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Protein

Olfactory receptor 14I1

Gene

OR14I1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 14I1
Alternative name(s):
Olfactory receptor 5BU1
Gene namesi
Name:OR14I1
Synonyms:OR5BU1, OR5BU1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:19575. OR14I1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence analysisAdd
BLAST
Transmembranei27 – 4721Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini48 – 558CytoplasmicSequence analysis
Transmembranei56 – 7621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini77 – 9216ExtracellularSequence analysisAdd
BLAST
Transmembranei93 – 11321Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini114 – 14128CytoplasmicSequence analysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini163 – 18927ExtracellularSequence analysisAdd
BLAST
Transmembranei190 – 21021Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini211 – 24131CytoplasmicSequence analysisAdd
BLAST
Transmembranei242 – 26221Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini263 – 2697ExtracellularSequence analysis
Transmembranei270 – 29021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini291 – 31121CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162398443.

Polymorphism and mutation databases

BioMutaiOR14I1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Olfactory receptor 14I1PRO_0000310414Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Disulfide bondi95 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6ND48.
PRIDEiA6ND48.

PTM databases

iPTMnetiA6ND48.
PhosphoSiteiA6ND48.

Expressioni

Gene expression databases

BgeeiENSG00000189181.
CleanExiHS_OR14I1.

Interactioni

Protein-protein interaction databases

BioGridi135302. 1 interaction.
STRINGi9606.ENSP00000339726.

Structurei

3D structure databases

ProteinModelPortaliA6ND48.
SMRiA6ND48. Positions 21-147.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE8E. Eukaryota.
ENOG4111AED. LUCA.
GeneTreeiENSGT00760000118849.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6ND48.
KOiK04257.
OMAiVLHAGLF.
OrthoDBiEOG091G0CU6.
PhylomeDBiA6ND48.
TreeFamiTF352740.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6ND48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNLTKVTEF LLMEFSGIWE LQVLHAGLFL LIYLAVLVGN LLIIAVITLD
60 70 80 90 100
QHLHTPMYFF LKNLSVLDLC YISVTVPKSI RNSLTRRSSI SYLGCVAQVY
110 120 130 140 150
FFSAFASAEL AFLTVMSYDR YVAICHPLQY RAVMTSGGCY QMAVTTWLSC
160 170 180 190 200
FSYAAVHTGN MFREHVCRSS VIHQFFRDIP HVLALVSCEV FFVEFLTLAL
210 220 230 240 250
SSCLVLGCFI LMMISYFQIF STVLRIPSGQ SRAKAFSTCS PQLIVIMLFL
260 270 280 290 300
TTGLFAALGP IAKALSIQDL VIALTYTVLP PFLNPIIYSL RNKEIKTAMW
310
RLFVKIYFLQ K
Length:311
Mass (Da):35,175
Last modified:July 24, 2007 - v1
Checksum:i2AC007546D7A9C59
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti36 – 361V → A.
Corresponds to variant rs4462184 [ dbSNP | Ensembl ].
VAR_037030
Natural varianti50 – 501D → N.
Corresponds to variant rs4509608 [ dbSNP | Ensembl ].
VAR_037031
Natural varianti84 – 841L → M.
Corresponds to variant rs41311583 [ dbSNP | Ensembl ].
VAR_062073
Natural varianti170 – 1701S → N.
Corresponds to variant rs2000390 [ dbSNP | Ensembl ].
VAR_037032
Natural varianti216 – 2161Y → C.
Corresponds to variant rs55871516 [ dbSNP | Ensembl ].
VAR_062074

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC098483 Genomic DNA. No translation available.
CCDSiCCDS31125.1.
RefSeqiNP_001004734.1. NM_001004734.1.
XP_005273189.1. XM_005273132.3.
UniGeneiHs.449973.

Genome annotation databases

EnsembliENST00000342623; ENSP00000339726; ENSG00000189181.
GeneIDi401994.
KEGGihsa:401994.
UCSCiuc001ieu.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC098483 Genomic DNA. No translation available.
CCDSiCCDS31125.1.
RefSeqiNP_001004734.1. NM_001004734.1.
XP_005273189.1. XM_005273132.3.
UniGeneiHs.449973.

3D structure databases

ProteinModelPortaliA6ND48.
SMRiA6ND48. Positions 21-147.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi135302. 1 interaction.
STRINGi9606.ENSP00000339726.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiA6ND48.
PhosphoSiteiA6ND48.

Polymorphism and mutation databases

BioMutaiOR14I1.

Proteomic databases

PaxDbiA6ND48.
PRIDEiA6ND48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342623; ENSP00000339726; ENSG00000189181.
GeneIDi401994.
KEGGihsa:401994.
UCSCiuc001ieu.1. human.

Organism-specific databases

CTDi401994.
GeneCardsiOR14I1.
HGNCiHGNC:19575. OR14I1.
neXtProtiNX_A6ND48.
PharmGKBiPA162398443.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE8E. Eukaryota.
ENOG4111AED. LUCA.
GeneTreeiENSGT00760000118849.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6ND48.
KOiK04257.
OMAiVLHAGLF.
OrthoDBiEOG091G0CU6.
PhylomeDBiA6ND48.
TreeFamiTF352740.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii401994.
PROiA6ND48.

Gene expression databases

BgeeiENSG00000189181.
CleanExiHS_OR14I1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO14I1_HUMAN
AccessioniPrimary (citable) accession number: A6ND48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.