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Protein

Microtubule-associated proteins 1A/1B light chain 3 beta 2

Gene

MAP1LC3B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processAutophagy, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated proteins 1A/1B light chain 3 beta 2
Alternative name(s):
Microtubule-associated proteins 1A/1B light chain 3B-like
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000258102.3
HGNCiHGNC:34390 MAP1LC3B2
neXtProtiNX_A6NCE7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000258102
PharmGKBiPA162394969

Polymorphism and mutation databases

BioMutaiMAP1LC3B2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003437321 – 120Microtubule-associated proteins 1A/1B light chain 3 beta 2Add BLAST120
PropeptideiPRO_0000343733121 – 125Removed in mature formBy similarity5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi120Phosphatidylethanolamine amidated glycineBy similarity1

Post-translational modificationi

The precursor molecule is cleaved by APG4B/ATG4B to form LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form LC3-II.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei120 – 121Cleavage; by ATG4BBy similarity2

Keywords - PTMi

Lipoprotein

Proteomic databases

EPDiA6NCE7
MaxQBiA6NCE7
PaxDbiA6NCE7
PRIDEiA6NCE7
ProteomicsDBi828
TopDownProteomicsiA6NCE7

PTM databases

iPTMnetiA6NCE7
PhosphoSitePlusiA6NCE7

Expressioni

Gene expression databases

BgeeiENSG00000258102
CleanExiHS_MAP1LC3B2
GenevisibleiA6NCE7 HS

Organism-specific databases

HPAiHPA052474
HPA052484
HPA053767

Interactioni

Subunit structurei

3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins.By similarity

Protein-protein interaction databases

BioGridi568619, 9 interactors
IntActiA6NCE7, 3 interactors
STRINGi9606.ENSP00000305059

Structurei

3D structure databases

ProteinModelPortaliA6NCE7
SMRiA6NCE7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG8 family.Curated

Phylogenomic databases

eggNOGiKOG1654 Eukaryota
ENOG4111JAT LUCA
GeneTreeiENSGT00390000012937
HOGENOMiHOG000232034
HOVERGENiHBG051706
InParanoidiA6NCE7
OMAiCLENLAC
OrthoDBiEOG091G18ST
PhylomeDBiA6NCE7
TreeFamiTF312964

Family and domain databases

CDDicd01611 GABARAP, 1 hit
InterProiView protein in InterPro
IPR004241 Atg8-like
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10969 PTHR10969, 1 hit
PfamiView protein in Pfam
PF02991 Atg8, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6NCE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSEKTFKQR RTFEQRVEDV RLIREQHPTK IPVIIERYKG EKQLPVLDKT
60 70 80 90 100
KFLVPDHVNM SELIKIIRRR LQLNANQAFF LLVNGHSMVS VSTPISEVYE
110 120
SEKDEDGFLY MVCASQETFG MKLSV
Length:125
Mass (Da):14,628
Last modified:July 24, 2007 - v1
Checksum:iBB141DEC6AA1E83F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DN994744 mRNA No translation available.
AC125603 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW98085.1
CCDSiCCDS41841.1
RefSeqiNP_001078950.1, NM_001085481.1
UniGeneiHs.356061
Hs.506947

Genome annotation databases

EnsembliENST00000556529; ENSP00000450524; ENSG00000258102
GeneIDi643246
KEGGihsa:643246
UCSCiuc009zwk.2 human

Similar proteinsi

Entry informationi

Entry nameiMP3B2_HUMAN
AccessioniPrimary (citable) accession number: A6NCE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 24, 2007
Last modified: June 20, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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