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Protein

Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2

Gene

LRIT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2
Alternative name(s):
Leucine-rich repeat-containing protein 22
Gene namesi
Name:LRIT2
Synonyms:LRRC22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000204033.9
HGNCiHGNC:23443 LRIT2
neXtProtiNX_A6NDA9

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi340745
OpenTargetsiENSG00000204033
PharmGKBiPA162394344

Polymorphism and mutation databases

BioMutaiLRIT2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000030934420 – 550Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2Add BLAST531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi274 ↔ 327PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiA6NDA9
PaxDbiA6NDA9
PRIDEiA6NDA9

PTM databases

iPTMnetiA6NDA9
PhosphoSitePlusiA6NDA9

Expressioni

Gene expression databases

BgeeiENSG00000204033
CleanExiHS_LRIT2

Organism-specific databases

HPAiHPA037788

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000361185

Structurei

3D structure databases

ProteinModelPortaliA6NDA9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 54LRRNTAdd BLAST32
Repeati80 – 103LRR 1Add BLAST24
Repeati104 – 125LRR 2Add BLAST22
Repeati128 – 149LRR 3Add BLAST22
Repeati152 – 173LRR 4Add BLAST22
Domaini200 – 252LRRCTAdd BLAST53
Domaini253 – 341Ig-likeAdd BLAST89
Domaini361 – 451Fibronectin type-IIIAdd BLAST91

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00880000137863
HOGENOMiHOG000082676
HOVERGENiHBG060406
InParanoidiA6NDA9
OMAiFLNWPAY
OrthoDBiEOG091G06EG
PhylomeDBiA6NDA9
TreeFamiTF330861

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR003961 FN3_dom
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR020901 Prtase_inh_Kunz-CS
PfamiView protein in Pfam
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 4 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 4 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NDA9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASVFHYFLL VLVFLDTHAA QPFCLPGCTC SEESFGRTLQ CTSVSLGKIP
60 70 80 90 100
GNLSEEFKQV RIENSPLFEM PQGSFINMST LEYLWLNFNN ISVIHLGALE
110 120 130 140 150
HLPELRELRL EGNKLCSVPW TAFRATPLLR VLDLKRNKID ALPELALQFL
160 170 180 190 200
VSLTYLDLSS NRLTVVSKSV FLNWPAYQKC RQPDCGAEIL SSLVVALHDN
210 220 230 240 250
PWVCDCRLRG LVQFVKSITL PVILVNSYLI CQGPLSKAGQ LFHETELSAC
260 270 280 290 300
MKPQISTPSA NITIRAGQNV TLRCLAQASP SPSIAWTYPL SMWREFDVLT
310 320 330 340 350
SSTGEDTALS ELAIPAAHLV DSGNYTCMAS NSIGKSNLVI SLHVQPAQAL
360 370 380 390 400
HAPDSLSIPS EGNAYIDLRV VKQTVHGILL EWLAVADTSK EEWFTLYIAS
410 420 430 440 450
DEAFRKEVVH IGPGINTYAV DDLLPGTKYE ACLSLEGQPP HQGQCVAFVT
460 470 480 490 500
GRDAGGLEAR EHLLHVTVVL CVVLLAVPVG AYAWAAQGPC SCSKWVLRGC
510 520 530 540 550
LHRRKAPSCT PAAPQSKDGS FREHPAVCDD GEGHIDTEGD KEKGGTEDNS
Length:550
Mass (Da):60,168
Last modified:July 24, 2007 - v1
Checksum:iF9891BB309EDD630
GO
Isoform 2 (identifier: A6NDA9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     297-297: D → DGLLGGKHLTP

Note: No experimental confirmation available.
Show »
Length:560
Mass (Da):61,142
Checksum:i007156D0DA7A8ED9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03693528C → Y. Corresponds to variant dbSNP:rs12773843Ensembl.1
Natural variantiVAR_036936179K → N. Corresponds to variant dbSNP:rs11200927Ensembl.1
Natural variantiVAR_036937220L → F. Corresponds to variant dbSNP:rs11200925Ensembl.1
Natural variantiVAR_036938496V → A. Corresponds to variant dbSNP:rs12217769Ensembl.1
Natural variantiVAR_036939510T → P. Corresponds to variant dbSNP:rs6585847Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054539297D → DGLLGGKHLTP in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX648524 mRNA No translation available.
AC022389 Genomic DNA No translation available.
BC140765 mRNA Translation: AAI40766.1
BC144475 mRNA Translation: AAI44476.1
CCDSiCCDS31234.1 [A6NDA9-1]
CCDS60581.1 [A6NDA9-2]
RefSeqiNP_001017924.1, NM_001017924.3 [A6NDA9-1]
NP_001271152.1, NM_001284223.1 [A6NDA9-2]
UniGeneiHs.450425

Genome annotation databases

EnsembliENST00000372113; ENSP00000361185; ENSG00000204033 [A6NDA9-1]
ENST00000538192; ENSP00000438264; ENSG00000204033 [A6NDA9-2]
GeneIDi340745
KEGGihsa:340745
UCSCiuc001kcy.5 human [A6NDA9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLRIT2_HUMAN
AccessioniPrimary (citable) accession number: A6NDA9
Secondary accession number(s): B7ZME6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: February 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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