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Protein

Putative keratin-87 protein

Gene

KRT87P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Putative keratin-87 protein
Alternative name(s):
Keratin, hair, basic pseudogene 4
Keratin-121 pseudogene
Gene namesi
Name:KRT87P
Synonyms:KRT121P, KRTHBP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:30198. KRT87P.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB
  • keratin filament Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

DisGeNETi85349.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003406611 – 255Putative keratin-87 proteinAdd BLAST255

Proteomic databases

EPDiA6NCN2.
PRIDEiA6NCN2.

PTM databases

SwissPalmiA6NCN2.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Structurei

3D structure databases

ProteinModelPortaliA6NCN2.
SMRiA6NCN2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili19 – 81Sequence analysisAdd BLAST63
Coiled coili147 – 227Sequence analysisAdd BLAST81

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiA6NCN2.

Family and domain databases

InterProiIPR001664. IF.
IPR003054. Keratin_II.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NCN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEANSGRLAS ELNHVQEVLE GYKKKYEEEV ALRATAENEF VALKKDVDCA
60 70 80 90 100
YLRKSDLEAN VEALTQEIDF LRRLYEEEIR VLQSHISDTS VVVKMDNSRD
110 120 130 140 150
LNMHCVITEI KAQYDDIATR SRAEAESWYR SKCEEMKATV IRHGETLRRT
160 170 180 190 200
KEEINELNRM IQRLTAEVEN AKCQNSKLEA AVAQSEQQGE AALSDARCKL
210 220 230 240 250
AELEGALQKA KQDMACLIRE YQEVMNSKLA WTLRSPPTGA CWRARSRGCV

RALVL
Length:255
Mass (Da):29,117
Last modified:October 31, 2012 - v4
Checksum:i899BC0E5C9D3659D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4N → D in BAG61913 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300121 mRNA. Translation: BAG61913.1.
AC021066 Genomic DNA. No translation available.
UniGeneiHs.584773.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300121 mRNA. Translation: BAG61913.1.
AC021066 Genomic DNA. No translation available.
UniGeneiHs.584773.

3D structure databases

ProteinModelPortaliA6NCN2.
SMRiA6NCN2.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

SwissPalmiA6NCN2.

Proteomic databases

EPDiA6NCN2.
PRIDEiA6NCN2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi85349.
GeneCardsiKRT87P.
HGNCiHGNC:30198. KRT87P.
neXtProtiNX_A6NCN2.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiA6NCN2.

Family and domain databases

InterProiIPR001664. IF.
IPR003054. Keratin_II.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKR87P_HUMAN
AccessioniPrimary (citable) accession number: A6NCN2
Secondary accession number(s): B4DTA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 31, 2012
Last modified: November 2, 2016
This is version 70 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.