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A6NCL1

- GEMC1_HUMAN

UniProt

A6NCL1 - GEMC1_HUMAN

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Protein

Geminin coiled-coil domain-containing protein 1

Gene

GMNC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2-dependent recruitment of CDC45L onto replication origins (By similarity).By similarity

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell proliferation Source: UniProtKB
  3. DNA replication initiation Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell cycle, DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
Geminin coiled-coil domain-containing protein 1
Gene namesi
Name:GMNC
Synonyms:GEMC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:40049. GMNC.

Subcellular locationi

Nucleus By similarity
Note: Associates with chromatin during pre-replication complex (pre-RC) formation.By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334Geminin coiled-coil domain-containing protein 1PRO_0000346425Add
BLAST

Post-translational modificationi

Highly phosphorylated by CDK2; stimulates initiation of DNA replication.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA6NCL1.
PRIDEiA6NCL1.

Expressioni

Gene expression databases

BgeeiA6NCL1.
ExpressionAtlasiA6NCL1. baseline and differential.
GenevestigatoriA6NCL1.

Organism-specific databases

HPAiHPA043663.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000406164.

Structurei

3D structure databases

ProteinModelPortaliA6NCL1.
SMRiA6NCL1. Positions 79-133.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili82 – 11938Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the GEMC1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG78102.
GeneTreeiENSGT00390000018271.
HOGENOMiHOG000155495.
HOVERGENiHBG108697.
InParanoidiA6NCL1.
OMAiPHPKNAK.
OrthoDBiEOG79CZ1Q.
PhylomeDBiA6NCL1.
TreeFamiTF344118.

Family and domain databases

InterProiIPR029700. GEMC1.
[Graphical view]
PANTHERiPTHR13372:SF2. PTHR13372:SF2. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NCL1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTILPCQDQ YFVGGQSYNC PYSTTTSESS VDVSTETWVS FWAAGLLDNR
60 70 80 90 100
ELQQAPQAQE SFSDSNFPLP DLCSWEEAQL SSQLYRNKQL QDTLVQKEEE
110 120 130 140 150
LARLHEENNH LRQYLNSALV KCLEEKAKKL LSSDEFSKAY GKFRKGKRKS
160 170 180 190 200
KEQRYSPAEI PHPKNAKRNL SSEFANCEEQ AGPPVDPWVL QTLGLKDLDT
210 220 230 240 250
IDDTSSANYS ALASHPRRVA STFSQFPDDA VDYKNIPRED MPIDYRGDRT
260 270 280 290 300
TPLHSTATHG EDFHILSQLS NPPVGLKTLP YYTAHVSPNK TEMAFSTSLS
310 320 330
PHCNVKTHSF HQGQAFVRRD EEGGWKFTWV PKQS
Length:334
Mass (Da):37,887
Last modified:September 2, 2008 - v2
Checksum:i4D6370B1E25DCA40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092952 Genomic DNA. No translation available.
CCDSiCCDS54697.1.
RefSeqiNP_001140158.1. NM_001146686.2.
UniGeneiHs.518490.

Genome annotation databases

EnsembliENST00000442080; ENSP00000406164; ENSG00000205835.
GeneIDi647309.
KEGGihsa:647309.
UCSCiuc011bsl.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092952 Genomic DNA. No translation available.
CCDSi CCDS54697.1.
RefSeqi NP_001140158.1. NM_001146686.2.
UniGenei Hs.518490.

3D structure databases

ProteinModelPortali A6NCL1.
SMRi A6NCL1. Positions 79-133.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000406164.

Proteomic databases

PaxDbi A6NCL1.
PRIDEi A6NCL1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000442080 ; ENSP00000406164 ; ENSG00000205835 .
GeneIDi 647309.
KEGGi hsa:647309.
UCSCi uc011bsl.1. human.

Organism-specific databases

CTDi 647309.
GeneCardsi GC03M190572.
HGNCi HGNC:40049. GMNC.
HPAi HPA043663.
MIMi 614448. gene.
neXtProti NX_A6NCL1.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG78102.
GeneTreei ENSGT00390000018271.
HOGENOMi HOG000155495.
HOVERGENi HBG108697.
InParanoidi A6NCL1.
OMAi PHPKNAK.
OrthoDBi EOG79CZ1Q.
PhylomeDBi A6NCL1.
TreeFami TF344118.

Miscellaneous databases

GenomeRNAii 647309.
NextBioi 120089.
PROi A6NCL1.
SOURCEi Search...

Gene expression databases

Bgeei A6NCL1.
ExpressionAtlasi A6NCL1. baseline and differential.
Genevestigatori A6NCL1.

Family and domain databases

InterProi IPR029700. GEMC1.
[Graphical view ]
PANTHERi PTHR13372:SF2. PTHR13372:SF2. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiGEMC1_HUMAN
AccessioniPrimary (citable) accession number: A6NCL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: October 29, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3