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Protein

Ankyrin repeat domain-containing protein 33B

Gene

ANKRD33B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 33B
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:35240. ANKRD33B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164715326.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Ankyrin repeat domain-containing protein 33BPRO_0000328769Add
BLAST

Proteomic databases

PaxDbiA6NCL7.
PRIDEiA6NCL7.

PTM databases

PhosphoSiteiA6NCL7.

Expressioni

Gene expression databases

BgeeiA6NCL7.
ExpressionAtlasiA6NCL7. baseline.
GenevestigatoriA6NCL7.

Organism-specific databases

HPAiHPA056974.

Structurei

3D structure databases

ProteinModelPortaliA6NCL7.
SMRiA6NCL7. Positions 89-245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati84 – 11330ANK 1Add
BLAST
Repeati120 – 15031ANK 2Add
BLAST
Repeati154 – 18330ANK 3Add
BLAST
Repeati189 – 21830ANK 4Add
BLAST
Repeati223 – 25533ANK 5Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili459 – 48830Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi19 – 257Poly-Pro
Compositional biasi264 – 2674Poly-Pro

Sequence similaritiesi

Contains 5 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00500000044852.
HOGENOMiHOG000033933.
HOVERGENiHBG095573.
InParanoidiA6NCL7.
OMAiQGRTECV.
PhylomeDBiA6NCL7.
TreeFamiTF332022.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NCL7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLLAGTGPE GGGARCMTPP PPSPPRGAQV EEDPADYEEF EDFSSLPDTR
60 70 80 90 100
SIASDDSFYP FEDEEEHGVE SAESVPEGVP ESVPETATLL RAACANNVGL
110 120 130 140 150
LRTLVRRGVS VEEAQETDRN GRTGLIVACY HGFVDTVVAL AECPHVDVNW
160 170 180 190 200
QDSEGNTALI TAAQAGHAII TNYLLNYFPG LDLERRNAFG FTALMKAAMQ
210 220 230 240 250
GRTDCIRALM LAGADVHARD PRRGMSPQEW ATYTGRVDAV RLMQRLLERP
260 270 280 290 300
CPEQFWEKYR PELPPPPEAA RKPAGSKNCL QRLTDCVLSV LTPRSVRGPE
310 320 330 340 350
DGGVLDHMVR MTTSLYSPAV AIVCQTVCPE SPPSVGKRRL AVQEILAARA
360 370 380 390 400
ARGPQAQEED EVGGAGQRGR TGQEDADSRE GSPRAGLPPA LGSRGPAAPA
410 420 430 440 450
PRKASLLPLQ RLRRRSVRPG VVVPRVRVSK APAPTFQPER PARKGSTKDS
460 470 480 490
GHLQIPKWRY KEAKEEKRKA EEAEKKRQAE AQKERRTAPW KKRT
Length:494
Mass (Da):53,975
Last modified:July 24, 2007 - v1
Checksum:i18723DD152CBDB14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112200 Genomic DNA. No translation available.
CCDSiCCDS47191.1.
RefSeqiNP_001157912.1. NM_001164440.1.
UniGeneiHs.26039.

Genome annotation databases

EnsembliENST00000296657; ENSP00000296657; ENSG00000164236.
GeneIDi651746.
KEGGihsa:651746.
UCSCiuc021xwp.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112200 Genomic DNA. No translation available.
CCDSiCCDS47191.1.
RefSeqiNP_001157912.1. NM_001164440.1.
UniGeneiHs.26039.

3D structure databases

ProteinModelPortaliA6NCL7.
SMRiA6NCL7. Positions 89-245.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiA6NCL7.

Proteomic databases

PaxDbiA6NCL7.
PRIDEiA6NCL7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296657; ENSP00000296657; ENSG00000164236.
GeneIDi651746.
KEGGihsa:651746.
UCSCiuc021xwp.1. human.

Organism-specific databases

CTDi651746.
GeneCardsiGC05P010564.
HGNCiHGNC:35240. ANKRD33B.
HPAiHPA056974.
neXtProtiNX_A6NCL7.
PharmGKBiPA164715326.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00500000044852.
HOGENOMiHOG000033933.
HOVERGENiHBG095573.
InParanoidiA6NCL7.
OMAiQGRTECV.
PhylomeDBiA6NCL7.
TreeFamiTF332022.

Miscellaneous databases

GenomeRNAii651746.
NextBioi121730.
PROiA6NCL7.

Gene expression databases

BgeeiA6NCL7.
ExpressionAtlasiA6NCL7. baseline.
GenevestigatoriA6NCL7.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiAN33B_HUMAN
AccessioniPrimary (citable) accession number: A6NCL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 24, 2007
Last modified: January 7, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.