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Protein

Kelch-like protein 33

Gene

KLHL33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 33
Gene namesi
Name:KLHL33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:31952. KLHL33.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162393579.

Polymorphism and mutation databases

BioMutaiKLHL33.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 533533Kelch-like protein 33PRO_0000324769Add
BLAST

Proteomic databases

PaxDbiA6NCF5.
PRIDEiA6NCF5.

PTM databases

PhosphoSiteiA6NCF5.

Expressioni

Gene expression databases

BgeeiA6NCF5.
CleanExiHS_KLHL33.

Organism-specific databases

HPAiHPA056560.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125816. 12 interactions.
IntActiA6NCF5. 1 interaction.
STRINGi9606.ENSP00000341549.

Structurei

3D structure databases

ProteinModelPortaliA6NCF5.
SMRiA6NCF5. Positions 1-144, 250-494.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati210 – 25849Kelch 1Add
BLAST
Repeati273 – 32250Kelch 2Add
BLAST
Repeati323 – 36947Kelch 3Add
BLAST
Repeati371 – 41848Kelch 4Add
BLAST
Repeati419 – 46547Kelch 5Add
BLAST
Repeati467 – 51448Kelch 6Add
BLAST

Sequence similaritiesi

Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG1072. Eukaryota.
ENOG4110X8D. LUCA.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000113236.
HOVERGENiHBG108067.
InParanoidiA6NCF5.
KOiK13957.
OMAiRESQGTE.
OrthoDBiEOG7M98FX.
PhylomeDBiA6NCF5.
TreeFamiTF328485.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR030609. KLHL33.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF195. PTHR24412:SF195. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00612. Kelch. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NCF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLSGMRESQ GTEVSLRTIS TQDLRLLVSF AYSGVVRARW PGLLRAAQAA
60 70 80 90 100
LQYQSSSCLD LCQKGLARGL SPARCLALFP MAEAPGLERL WSKARHYLLT
110 120 130 140 150
HLPAVALCPA FPSLPAACLA ELLDSDELHV QEEFEAFVAA RCWLAANPET
160 170 180 190 200
QESEAKALLR CVRFGRMSTR ELRRVRAAGL LPPLTPDLLH QLMVEADVPG
210 220 230 240 250
QERRREPDRA LVVIGGDGLR PDMALRQPSR AVWWARAFRC GVGLVRTVEW
260 270 280 290 300
GQLPALPAPG RFRHGAASLA GSELYVCGGQ DFYSHSNTLA STLRWEPSQE
310 320 330 340 350
DWEEMAPLSQ ARSLFSLVAL DGKLYALGGR HNDVALDSVE TYNPELNVWR
360 370 380 390 400
PAPALPAPCF AHAAAILEGQ LYVSGGCGGT GQYLASLMHY DPKLEKPGTF
410 420 430 440 450
LSPMGVPRAG HVMAALGGRL YVAGGLGETE DLLSFEAYEL RTDSWTHLAP
460 470 480 490 500
LPSPHVGAAS AVLQGELLVL GGYSHRTYAL SHLIHAYCPG LGRWLCLGTL
510 520 530
PRPRAEMPAC ILTLPAVQHI ALVPTPHQTK PAG
Length:533
Mass (Da):57,810
Last modified:March 18, 2008 - v2
Checksum:i4B3DC69910F83FBF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti163 – 1631R → H.
Corresponds to variant rs12587478 [ dbSNP | Ensembl ].
VAR_039878
Natural varianti176 – 1761R → Q.
Corresponds to variant rs17242648 [ dbSNP | Ensembl ].
VAR_039879
Natural varianti345 – 3451E → G.
Corresponds to variant rs1953225 [ dbSNP | Ensembl ].
VAR_039880
Natural varianti516 – 5161A → T.
Corresponds to variant rs7145318 [ dbSNP | Ensembl ].
VAR_039881

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355075 Genomic DNA. No translation available.
CCDSiCCDS53882.1.
RefSeqiNP_001103467.2. NM_001109997.2.
UniGeneiHs.556014.

Genome annotation databases

EnsembliENST00000344581; ENSP00000341549; ENSG00000185271.
GeneIDi123103.
KEGGihsa:123103.
UCSCiuc010tli.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355075 Genomic DNA. No translation available.
CCDSiCCDS53882.1.
RefSeqiNP_001103467.2. NM_001109997.2.
UniGeneiHs.556014.

3D structure databases

ProteinModelPortaliA6NCF5.
SMRiA6NCF5. Positions 1-144, 250-494.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125816. 12 interactions.
IntActiA6NCF5. 1 interaction.
STRINGi9606.ENSP00000341549.

PTM databases

PhosphoSiteiA6NCF5.

Polymorphism and mutation databases

BioMutaiKLHL33.

Proteomic databases

PaxDbiA6NCF5.
PRIDEiA6NCF5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344581; ENSP00000341549; ENSG00000185271.
GeneIDi123103.
KEGGihsa:123103.
UCSCiuc010tli.2. human.

Organism-specific databases

CTDi123103.
GeneCardsiKLHL33.
HGNCiHGNC:31952. KLHL33.
HPAiHPA056560.
neXtProtiNX_A6NCF5.
PharmGKBiPA162393579.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1072. Eukaryota.
ENOG4110X8D. LUCA.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000113236.
HOVERGENiHBG108067.
InParanoidiA6NCF5.
KOiK13957.
OMAiRESQGTE.
OrthoDBiEOG7M98FX.
PhylomeDBiA6NCF5.
TreeFamiTF328485.

Miscellaneous databases

GenomeRNAii123103.
NextBioi81077.
PROiA6NCF5.

Gene expression databases

BgeeiA6NCF5.
CleanExiHS_KLHL33.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR030609. KLHL33.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF195. PTHR24412:SF195. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00612. Kelch. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKLH33_HUMAN
AccessioniPrimary (citable) accession number: A6NCF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: February 17, 2016
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.