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A6NCC3 (GOG8O_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Golgin subfamily A member 8O
Alternative name(s):
Golgin subfamily A member 6-like protein 11
Gene names
Name:GOLGA8O
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length632 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Post-translational modification

Isoform 2 is phosphorylated on Ser-251.

Sequence similarities

Belongs to the GOLGA6 family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

P299913EBI-8827490,EBI-8826747From a different organism.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A6NCC3-2)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: A6NCC3-1)

The sequence of this isoform differs from the canonical sequence as follows:
     104-262: Missing.
     401-456: EHLEAASQQN...PEDPESREAM → VKETETSTPS...VLRLFLASCL
     457-632: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 632632Golgin subfamily A member 8O
PRO_0000342409

Regions

Coiled coil85 – 15066 Potential
Coiled coil209 – 421213 Potential

Natural variations

Alternative sequence104 – 262159Missing in isoform 2.
VSP_044760
Alternative sequence401 – 45656EHLEA…SREAM → VKETETSTPSKKGWEAGSSL LGGEVPGQRQLPAWGLVTTA PRRAVLRLFLASCL in isoform 2.
VSP_044761
Alternative sequence457 – 632176Missing in isoform 2.
VSP_044762

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 9, 2013. Version 3.
Checksum: D47C8F62C7FC0B4A

FASTA63271,536
        10         20         30         40         50         60 
MAEETQHNKL AAAKKKLKEY WQKNRPRVPA GVNRNRKTNG SIPETATSGG CQPPGDSATG 

        70         80         90        100        110        120 
FHREGPTSSA TLKDLESPCQ ERAVVLDSTS VKISRLKNTI KSLKQQKKQV EHQLEEEKKA 

       130        140        150        160        170        180 
NNERQKAERE LEVQIQTLII QKEELNTDLY HMERSLRYFE EESKDLAVRL QHSLQCKGEL 

       190        200        210        220        230        240 
ESALSAVIAT EKKKANQLSS CSKAHTEWEL EQSLQDQALL KAQLTQLKES FQQLQLERDE 

       250        260        270        280        290        300 
CAEHIEGERA RWHQRMSKMS QEICTLKKEK QQDMRRVEEL ERSLSKLKNQ MAEPLPPEPP 

       310        320        330        340        350        360 
AVPSEVELQH LRKELERVAG ELQSQVKNNQ HISLLNRRQE ERIREQEERL RKQEERLQEQ 

       370        380        390        400        410        420 
HEKLRQLAKP QSVFEELNNE NKSTLQLEQQ VKELQEKLGE EHLEAASQQN QQLTAQLSLM 

       430        440        450        460        470        480 
ALPGEGHGGE HLDSEGEEAP RPMPSVPEDP ESREAMSSFM DHLKEKADLS ELVKKQELRF 

       490        500        510        520        530        540 
IQYWQERCHQ KIHHLLSEPG GRAKDAALGG GHHQAGAQGG DEGEAAGAAA DGIAAYSNYN 

       550        560        570        580        590        600 
NGHRKFLAAA HNSADEPGPG APAPQELGAA DKHGDLREVT LTSSAQGEAR EDPLLDKPTA 

       610        620        630 
QPIVQDHQEH PGLGSNCCVP LFCWAWLPRR RR 

« Hide

Isoform 2 [UniParc].

Checksum: D9A033A49C9FA7C9
Show »

FASTA29533,450

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC123768 Genomic DNA. No translation available.
AC135983 Genomic DNA. No translation available.
RefSeqNP_001264237.1. NM_001277308.1.
UniGeneHs.525905.
Hs.672754.

3D structure databases

ProteinModelPortalA6NCC3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-58933N.
IntActA6NCC3. 1 interaction.

PTM databases

PhosphoSiteA6NCC3.

Proteomic databases

PaxDbA6NCC3.
PRIDEA6NCC3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000414865; ENSP00000403486; ENSG00000206127. [A6NCC3-1]
ENST00000509311; ENSP00000423159; ENSG00000206127. [A6NCC3-2]
GeneID728047.
KEGGhsa:728047.
UCSCuc010ubv.2. human. [A6NCC3-2]

Organism-specific databases

CTD728047.
GeneCardsGC15M032749.
HGNCHGNC:44406. GOLGA8O.
neXtProtNX_A6NCC3.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG268041.
HOGENOMHOG000218631.
HOVERGENHBG107946.
InParanoidA6NCC3.

Gene expression databases

BgeeA6NCC3.
GenevestigatorA6NCC3.

Family and domain databases

InterProIPR024858. Golgin_A.
[Graphical view]
PANTHERPTHR10881. PTHR10881. 1 hit.
ProtoNetSearch...

Other

NextBio125955.

Entry information

Entry nameGOG8O_HUMAN
AccessionPrimary (citable) accession number: A6NCC3
Secondary accession number(s): A6NHZ1, E7ENU5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: January 9, 2013
Last modified: April 16, 2014
This is version 50 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM