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A6NCL1 (GEMC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Geminin coiled-coil domain-containing protein 1
Gene names
Name:GMNC
Synonyms:GEMC1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2-dependent recruitment of CDC45L onto replication origins By similarity.

Subcellular location

Nucleus By similarity. Note: Associates with chromatin during pre-replication complex (pre-RC) formation By similarity.

Post-translational modification

Highly phosphorylated by CDK2; stimulates initiation of DNA replication By similarity.

Sequence similarities

Belongs to the GEMC1 family.

Ontologies

Keywords
   Biological processCell cycle
DNA replication
   Cellular componentNucleus
   DomainCoiled coil
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

cell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of DNA replication

Inferred from electronic annotation. Source: InterPro

   Cellular_componentnucleus

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionchromatin binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334Geminin coiled-coil domain-containing protein 1
PRO_0000346425

Regions

Coiled coil82 – 11938 Potential

Sequences

Sequence LengthMass (Da)Tools
A6NCL1 [UniParc].

Last modified September 2, 2008. Version 2.
Checksum: 4D6370B1E25DCA40

FASTA33437,887
        10         20         30         40         50         60 
MNTILPCQDQ YFVGGQSYNC PYSTTTSESS VDVSTETWVS FWAAGLLDNR ELQQAPQAQE 

        70         80         90        100        110        120 
SFSDSNFPLP DLCSWEEAQL SSQLYRNKQL QDTLVQKEEE LARLHEENNH LRQYLNSALV 

       130        140        150        160        170        180 
KCLEEKAKKL LSSDEFSKAY GKFRKGKRKS KEQRYSPAEI PHPKNAKRNL SSEFANCEEQ 

       190        200        210        220        230        240 
AGPPVDPWVL QTLGLKDLDT IDDTSSANYS ALASHPRRVA STFSQFPDDA VDYKNIPRED 

       250        260        270        280        290        300 
MPIDYRGDRT TPLHSTATHG EDFHILSQLS NPPVGLKTLP YYTAHVSPNK TEMAFSTSLS 

       310        320        330 
PHCNVKTHSF HQGQAFVRRD EEGGWKFTWV PKQS 

« Hide

References

[1]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC092952 Genomic DNA. No translation available.
CCDSCCDS54697.1.
RefSeqNP_001140158.1. NM_001146686.2.
UniGeneHs.518490.

3D structure databases

ProteinModelPortalA6NCL1.
SMRA6NCL1. Positions 79-133.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000406164.

Proteomic databases

PaxDbA6NCL1.
PRIDEA6NCL1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000442080; ENSP00000406164; ENSG00000205835.
GeneID647309.
KEGGhsa:647309.
UCSCuc011bsl.1. human.

Organism-specific databases

CTD647309.
GeneCardsGC03M190572.
HGNCHGNC:40049. GMNC.
HPAHPA043663.
MIM614448. gene.
neXtProtNX_A6NCL1.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG78102.
HOGENOMHOG000155495.
HOVERGENHBG108697.
InParanoidA6NCL1.
OMAPHPKNAK.
OrthoDBEOG79CZ1Q.
PhylomeDBA6NCL1.
TreeFamTF344118.

Gene expression databases

ArrayExpressA6NCL1.
BgeeA6NCL1.
GenevestigatorA6NCL1.

Family and domain databases

ProtoNetSearch...

Other

NextBio120089.
PROA6NCL1.
SOURCESearch...

Entry information

Entry nameGEMC1_HUMAN
AccessionPrimary (citable) accession number: A6NCL1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: July 9, 2014
This is version 52 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM