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A6NCW0

- U17L3_HUMAN

UniProt

A6NCW0 - U17L3_HUMAN

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Protein

Ubiquitin carboxyl-terminal hydrolase 17-like protein 3

Gene

USP17L3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891NucleophilePROSITE-ProRule annotation
Active sitei334 – 3341Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitinyl hydrolase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Apoptosis, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 17-like protein 3 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 17-like protein 3
Ubiquitin thioesterase 17-like protein 3
Ubiquitin-specific-processing protease 17-like protein 3
Gene namesi
Name:USP17L3
Synonyms:USP17B, USP17F
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:37175. USP17L3.

Subcellular locationi

Nucleus By similarity. Endoplasmic reticulum By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Ubiquitin carboxyl-terminal hydrolase 17-like protein 3PRO_0000331645Add
BLAST

Proteomic databases

PRIDEiA6NCW0.

Expressioni

Gene expression databases

GenevestigatoriA6NCW0.

Organism-specific databases

HPAiHPA045642.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000327703.

Structurei

3D structure databases

ProteinModelPortaliA6NCW0.
SMRiA6NCW0. Positions 49-372.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 375296USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family. USP17 subfamily.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

GeneTreeiENSGT00760000119279.
HOGENOMiHOG000144638.
HOVERGENiHBG007129.
InParanoidiA6NCW0.
PhylomeDBiA6NCW0.

Family and domain databases

InterProiIPR006861. HABP4_PAIRBP1-bd.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF04774. HABP4_PAI-RBP1. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NCW0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGDDSLYLGG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSSETRVD
60 70 80 90 100
LCDDLAPVAR QLAPREKLPL SSRRPAAVGA GLQNMGNTCY ENASLQCLTY
110 120 130 140 150
TLPLANYMLS REHSQTCQRP KCCMLCTMQA HITWALHSPG HVIQPSQALA
160 170 180 190 200
SGFHRGKQED VHEFLMFTVD AMKKACLPGH KQVDHHSKDT TLIHQIFGGC
210 220 230 240 250
WRSQIKCLHC HGISDTFDPY LDIALDIQAA QSVKQALEQL VKPEELNGEN
260 270 280 290 300
AYHCGLCLQR APASNTLTLH TSAKVLILVL KRFSDVAGNK LAKNVQYPEC
310 320 330 340 350
LDMQPYMSQQ NTGPLVYVLY AVLVHAGWSC HDGHYFSYVK AQEGQWYKMD
360 370 380 390 400
DAEVTVCSIT SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD
410 420 430 440 450
RRAKQGELKR DHPCLQAPEL DEHLVERATQ ESTLDHWKFL QEQNKTKPEF
460 470 480 490 500
NVGKVEGTLP PNALVIHQSK YKCGMKNHHP EQQSSLLNLS STTRTDQESM
510 520 530
NTGTLASLQG RTRRAKGKNK HSKRALLVCQ
Length:530
Mass (Da):59,536
Last modified:July 24, 2007 - v1
Checksum:iE7452B190523A0F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130365 Genomic DNA. No translation available.
RefSeqiNP_001243800.1. NM_001256871.1.
UniGeneiHs.741131.

Genome annotation databases

EnsembliENST00000530484; ENSP00000485323; ENSG00000225327.
GeneIDi645836.
KEGGihsa:645836.
UCSCiuc031taf.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130365 Genomic DNA. No translation available.
RefSeqi NP_001243800.1. NM_001256871.1.
UniGenei Hs.741131.

3D structure databases

ProteinModelPortali A6NCW0.
SMRi A6NCW0. Positions 49-372.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000327703.

Proteomic databases

PRIDEi A6NCW0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000530484 ; ENSP00000485323 ; ENSG00000225327 .
GeneIDi 645836.
KEGGi hsa:645836.
UCSCi uc031taf.1. human.

Organism-specific databases

CTDi 645836.
GeneCardsi GC08M007833.
HGNCi HGNC:37175. USP17L3.
HPAi HPA045642.
neXtProti NX_A6NCW0.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000119279.
HOGENOMi HOG000144638.
HOVERGENi HBG007129.
InParanoidi A6NCW0.
PhylomeDBi A6NCW0.

Miscellaneous databases

GenomeRNAii 645836.
NextBioi 118020.
PROi A6NCW0.

Gene expression databases

Genevestigatori A6NCW0.

Family and domain databases

InterProi IPR006861. HABP4_PAIRBP1-bd.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF04774. HABP4_PAI-RBP1. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence."
    Burrows J.F., McGrattan M.J., Johnston J.A.
    Genomics 85:524-529(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, NOMENCLATURE.
  3. "Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability."
    Shin J.-M., Yoo K.-J., Kim M.-S., Kim D., Baek K.-H.
    BMC Genomics 7:292-292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.

Entry informationi

Entry nameiU17L3_HUMAN
AccessioniPrimary (citable) accession number: A6NCW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 24, 2007
Last modified: November 26, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of the USP17 gene. It is present with an interindividual variation in copy number, ranging from 20 to 103, and can be found in the genome both on chromosome 4 and chromosome 8. The high similarity between the UPS17-like genes makes impossible to clearly assign data to one of the genes of the family. Oligonucleotides designed in RNAi experiments are for instance not specific of a given UPS17-like gene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3