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A6NDI0 (TR49B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative tripartite motif-containing protein 49B
Alternative name(s):
RING finger protein 18B
Gene names
Name:TRIM49B
Synonyms:RNF18B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length452 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the TRIM/RBCC family.

Contains 1 B box-type zinc finger.

Contains 1 B30.2/SPRY domain.

Contains 1 RING-type zinc finger.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainZinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 452452Putative tripartite motif-containing protein 49B
PRO_0000328997

Regions

Domain269 – 452184B30.2/SPRY
Zinc finger15 – 5642RING-type
Zinc finger88 – 12942B box-type

Natural variations

Natural variant3981L → M.
Corresponds to variant rs2696914 [ dbSNP | Ensembl ].
VAR_042601

Sequences

Sequence LengthMass (Da)Tools
A6NDI0 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: F6A703FD7A1E10BE

FASTA45252,747
        10         20         30         40         50         60 
MNSGILQVFQ RELICPICMN YFIDPVTIDC GHSFCRPCFY LNWKDSPFLV QCSECTKSTG 

        70         80         90        100        110        120 
QINLKTNIHF KKMASLARKV SLWLFLSSEE QMCGTHRETK KMFCEVDRSL LCLLCSSSQE 

       130        140        150        160        170        180 
HRDHRHCPIE SAAEEHQEKL LQKMQSLWEK ACENHRNLNV ETTRTRCWKD YVNLRLEAIR 

       190        200        210        220        230        240 
AEYQKMPAFH HEEEKHNLEM LKKKGKDIFH RLHLSKAKMA HRREILRGMY EELNEMCHKP 

       250        260        270        280        290        300 
DVELLQAFGD ILHRSESVLL HMPQPLNPEL SAGPITGLRD RLNQFRVHIT LHHEEANSDI 

       310        320        330        340        350        360 
FLCEILRSMC IGCDHQDVPY FTATPRSFLA WGAQTFTSGK YYWEVHVGDS WNWAFGVCNM 

       370        380        390        400        410        420 
YWKEKNQNEK IDGEDGLFLL GCVKNDIQRS LFTTSPLLLQ YIPRPTSRVG LFLDCEAKTV 

       430        440        450 
SFVDVNQSSL IYTIPNCSFS PPLRPIFCCI HF 

« Hide

References

« Hide 'large scale' references
[1]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Identification of a genomic reservoir for new TRIM genes in primate genomes."
Han K., Lou D.I., Sawyer S.L.
PLoS Genet. 7:E1002388-E1002388(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 39-223.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC084851 Genomic DNA. No translation available.
JF968463 mRNA. No translation available.
RefSeqNP_001193555.1. NM_001206626.1.
UniGeneHs.448644.

3D structure databases

ProteinModelPortalA6NDI0.
SMRA6NDI0. Positions 9-55, 91-129, 287-447.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid129465. 1 interaction.
STRING9606.ENSP00000330216.

PTM databases

PhosphoSiteA6NDI0.

Proteomic databases

PaxDbA6NDI0.
PRIDEA6NDI0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000332682; ENSP00000330216; ENSG00000182053.
GeneID283116.
KEGGhsa:283116.
UCSCuc021qix.1. human.

Organism-specific databases

CTD283116.
GeneCardsGC11P049050.
HGNCHGNC:42955. TRIM49B.
neXtProtNX_A6NDI0.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG278898.
HOGENOMHOG000234135.
HOVERGENHBG108727.
InParanoidA6NDI0.
KOK12019.
OMAICPICMN.
OrthoDBEOG7MD4Q8.
PhylomeDBA6NDI0.
TreeFamTF338674.

Gene expression databases

BgeeA6NDI0.
GenevestigatorA6NDI0.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR008985. ConA-like_lec_gl_sf.
IPR003877. SPRY_rcpt.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSPR01407. BUTYPHLNCDUF.
SMARTSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi283116.
NextBio93631.
PROA6NDI0.

Entry information

Entry nameTR49B_HUMAN
AccessionPrimary (citable) accession number: A6NDI0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM