ID   GEMC1_HUMAN             Reviewed;         334 AA.
AC   A6NCL1;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 2.
DT   24-JAN-2024, entry version 105.
DE   RecName: Full=Geminin coiled-coil domain-containing protein 1;
GN   Name=GMNC; Synonyms=GEMC1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
CC   -!- FUNCTION: Regulator of DNA replication. Promotes initiation of
CC       chromosomal DNA replication by mediating TOPBP1- and CDK2-dependent
CC       recruitment of CDC45L onto replication origins (By similarity).
CC       {ECO:0000250}.
CC   -!- INTERACTION:
CC       A6NCL1; P24864: CCNE1; NbExp=3; IntAct=EBI-18587381, EBI-519526;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Associates with
CC       chromatin during pre-replication complex (pre-RC) formation.
CC       {ECO:0000250}.
CC   -!- PTM: Highly phosphorylated by CDK2; stimulates initiation of DNA
CC       replication. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GEMC1 family. {ECO:0000305}.
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DR   EMBL; AC092952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS54697.1; -.
DR   RefSeq; NP_001140158.1; NM_001146686.2.
DR   PDB; 5C9N; X-ray; 2.20 A; A/B=64-148.
DR   PDBsum; 5C9N; -.
DR   AlphaFoldDB; A6NCL1; -.
DR   SMR; A6NCL1; -.
DR   BioGRID; 572083; 2.
DR   IntAct; A6NCL1; 1.
DR   STRING; 9606.ENSP00000406164; -.
DR   iPTMnet; A6NCL1; -.
DR   PhosphoSitePlus; A6NCL1; -.
DR   BioMuta; GMNC; -.
DR   PaxDb; 9606-ENSP00000406164; -.
DR   PeptideAtlas; A6NCL1; -.
DR   ProteomicsDB; 842; -.
DR   Antibodypedia; 49140; 77 antibodies from 18 providers.
DR   DNASU; 647309; -.
DR   Ensembl; ENST00000442080.6; ENSP00000406164.1; ENSG00000205835.9.
DR   GeneID; 647309; -.
DR   KEGG; hsa:647309; -.
DR   MANE-Select; ENST00000442080.6; ENSP00000406164.1; NM_001146686.3; NP_001140158.1.
DR   UCSC; uc011bsl.2; human.
DR   AGR; HGNC:40049; -.
DR   CTD; 647309; -.
DR   DisGeNET; 647309; -.
DR   GeneCards; GMNC; -.
DR   HGNC; HGNC:40049; GMNC.
DR   HPA; ENSG00000205835; Tissue enhanced (choroid plexus, fallopian tube, liver).
DR   MIM; 614448; gene.
DR   neXtProt; NX_A6NCL1; -.
DR   OpenTargets; ENSG00000205835; -.
DR   VEuPathDB; HostDB:ENSG00000205835; -.
DR   eggNOG; ENOG502RE7T; Eukaryota.
DR   GeneTree; ENSGT00940000153270; -.
DR   HOGENOM; CLU_071972_0_0_1; -.
DR   InParanoid; A6NCL1; -.
DR   OMA; TRGWRGW; -.
DR   OrthoDB; 4059030at2759; -.
DR   PhylomeDB; A6NCL1; -.
DR   TreeFam; TF344118; -.
DR   PathwayCommons; A6NCL1; -.
DR   SignaLink; A6NCL1; -.
DR   BioGRID-ORCS; 647309; 10 hits in 1143 CRISPR screens.
DR   GenomeRNAi; 647309; -.
DR   Pharos; A6NCL1; Tbio.
DR   PRO; PR:A6NCL1; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; A6NCL1; Protein.
DR   Bgee; ENSG00000205835; Expressed in right uterine tube and 54 other cell types or tissues.
DR   ExpressionAtlas; A6NCL1; baseline and differential.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0045786; P:negative regulation of cell cycle; IBA:GO_Central.
DR   GO; GO:0008156; P:negative regulation of DNA replication; IBA:GO_Central.
DR   CDD; cd22588; GemC1_CC; 1.
DR   Gene3D; 1.20.5.1180; Geminin coiled-coil domain; 1.
DR   PANTHER; PTHR13372; GEMININ; 1.
DR   PANTHER; PTHR13372:SF2; GEMININ COILED-COIL DOMAIN-CONTAINING PROTEIN 1; 1.
DR   Genevisible; A6NCL1; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Cell cycle; Coiled coil; DNA replication; Nucleus;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..334
FT                   /note="Geminin coiled-coil domain-containing protein 1"
FT                   /id="PRO_0000346425"
FT   REGION          143..167
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          82..119
FT                   /evidence="ECO:0000255"
FT   HELIX           70..130
FT                   /evidence="ECO:0007829|PDB:5C9N"
SQ   SEQUENCE   334 AA;  37887 MW;  4D6370B1E25DCA40 CRC64;
     MNTILPCQDQ YFVGGQSYNC PYSTTTSESS VDVSTETWVS FWAAGLLDNR ELQQAPQAQE
     SFSDSNFPLP DLCSWEEAQL SSQLYRNKQL QDTLVQKEEE LARLHEENNH LRQYLNSALV
     KCLEEKAKKL LSSDEFSKAY GKFRKGKRKS KEQRYSPAEI PHPKNAKRNL SSEFANCEEQ
     AGPPVDPWVL QTLGLKDLDT IDDTSSANYS ALASHPRRVA STFSQFPDDA VDYKNIPRED
     MPIDYRGDRT TPLHSTATHG EDFHILSQLS NPPVGLKTLP YYTAHVSPNK TEMAFSTSLS
     PHCNVKTHSF HQGQAFVRRD EEGGWKFTWV PKQS
//