A6NCW0 (U17L3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin carboxyl-terminal hydrolase 17-like protein 3
EC=3.4.19.12

Alternative name(s):
Deubiquitinating enzyme 17-like protein 3
Ubiquitin thiolesterase 17-like protein 3
Ubiquitin-specific-processing protease 17-like protein 3

Gene names

Name:	USP17L3
Synonyms:	USP17B, USP17F

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Functions in cell apoptosis. Cleaves ubiquitin fusion protein substrates By similarity.
Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the peptidase C19 family. USP17 subfamily.
Caution	The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of USP17. It is present with an interindividual variation in copy number and between 20 to 103 copies can be found in the genome both on chromosome 4 and chromosome 8.

Ontologies

Keywords
Biological process	Apoptosis Ubl conjugation pathway
Cellular component	Nucleus
Molecular function	Hydrolase Protease Thiol protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin thiolesterase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 530	530	Ubiquitin carboxyl-terminal hydrolase 17-like protein 3		PRO_0000331645
Sites
	Active site	89	1	Nucleophile By similarity
	Active site	334	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6NCW0 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: E7452B190523A0F3	FASTA	530	59,536
	10 20 30 40 50 60 MGDDSLYLGG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSSETRVD LCDDLAPVAR 70 80 90 100 110 120 QLAPREKLPL SSRRPAAVGA GLQNMGNTCY ENASLQCLTY TLPLANYMLS REHSQTCQRP 130 140 150 160 170 180 KCCMLCTMQA HITWALHSPG HVIQPSQALA SGFHRGKQED VHEFLMFTVD AMKKACLPGH 190 200 210 220 230 240 KQVDHHSKDT TLIHQIFGGC WRSQIKCLHC HGISDTFDPY LDIALDIQAA QSVKQALEQL 250 260 270 280 290 300 VKPEELNGEN AYHCGLCLQR APASNTLTLH TSAKVLILVL KRFSDVAGNK LAKNVQYPEC 310 320 330 340 350 360 LDMQPYMSQQ NTGPLVYVLY AVLVHAGWSC HDGHYFSYVK AQEGQWYKMD DAEVTVCSIT 370 380 390 400 410 420 SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD RRAKQGELKR DHPCLQAPEL 430 440 450 460 470 480 DEHLVERATQ ESTLDHWKFL QEQNKTKPEF NVGKVEGTLP PNALVIHQSK YKCGMKNHHP 490 500 510 520 530 EQQSSLLNLS STTRTDQESM NTGTLASLQG RTRRAKGKNK HSKRALLVCQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed: 16421571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence." Burrows J.F., McGrattan M.J., Johnston J.A. Genomics 85:524-529(2005) [PubMed: 15780755] [Abstract] Cited for: IDENTIFICATION, NOMENCLATURE.
[3]	"Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability." Shin J.-M., Yoo K.-J., Kim M.-S., Kim D., Baek K.-H. BMC Genomics 7:292-292(2006) [PubMed: 17109758] [Abstract] Cited for: NOMENCLATURE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC130365 Genomic DNA. No translation available.
IPI	IPI00736169.
3D structure databases
ProteinModelPortal	A6NCW0.
SMR	A6NCW0. Positions 80-374.
ModBase	Search...
Protein-protein interaction databases
STRING	A6NCW0.
Proteomic databases
PRIDE	A6NCW0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000329157; ENSP00000327703; ENSG00000225327.
Organism-specific databases
GeneCards	GC08M007833.
HGNC	HGNC:37175. USP17L3.
neXtProt	NX_A6NCW0.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14403.
GeneTree	ENSGT00600000084018.
HOGENOM	HBG506630.
HOVERGEN	HBG007129.
InParanoid	A6NCW0.
OMA	KHRINEI.
OrthoDB	EOG42V8G0.
PhylomeDB	A6NCW0.
Gene expression databases
Genevestigator	A6NCW0.
Family and domain databases
InterPro	IPR006861. HABP4_PAIRBP1-bd. IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. [Graphical view]
Pfam	PF04774. HABP4_PAI-RBP1. 1 hit. PF00443. UCH. 1 hit. [Graphical view]
PROSITE	PS00972. UCH_2_1. False negative. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	118020.

Entry information

Entry name

U17L3_HUMAN

Accession

Primary (citable) accession number: A6NCW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	July 24, 2007
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.