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Protein

Ankyrin repeat domain-containing protein 33B

Gene

ANKRD33B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 33B
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:35240. ANKRD33B.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164236.
PharmGKBiPA164715326.

Polymorphism and mutation databases

BioMutaiANKRD33B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003287691 – 494Ankyrin repeat domain-containing protein 33BAdd BLAST494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei405PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA6NCL7.
PaxDbiA6NCL7.
PRIDEiA6NCL7.

PTM databases

iPTMnetiA6NCL7.
PhosphoSitePlusiA6NCL7.

Expressioni

Gene expression databases

BgeeiENSG00000164236.
ExpressionAtlasiA6NCL7. baseline and differential.
GenevisibleiA6NCL7. HS.

Organism-specific databases

HPAiHPA056974.

Interactioni

Protein-protein interaction databases

BioGridi574599. 1 interactor.
STRINGi9606.ENSP00000296657.

Structurei

3D structure databases

ProteinModelPortaliA6NCL7.
SMRiA6NCL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati84 – 113ANK 1Add BLAST30
Repeati120 – 150ANK 2Add BLAST31
Repeati154 – 183ANK 3Add BLAST30
Repeati189 – 218ANK 4Add BLAST30
Repeati223 – 255ANK 5Add BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili459 – 488Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi19 – 25Poly-Pro7
Compositional biasi264 – 267Poly-Pro4

Sequence similaritiesi

Contains 5 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IFWP. Eukaryota.
ENOG4111JDG. LUCA.
GeneTreeiENSGT00500000044852.
HOGENOMiHOG000033933.
HOVERGENiHBG095573.
InParanoidiA6NCL7.
OMAiKDSAHLQ.
OrthoDBiEOG091G0WU0.
PhylomeDBiA6NCL7.
TreeFamiTF332022.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NCL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLAGTGPE GGGARCMTPP PPSPPRGAQV EEDPADYEEF EDFSSLPDTR
60 70 80 90 100
SIASDDSFYP FEDEEEHGVE SAESVPEGVP ESVPETATLL RAACANNVGL
110 120 130 140 150
LRTLVRRGVS VEEAQETDRN GRTGLIVACY HGFVDTVVAL AECPHVDVNW
160 170 180 190 200
QDSEGNTALI TAAQAGHAII TNYLLNYFPG LDLERRNAFG FTALMKAAMQ
210 220 230 240 250
GRTDCIRALM LAGADVHARD PRRGMSPQEW ATYTGRVDAV RLMQRLLERP
260 270 280 290 300
CPEQFWEKYR PELPPPPEAA RKPAGSKNCL QRLTDCVLSV LTPRSVRGPE
310 320 330 340 350
DGGVLDHMVR MTTSLYSPAV AIVCQTVCPE SPPSVGKRRL AVQEILAARA
360 370 380 390 400
ARGPQAQEED EVGGAGQRGR TGQEDADSRE GSPRAGLPPA LGSRGPAAPA
410 420 430 440 450
PRKASLLPLQ RLRRRSVRPG VVVPRVRVSK APAPTFQPER PARKGSTKDS
460 470 480 490
GHLQIPKWRY KEAKEEKRKA EEAEKKRQAE AQKERRTAPW KKRT
Length:494
Mass (Da):53,975
Last modified:July 24, 2007 - v1
Checksum:i18723DD152CBDB14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112200 Genomic DNA. No translation available.
CCDSiCCDS47191.1.
RefSeqiNP_001157912.1. NM_001164440.1.
UniGeneiHs.26039.

Genome annotation databases

EnsembliENST00000296657; ENSP00000296657; ENSG00000164236.
GeneIDi651746.
KEGGihsa:651746.
UCSCiuc021xwp.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112200 Genomic DNA. No translation available.
CCDSiCCDS47191.1.
RefSeqiNP_001157912.1. NM_001164440.1.
UniGeneiHs.26039.

3D structure databases

ProteinModelPortaliA6NCL7.
SMRiA6NCL7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi574599. 1 interactor.
STRINGi9606.ENSP00000296657.

PTM databases

iPTMnetiA6NCL7.
PhosphoSitePlusiA6NCL7.

Polymorphism and mutation databases

BioMutaiANKRD33B.

Proteomic databases

EPDiA6NCL7.
PaxDbiA6NCL7.
PRIDEiA6NCL7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296657; ENSP00000296657; ENSG00000164236.
GeneIDi651746.
KEGGihsa:651746.
UCSCiuc021xwp.2. human.

Organism-specific databases

CTDi651746.
GeneCardsiANKRD33B.
HGNCiHGNC:35240. ANKRD33B.
HPAiHPA056974.
neXtProtiNX_A6NCL7.
OpenTargetsiENSG00000164236.
PharmGKBiPA164715326.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFWP. Eukaryota.
ENOG4111JDG. LUCA.
GeneTreeiENSGT00500000044852.
HOGENOMiHOG000033933.
HOVERGENiHBG095573.
InParanoidiA6NCL7.
OMAiKDSAHLQ.
OrthoDBiEOG091G0WU0.
PhylomeDBiA6NCL7.
TreeFamiTF332022.

Miscellaneous databases

GenomeRNAii651746.
PROiA6NCL7.

Gene expression databases

BgeeiENSG00000164236.
ExpressionAtlasiA6NCL7. baseline and differential.
GenevisibleiA6NCL7. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAN33B_HUMAN
AccessioniPrimary (citable) accession number: A6NCL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 24, 2007
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.