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A6NCQ9

- RN222_HUMAN

UniProt

A6NCQ9 - RN222_HUMAN

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Protein
RING finger protein 222
Gene
RNF222
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri14 – 6552RING-type
Add
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 222
Gene namesi
Name:RNF222
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:34517. RNF222.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei196 – 21621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164725453.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220RING finger protein 222
PRO_0000329085Add
BLAST

Proteomic databases

PaxDbiA6NCQ9.
PRIDEiA6NCQ9.

Expressioni

Gene expression databases

BgeeiA6NCQ9.
GenevestigatoriA6NCQ9.

Organism-specific databases

HPAiHPA048916.

Interactioni

Protein-protein interaction databases

BioGridi569148. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliA6NCQ9.
SMRiA6NCQ9. Positions 9-68.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiNOG39960.
HOGENOMiHOG000137599.
HOVERGENiHBG054934.
InParanoidiA6NCQ9.
OMAiLGHTNPL.
OrthoDBiEOG7VX8XF.
PhylomeDBiA6NCQ9.
TreeFamiTF333220.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NCQ9-1 [UniParc]FASTAAdd to Basket

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MSEGESKDSS GSECPVCYEK FRDLEGASRT LSCGHVFCHD CLVKYLLSTR    50
VDGQVQRTLV CPICRYVTFL SKKSSRWPSM LDKSSQTLAV PVGLPSVPPL 100
DSLGHTNPLA ASSPAWRPPP GQARPPGSPG QSAQLPLDLL PSLPRESQIF 150
VISRHGMPLG EQDSVLPRRS LAELSEASLA PRSARAFCCR SRALLLITLI 200
AVVAVVAAIL PWVLLVRKQA 220
Length:220
Mass (Da):23,767
Last modified:July 24, 2007 - v1
Checksum:i67080B8736DBDD1B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC026130 Genomic DNA. No translation available.
CCDSiCCDS45608.1.
RefSeqiNP_001140156.1. NM_001146684.2.
UniGeneiHs.526550.

Genome annotation databases

EnsembliENST00000344001; ENSP00000343799; ENSG00000189051.
ENST00000399398; ENSP00000382330; ENSG00000189051.
GeneIDi643904.
KEGGihsa:643904.
UCSCiuc010vuy.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC026130 Genomic DNA. No translation available.
CCDSi CCDS45608.1.
RefSeqi NP_001140156.1. NM_001146684.2.
UniGenei Hs.526550.

3D structure databases

ProteinModelPortali A6NCQ9.
SMRi A6NCQ9. Positions 9-68.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 569148. 1 interaction.

Proteomic databases

PaxDbi A6NCQ9.
PRIDEi A6NCQ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000344001 ; ENSP00000343799 ; ENSG00000189051 .
ENST00000399398 ; ENSP00000382330 ; ENSG00000189051 .
GeneIDi 643904.
KEGGi hsa:643904.
UCSCi uc010vuy.1. human.

Organism-specific databases

CTDi 643904.
GeneCardsi GC17M008295.
HGNCi HGNC:34517. RNF222.
HPAi HPA048916.
neXtProti NX_A6NCQ9.
PharmGKBi PA164725453.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39960.
HOGENOMi HOG000137599.
HOVERGENi HBG054934.
InParanoidi A6NCQ9.
OMAi LGHTNPL.
OrthoDBi EOG7VX8XF.
PhylomeDBi A6NCQ9.
TreeFami TF333220.

Miscellaneous databases

GenomeRNAii 643904.
NextBioi 115567.
PROi A6NCQ9.

Gene expression databases

Bgeei A6NCQ9.
Genevestigatori A6NCQ9.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF13639. zf-RING_2. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
[Graphical view ]
PROSITEi PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRN222_HUMAN
AccessioniPrimary (citable) accession number: A6NCQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 24, 2007
Last modified: July 9, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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