A6NCL7 (AN33B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ankyrin repeat domain-containing protein 33B

Gene names

Name:

ANKRD33B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	494 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 5 ANK repeats.

Ontologies

Keywords
Domain	ANK repeat Coiled coil Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 494	494	Ankyrin repeat domain-containing protein 33B		PRO_0000328769
Regions
	Repeat	84 – 113	30	ANK 1
	Repeat	120 – 150	31	ANK 2
	Repeat	154 – 183	30	ANK 3
	Repeat	189 – 218	30	ANK 4
	Repeat	223 – 255	33	ANK 5
	Coiled coil	459 – 488	30	Potential
	Compositional bias	19 – 25	7	Poly-Pro
	Compositional bias	264 – 267	4	Poly-Pro

Sequences

	Sequence		Length	Mass (Da)
	A6NCL7 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 18723DD152CBDB14	FASTA	494	53,975
	10 20 30 40 50 60 MVLLAGTGPE GGGARCMTPP PPSPPRGAQV EEDPADYEEF EDFSSLPDTR SIASDDSFYP 70 80 90 100 110 120 FEDEEEHGVE SAESVPEGVP ESVPETATLL RAACANNVGL LRTLVRRGVS VEEAQETDRN 130 140 150 160 170 180 GRTGLIVACY HGFVDTVVAL AECPHVDVNW QDSEGNTALI TAAQAGHAII TNYLLNYFPG 190 200 210 220 230 240 LDLERRNAFG FTALMKAAMQ GRTDCIRALM LAGADVHARD PRRGMSPQEW ATYTGRVDAV 250 260 270 280 290 300 RLMQRLLERP CPEQFWEKYR PELPPPPEAA RKPAGSKNCL QRLTDCVLSV LTPRSVRGPE 310 320 330 340 350 360 DGGVLDHMVR MTTSLYSPAV AIVCQTVCPE SPPSVGKRRL AVQEILAARA ARGPQAQEED 370 380 390 400 410 420 EVGGAGQRGR TGQEDADSRE GSPRAGLPPA LGSRGPAAPA PRKASLLPLQ RLRRRSVRPG 430 440 450 460 470 480 VVVPRVRVSK APAPTFQPER PARKGSTKDS GHLQIPKWRY KEAKEEKRKA EEAEKKRQAE 490 AQKERRTAPW KKRT

References

[1]

"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC112200 Genomic DNA. No translation available.
IPI	IPI00235708.
RefSeq	NP_001157912.1. NM_001164440.1.
UniGene	Hs.26039.
3D structure databases
ProteinModelPortal	A6NCL7.
ModBase	Search...
PTM databases
PhosphoSite	A6NCL7.
Proteomic databases
PaxDb	A6NCL7.
PRIDE	A6NCL7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000296657; ENSP00000296657; ENSG00000164236.
GeneID	651746.
KEGG	hsa:651746.
UCSC	uc021xwp.1. human.
Organism-specific databases
CTD	651746.
GeneCards	GC05P010564.
HGNC	HGNC:35240. ANKRD33B.
HPA	HPA056974.
neXtProt	NX_A6NCL7.
PharmGKB	PA164715326.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0666.
HOGENOM	HOG000033933.
HOVERGEN	HBG095573.
InParanoid	A6NCL7.
OMA	VCPESPP.
Gene expression databases
ArrayExpress	A6NCL7.
Bgee	A6NCL7.
Genevestigator	A6NCL7.
Family and domain databases
Gene3D	1.25.40.20. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Pfam	PF00023. Ank. 1 hit. PF12796. Ank_2. 1 hit. [Graphical view]
SMART	SM00248. ANK. 5 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	651746.
NextBio	121730.

Entry information

Entry name

AN33B_HUMAN

Accession

Primary (citable) accession number: A6NCL7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	July 24, 2007
Last modified:	May 1, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.