A6ND01 (FOLR4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable folate receptor delta
Short name=FR-delta

Alternative name(s):
Folate receptor 4

Gene names

Name:

FOLR4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Secreted Potential.
Post-translational modification	Eight disulfide bonds are present Potential.
Sequence similarities	Belongs to the folate receptor family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Signal
Ligand	Folate-binding
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	folic acid binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A6ND01-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available. Gene prediction based on EST data.

Isoform 2 (identifier: A6ND01-2)

The sequence of this isoform differs from the canonical sequence as follows:
     110-116: Missing.

Note: No experimental confirmation available. Gene prediction based on similarity to orthologs.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 250	231	Probable folate receptor delta		PRO_0000332987
Amino acid modifications
	Glycosylation	73	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	110 – 116	7	Missing in isoform 2.		VSP_040470

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 11, 2011. Version 3. Checksum: CBF2FD967ABAF6E7	FASTA	250	28,672
	10 20 30 40 50 60 MACWWPLLLE LWTVMPTWAG DELLNICMNA KHHKRVPSPE DKLYEECIPW KDNACCTLTT 70 80 90 100 110 120 SWEAHLDVSP LYNFSLFHCG LLMPGCRKHF IQAICFYECS PNLGPWIQPV GSLGWEVAPS 130 140 150 160 170 180 GQGERVVNVP LCQEDCEEWW EDCRMSYTCK SNWRGGWDWS QGKNRCPKGA QCLPFSHYFP 190 200 210 220 230 240 TPADLCEKTW SNSFKASPER RNSGRCLQKW FEPAQGNPNV AVARLFASSA PSWELSYTIM 250 VCSLFLPFLS
	Isoform 2 [UniParc]. Checksum: 814B8F7C842BAFBF	FASTA	243	27,943
	10 20 30 40 50 60 MACWWPLLLE LWTVMPTWAG DELLNICMNA KHHKRVPSPE DKLYEECIPW KDNACCTLTT 70 80 90 100 110 120 SWEAHLDVSP LYNFSLFHCG LLMPGCRKHF IQAICFYECS PNLGPWIQPV APSGQGERVV 130 140 150 160 170 180 NVPLCQEDCE EWWEDCRMSY TCKSNWRGGW DWSQGKNRCP KGAQCLPFSH YFPTPADLCE 190 200 210 220 230 240 KTWSNSFKAS PERRNSGRCL QKWFEPAQGN PNVAVARLFA SSAPSWELSY TIMVCSLFLP FLS

References

[1]

"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP002784 Genomic DNA. No translation available.
IPI	IPI00375752. IPI00939736.
RefSeq	NP_001186135.1. NM_001199206.1.
UniGene	Hs.553758.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000416935.
Proteomic databases
PaxDb	A6ND01.
PRIDE	A6ND01.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000440961; ENSP00000416935; ENSG00000183560.
GeneID	390243.
KEGG	hsa:390243.
UCSC	uc021qou.1. human.
Organism-specific databases
CTD	390243.
GeneCards	GC11P094038.
HGNC	HGNC:32565. FOLR4.
neXtProt	NX_A6ND01.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG44097.
HOGENOM	HOG000006539.
HOVERGEN	HBG039612.
InParanoid	A6ND01.
KO	K13649.
OMA	GRCLQKW.
OrthoDB	EOG4HDSV6.
Gene expression databases
Bgee	A6ND01.
Genevestigator	A6ND01.
Family and domain databases
InterPro	IPR004269. Folate_rcpt. IPR018143. Folate_rcpt-like. [Graphical view]
PANTHER	PTHR10517. PTHR10517. 1 hit.
Pfam	PF03024. Folate_rec. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	390243.
NextBio	103567.

Entry information

Entry name

FOLR4_HUMAN

Accession

Primary (citable) accession number: A6ND01

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	January 11, 2011
Last modified:	April 3, 2013
This is version 43 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.