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Protein

Kelch-like protein 33

Gene

KLHL33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32438-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 33
Gene namesi
Name:KLHL33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:31952. KLHL33.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185271.
PharmGKBiPA162393579.

Polymorphism and mutation databases

BioMutaiKLHL33.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003247691 – 533Kelch-like protein 33Add BLAST533

Proteomic databases

PaxDbiA6NCF5.
PRIDEiA6NCF5.

PTM databases

iPTMnetiA6NCF5.
PhosphoSitePlusiA6NCF5.

Expressioni

Gene expression databases

BgeeiENSG00000185271.
CleanExiHS_KLHL33.

Organism-specific databases

HPAiHPA056560.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125816. 12 interactors.
IntActiA6NCF5. 1 interactor.
STRINGi9606.ENSP00000341549.

Structurei

3D structure databases

ProteinModelPortaliA6NCF5.
SMRiA6NCF5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati210 – 258Kelch 1Add BLAST49
Repeati273 – 322Kelch 2Add BLAST50
Repeati323 – 369Kelch 3Add BLAST47
Repeati371 – 418Kelch 4Add BLAST48
Repeati419 – 465Kelch 5Add BLAST47
Repeati467 – 514Kelch 6Add BLAST48

Sequence similaritiesi

Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG1072. Eukaryota.
ENOG4110X8D. LUCA.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000113236.
HOVERGENiHBG108067.
InParanoidiA6NCF5.
KOiK13957.
OMAiRESQGTE.
OrthoDBiEOG091G0328.
PhylomeDBiA6NCF5.
TreeFamiTF328485.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR030609. KLHL33.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF195. PTHR24412:SF195. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00612. Kelch. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NCF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLSGMRESQ GTEVSLRTIS TQDLRLLVSF AYSGVVRARW PGLLRAAQAA
60 70 80 90 100
LQYQSSSCLD LCQKGLARGL SPARCLALFP MAEAPGLERL WSKARHYLLT
110 120 130 140 150
HLPAVALCPA FPSLPAACLA ELLDSDELHV QEEFEAFVAA RCWLAANPET
160 170 180 190 200
QESEAKALLR CVRFGRMSTR ELRRVRAAGL LPPLTPDLLH QLMVEADVPG
210 220 230 240 250
QERRREPDRA LVVIGGDGLR PDMALRQPSR AVWWARAFRC GVGLVRTVEW
260 270 280 290 300
GQLPALPAPG RFRHGAASLA GSELYVCGGQ DFYSHSNTLA STLRWEPSQE
310 320 330 340 350
DWEEMAPLSQ ARSLFSLVAL DGKLYALGGR HNDVALDSVE TYNPELNVWR
360 370 380 390 400
PAPALPAPCF AHAAAILEGQ LYVSGGCGGT GQYLASLMHY DPKLEKPGTF
410 420 430 440 450
LSPMGVPRAG HVMAALGGRL YVAGGLGETE DLLSFEAYEL RTDSWTHLAP
460 470 480 490 500
LPSPHVGAAS AVLQGELLVL GGYSHRTYAL SHLIHAYCPG LGRWLCLGTL
510 520 530
PRPRAEMPAC ILTLPAVQHI ALVPTPHQTK PAG
Length:533
Mass (Da):57,810
Last modified:March 18, 2008 - v2
Checksum:i4B3DC69910F83FBF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039878163R → H.Corresponds to variant rs12587478dbSNPEnsembl.1
Natural variantiVAR_039879176R → Q.Corresponds to variant rs17242648dbSNPEnsembl.1
Natural variantiVAR_039880345E → G.Corresponds to variant rs1953225dbSNPEnsembl.1
Natural variantiVAR_039881516A → T.Corresponds to variant rs7145318dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355075 Genomic DNA. No translation available.
CCDSiCCDS53882.1.
RefSeqiNP_001103467.2. NM_001109997.2.
UniGeneiHs.556014.

Genome annotation databases

EnsembliENST00000344581; ENSP00000341549; ENSG00000185271.
GeneIDi123103.
KEGGihsa:123103.
UCSCiuc010tli.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355075 Genomic DNA. No translation available.
CCDSiCCDS53882.1.
RefSeqiNP_001103467.2. NM_001109997.2.
UniGeneiHs.556014.

3D structure databases

ProteinModelPortaliA6NCF5.
SMRiA6NCF5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125816. 12 interactors.
IntActiA6NCF5. 1 interactor.
STRINGi9606.ENSP00000341549.

PTM databases

iPTMnetiA6NCF5.
PhosphoSitePlusiA6NCF5.

Polymorphism and mutation databases

BioMutaiKLHL33.

Proteomic databases

PaxDbiA6NCF5.
PRIDEiA6NCF5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344581; ENSP00000341549; ENSG00000185271.
GeneIDi123103.
KEGGihsa:123103.
UCSCiuc010tli.2. human.

Organism-specific databases

CTDi123103.
GeneCardsiKLHL33.
HGNCiHGNC:31952. KLHL33.
HPAiHPA056560.
neXtProtiNX_A6NCF5.
OpenTargetsiENSG00000185271.
PharmGKBiPA162393579.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1072. Eukaryota.
ENOG4110X8D. LUCA.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000113236.
HOVERGENiHBG108067.
InParanoidiA6NCF5.
KOiK13957.
OMAiRESQGTE.
OrthoDBiEOG091G0328.
PhylomeDBiA6NCF5.
TreeFamiTF328485.

Enzyme and pathway databases

BioCyciZFISH:G66-32438-MONOMER.

Miscellaneous databases

GenomeRNAii123103.
PROiA6NCF5.

Gene expression databases

BgeeiENSG00000185271.
CleanExiHS_KLHL33.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR030609. KLHL33.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF195. PTHR24412:SF195. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00612. Kelch. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKLH33_HUMAN
AccessioniPrimary (citable) accession number: A6NCF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: November 2, 2016
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.