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A6NCQ9 (RN222_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RING finger protein 222
Gene names
Name:RNF222
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Contains 1 RING-type zinc finger.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 220220RING finger protein 222
PRO_0000329085

Regions

Transmembrane196 – 21621Helical; Potential
Zinc finger14 – 6552RING-type

Sequences

Sequence LengthMass (Da)Tools
A6NCQ9 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 67080B8736DBDD1B

FASTA22023,767
        10         20         30         40         50         60 
MSEGESKDSS GSECPVCYEK FRDLEGASRT LSCGHVFCHD CLVKYLLSTR VDGQVQRTLV 

        70         80         90        100        110        120 
CPICRYVTFL SKKSSRWPSM LDKSSQTLAV PVGLPSVPPL DSLGHTNPLA ASSPAWRPPP 

       130        140        150        160        170        180 
GQARPPGSPG QSAQLPLDLL PSLPRESQIF VISRHGMPLG EQDSVLPRRS LAELSEASLA 

       190        200        210        220 
PRSARAFCCR SRALLLITLI AVVAVVAAIL PWVLLVRKQA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC026130 Genomic DNA. No translation available.
RefSeqNP_001140156.1. NM_001146684.2.
UniGeneHs.526550.

3D structure databases

ProteinModelPortalA6NCQ9.
SMRA6NCQ9. Positions 5-68.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbA6NCQ9.
PRIDEA6NCQ9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000344001; ENSP00000343799; ENSG00000189051.
ENST00000399398; ENSP00000382330; ENSG00000189051.
GeneID643904.
KEGGhsa:643904.
UCSCuc010vuy.1. human.

Organism-specific databases

CTD643904.
GeneCardsGC17M008295.
HGNCHGNC:34517. RNF222.
HPAHPA048916.
neXtProtNX_A6NCQ9.
PharmGKBPA164725453.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39960.
HOGENOMHOG000137599.
HOVERGENHBG054934.
InParanoidA6NCQ9.
OMACPICRYV.
OrthoDBEOG7VX8XF.
PhylomeDBA6NCQ9.
TreeFamTF333220.

Gene expression databases

BgeeA6NCQ9.
GenevestigatorA6NCQ9.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTSM00184. RING. 1 hit.
[Graphical view]
PROSITEPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi643904.
NextBio115567.
PROA6NCQ9.

Entry information

Entry nameRN222_HUMAN
AccessionPrimary (citable) accession number: A6NCQ9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM