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Protein

von Willebrand factor A domain-containing protein 3A

Gene

VWA3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
von Willebrand factor A domain-containing protein 3A
Gene namesi
Name:VWA3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:27088. VWA3A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162408933.

Polymorphism and mutation databases

BioMutaiVWA3A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 11841160von Willebrand factor A domain-containing protein 3APRO_0000324623Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi709 – 7091N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA6NCI4.
PRIDEiA6NCI4.

PTM databases

iPTMnetiA6NCI4.
PhosphoSiteiA6NCI4.

Expressioni

Gene expression databases

BgeeiENSG00000175267.
CleanExiHS_VWA3A.
ExpressionAtlasiA6NCI4. baseline and differential.
GenevisibleiA6NCI4. HS.

Organism-specific databases

HPAiHPA041696.
HPA042044.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000374049.

Structurei

3D structure databases

ProteinModelPortaliA6NCI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini511 – 708198VWFA 1PROSITE-ProRule annotationAdd
BLAST
Domaini959 – 1131173VWFA 2PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili333 – 35725Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 2 VWFA domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IGU6. Eukaryota.
ENOG410XS5K. LUCA.
GeneTreeiENSGT00530000063623.
HOVERGENiHBG108660.
InParanoidiA6NCI4.
OMAiWEQLRKH.
OrthoDBiEOG091G022C.
PhylomeDBiA6NCI4.
TreeFamiTF328978.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR002035. VWF_A.
[Graphical view]
PfamiPF13768. VWA_3. 3 hits.
[Graphical view]
SMARTiSM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 3 hits.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NCI4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKYRKISIG CFAMATQTSH VFHGQENMFL ENHCIRRNTG RDSKKPLKQK
60 70 80 90 100
NMNGLGQNSD NGLLVTHVNQ TQDLLRLQGS ETQSSDWEDS EDWLSAHSLK
110 120 130 140 150
CQKLTLADLI SQGTEVLEEG TNVVQKICFS TQIIRHFESK LSDTIEVYQE
160 170 180 190 200
RIQWLTENSK KAFGLIKGAR VSILIDVSAI SSGPQKEEFQ KDLMSLIDEQ
210 220 230 240 250
LSHKEKLFVL SFGTNAGSLW PDPMEVSAST LQELKLWVKT LQPDGGSNLL
260 270 280 290 300
QALKKIFTLK GLDSLVAIMR SCPDQPSEIL SDYIQQSTMG RDLIIHFITY
310 320 330 340 350
RCDDQMPPAV LKNLAEAVRG YYHCYSPKME HYTSRDMDEL LAEIQKAQSL
360 370 380 390 400
LSHVQALQHS SPCEALTCTM EEISTEITNG PLISLLPKPP KHDAPLTIEF
410 420 430 440 450
PNLDKTSAEW LKVNGLKAKK LSLYQVLAPN AFSPVEEFVP ILQKTVSSTI
460 470 480 490 500
HEKAMIQFEW HDGTVKNIHV DPPFLYKYQQ QLSRAMRMYE RRIEWLSLAS
510 520 530 540 550
RRIWGTVCEK RVVVLLDISA TNSMYIIHIQ HSLRLLLEEQ LSNKDCFNLI
560 570 580 590 600
AFGSTIESWR PEMVPVSHNN LQSAWRWALN LRCRGSRNVL SALRKAVEVD
610 620 630 640 650
FKDKDKHQSQ GIYLFTGGIP DQDMPTLSAY MAEACGGCDL QLNVCLFYVG
660 670 680 690 700
EPKMDTTPPA RYASHTDTAA AYKEVTRAAG GRFHWFGDTG IYESDDINSI
710 720 730 740 750
MSEMEKALNY SQKCAFLMAS LKNHSGKVLG SSALPKEKPK TLQLRSQPKK
760 770 780 790 800
LCPPRPTVPL GARMSIKDDP DREKSPPLKS LKWRPLSSRV GISPAAAQPT
810 820 830 840 850
KEGMMELRRK TKSREAETSL LLFYTEKGND VGSVYKKYPQ GRGLRRTSSS
860 870 880 890 900
IDLPRKDTVC SSQEWVAKYG LKKLKLEISR CMGPNCTHQK SGQRSASAKH
910 920 930 940 950
CSIFPSVEIH GVVRHIQWTP REMEVYIRHL EKVLRRYVQR LQWLLSGSRR
960 970 980 990 1000
LFGTVLESKV CILLDTSGSM GPYLQQVKTE LVLLIWEQLR KCCDSFNLLS
1010 1020 1030 1040 1050
FAESFQSWQD TLVETTDAAC HEAMQWVTHL QAQGSTSILQ ALLKAFSFHD
1060 1070 1080 1090 1100
LEGLYLLTDG KPDTSCSLVL NEVQKLREKR DVKVHTISLN CSDRAAVEFL
1110 1120 1130 1140 1150
RKLASFTGGR YHCPVGEDTL SKIHSLLTKG FINEKDPTLP PFEGDDLRIL
1160 1170 1180
AQEITKARSF LWQAQSFRSQ LQKKNDAEPK VTLS
Length:1,184
Mass (Da):134,020
Last modified:March 18, 2008 - v3
Checksum:i1CA57332FA8879F0
GO
Isoform 2 (identifier: A6NCI4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     7-382: Missing.

Note: No experimental confirmation available.
Show »
Length:808
Mass (Da):91,786
Checksum:i4578FB1A753C1601
GO
Isoform 3 (identifier: A6NCI4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-922: Missing.

