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Protein

RNA-binding motif protein, Y chromosome, family 1 member B

Gene

RBMY1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • RNA binding Source: UniProtKB

GO - Biological processi

  • male gonad development Source: UniProtKB
  • mRNA processing Source: UniProtKB-KW
  • RNA splicing Source: UniProtKB
  • spermatogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding motif protein, Y chromosome, family 1 member B
Gene namesi
Name:RBMY1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome Y

Organism-specific databases

HGNCiHGNC:23914. RBMY1B.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134872137.

Polymorphism and mutation databases

BioMutaiRBMY1B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496RNA-binding motif protein, Y chromosome, family 1 member BPRO_0000341537Add
BLAST

Proteomic databases

EPDiA6NDE4.
PaxDbiA6NDE4.
PRIDEiA6NDE4.

PTM databases

iPTMnetiA6NDE4.

Expressioni

Tissue specificityi

Testis-specific.

Developmental stagei

Expressed in all of the transcriptionally active stages of germ cell development from spermatogonia through spermatocytes to round spermatids.

Gene expression databases

BgeeiA6NDE4.
CleanExiHS_RBMY1B.
ExpressionAtlasiA6NDE4. baseline.
GenevisibleiA6NDE4. HS.

Organism-specific databases

HPAiHPA001534.
HPA053147.

Interactioni

Subunit structurei

Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3.

Structurei

3D structure databases

ProteinModelPortaliA6NDE4.
SMRiA6NDE4. Positions 1-108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 8578RRMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi254 – 34087Arg-richAdd
BLAST

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410J6JX. Eukaryota.
ENOG4111GI6. LUCA.
GeneTreeiENSGT00710000106295.
HOGENOMiHOG000276235.
HOVERGENiHBG063314.
InParanoidiA6NDE4.
OrthoDBiEOG780RPD.
PhylomeDBiA6NDE4.
TreeFamiTF331833.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR012604. RBM1CTR.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF08081. RBM1CTR. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NDE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEADHPGKL FIGGLNRETN EKMLKAVFGK HGPISEVLLI KDRTSKSRGF
60 70 80 90 100
AFITFENPAD AKNAAKDMNG KSLHGKAIKV EQAKKPSFQS GGRRRPPASS
110 120 130 140 150
RNRSPSGSLR SARGSRGGTR GWLPSQEGHL DDGGYTPDLK MSYSRGLIPV
160 170 180 190 200
KRGPSSRSGG PPPKKSAPSA VARSNSWMGS QGPMSQRREN YGVPPRRATI
210 220 230 240 250
SSWRNDRMST RHDGYATNDG NHPSCQETRD YAPPSRGYAY RDNGHSNRDE
260 270 280 290 300
HSSRGYRNHR SSRETRDYAP PSRGHAYRDY GHSRRDESYS RGYRNRRSSR
310 320 330 340 350
ETREYAPPSR GHGYRDYGHS RRHESYSRGY RNHPSSRETR DYAPPHRDYA
360 370 380 390 400
YRDYGHSSWD EHSSRGYSYH DGYGEALGRD HSEHLSGSSY RDALQRYGTS
410 420 430 440 450
HGAPPARGPR MSYGGSTCHA YSNTRDRYGR SWESYSSCGD FHYCDREHVC
460 470 480 490
RKDQRNPPSL GRVLPDPREA YGSSSYVASI VDGGESRSEK GDSSRY
Length:496
Mass (Da):55,835
Last modified:January 15, 2008 - v2
Checksum:i465F9F6BF5D72C1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010141 Genomic DNA. No translation available.
CCDSiCCDS35479.1.
RefSeqiNP_001006121.1. NM_001006121.3.
XP_011529734.1. XM_011531432.1.
UniGeneiHs.380450.

Genome annotation databases

EnsembliENST00000383020; ENSP00000372484; ENSG00000242875.
GeneIDi378948.
KEGGihsa:378948.
UCSCiuc004fuo.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010141 Genomic DNA. No translation available.
CCDSiCCDS35479.1.
RefSeqiNP_001006121.1. NM_001006121.3.
XP_011529734.1. XM_011531432.1.
UniGeneiHs.380450.

3D structure databases

ProteinModelPortaliA6NDE4.
SMRiA6NDE4. Positions 1-108.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiA6NDE4.

Polymorphism and mutation databases

BioMutaiRBMY1B.

Proteomic databases

EPDiA6NDE4.
PaxDbiA6NDE4.
PRIDEiA6NDE4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383020; ENSP00000372484; ENSG00000242875.
GeneIDi378948.
KEGGihsa:378948.
UCSCiuc004fuo.4. human.

Organism-specific databases

CTDi378948.
GeneCardsiRBMY1B.
HGNCiHGNC:23914. RBMY1B.
HPAiHPA001534.
HPA053147.
neXtProtiNX_A6NDE4.
PharmGKBiPA134872137.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J6JX. Eukaryota.
ENOG4111GI6. LUCA.
GeneTreeiENSGT00710000106295.
HOGENOMiHOG000276235.
HOVERGENiHBG063314.
InParanoidiA6NDE4.
OrthoDBiEOG780RPD.
PhylomeDBiA6NDE4.
TreeFamiTF331833.

Miscellaneous databases

GenomeRNAii378948.
PROiA6NDE4.

Gene expression databases

BgeeiA6NDE4.
CleanExiHS_RBMY1B.
ExpressionAtlasiA6NDE4. baseline.
GenevisibleiA6NDE4. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR012604. RBM1CTR.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF08081. RBM1CTR. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRBY1B_HUMAN
AccessioniPrimary (citable) accession number: A6NDE4
Secondary accession number(s): A6NCZ8, A6NE80, A8MSJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: January 15, 2008
Last modified: June 8, 2016
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.