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A6ND05 (A6ND05_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Potassium voltage-gated channel subfamily KQT member 2 Ensembl ENSP00000346601
Gene names
Name:KCNQ2 Ensembl ENSP00000346601
OrganismHomo sapiens (Human) [Reference proteome] Ensembl ENSP00000346601
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length880 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000346601

Ontologies

Keywords
   Biological processIon transport
Potassium transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix SAAS SAAS003091
   LigandPotassium
   Molecular functionIon channel
Potassium channel SAAS SAAS003091
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentvoltage-gated potassium channel complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionvoltage-gated potassium channel activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
A6ND05 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 1A771BD15A46FF14

FASTA88096,968
        10         20         30         40         50         60 
MVQKSRNGGV YPGPSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEAPKR GSILSKPRAG 

        70         80         90        100        110        120 
GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF LLVFSCLVLS VFSTIKEYEK 

       130        140        150        160        170        180 
SSEGALYILE IVTIVVFGVE YFVRIWAAGC CCRYRGWRGR LKFARKPFCV IDIMVLIASI 

       190        200        210        220        230        240 
AVLAAGSQGN VFATSALRSL RFLQILRMIR MDRRGGTWKL LGSVVYAHSK ELVTAWYIGF 

       250        260        270        280        290        300 
LCLILASFLV YLAEKGENDH FDTYADALWW GLITLTTIGY GDKYPQTWNG RLLAATFTLI 

       310        320        330        340        350        360 
GVSFFALPAG ILGSGFALKV QEQHRQKHFE KRRNPAAGLI QSAWRFYATN LSRTDLHSTW 

       370        380        390        400        410        420 
QYYERTVTVP MYRLIPPLNQ LELLRNLKSK SGLAFRKDPP PEPSPSQKVS LKDRVFSSPR 

       430        440        450        460        470        480 
GVAAKGKGSP QAQTVRRSPS ADQSLEDSPS KVPKSWSFGD RSRARQAFRI KGAASRQNSE 

       490        500        510        520        530        540 
EASLPGEDIV DDKSCPCEFV TEDLTPGLKV SIRAVCVMRF LVSKRKFKES LRPYDVMDVI 

       550        560        570        580        590        600 
EQYSAGHLDM LSRIKSLQTG IDMIVGPPPP STPRHKKYPT KGPTAPPRES PQYSPRVDQI 

       610        620        630        640        650        660 
VGRGPAITDK DRTKGPAEAE LPEDPSMMGR LGKVEKQVLS MEKKLDFLVN IYMQRMGIPP 

       670        680        690        700        710        720 
TETEAYFGAK EPEPAPPYHS PEDSREHVDR HGCIVKIVRS SSSTGQKNFS APPAAPPVQC 

       730        740        750        760        770        780 
PPSTSWQPQS HPRQGHGTSP VGDHGSLVRI PPPPAHERSL SAYGGGNRAS MEFLRQEDTP 

       790        800        810        820        830        840 
GCRPPEGNLR DSDTSISIPS VDHEELERSF SGFSISQSKE NLDALNSCYA AVAPCAKVRP 

       850        860        870        880 
YIAEGESDTD SDLCTPCGPP PRSATGEGPF GDVGWAGPRK

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Ensembl
Submitted (JUL-2011) to UniProtKB
Cited for: IDENTIFICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL121827 Genomic DNA. No translation available.
AL121829 Genomic DNA. No translation available.
AL353658 Genomic DNA. No translation available.
IPIIPI00386577.

3D structure databases

ProteinModelPortalA6ND05.
SMRA6ND05. Positions 65-316, 502-527.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6ND05.

Proteomic databases

PRIDEA6ND05.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000354587; ENSP00000346601; ENSG00000075043.

Organism-specific databases

HGNCHGNC:6296. KCNQ2.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000220839.
HOVERGENHBG059014.

Gene expression databases

ArrayExpressA6ND05.
BgeeA6ND05.

Family and domain databases

InterProIPR020969. Ankyrin-G_BS.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003937. K_chnl_volt-dep_KCNQ.
IPR003947. K_chnl_volt-dep_KCNQ2.
IPR013821. K_chnl_volt-dep_KCNQ_C.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF00520. Ion_trans. 1 hit.
PF03520. KCNQ_channel. 2 hits.
PF11956. KCNQC3-Ank-G_bd. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01461. KCNQ2CHANNEL.
PR01459. KCNQCHANNEL.
ProtoNetSearch...

Other

ChiTaRSKCNQ2. human.
NextBio35462465.

Entry information

Entry nameA6ND05_HUMAN
AccessionPrimary (citable) accession number: A6ND05
Entry history
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: May 1, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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