ID   RN222_HUMAN             Reviewed;         220 AA.
AC   A6NCQ9;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   24-JAN-2024, entry version 116.
DE   RecName: Full=RING finger protein 222;
GN   Name=RNF222;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AC026130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS45608.1; -.
DR   RefSeq; NP_001140156.1; NM_001146684.2.
DR   RefSeq; XP_011522280.1; XM_011523978.2.
DR   RefSeq; XP_011522281.1; XM_011523979.2.
DR   RefSeq; XP_011522282.1; XM_011523980.2.
DR   RefSeq; XP_011522283.1; XM_011523981.2.
DR   AlphaFoldDB; A6NCQ9; -.
DR   BioGRID; 569148; 1.
DR   STRING; 9606.ENSP00000382330; -.
DR   iPTMnet; A6NCQ9; -.
DR   PhosphoSitePlus; A6NCQ9; -.
DR   BioMuta; RNF222; -.
DR   MassIVE; A6NCQ9; -.
DR   PaxDb; 9606-ENSP00000382330; -.
DR   PeptideAtlas; A6NCQ9; -.
DR   Antibodypedia; 62437; 6 antibodies from 6 providers.
DR   DNASU; 643904; -.
DR   Ensembl; ENST00000344001.3; ENSP00000343799.3; ENSG00000189051.6.
DR   Ensembl; ENST00000399398.3; ENSP00000382330.1; ENSG00000189051.6.
DR   GeneID; 643904; -.
DR   KEGG; hsa:643904; -.
DR   MANE-Select; ENST00000399398.3; ENSP00000382330.1; NM_001146684.3; NP_001140156.1.
DR   UCSC; uc010vuy.2; human.
DR   AGR; HGNC:34517; -.
DR   CTD; 643904; -.
DR   GeneCards; RNF222; -.
DR   HGNC; HGNC:34517; RNF222.
DR   HPA; ENSG00000189051; Tissue enhanced (esophagus, skin, vagina).
DR   neXtProt; NX_A6NCQ9; -.
DR   OpenTargets; ENSG00000189051; -.
DR   PharmGKB; PA164725453; -.
DR   VEuPathDB; HostDB:ENSG00000189051; -.
DR   eggNOG; ENOG502S4BM; Eukaryota.
DR   GeneTree; ENSGT00390000002856; -.
DR   HOGENOM; CLU_1242627_0_0_1; -.
DR   InParanoid; A6NCQ9; -.
DR   OMA; TRSFCCR; -.
DR   OrthoDB; 901818at2759; -.
DR   PhylomeDB; A6NCQ9; -.
DR   TreeFam; TF333220; -.
DR   PathwayCommons; A6NCQ9; -.
DR   SignaLink; A6NCQ9; -.
DR   SIGNOR; A6NCQ9; -.
DR   BioGRID-ORCS; 643904; 7 hits in 1177 CRISPR screens.
DR   GenomeRNAi; 643904; -.
DR   Pharos; A6NCQ9; Tdark.
DR   PRO; PR:A6NCQ9; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; A6NCQ9; Protein.
DR   Bgee; ENSG00000189051; Expressed in lower esophagus mucosa and 21 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd16564; RING-HC_RNF222; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR042973; RNF222.
DR   InterPro; IPR027370; Znf-RING_euk.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR47095; RING FINGER PROTEIN 222; 1.
DR   PANTHER; PTHR47095:SF1; RING FINGER PROTEIN 222; 1.
DR   Pfam; PF13445; zf-RING_UBOX; 1.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Membrane; Metal-binding; Reference proteome; Transmembrane;
KW   Transmembrane helix; Zinc; Zinc-finger.
FT   CHAIN           1..220
FT                   /note="RING finger protein 222"
FT                   /id="PRO_0000329085"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         14..65
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          108..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   220 AA;  23767 MW;  67080B8736DBDD1B CRC64;
     MSEGESKDSS GSECPVCYEK FRDLEGASRT LSCGHVFCHD CLVKYLLSTR VDGQVQRTLV
     CPICRYVTFL SKKSSRWPSM LDKSSQTLAV PVGLPSVPPL DSLGHTNPLA ASSPAWRPPP
     GQARPPGSPG QSAQLPLDLL PSLPRESQIF VISRHGMPLG EQDSVLPRRS LAELSEASLA
     PRSARAFCCR SRALLLITLI AVVAVVAAIL PWVLLVRKQA
//