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Protein

RING finger protein 222

Gene

RNF222

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri14 – 65RING-typePROSITE-ProRule annotationAdd BLAST52

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 222
Gene namesi
Name:RNF222
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:34517. RNF222.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000189051.
PharmGKBiPA164725453.

Polymorphism and mutation databases

BioMutaiRNF222.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003290851 – 220RING finger protein 222Add BLAST220

Proteomic databases

PaxDbiA6NCQ9.
PRIDEiA6NCQ9.

PTM databases

iPTMnetiA6NCQ9.
PhosphoSitePlusiA6NCQ9.

Expressioni

Gene expression databases

BgeeiENSG00000189051.

Organism-specific databases

HPAiHPA048916.

Interactioni

Protein-protein interaction databases

BioGridi569148. 1 interactor.
STRINGi9606.ENSP00000343799.

Structurei

3D structure databases

ProteinModelPortaliA6NCQ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri14 – 65RING-typePROSITE-ProRule annotationAdd BLAST52

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiENOG410J277. Eukaryota.
ENOG411286J. LUCA.
GeneTreeiENSGT00390000002856.
HOGENOMiHOG000137599.
HOVERGENiHBG054934.
InParanoidiA6NCQ9.
OMAiCPICRYV.
OrthoDBiEOG091G0KNP.
PhylomeDBiA6NCQ9.
TreeFamiTF333220.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR027370. Znf-RING_LisH.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
PfamiView protein in Pfam
PF13445. zf-RING_UBOX. 1 hit.
SMARTiView protein in SMART
SM00184. RING. 1 hit.
PROSITEiView protein in PROSITE
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NCQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEGESKDSS GSECPVCYEK FRDLEGASRT LSCGHVFCHD CLVKYLLSTR
60 70 80 90 100
VDGQVQRTLV CPICRYVTFL SKKSSRWPSM LDKSSQTLAV PVGLPSVPPL
110 120 130 140 150
DSLGHTNPLA ASSPAWRPPP GQARPPGSPG QSAQLPLDLL PSLPRESQIF
160 170 180 190 200
VISRHGMPLG EQDSVLPRRS LAELSEASLA PRSARAFCCR SRALLLITLI
210 220
AVVAVVAAIL PWVLLVRKQA
Length:220
Mass (Da):23,767
Last modified:July 24, 2007 - v1
Checksum:i67080B8736DBDD1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC026130 Genomic DNA. No translation available.
CCDSiCCDS45608.1.
RefSeqiNP_001140156.1. NM_001146684.2.
XP_011522280.1. XM_011523978.2.
XP_011522281.1. XM_011523979.2.
XP_011522282.1. XM_011523980.2.
XP_011522283.1. XM_011523981.2.
UniGeneiHs.526550.

Genome annotation databases

EnsembliENST00000344001; ENSP00000343799; ENSG00000189051.
ENST00000399398; ENSP00000382330; ENSG00000189051.
GeneIDi643904.
KEGGihsa:643904.
UCSCiuc010vuy.2. human.

Similar proteinsi

Entry informationi

Entry nameiRN222_HUMAN
AccessioniPrimary (citable) accession number: A6NCQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 24, 2007
Last modified: August 30, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM