A6NDE4 (RBY1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RNA-binding motif protein, Y chromosome, family 1 member B

Gene names

Name:

RBMY1B

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	496 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.
Subunit structure	Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3.
Subcellular location	Nucleus.
Tissue specificity	Testis-specific.
Developmental stage	Expressed in all of the transcriptionally active stages of germ cell development from spermatogonia through spermatocytes to round spermatids.
Miscellaneous	The RBMY1 proteins are encoded by strongly repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individues, and some of them may represent pseudogenes. The proteins are very similar, which gives their indidual characterization difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins.
Sequence similarities	Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Nucleus
Ligand	RNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	RNA splicing Inferred from direct assay. Source: UniProtKB mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW male gonad development Inferred from mutant phenotype. Source: UniProtKB spermatogenesis Traceable author statement. Source: UniProtKB
Cellular component	nucleus Traceable author statement. Source: UniProtKB
Molecular function	RNA binding Non-traceable author statement. Source: UniProtKB nucleotide binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 496	496	RNA-binding motif protein, Y chromosome, family 1 member B		PRO_0000341537
Regions
	Domain	8 – 85	78	RRM
	Compositional bias	254 – 340	87	Arg-rich

Sequences

	Sequence		Length	Mass (Da)
	A6NDE4 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: 465F9F6BF5D72C1B	FASTA	496	55,835
	10 20 30 40 50 60 MVEADHPGKL FIGGLNRETN EKMLKAVFGK HGPISEVLLI KDRTSKSRGF AFITFENPAD 70 80 90 100 110 120 AKNAAKDMNG KSLHGKAIKV EQAKKPSFQS GGRRRPPASS RNRSPSGSLR SARGSRGGTR 130 140 150 160 170 180 GWLPSQEGHL DDGGYTPDLK MSYSRGLIPV KRGPSSRSGG PPPKKSAPSA VARSNSWMGS 190 200 210 220 230 240 QGPMSQRREN YGVPPRRATI SSWRNDRMST RHDGYATNDG NHPSCQETRD YAPPSRGYAY 250 260 270 280 290 300 RDNGHSNRDE HSSRGYRNHR SSRETRDYAP PSRGHAYRDY GHSRRDESYS RGYRNRRSSR 310 320 330 340 350 360 ETREYAPPSR GHGYRDYGHS RRHESYSRGY RNHPSSRETR DYAPPHRDYA YRDYGHSSWD 370 380 390 400 410 420 EHSSRGYSYH DGYGEALGRD HSEHLSGSSY RDALQRYGTS HGAPPARGPR MSYGGSTCHA 430 440 450 460 470 480 YSNTRDRYGR SWESYSSCGD FHYCDREHVC RKDQRNPPSL GRVLPDPREA YGSSSYVASI 490 VDGGESRSEK GDSSRY

References

[1]

"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes." Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. , Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H., Wilson R.K., Rozen S., Page D.C. Nature 423:825-837(2003) [PubMed: 12815422] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC010141 Genomic DNA. No translation available.
IPI	IPI00479500.
RefSeq	NP_001006121.1. NM_001006121.2.
UniGene	Hs.380450. Hs.725744.
3D structure databases
ProteinModelPortal	A6NDE4.
SMR	A6NDE4. Positions 1-108.
ModBase	Search...
Protein-protein interaction databases
STRING	A6NDE4.
Proteomic databases
PRIDE	A6NDE4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000383020; ENSP00000372484; ENSG00000242875.
GeneID	378948.
KEGG	hsa:378948.
UCSC	uc004fuo.2. human.
Organism-specific databases
CTD	378948.
GeneCards	GC0YP023674.
HGNC	HGNC:23914. RBMY1B.
HPA	HPA001534.
neXtProt	NX_A6NDE4.
PharmGKB	PA134872137.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG714549.
HOVERGEN	HBG063314.
InParanoid	A6NDE4.
OrthoDB	EOG4TF0N7.
PhylomeDB	A6NDE4.
Gene expression databases
Bgee	A6NDE4.
CleanEx	HS_RBMY1B.
Genevestigator	A6NDE4.
Family and domain databases
InterPro	IPR012677. Nucleotide-bd_a/b_plait. IPR012604. RBM1CTR. IPR000504. RRM_dom. [Graphical view]
Gene3D	G3DSA:3.30.70.330. a_b_plait_nuc_bd. 1 hit.
Pfam	PF08081. RBM1CTR. 1 hit. PF00076. RRM_1. 1 hit. [Graphical view]
SMART	SM00360. RRM. 1 hit. [Graphical view]
PROSITE	PS50102. RRM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	100871.

Entry information

Entry name

RBY1B_HUMAN

Accession

Primary (citable) accession number: A6NDE4
Secondary accession number(s): A6NCZ8, A6NE80, A8MSJ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	January 15, 2008
Last modified:	December 14, 2011
This is version 42 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.