Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

von Willebrand factor A domain-containing protein 3A

Gene

VWA3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
von Willebrand factor A domain-containing protein 3A
Gene namesi
Name:VWA3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000175267.14
HGNCiHGNC:27088 VWA3A
neXtProtiNX_A6NCI4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi146177
OpenTargetsiENSG00000175267
PharmGKBiPA162408933

Polymorphism and mutation databases

BioMutaiVWA3A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000032462325 – 1184von Willebrand factor A domain-containing protein 3AAdd BLAST1160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi709N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA6NCI4
PRIDEiA6NCI4

PTM databases

iPTMnetiA6NCI4
PhosphoSitePlusiA6NCI4

Expressioni

Gene expression databases

BgeeiENSG00000175267
CleanExiHS_VWA3A
ExpressionAtlasiA6NCI4 baseline and differential
GenevisibleiA6NCI4 HS

Organism-specific databases

HPAiHPA041696
HPA042044

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000374049

Structurei

3D structure databases

ProteinModelPortaliA6NCI4
SMRiA6NCI4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini511 – 708VWFA 1PROSITE-ProRule annotationAdd BLAST198
Domaini959 – 1131VWFA 2PROSITE-ProRule annotationAdd BLAST173

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili333 – 357Sequence analysisAdd BLAST25

Keywords - Domaini

Coiled coil, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IGU6 Eukaryota
ENOG410XS5K LUCA
GeneTreeiENSGT00530000063623
HOVERGENiHBG108660
InParanoidiA6NCI4
OMAiQGIYLFT
OrthoDBiEOG091G022C
PhylomeDBiA6NCI4
TreeFamiTF328978

Family and domain databases

Gene3Di3.40.50.410, 3 hits
InterProiView protein in InterPro
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF13768 VWA_3, 3 hits
SMARTiView protein in SMART
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 3 hits
PROSITEiView protein in PROSITE
PS50234 VWFA, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NCI4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKYRKISIG CFAMATQTSH VFHGQENMFL ENHCIRRNTG RDSKKPLKQK
60 70 80 90 100
NMNGLGQNSD NGLLVTHVNQ TQDLLRLQGS ETQSSDWEDS EDWLSAHSLK
110 120 130 140 150
CQKLTLADLI SQGTEVLEEG TNVVQKICFS TQIIRHFESK LSDTIEVYQE
160 170 180 190 200
RIQWLTENSK KAFGLIKGAR VSILIDVSAI SSGPQKEEFQ KDLMSLIDEQ
210 220 230 240 250
LSHKEKLFVL SFGTNAGSLW PDPMEVSAST LQELKLWVKT LQPDGGSNLL
260 270 280 290 300
QALKKIFTLK GLDSLVAIMR SCPDQPSEIL SDYIQQSTMG RDLIIHFITY
310 320 330 340 350
RCDDQMPPAV LKNLAEAVRG YYHCYSPKME HYTSRDMDEL LAEIQKAQSL
360 370 380 390 400
LSHVQALQHS SPCEALTCTM EEISTEITNG PLISLLPKPP KHDAPLTIEF
410 420 430 440 450
PNLDKTSAEW LKVNGLKAKK LSLYQVLAPN AFSPVEEFVP ILQKTVSSTI
460 470 480 490 500
HEKAMIQFEW HDGTVKNIHV DPPFLYKYQQ QLSRAMRMYE RRIEWLSLAS
510 520 530 540 550
RRIWGTVCEK RVVVLLDISA TNSMYIIHIQ HSLRLLLEEQ LSNKDCFNLI
560 570 580 590 600
AFGSTIESWR PEMVPVSHNN LQSAWRWALN LRCRGSRNVL SALRKAVEVD
610 620 630 640 650
FKDKDKHQSQ GIYLFTGGIP DQDMPTLSAY MAEACGGCDL QLNVCLFYVG
660 670 680 690 700
EPKMDTTPPA RYASHTDTAA AYKEVTRAAG GRFHWFGDTG IYESDDINSI
710 720 730 740 750
MSEMEKALNY SQKCAFLMAS LKNHSGKVLG SSALPKEKPK TLQLRSQPKK
760 770 780 790 800
LCPPRPTVPL GARMSIKDDP DREKSPPLKS LKWRPLSSRV GISPAAAQPT
810 820 830 840 850
KEGMMELRRK TKSREAETSL LLFYTEKGND VGSVYKKYPQ GRGLRRTSSS
860 870 880 890 900
IDLPRKDTVC SSQEWVAKYG LKKLKLEISR CMGPNCTHQK SGQRSASAKH
910 920 930 940 950
CSIFPSVEIH GVVRHIQWTP REMEVYIRHL EKVLRRYVQR LQWLLSGSRR
960 970 980 990 1000
LFGTVLESKV CILLDTSGSM GPYLQQVKTE LVLLIWEQLR KCCDSFNLLS
1010 1020 1030 1040 1050
FAESFQSWQD TLVETTDAAC HEAMQWVTHL QAQGSTSILQ ALLKAFSFHD
1060 1070 1080 1090 1100
LEGLYLLTDG KPDTSCSLVL NEVQKLREKR DVKVHTISLN CSDRAAVEFL
1110 1120 1130 1140 1150
RKLASFTGGR YHCPVGEDTL SKIHSLLTKG FINEKDPTLP PFEGDDLRIL
1160 1170 1180
AQEITKARSF LWQAQSFRSQ LQKKNDAEPK VTLS
Length:1,184
Mass (Da):134,020
Last modified:March 18, 2008 - v3
Checksum:i1CA57332FA8879F0
GO
Isoform 2 (identifier: A6NCI4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     7-382: Missing.

