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Protein

Olfactory receptor 5H15

Gene

OR5H15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-31693-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5H15
Gene namesi
Name:OR5H15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:31287. OR5H15.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 49Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini50 – 56CytoplasmicSequence analysis7
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 119Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini120 – 143CytoplasmicSequence analysisAdd BLAST24
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 195ExtracellularSequence analysisAdd BLAST31
Transmembranei196 – 216Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini217 – 240CytoplasmicSequence analysisAdd BLAST24
Transmembranei241 – 261Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini262 – 271ExtracellularSequence analysis10
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 313CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000233412.
PharmGKBiPA134956122.

Polymorphism and mutation databases

BioMutaiOR5H15.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003104131 – 313Olfactory receptor 5H15Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NDH6.
PRIDEiA6NDH6.

PTM databases

iPTMnetiA6NDH6.
PhosphoSitePlusiA6NDH6.

Expressioni

Gene expression databases

CleanExiHS_OR5H15.
GenevisibleiA6NDH6. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000373195.

Structurei

3D structure databases

ProteinModelPortaliA6NDH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J97S. Eukaryota.
ENOG4111537. LUCA.
GeneTreeiENSGT00550000074564.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6NDH6.
KOiK04257.
OMAiLLLMYVG.
OrthoDBiEOG091G0C7C.
PhylomeDBiA6NDH6.
TreeFamiTF352737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NDH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEENATLLT EFVLTGFLYQ PQWKIPLFLA FLVIYLITIM GNLGLIAVIW
60 70 80 90 100
KDPHLHIPMY LLLGNLAFVD AWISSTVTPK MLNNFLAKSK MISLSECKIQ
110 120 130 140 150
FFSIAIGVTT ECFLLATMAY DRYVAICKPL LYPAIMTNGL CIRLLILSYI
160 170 180 190 200
AGILHALIHE GFLFRLTFCN SNIVHHIYCD TIPLSKISCT DSSINFLMVF
210 220 230 240 250
IFSGSIQVFS IVTILISYTF VLFTVLEKKS DKGVRKAFST CGAHLFSVCL
260 270 280 290 300
YYGPLLLMYV GPASPQADGQ NMVEPLFYTV IIPLLNPIIY SLRNKQVIVS
310
FIKMLKRNVK VSY
Length:313
Mass (Da):35,352
Last modified:July 24, 2007 - v1
Checksum:i1298D50481425F26
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037027108V → I.Corresponds to variant rs4133320dbSNPEnsembl.1
Natural variantiVAR_037028148S → T.Corresponds to variant rs4133321dbSNPEnsembl.1
Natural variantiVAR_037029167T → S.Corresponds to variant rs4133322dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117460 Genomic DNA. No translation available.
CCDSiCCDS33799.1.
RefSeqiNP_001005515.1. NM_001005515.1.
UniGeneiHs.554713.

Genome annotation databases

EnsembliENST00000356526; ENSP00000373195; ENSG00000233412.
GeneIDi403274.
KEGGihsa:403274.
UCSCiuc011bgu.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117460 Genomic DNA. No translation available.
CCDSiCCDS33799.1.
RefSeqiNP_001005515.1. NM_001005515.1.
UniGeneiHs.554713.

3D structure databases

ProteinModelPortaliA6NDH6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000373195.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiA6NDH6.
PhosphoSitePlusiA6NDH6.

Polymorphism and mutation databases

BioMutaiOR5H15.

Proteomic databases

PaxDbiA6NDH6.
PRIDEiA6NDH6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356526; ENSP00000373195; ENSG00000233412.
GeneIDi403274.
KEGGihsa:403274.
UCSCiuc011bgu.2. human.

Organism-specific databases

CTDi403274.
GeneCardsiOR5H15.
HGNCiHGNC:31287. OR5H15.
neXtProtiNX_A6NDH6.
OpenTargetsiENSG00000233412.
PharmGKBiPA134956122.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J97S. Eukaryota.
ENOG4111537. LUCA.
GeneTreeiENSGT00550000074564.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6NDH6.
KOiK04257.
OMAiLLLMYVG.
OrthoDBiEOG091G0C7C.
PhylomeDBiA6NDH6.
TreeFamiTF352737.

Enzyme and pathway databases

BioCyciZFISH:G66-31693-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii403274.
PROiA6NDH6.

Gene expression databases

CleanExiHS_OR5H15.
GenevisibleiA6NDH6. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO5H15_HUMAN
AccessioniPrimary (citable) accession number: A6NDH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: November 2, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.