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Protein

Olfactory receptor 6C74

Gene

OR6C74

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6C74
Gene namesi
Name:OR6C74
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:31303. OR6C74.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence analysisAdd
BLAST
Transmembranei24 – 4421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini45 – 6319CytoplasmicSequence analysisAdd
BLAST
Transmembranei64 – 8421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini85 – 9511ExtracellularSequence analysisAdd
BLAST
Transmembranei96 – 11621Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini117 – 14024CytoplasmicSequence analysisAdd
BLAST
Transmembranei141 – 16121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini162 – 19433ExtracellularSequence analysisAdd
BLAST
Transmembranei195 – 21521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini216 – 23722CytoplasmicSequence analysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 26911ExtracellularSequence analysisAdd
BLAST
Transmembranei270 – 29021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini291 – 31222CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134897737.

Polymorphism and mutation databases

BioMutaiOR6C74.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 6C74PRO_0000309619Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Disulfide bondi95 ↔ 177PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NCV1.
PRIDEiA6NCV1.
TopDownProteomicsiA6NCV1.

PTM databases

iPTMnetiA6NCV1.
PhosphoSiteiA6NCV1.

Expressioni

Gene expression databases

CleanExiHS_OR6C74.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000342836.

Structurei

3D structure databases

ProteinModelPortaliA6NCV1.
SMRiA6NCV1. Positions 34-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIV6. Eukaryota.
ENOG411142A. LUCA.
GeneTreeiENSGT00760000118790.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6NCV1.
KOiK04257.
OMAiTDIIELM.
OrthoDBiEOG7KH9K8.
PhylomeDBiA6NCV1.
TreeFamiTF336833.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NCV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNHTTVANF ILLGLTDDPQ LQVIIFLLLF FTYMLSITGN LTIITLTLLD
60 70 80 90 100
LHLKTPMYFF LRNFSFLEVS FTTVYIPKFL VSMATGDKTI SYNDCAAQLF
110 120 130 140 150
FTILLGATEF FLLAAMSYER YVAICKPLHY TTIMSSRVCS LLVFASWMAG
160 170 180 190 200
FLIIFPPLLM GLQLDFCAAN TVDHFFCDVS PILQLSCTDT DIIELMMLLS
210 220 230 240 250
AILTLLVTLV LVILSYTNII RTILKIPSSQ QRKKAFSTCS SHMVVVSISY
260 270 280 290 300
GSCIFMYVKP SAKERVSLNK GIALLSTSVA PMLNPFIYTL RNKQVKDVFK
310
HTVKKIELFS MK
Length:312
Mass (Da):35,253
Last modified:July 24, 2007 - v1
Checksum:i90C62992CA8844AA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21R → G.
Corresponds to variant rs7301705 [ dbSNP | Ensembl ].
VAR_036981
Natural varianti61 – 611L → F.
Corresponds to variant rs11171388 [ dbSNP | Ensembl ].
VAR_036982
Natural varianti75 – 751Y → C.
Corresponds to variant rs4388990 [ dbSNP | Ensembl ].
VAR_036983
Natural varianti86 – 861G → D.
Corresponds to variant rs6581025 [ dbSNP | Ensembl ].
VAR_036984
Natural varianti120 – 1201R → C.
Corresponds to variant rs4321039 [ dbSNP | Ensembl ].
VAR_036985

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122684 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW96805.1.
CCDSiCCDS31816.1.
RefSeqiNP_001005490.1. NM_001005490.1.
XP_011536430.1. XM_011538128.1.
UniGeneiHs.554556.

Genome annotation databases

EnsembliENST00000343870; ENSP00000342836; ENSG00000197706.
GeneIDi254783.
KEGGihsa:254783.
UCSCiuc010spg.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122684 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW96805.1.
CCDSiCCDS31816.1.
RefSeqiNP_001005490.1. NM_001005490.1.
XP_011536430.1. XM_011538128.1.
UniGeneiHs.554556.

3D structure databases

ProteinModelPortaliA6NCV1.
SMRiA6NCV1. Positions 34-304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000342836.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiA6NCV1.
PhosphoSiteiA6NCV1.

Polymorphism and mutation databases

BioMutaiOR6C74.

Proteomic databases

PaxDbiA6NCV1.
PRIDEiA6NCV1.
TopDownProteomicsiA6NCV1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343870; ENSP00000342836; ENSG00000197706.
GeneIDi254783.
KEGGihsa:254783.
UCSCiuc010spg.3. human.

Organism-specific databases

CTDi254783.
GeneCardsiOR6C74.
HGNCiHGNC:31303. OR6C74.
neXtProtiNX_A6NCV1.
PharmGKBiPA134897737.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIV6. Eukaryota.
ENOG411142A. LUCA.
GeneTreeiENSGT00760000118790.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6NCV1.
KOiK04257.
OMAiTDIIELM.
OrthoDBiEOG7KH9K8.
PhylomeDBiA6NCV1.
TreeFamiTF336833.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii254783.
NextBioi92389.
PROiA6NCV1.

Gene expression databases

CleanExiHS_OR6C74.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiO6C74_HUMAN
AccessioniPrimary (citable) accession number: A6NCV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: March 16, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.