Note: No experimental confirmation available.
Show »
Length:808
Mass (Da):91,786
Checksum:i4578FB1A753C1601
GO
Isoform 3 (identifier: A6NCI4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-922: Missing.

Note: No experimental confirmation available.
Show »
Length:262
Mass (Da):29,895
Checksum:i571FE447BB140D4D
GO
Isoform 4 (identifier: A6NCI4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-898: Missing.
     899-945: KHCSIFPSVE...RYVQRLQWLL → MEVYIRHLEK...MDRGVMMTAA

Note: No experimental confirmation available.
Show »
Length:286
Mass (Da):32,582
Checksum:iAEDDF2BC529CCA50
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti885N → S in AAH38400 (PubMed:15489334).Curated1
Sequence conflicti1005F → L in AAQ62968 (Ref. 1) Curated1
Sequence conflicti1005F → L in BAC04176 (PubMed:14702039).Curated1
Sequence conflicti1005F → L in BAC87526 (PubMed:14702039).Curated1
Sequence conflicti1005F → L in EAW50598 (Ref. 4) Curated1
Sequence conflicti1005F → L in AAH38400 (PubMed:15489334).Curated1
Sequence conflicti1005F → L in AAI09296 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059738464T → I. Corresponds to variant dbSNP:rs1105929Ensembl.1
Natural variantiVAR_057020657T → I1 PublicationCorresponds to variant dbSNP:rs1105929Ensembl.1
Natural variantiVAR_0570211165Q → P. Corresponds to variant dbSNP:rs16972517Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0323181 – 922Missing in isoform 3. 1 PublicationAdd BLAST922
Alternative sequenceiVSP_0323191 – 898Missing in isoform 4. 1 PublicationAdd BLAST898
Alternative sequenceiVSP_0323207 – 382Missing in isoform 2. 1 PublicationAdd BLAST376
Alternative sequenceiVSP_032321899 – 945KHCSI…LQWLL → MEVYIRHLEKVLRRYVQRLQ WLLSGPVLCSRTWYRQSMDR GVMMTAA in isoform 4. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY360464 mRNA Translation: AAQ62968.1
AK093467 mRNA Translation: BAC04176.1
AK128606 mRNA Translation: BAC87526.1
AC009019 Genomic DNA No translation available.
CH471249 Genomic DNA Translation: EAW50598.1
BC038400 mRNA Translation: AAH38400.1
BC109295 mRNA Translation: AAI09296.1
CCDSiCCDS45441.1 [A6NCI4-1]
RefSeqiNP_775886.3, NM_173615.4 [A6NCI4-1]
UniGeneiHs.10697

Genome annotation databases

EnsembliENST00000389398; ENSP00000374049; ENSG00000175267 [A6NCI4-1]
ENST00000563755; ENSP00000456513; ENSG00000175267 [A6NCI4-4]
GeneIDi146177
KEGGihsa:146177
UCSCiuc010bxe.2 human [A6NCI4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiVWA3A_HUMAN
AccessioniPrimary (citable) accession number: A6NCI4
Secondary accession number(s): A4QMU8
, A6NNC0, Q6UTX4, Q6ZQZ9, Q8IUY6, Q8N9W1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: April 25, 2018
This is version 80 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health