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A6NCC3

- GOG8O_HUMAN

UniProt

A6NCC3 - GOG8O_HUMAN

Protein

Golgin subfamily A member 8O

Gene

GOLGA8O

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 3 (09 Jan 2013)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Golgin subfamily A member 8O
    Alternative name(s):
    Golgin subfamily A member 6-like protein 11
    Gene namesi
    Name:GOLGA8O
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:44406. GOLGA8O.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 632632Golgin subfamily A member 8OPRO_0000342409Add
    BLAST

    Proteomic databases

    PaxDbiA6NCC3.
    PRIDEiA6NCC3.

    PTM databases

    PhosphoSiteiA6NCC3.

    Expressioni

    Gene expression databases

    BgeeiA6NCC3.
    GenevestigatoriA6NCC3.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    P299913EBI-8827490,EBI-8826747From a different organism.

    Protein-protein interaction databases

    DIPiDIP-58933N.
    IntActiA6NCC3. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NCC3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili85 – 15066Sequence AnalysisAdd
    BLAST
    Coiled coili209 – 421213Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GOLGA6 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG268041.
    HOGENOMiHOG000218631.
    HOVERGENiHBG107946.
    InParanoidiA6NCC3.
    OMAiTMEEYRT.
    PhylomeDBiA6NCC3.

    Family and domain databases

    InterProiIPR024858. Golgin_A.
    [Graphical view]
    PANTHERiPTHR10881. PTHR10881. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A6NCC3-2) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAEETQHNKL AAAKKKLKEY WQKNRPRVPA GVNRNRKTNG SIPETATSGG    50
    CQPPGDSATG FHREGPTSSA TLKDLESPCQ ERAVVLDSTS VKISRLKNTI 100
    KSLKQQKKQV EHQLEEEKKA NNERQKAERE LEVQIQTLII QKEELNTDLY 150
    HMERSLRYFE EESKDLAVRL QHSLQCKGEL ESALSAVIAT EKKKANQLSS 200
    CSKAHTEWEL EQSLQDQALL KAQLTQLKES FQQLQLERDE CAEHIEGERA 250
    RWHQRMSKMS QEICTLKKEK QQDMRRVEEL ERSLSKLKNQ MAEPLPPEPP 300
    AVPSEVELQH LRKELERVAG ELQSQVKNNQ HISLLNRRQE ERIREQEERL 350
    RKQEERLQEQ HEKLRQLAKP QSVFEELNNE NKSTLQLEQQ VKELQEKLGE 400
    EHLEAASQQN QQLTAQLSLM ALPGEGHGGE HLDSEGEEAP RPMPSVPEDP 450
    ESREAMSSFM DHLKEKADLS ELVKKQELRF IQYWQERCHQ KIHHLLSEPG 500
    GRAKDAALGG GHHQAGAQGG DEGEAAGAAA DGIAAYSNYN NGHRKFLAAA 550
    HNSADEPGPG APAPQELGAA DKHGDLREVT LTSSAQGEAR EDPLLDKPTA 600
    QPIVQDHQEH PGLGSNCCVP LFCWAWLPRR RR 632

    Note: No experimental confirmation available.

    Length:632
    Mass (Da):71,536
    Last modified:January 9, 2013 - v3
    Checksum:iD47C8F62C7FC0B4A
    GO
    Isoform 2 (identifier: A6NCC3-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         104-262: Missing.
         401-456: EHLEAASQQN...PEDPESREAM → VKETETSTPS...VLRLFLASCL
         457-632: Missing.

    Show »
    Length:295
    Mass (Da):33,450
    Checksum:iD9A033A49C9FA7C9
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei104 – 262159Missing in isoform 2. CuratedVSP_044760Add
    BLAST
    Alternative sequencei401 – 45656EHLEA…SREAM → VKETETSTPSKKGWEAGSSL LGGEVPGQRQLPAWGLVTTA PRRAVLRLFLASCL in isoform 2. CuratedVSP_044761Add
    BLAST
    Alternative sequencei457 – 632176Missing in isoform 2. CuratedVSP_044762Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC123768 Genomic DNA. No translation available.
    AC135983 Genomic DNA. No translation available.
    CCDSiCCDS59252.1. [A6NCC3-2]
    RefSeqiNP_001264237.1. NM_001277308.1. [A6NCC3-2]
    UniGeneiHs.525905.
    Hs.672754.

    Genome annotation databases

    EnsembliENST00000509311; ENSP00000423159; ENSG00000206127. [A6NCC3-2]
    GeneIDi728047.
    KEGGihsa:728047.
    UCSCiuc010ubv.2. human. [A6NCC3-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC123768 Genomic DNA. No translation available.
    AC135983 Genomic DNA. No translation available.
    CCDSi CCDS59252.1. [A6NCC3-2 ]
    RefSeqi NP_001264237.1. NM_001277308.1. [A6NCC3-2 ]
    UniGenei Hs.525905.
    Hs.672754.

    3D structure databases

    ProteinModelPortali A6NCC3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-58933N.
    IntActi A6NCC3. 1 interaction.

    PTM databases

    PhosphoSitei A6NCC3.

    Proteomic databases

    PaxDbi A6NCC3.
    PRIDEi A6NCC3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000509311 ; ENSP00000423159 ; ENSG00000206127 . [A6NCC3-2 ]
    GeneIDi 728047.
    KEGGi hsa:728047.
    UCSCi uc010ubv.2. human. [A6NCC3-2 ]

    Organism-specific databases

    CTDi 728047.
    GeneCardsi GC15M032749.
    HGNCi HGNC:44406. GOLGA8O.
    neXtProti NX_A6NCC3.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG268041.
    HOGENOMi HOG000218631.
    HOVERGENi HBG107946.
    InParanoidi A6NCC3.
    OMAi TMEEYRT.
    PhylomeDBi A6NCC3.

    Miscellaneous databases

    NextBioi 125955.

    Gene expression databases

    Bgeei A6NCC3.
    Genevestigatori A6NCC3.

    Family and domain databases

    InterProi IPR024858. Golgin_A.
    [Graphical view ]
    PANTHERi PTHR10881. PTHR10881. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiGOG8O_HUMAN
    AccessioniPrimary (citable) accession number: A6NCC3
    Secondary accession number(s): A6NHZ1, E7ENU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: January 9, 2013
    Last modified: October 1, 2014
    This is version 54 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3