A6NCD4 (CJ131_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C10orf131

Gene names

Name:

C10orf131

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A6NCD4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A6NCD4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGVQM
     167-256: VVNQRKLPKD...PLLKTIYRKL → GNILSQ

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 256	256	Uncharacterized protein C10orf131		PRO_0000320923
Regions
	Coiled coil	136 – 159	24	Potential
	Coiled coil	194 – 214	21	Potential
Natural variations
	Alternative sequence	1	1	M → MGVQM in isoform 2.		VSP_045322
	Alternative sequence	167 – 256	90	VVNQR…IYRKL → GNILSQ in isoform 2.		VSP_045323

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 22, 2008. Version 3. Checksum: 9418473D2366F675	FASTA	256	29,615
	10 20 30 40 50 60 MSEEMDNITA EEIIDKHLQK DLDAEENQNV AKTLRGKVRE KLKISKINKG EKSSTEQLID 70 80 90 100 110 120 SEIHQRSKLS PQTEVSLDES LSFFILSGEE GSALGKSSEQ RPVNRSYPKC FSLGVNLQNV 130 140 150 160 170 180 AESEEEEFMK EFILTDILKV KAADYEDDQE QIKKQKANIF VPSSSPVVNQ RKLPKDMMPR 190 200 210 220 230 240 ILEDEGFYIQ RKPEIYKKTC NKMENRLLKL EEAKCWFGES GEIMSLPTPI KQSWNFRLNV 250 RKEPLNPLLK TIYRKL
	Isoform 2 [UniParc]. Checksum: 9765C52C1E321CD2	FASTA	176	19,808
	10 20 30 40 50 60 MGVQMSEEMD NITAEEIIDK HLQKDLDAEE NQNVAKTLRG KVREKLKISK INKGEKSSTE 70 80 90 100 110 120 QLIDSEIHQR SKLSPQTEVS LDESLSFFIL SGEEGSALGK SSEQRPVNRS YPKCFSLGVN 130 140 150 160 170 LQNVAESEEE EFMKEFILTD ILKVKAADYE DDQEQIKKQK ANIFVPSSSP GNILSQ

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Amygdala.

[2]

"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK294399 mRNA. Translation: BAG57652.1. AL513355, AL356155 Genomic DNA. Translation: CAH71690.1. AL356155, AL513355 Genomic DNA. Translation: CAI16400.1.
IPI	IPI00164170.
RefSeq	NP_001123918.2. NM_001130446.2.
UniGene	Hs.719076.
3D structure databases
ProteinModelPortal	A6NCD4.
ModBase	Search...
Proteomic databases
PaxDb	A6NCD4.
PRIDE	A6NCD4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371202; ENSP00000360245; ENSG00000173088. ENST00000423344; ENSP00000411850; ENSG00000173088.
GeneID	100127889.
KEGG	hsa:100127889.
Organism-specific databases
GeneCards	GC10P097620.
HGNC	HGNC:31667. C10orf131.
HPA	HPA044091.
neXtProt	NX_A6NCD4.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG255795.
HOGENOM	HOG000111716.
HOVERGEN	HBG098298.
InParanoid	A6NCD4.
OMA	ADYEDDQ.
OrthoDB	EOG48D0W3.
Gene expression databases
ArrayExpress	A6NCD4.
Bgee	A6NCD4.
Genevestigator	A6NCD4.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	100127889.
NextBio	20789158.

Entry information

Entry name

CJ131_HUMAN

Accession

Primary (citable) accession number: A6NCD4
Secondary accession number(s): B1AMZ2, B4DG41

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	July 22, 2008
Last modified:	May 1, 2013
This is version 38 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.