.
    PLoS Genet. 7:E1002388-E1002388(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 39-223.

Entry informationi

Entry nameiTR49B_HUMAN
AccessioniPrimary (citable) accession number: A6NDI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 24, 2007
Last modified: January 7, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.