A6NDE4 (RBY1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 42.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: RNA-binding motif protein, Y chromosome, family 1 member B | ||
| Gene names |
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| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 496 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. |
| Subunit structure | Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3. |
| Subcellular location | |
| Tissue specificity | Testis-specific. |
| Developmental stage | Expressed in all of the transcriptionally active stages of germ cell development from spermatogonia through spermatocytes to round spermatids. |
| Miscellaneous | The RBMY1 proteins are encoded by strongly repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individues, and some of them may represent pseudogenes. The proteins are very similar, which gives their indidual characterization difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins. |
| Sequence similarities | Contains 1 RRM (RNA recognition motif) domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | mRNA processing mRNA splicing |
| Cellular component | Nucleus |
| Ligand | RNA-binding |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | RNA splicing Inferred from direct assay. Source: UniProtKB mRNA processingInferred from electronic annotation. Source: UniProtKB-KW male gonad developmentInferred from mutant phenotype. Source: UniProtKB spermatogenesisTraceable author statement. Source: UniProtKB |
| Cellular component | nucleus Traceable author statement. Source: UniProtKB |
| Molecular function | RNA binding Non-traceable author statement. Source: UniProtKB nucleotide bindingInferred from electronic annotation. Source: InterPro protein bindingInferred from physical interaction. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes." Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. Page D.C.Nature 423:825-837(2003) [PubMed: 12815422] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AC010141 Genomic DNA. No translation available. |
| IPI | IPI00479500. |
| RefSeq | NP_001006121.1. NM_001006121.2. |
| UniGene | Hs.380450. Hs.725744. |
3D structure databases | |
| ProteinModelPortal | A6NDE4. |
| SMR | A6NDE4. Positions 1-108. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A6NDE4. |
Proteomic databases | |
| PRIDE | A6NDE4. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000383020; ENSP00000372484; ENSG00000242875. |
| GeneID | 378948. |
| KEGG | hsa:378948. |
| UCSC | uc004fuo.2. human. |
Organism-specific databases | |
| CTD | 378948. |
| GeneCards | GC0YP023674. |
| HGNC | HGNC:23914. RBMY1B. |
| HPA | HPA001534. |
| neXtProt | NX_A6NDE4. |
| PharmGKB | PA134872137. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | HBG714549. |
| HOVERGEN | HBG063314. |
| InParanoid | A6NDE4. |
| OrthoDB | EOG4TF0N7. |
| PhylomeDB | A6NDE4. |
Gene expression databases | |
| Bgee | A6NDE4. |
| CleanEx | HS_RBMY1B. |
| Genevestigator | A6NDE4. |
Family and domain databases | |
| InterPro | IPR012677. Nucleotide-bd_a/b_plait. IPR012604. RBM1CTR. IPR000504. RRM_dom. [Graphical view] |
| Gene3D | G3DSA:3.30.70.330. a_b_plait_nuc_bd. 1 hit. |
| Pfam | PF08081. RBM1CTR. 1 hit. PF00076. RRM_1. 1 hit. [Graphical view] |
| SMART | SM00360. RRM. 1 hit. [Graphical view] |
| PROSITE | PS50102. RRM. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 100871. |
Entry information
| Entry name | RBY1B_HUMAN | ||||||||
| Accession | Primary (citable) accession number: A6NDE4 Secondary accession number(s): A6NCZ8, A6NE80, A8MSJ6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome Y Human chromosome Y: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |

Clusters with