ID   GOG8O_HUMAN             Reviewed;         632 AA.
AC   A6NCC3; A6NHZ1; E7ENU5;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 3.
DT   27-MAR-2024, entry version 106.
DE   RecName: Full=Golgin subfamily A member 8O;
GN   Name=GOLGA8O;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA   Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA   Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
CC   -!- INTERACTION:
CC       A6NCC3; PRO_0000308465 [P29991]; Xeno; NbExp=3; IntAct=EBI-8827490, EBI-8826747;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A6NCC3-2; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A6NCC3-1; Sequence=VSP_044760, VSP_044761, VSP_044762;
CC   -!- SIMILARITY: Belongs to the GOLGA6 family. {ECO:0000305}.
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DR   EMBL; AC123768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC135983; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS59252.1; -. [A6NCC3-2]
DR   RefSeq; NP_001264237.1; NM_001277308.1. [A6NCC3-2]
DR   AlphaFoldDB; A6NCC3; -.
DR   SMR; A6NCC3; -.
DR   BioGRID; 608483; 5.
DR   DIP; DIP-58933N; -.
DR   IntAct; A6NCC3; 1.
DR   STRING; 9606.ENSP00000423159; -.
DR   iPTMnet; A6NCC3; -.
DR   PhosphoSitePlus; A6NCC3; -.
DR   BioMuta; GOLGA8O; -.
DR   jPOST; A6NCC3; -.
DR   MassIVE; A6NCC3; -.
DR   MaxQB; A6NCC3; -.
DR   PaxDb; 9606-ENSP00000423159; -.
DR   PeptideAtlas; A6NCC3; -.
DR   Antibodypedia; 73751; 18 antibodies from 2 providers.
DR   DNASU; 728047; -.
DR   Ensembl; ENST00000509311.7; ENSP00000423159.2; ENSG00000206127.11. [A6NCC3-2]
DR   GeneID; 728047; -.
DR   KEGG; hsa:728047; -.
DR   MANE-Select; ENST00000509311.7; ENSP00000423159.2; NM_001277308.1; NP_001264237.1.
DR   UCSC; uc031qrg.2; human. [A6NCC3-2]
DR   AGR; HGNC:44406; -.
DR   CTD; 728047; -.
DR   GeneCards; GOLGA8O; -.
DR   HGNC; HGNC:44406; GOLGA8O.
DR   HPA; ENSG00000206127; Group enriched (bone marrow, epididymis, testis, thyroid gland).
DR   neXtProt; NX_A6NCC3; -.
DR   VEuPathDB; HostDB:ENSG00000206127; -.
DR   eggNOG; KOG4725; Eukaryota.
DR   GeneTree; ENSGT00530000062932; -.
DR   HOGENOM; CLU_012403_1_2_1; -.
DR   InParanoid; A6NCC3; -.
DR   OrthoDB; 4705344at2759; -.
DR   PhylomeDB; A6NCC3; -.
DR   PathwayCommons; A6NCC3; -.
DR   SignaLink; A6NCC3; -.
DR   BioGRID-ORCS; 728047; 35 hits in 627 CRISPR screens.
DR   GenomeRNAi; 728047; -.
DR   Pharos; A6NCC3; Tdark.
DR   PRO; PR:A6NCC3; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; A6NCC3; Protein.
DR   Bgee; ENSG00000206127; Expressed in right lobe of thyroid gland and 95 other cell types or tissues.
DR   ExpressionAtlas; A6NCC3; baseline and differential.
DR   GO; GO:0005801; C:cis-Golgi network; IBA:GO_Central.
DR   GO; GO:0000137; C:Golgi cis cisterna; IBA:GO_Central.
DR   GO; GO:0032580; C:Golgi cisterna membrane; IBA:GO_Central.
DR   GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR   InterPro; IPR043937; GM130_C.
DR   InterPro; IPR043976; GOLGA_cons_dom.
DR   InterPro; IPR024858; Golgin_A.
DR   PANTHER; PTHR10881:SF62; GOLGIN SUBFAMILY A MEMBER 8C-RELATED; 1.
DR   PANTHER; PTHR10881; GOLGIN SUBFAMILY A MEMBER-RELATED; 1.
DR   Pfam; PF19046; GM130_C; 1.
DR   Pfam; PF15070; GOLGA2L5; 2.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Reference proteome.
FT   CHAIN           1..632
FT                   /note="Golgin subfamily A member 8O"
FT                   /id="PRO_0000342409"
FT   REGION          1..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          423..452
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          505..524
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          552..612
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          85..150
FT                   /evidence="ECO:0000255"
FT   COILED          209..421
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..23
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..54
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        428..452
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         104..262
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_044760"
FT   VAR_SEQ         401..456
FT                   /note="EHLEAASQQNQQLTAQLSLMALPGEGHGGEHLDSEGEEAPRPMPSVPEDPES
FT                   REAM -> VKETETSTPSKKGWEAGSSLLGGEVPGQRQLPAWGLVTTAPRRAVLRLFLA
FT                   SCL (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_044761"
FT   VAR_SEQ         457..632
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_044762"
SQ   SEQUENCE   632 AA;  71536 MW;  D47C8F62C7FC0B4A CRC64;
     MAEETQHNKL AAAKKKLKEY WQKNRPRVPA GVNRNRKTNG SIPETATSGG CQPPGDSATG
     FHREGPTSSA TLKDLESPCQ ERAVVLDSTS VKISRLKNTI KSLKQQKKQV EHQLEEEKKA
     NNERQKAERE LEVQIQTLII QKEELNTDLY HMERSLRYFE EESKDLAVRL QHSLQCKGEL
     ESALSAVIAT EKKKANQLSS CSKAHTEWEL EQSLQDQALL KAQLTQLKES FQQLQLERDE
     CAEHIEGERA RWHQRMSKMS QEICTLKKEK QQDMRRVEEL ERSLSKLKNQ MAEPLPPEPP
     AVPSEVELQH LRKELERVAG ELQSQVKNNQ HISLLNRRQE ERIREQEERL RKQEERLQEQ
     HEKLRQLAKP QSVFEELNNE NKSTLQLEQQ VKELQEKLGE EHLEAASQQN QQLTAQLSLM
     ALPGEGHGGE HLDSEGEEAP RPMPSVPEDP ESREAMSSFM DHLKEKADLS ELVKKQELRF
     IQYWQERCHQ KIHHLLSEPG GRAKDAALGG GHHQAGAQGG DEGEAAGAAA DGIAAYSNYN
     NGHRKFLAAA HNSADEPGPG APAPQELGAA DKHGDLREVT LTSSAQGEAR EDPLLDKPTA
     QPIVQDHQEH PGLGSNCCVP LFCWAWLPRR RR
//