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A6NCL1

- GEMC1_HUMAN

UniProt

A6NCL1 - GEMC1_HUMAN

Protein

Geminin coiled-coil domain-containing protein 1

Gene

GMNC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 2 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2-dependent recruitment of CDC45L onto replication origins By similarity.By similarity

    GO - Molecular functioni

    1. chromatin binding Source: UniProtKB

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell proliferation Source: UniProtKB
    3. DNA replication Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, DNA replication

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Geminin coiled-coil domain-containing protein 1
    Gene namesi
    Name:GMNC
    Synonyms:GEMC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:40049. GMNC.

    Subcellular locationi

    Nucleus By similarity
    Note: Associates with chromatin during pre-replication complex (pre-RC) formation.By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 334334Geminin coiled-coil domain-containing protein 1PRO_0000346425Add
    BLAST

    Post-translational modificationi

    Highly phosphorylated by CDK2; stimulates initiation of DNA replication.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiA6NCL1.
    PRIDEiA6NCL1.

    Expressioni

    Gene expression databases

    ArrayExpressiA6NCL1.
    BgeeiA6NCL1.
    GenevestigatoriA6NCL1.

    Organism-specific databases

    HPAiHPA043663.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000406164.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NCL1.
    SMRiA6NCL1. Positions 79-133.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili82 – 11938Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GEMC1 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG78102.
    HOGENOMiHOG000155495.
    HOVERGENiHBG108697.
    InParanoidiA6NCL1.
    OMAiPHPKNAK.
    OrthoDBiEOG79CZ1Q.
    PhylomeDBiA6NCL1.
    TreeFamiTF344118.

    Family and domain databases

    InterProiIPR029700. GEMC1.
    [Graphical view]
    PANTHERiPTHR13372:SF2. PTHR13372:SF2. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6NCL1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNTILPCQDQ YFVGGQSYNC PYSTTTSESS VDVSTETWVS FWAAGLLDNR    50
    ELQQAPQAQE SFSDSNFPLP DLCSWEEAQL SSQLYRNKQL QDTLVQKEEE 100
    LARLHEENNH LRQYLNSALV KCLEEKAKKL LSSDEFSKAY GKFRKGKRKS 150
    KEQRYSPAEI PHPKNAKRNL SSEFANCEEQ AGPPVDPWVL QTLGLKDLDT 200
    IDDTSSANYS ALASHPRRVA STFSQFPDDA VDYKNIPRED MPIDYRGDRT 250
    TPLHSTATHG EDFHILSQLS NPPVGLKTLP YYTAHVSPNK TEMAFSTSLS 300
    PHCNVKTHSF HQGQAFVRRD EEGGWKFTWV PKQS 334
    Length:334
    Mass (Da):37,887
    Last modified:September 2, 2008 - v2
    Checksum:i4D6370B1E25DCA40
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC092952 Genomic DNA. No translation available.
    CCDSiCCDS54697.1.
    RefSeqiNP_001140158.1. NM_001146686.2.
    UniGeneiHs.518490.

    Genome annotation databases

    EnsembliENST00000442080; ENSP00000406164; ENSG00000205835.
    GeneIDi647309.
    KEGGihsa:647309.
    UCSCiuc011bsl.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC092952 Genomic DNA. No translation available.
    CCDSi CCDS54697.1.
    RefSeqi NP_001140158.1. NM_001146686.2.
    UniGenei Hs.518490.

    3D structure databases

    ProteinModelPortali A6NCL1.
    SMRi A6NCL1. Positions 79-133.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000406164.

    Proteomic databases

    PaxDbi A6NCL1.
    PRIDEi A6NCL1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000442080 ; ENSP00000406164 ; ENSG00000205835 .
    GeneIDi 647309.
    KEGGi hsa:647309.
    UCSCi uc011bsl.1. human.

    Organism-specific databases

    CTDi 647309.
    GeneCardsi GC03M190572.
    HGNCi HGNC:40049. GMNC.
    HPAi HPA043663.
    MIMi 614448. gene.
    neXtProti NX_A6NCL1.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG78102.
    HOGENOMi HOG000155495.
    HOVERGENi HBG108697.
    InParanoidi A6NCL1.
    OMAi PHPKNAK.
    OrthoDBi EOG79CZ1Q.
    PhylomeDBi A6NCL1.
    TreeFami TF344118.

    Miscellaneous databases

    NextBioi 120089.
    PROi A6NCL1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A6NCL1.
    Bgeei A6NCL1.
    Genevestigatori A6NCL1.

    Family and domain databases

    InterProi IPR029700. GEMC1.
    [Graphical view ]
    PANTHERi PTHR13372:SF2. PTHR13372:SF2. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiGEMC1_HUMAN
    AccessioniPrimary (citable) accession number: A6NCL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 54 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3