A6ND91 (ASPD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative L-aspartate dehydrogenase
EC=1.4.1.21

Alternative name(s):
Aspartate dehydrogenase domain-containing protein

Gene names

Name:

ASPDH

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	283 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate By similarity.
Catalytic activity	L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1.
Miscellaneous	The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia By similarity.
Sequence similarities	Belongs to the L-aspartate dehydrogenase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	NAD NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	NAD biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway NADP catabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	NADP binding Inferred from electronic annotation. Source: InterPro aspartate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A6ND91-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A6ND91-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2-65: ADRGPWRVGVVGYGRLGQSLVSRLLAQGPELGLELVFVWNRDPGRMAGSVPPSLQLQNLAALGE → GDRVKGSKS
     95-144: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 283	283	Putative L-aspartate dehydrogenase		PRO_0000300623
Sites
	Binding site	127	1	NAD; via amide nitrogen By similarity
	Binding site	192	1	NAD By similarity
Natural variations
	Alternative sequence	2 – 65	64	ADRGP…AALGE → GDRVKGSKS in isoform 2.		VSP_038742
	Alternative sequence	95 – 144	50	Missing in isoform 2.		VSP_038743
	Natural variant	266	1	Q → R. Ref.1 Ref.3 Corresponds to variant rs12977172 [ dbSNP | Ensembl ].		VAR_062676

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 11, 2007. Version 2. Checksum: FF4254EF3F14D840	FASTA	283	29,946
	10 20 30 40 50 60 MADRGPWRVG VVGYGRLGQS LVSRLLAQGP ELGLELVFVW NRDPGRMAGS VPPSLQLQNL 70 80 90 100 110 120 AALGERRPDL VVEVAHPKII HESGAQILRH ANLLVGSPSA LSDQTTERQL LEASQHWDHA 130 140 150 160 170 180 VFVARGALWG AEDIRRLDAA GGLRSLRVTM ATHPDGFRLE GPLAAAHSPG PCTVLYEGPV 190 200 210 220 230 240 RGLCPFAPRN SNTMAAAALA APSLGFDGVI GVLVADTSLT DMHVVDVELS GPRGPTGRSF 250 260 270 280 AVHTRRENPA EPGAVTGSAT VTAFWQSLLA CCQLPSRPGI HLC
	Isoform 2 [UniParc]. Checksum: 132E8AE73F175366	FASTA	178	18,655
	10 20 30 40 50 60 MGDRVKGSKS RRPDLVVEVA HPKIIHESGA QILRHANLLS LRVTMATHPD GFRLEGPLAA 70 80 90 100 110 120 AHSPGPCTVL YEGPVRGLCP FAPRNSNTMA AAALAAPSLG FDGVIGVLVA DTSLTDMHVV 130 140 150 160 170 DVELSGPRGP TGRSFAVHTR RENPAEPGAV TGSATVTAFW QSLLACCQLP SRPGIHLC

References

[1]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-266.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-266. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH471135 Genomic DNA. Translation: EAW71880.1. AC008743 Genomic DNA. No translation available. BC066359 mRNA. Translation: AAH66359.1.
IPI	IPI00419903. IPI00783370.
RefSeq	NP_001019827.2. NM_001024656.2. NP_001108070.1. NM_001114598.1.
UniGene	Hs.436338.
3D structure databases
ProteinModelPortal	A6ND91.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000373860.
PTM databases
PhosphoSite	A6ND91.
Proteomic databases
PaxDb	A6ND91.
PRIDE	A6ND91.
Protocols and materials databases
DNASU	554235.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000376916; ENSP00000366114; ENSG00000204653. ENST00000389208; ENSP00000373860; ENSG00000204653.
GeneID	554235.
KEGG	hsa:554235.
UCSC	uc002psr.4. human. uc010enz.3. human.
Organism-specific databases
CTD	554235.
GeneCards	GC19M051014.
HGNC	HGNC:33856. ASPDH.
HPA	HPA042631. HPA042654.
neXtProt	NX_A6ND91.
PharmGKB	PA164716234.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG73354.
HOGENOM	HOG000007399.
HOVERGEN	HBG062283.
InParanoid	A6ND91.
OMA	LAFVWNR.
Enzyme and pathway databases
UniPathway	UPA00253; UER00456.
Gene expression databases
Bgee	A6ND91.
Genevestigator	A6ND91.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR005106. Asp/hSer_DH_NAD-bd. IPR002811. Asp_DH. IPR011182. Asp_DH_NAD_syn. IPR016040. NAD(P)-bd_dom. [Graphical view]
Pfam	PF01958. DUF108. 1 hit. PF03447. NAD_binding_3. 1 hit. [Graphical view]
PIRSF	PIRSF005227. Asp_dh_NAD_syn. 1 hit.
ProtoNet	Search...
Other
NextBio	112458.

Entry information

Entry name

ASPD_HUMAN

Accession

Primary (citable) accession number: A6ND91
Secondary accession number(s): Q6NZ37

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 11, 2007
Last modified:	May 1, 2013
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.