Note: No experimental confirmation available.
Show »
Length:262
Mass (Da):29,895
Checksum:i571FE447BB140D4D
GO
Isoform 4 (identifier: A6NCI4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-898: Missing.
     899-945: KHCSIFPSVE...RYVQRLQWLL → MEVYIRHLEK...MDRGVMMTAA

Note: No experimental confirmation available.
Show »
Length:286
Mass (Da):32,582
Checksum:iAEDDF2BC529CCA50
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti885 – 8851N → S in AAH38400 (PubMed:15489334).Curated
Sequence conflicti1005 – 10051F → L in AAQ62968 (Ref. 1) Curated
Sequence conflicti1005 – 10051F → L in BAC04176 (PubMed:14702039).Curated
Sequence conflicti1005 – 10051F → L in BAC87526 (PubMed:14702039).Curated
Sequence conflicti1005 – 10051F → L in EAW50598 (Ref. 4) Curated
Sequence conflicti1005 – 10051F → L in AAH38400 (PubMed:15489334).Curated
Sequence conflicti1005 – 10051F → L in AAI09296 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti464 – 4641T → I.
Corresponds to variant rs1105929 [ dbSNP | Ensembl ].
VAR_059738
Natural varianti657 – 6571T → I.1 Publication
Corresponds to variant rs1105929 [ dbSNP | Ensembl ].
VAR_057020
Natural varianti1165 – 11651Q → P.
Corresponds to variant rs16972517 [ dbSNP | Ensembl ].
VAR_057021

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 922922Missing in isoform 3. 1 PublicationVSP_032318Add
BLAST
Alternative sequencei1 – 898898Missing in isoform 4. 1 PublicationVSP_032319Add
BLAST
Alternative sequencei7 – 382376Missing in isoform 2. 1 PublicationVSP_032320Add
BLAST
Alternative sequencei899 – 94547KHCSI…LQWLL → MEVYIRHLEKVLRRYVQRLQ WLLSGPVLCSRTWYRQSMDR GVMMTAA in isoform 4. 1 PublicationVSP_032321Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY360464 mRNA. Translation: AAQ62968.1.
AK093467 mRNA. Translation: BAC04176.1.
AK128606 mRNA. Translation: BAC87526.1.
AC009019 Genomic DNA. No translation available.
CH471249 Genomic DNA. Translation: EAW50598.1.
BC038400 mRNA. Translation: AAH38400.1.
BC109295 mRNA. Translation: AAI09296.1.
CCDSiCCDS45441.1. [A6NCI4-1]
RefSeqiNP_775886.3. NM_173615.4. [A6NCI4-1]
UniGeneiHs.10697.

Genome annotation databases

EnsembliENST00000389398; ENSP00000374049; ENSG00000175267. [A6NCI4-1]
ENST00000563755; ENSP00000456513; ENSG00000175267. [A6NCI4-4]
GeneIDi146177.
KEGGihsa:146177.
UCSCiuc010bxe.2. human. [A6NCI4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY360464 mRNA. Translation: AAQ62968.1.
AK093467 mRNA. Translation: BAC04176.1.
AK128606 mRNA. Translation: BAC87526.1.
AC009019 Genomic DNA. No translation available.
CH471249 Genomic DNA. Translation: EAW50598.1.
BC038400 mRNA. Translation: AAH38400.1.
BC109295 mRNA. Translation: AAI09296.1.
CCDSiCCDS45441.1. [A6NCI4-1]
RefSeqiNP_775886.3. NM_173615.4. [A6NCI4-1]
UniGeneiHs.10697.

3D structure databases

ProteinModelPortaliA6NCI4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000374049.

PTM databases

iPTMnetiA6NCI4.
PhosphoSiteiA6NCI4.

Polymorphism and mutation databases

BioMutaiVWA3A.

Proteomic databases

PaxDbiA6NCI4.
PRIDEiA6NCI4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389398; ENSP00000374049; ENSG00000175267. [A6NCI4-1]
ENST00000563755; ENSP00000456513; ENSG00000175267. [A6NCI4-4]
GeneIDi146177.
KEGGihsa:146177.
UCSCiuc010bxe.2. human. [A6NCI4-1]

Organism-specific databases

CTDi146177.
GeneCardsiVWA3A.
HGNCiHGNC:27088. VWA3A.
HPAiHPA041696.
HPA042044.
neXtProtiNX_A6NCI4.
PharmGKBiPA162408933.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGU6. Eukaryota.
ENOG410XS5K. LUCA.
GeneTreeiENSGT00530000063623.
HOVERGENiHBG108660.
InParanoidiA6NCI4.
OMAiWEQLRKH.
OrthoDBiEOG091G022C.
PhylomeDBiA6NCI4.
TreeFamiTF328978.

Miscellaneous databases

GenomeRNAii146177.
PROiA6NCI4.

Gene expression databases

BgeeiENSG00000175267.
CleanExiHS_VWA3A.
ExpressionAtlasiA6NCI4. baseline and differential.
GenevisibleiA6NCI4. HS.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR002035. VWF_A.
[Graphical view]
PfamiPF13768. VWA_3. 3 hits.
[Graphical view]
SMARTiSM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 3 hits.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVWA3A_HUMAN
AccessioniPrimary (citable) accession number: A6NCI4
Secondary accession number(s): A4QMU8
, A6NNC0, Q6UTX4, Q6ZQZ9, Q8IUY6, Q8N9W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: September 7, 2016
This is version 67 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.