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A6NCQ9

- RN222_HUMAN

UniProt

A6NCQ9 - RN222_HUMAN

Protein

RING finger protein 222

Gene

RNF222

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri14 – 6552RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RING finger protein 222
    Gene namesi
    Name:RNF222
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:34517. RNF222.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164725453.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 220220RING finger protein 222PRO_0000329085Add
    BLAST

    Proteomic databases

    PaxDbiA6NCQ9.
    PRIDEiA6NCQ9.

    Expressioni

    Gene expression databases

    BgeeiA6NCQ9.
    GenevestigatoriA6NCQ9.

    Organism-specific databases

    HPAiHPA048916.

    Interactioni

    Protein-protein interaction databases

    BioGridi569148. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NCQ9.
    SMRiA6NCQ9. Positions 9-68.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei196 – 21621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri14 – 6552RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Transmembrane, Transmembrane helix, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG39960.
    HOGENOMiHOG000137599.
    HOVERGENiHBG054934.
    InParanoidiA6NCQ9.
    OMAiLGHTNPL.
    OrthoDBiEOG7VX8XF.
    PhylomeDBiA6NCQ9.
    TreeFamiTF333220.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF13639. zf-RING_2. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    [Graphical view]
    PROSITEiPS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6NCQ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEGESKDSS GSECPVCYEK FRDLEGASRT LSCGHVFCHD CLVKYLLSTR    50
    VDGQVQRTLV CPICRYVTFL SKKSSRWPSM LDKSSQTLAV PVGLPSVPPL 100
    DSLGHTNPLA ASSPAWRPPP GQARPPGSPG QSAQLPLDLL PSLPRESQIF 150
    VISRHGMPLG EQDSVLPRRS LAELSEASLA PRSARAFCCR SRALLLITLI 200
    AVVAVVAAIL PWVLLVRKQA 220
    Length:220
    Mass (Da):23,767
    Last modified:July 24, 2007 - v1
    Checksum:i67080B8736DBDD1B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC026130 Genomic DNA. No translation available.
    CCDSiCCDS45608.1.
    RefSeqiNP_001140156.1. NM_001146684.2.
    UniGeneiHs.526550.

    Genome annotation databases

    EnsembliENST00000344001; ENSP00000343799; ENSG00000189051.
    ENST00000399398; ENSP00000382330; ENSG00000189051.
    GeneIDi643904.
    KEGGihsa:643904.
    UCSCiuc010vuy.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC026130 Genomic DNA. No translation available.
    CCDSi CCDS45608.1.
    RefSeqi NP_001140156.1. NM_001146684.2.
    UniGenei Hs.526550.

    3D structure databases

    ProteinModelPortali A6NCQ9.
    SMRi A6NCQ9. Positions 9-68.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 569148. 1 interaction.

    Proteomic databases

    PaxDbi A6NCQ9.
    PRIDEi A6NCQ9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000344001 ; ENSP00000343799 ; ENSG00000189051 .
    ENST00000399398 ; ENSP00000382330 ; ENSG00000189051 .
    GeneIDi 643904.
    KEGGi hsa:643904.
    UCSCi uc010vuy.1. human.

    Organism-specific databases

    CTDi 643904.
    GeneCardsi GC17M008295.
    HGNCi HGNC:34517. RNF222.
    HPAi HPA048916.
    neXtProti NX_A6NCQ9.
    PharmGKBi PA164725453.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39960.
    HOGENOMi HOG000137599.
    HOVERGENi HBG054934.
    InParanoidi A6NCQ9.
    OMAi LGHTNPL.
    OrthoDBi EOG7VX8XF.
    PhylomeDBi A6NCQ9.
    TreeFami TF333220.

    Miscellaneous databases

    GenomeRNAii 643904.
    NextBioi 115567.
    PROi A6NCQ9.

    Gene expression databases

    Bgeei A6NCQ9.
    Genevestigatori A6NCQ9.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF13639. zf-RING_2. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    [Graphical view ]
    PROSITEi PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiRN222_HUMAN
    AccessioniPrimary (citable) accession number: A6NCQ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3