ID   TKTI1_HUMAN             Reviewed;         209 AA.
AC   A6NCJ1;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   27-MAR-2024, entry version 90.
DE   RecName: Full=Tektin bundle-interacting protein 1 {ECO:0000312|HGNC:HGNC:34496};
GN   Name=TEKTIP1 {ECO:0000312|HGNC:HGNC:34496}; Synonyms=C19orf71;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
CC   -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC       doublet microtubules (DMTs) in cilia axoneme, which is required for
CC       motile cilia beating. Located at the center of the tektin bundle where
CC       may function to recruit tektins or stabilize the bundle.
CC       {ECO:0000250|UniProtKB:Q2M2T2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:Q2M2T2}.
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DR   EMBL; AC005786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS45918.1; -.
DR   RefSeq; NP_001129052.1; NM_001135580.1.
DR   AlphaFoldDB; A6NCJ1; -.
DR   BioGRID; 933564; 2.
DR   STRING; 9606.ENSP00000327950; -.
DR   iPTMnet; A6NCJ1; -.
DR   PhosphoSitePlus; A6NCJ1; -.
DR   BioMuta; C19orf71; -.
DR   MassIVE; A6NCJ1; -.
DR   PaxDb; 9606-ENSP00000327950; -.
DR   PeptideAtlas; A6NCJ1; -.
DR   ProteomicsDB; 839; -.
DR   Antibodypedia; 63437; 23 antibodies from 6 providers.
DR   DNASU; 100128569; -.
DR   Ensembl; ENST00000329493.6; ENSP00000327950.4; ENSG00000183397.6.
DR   GeneID; 100128569; -.
DR   KEGG; hsa:100128569; -.
DR   MANE-Select; ENST00000329493.6; ENSP00000327950.4; NM_001135580.2; NP_001129052.1.
DR   UCSC; uc010xhm.3; human.
DR   AGR; HGNC:34496; -.
DR   GeneCards; TEKTIP1; -.
DR   HGNC; HGNC:34496; TEKTIP1.
DR   HPA; ENSG00000183397; Tissue enhanced (testis).
DR   neXtProt; NX_A6NCJ1; -.
DR   OpenTargets; ENSG00000183397; -.
DR   VEuPathDB; HostDB:ENSG00000183397; -.
DR   eggNOG; ENOG502S0K8; Eukaryota.
DR   GeneTree; ENSGT00390000004282; -.
DR   HOGENOM; CLU_108079_0_0_1; -.
DR   InParanoid; A6NCJ1; -.
DR   OMA; EAWYNLP; -.
DR   OrthoDB; 5296886at2759; -.
DR   PhylomeDB; A6NCJ1; -.
DR   TreeFam; TF336002; -.
DR   PathwayCommons; A6NCJ1; -.
DR   SignaLink; A6NCJ1; -.
DR   BioGRID-ORCS; 100128569; 12 hits in 1123 CRISPR screens.
DR   GenomeRNAi; 100128569; -.
DR   Pharos; A6NCJ1; Tdark.
DR   PRO; PR:A6NCJ1; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; A6NCJ1; Protein.
DR   Bgee; ENSG00000183397; Expressed in right testis and 95 other cell types or tissues.
DR   GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR   InterPro; IPR029203; TKTI1.
DR   PANTHER; PTHR31254; HYPOTHETICAL PROTEIN LOC690617; 1.
DR   PANTHER; PTHR31254:SF1; HYPOTHETICAL PROTEIN LOC690617; 1.
DR   Pfam; PF15041; TKTI1; 1.
PE   3: Inferred from homology;
KW   Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..209
FT                   /note="Tektin bundle-interacting protein 1"
FT                   /id="PRO_0000332195"
FT   VARIANT         83
FT                   /note="P -> L (in dbSNP:rs12608919)"
FT                   /id="VAR_061253"
FT   VARIANT         137
FT                   /note="A -> V (in dbSNP:rs6510758)"
FT                   /id="VAR_061254"
SQ   SEQUENCE   209 AA;  24176 MW;  2D40E238DBA50289 CRC64;
     MQTLRQEAAR PCIPSGTLEA SFPAPLYSDD YLSLEGSRWP PAIRQATRWK YTPMGRDAAG
     QLWYTGLTNS DAWEAWYNLP RAPASPFREA YNRWHSCYQH RECSMPSAYT QHLRETAWHD
     PIVPAQYQAP STRWGSALWK DRPIRGKEYV LNRNRYGVEP LWRASDYVPS LSAPQRPPGT
     TQNYREWVLE PYCPSTCQRS PPSLTPTPR
//