ID   AN33B_HUMAN             Reviewed;         494 AA.
AC   A6NCL7;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   24-JAN-2024, entry version 110.
DE   RecName: Full=Ankyrin repeat domain-containing protein 33B;
GN   Name=ANKRD33B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA   Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA   Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA   Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA   Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA   Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA   Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
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DR   EMBL; AC112200; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS47191.1; -.
DR   RefSeq; NP_001157912.1; NM_001164440.1.
DR   AlphaFoldDB; A6NCL7; -.
DR   SMR; A6NCL7; -.
DR   BioGRID; 574599; 8.
DR   STRING; 9606.ENSP00000296657; -.
DR   GlyGen; A6NCL7; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; A6NCL7; -.
DR   PhosphoSitePlus; A6NCL7; -.
DR   BioMuta; ANKRD33B; -.
DR   EPD; A6NCL7; -.
DR   jPOST; A6NCL7; -.
DR   MassIVE; A6NCL7; -.
DR   PaxDb; 9606-ENSP00000296657; -.
DR   PeptideAtlas; A6NCL7; -.
DR   ProteomicsDB; 844; -.
DR   Antibodypedia; 58746; 17 antibodies from 7 providers.
DR   DNASU; 651746; -.
DR   Ensembl; ENST00000296657.7; ENSP00000296657.4; ENSG00000164236.12.
DR   GeneID; 651746; -.
DR   KEGG; hsa:651746; -.
DR   MANE-Select; ENST00000296657.7; ENSP00000296657.4; NM_001164440.2; NP_001157912.1.
DR   UCSC; uc021xwp.2; human.
DR   AGR; HGNC:35240; -.
DR   CTD; 651746; -.
DR   DisGeNET; 651746; -.
DR   GeneCards; ANKRD33B; -.
DR   HGNC; HGNC:35240; ANKRD33B.
DR   HPA; ENSG00000164236; Tissue enriched (retina).
DR   neXtProt; NX_A6NCL7; -.
DR   OpenTargets; ENSG00000164236; -.
DR   PharmGKB; PA164715326; -.
DR   VEuPathDB; HostDB:ENSG00000164236; -.
DR   eggNOG; ENOG502S4H1; Eukaryota.
DR   GeneTree; ENSGT00500000044852; -.
DR   HOGENOM; CLU_049994_1_0_1; -.
DR   InParanoid; A6NCL7; -.
DR   OMA; VTLCKAP; -.
DR   OrthoDB; 5480583at2759; -.
DR   PhylomeDB; A6NCL7; -.
DR   TreeFam; TF332022; -.
DR   PathwayCommons; A6NCL7; -.
DR   SignaLink; A6NCL7; -.
DR   BioGRID-ORCS; 651746; 13 hits in 1145 CRISPR screens.
DR   ChiTaRS; ANKRD33B; human.
DR   GenomeRNAi; 651746; -.
DR   Pharos; A6NCL7; Tdark.
DR   PRO; PR:A6NCL7; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; A6NCL7; Protein.
DR   Bgee; ENSG00000164236; Expressed in Brodmann (1909) area 23 and 123 other cell types or tissues.
DR   ExpressionAtlas; A6NCL7; baseline and differential.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   PANTHER; PTHR24173; ANKYRIN REPEAT CONTAINING; 1.
DR   PANTHER; PTHR24173:SF1; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 33B; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF13637; Ank_4; 1.
DR   SMART; SM00248; ANK; 5.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   Genevisible; A6NCL7; HS.
PE   3: Inferred from homology;
KW   ANK repeat; Coiled coil; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..494
FT                   /note="Ankyrin repeat domain-containing protein 33B"
FT                   /id="PRO_0000328769"
FT   REPEAT          84..113
FT                   /note="ANK 1"
FT   REPEAT          120..150
FT                   /note="ANK 2"
FT   REPEAT          154..183
FT                   /note="ANK 3"
FT   REPEAT          189..218
FT                   /note="ANK 4"
FT   REPEAT          223..255
FT                   /note="ANK 5"
FT   REGION          1..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          349..494
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          459..488
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        454..487
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         405
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3U0L2"
SQ   SEQUENCE   494 AA;  53975 MW;  18723DD152CBDB14 CRC64;
     MVLLAGTGPE GGGARCMTPP PPSPPRGAQV EEDPADYEEF EDFSSLPDTR SIASDDSFYP
     FEDEEEHGVE SAESVPEGVP ESVPETATLL RAACANNVGL LRTLVRRGVS VEEAQETDRN
     GRTGLIVACY HGFVDTVVAL AECPHVDVNW QDSEGNTALI TAAQAGHAII TNYLLNYFPG
     LDLERRNAFG FTALMKAAMQ GRTDCIRALM LAGADVHARD PRRGMSPQEW ATYTGRVDAV
     RLMQRLLERP CPEQFWEKYR PELPPPPEAA RKPAGSKNCL QRLTDCVLSV LTPRSVRGPE
     DGGVLDHMVR MTTSLYSPAV AIVCQTVCPE SPPSVGKRRL AVQEILAARA ARGPQAQEED
     EVGGAGQRGR TGQEDADSRE GSPRAGLPPA LGSRGPAAPA PRKASLLPLQ RLRRRSVRPG
     VVVPRVRVSK APAPTFQPER PARKGSTKDS GHLQIPKWRY KEAKEEKRKA EEAEKKRQAE
     AQKERRTAPW KKRT
//