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A6NCC3

- GOG8O_HUMAN

UniProt

A6NCC3 - GOG8O_HUMAN

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Protein

Golgin subfamily A member 8O

Gene

GOLGA8O

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 8O
Alternative name(s):
Golgin subfamily A member 6-like protein 11
Gene namesi
Name:GOLGA8O
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:44406. GOLGA8O.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 632632Golgin subfamily A member 8OPRO_0000342409Add
BLAST

Proteomic databases

PaxDbiA6NCC3.
PRIDEiA6NCC3.

PTM databases

PhosphoSiteiA6NCC3.

Expressioni

Gene expression databases

BgeeiA6NCC3.
ExpressionAtlasiA6NCC3. baseline.
GenevestigatoriA6NCC3.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
P299913EBI-8827490,EBI-8826747From a different organism.

Protein-protein interaction databases

DIPiDIP-58933N.
IntActiA6NCC3. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliA6NCC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili85 – 15066Sequence AnalysisAdd
BLAST
Coiled coili209 – 421213Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the GOLGA6 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG268041.
GeneTreeiENSGT00530000062932.
HOGENOMiHOG000218631.
HOVERGENiHBG107946.
InParanoidiA6NCC3.
OMAiTMEEYRT.
PhylomeDBiA6NCC3.

Family and domain databases

InterProiIPR024858. Golgin_A.
[Graphical view]
PANTHERiPTHR10881. PTHR10881. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A6NCC3-2) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEETQHNKL AAAKKKLKEY WQKNRPRVPA GVNRNRKTNG SIPETATSGG
60 70 80 90 100
CQPPGDSATG FHREGPTSSA TLKDLESPCQ ERAVVLDSTS VKISRLKNTI
110 120 130 140 150
KSLKQQKKQV EHQLEEEKKA NNERQKAERE LEVQIQTLII QKEELNTDLY
160 170 180 190 200
HMERSLRYFE EESKDLAVRL QHSLQCKGEL ESALSAVIAT EKKKANQLSS
210 220 230 240 250
CSKAHTEWEL EQSLQDQALL KAQLTQLKES FQQLQLERDE CAEHIEGERA
260 270 280 290 300
RWHQRMSKMS QEICTLKKEK QQDMRRVEEL ERSLSKLKNQ MAEPLPPEPP
310 320 330 340 350
AVPSEVELQH LRKELERVAG ELQSQVKNNQ HISLLNRRQE ERIREQEERL
360 370 380 390 400
RKQEERLQEQ HEKLRQLAKP QSVFEELNNE NKSTLQLEQQ VKELQEKLGE
410 420 430 440 450
EHLEAASQQN QQLTAQLSLM ALPGEGHGGE HLDSEGEEAP RPMPSVPEDP
460 470 480 490 500
ESREAMSSFM DHLKEKADLS ELVKKQELRF IQYWQERCHQ KIHHLLSEPG
510 520 530 540 550
GRAKDAALGG GHHQAGAQGG DEGEAAGAAA DGIAAYSNYN NGHRKFLAAA
560 570 580 590 600
HNSADEPGPG APAPQELGAA DKHGDLREVT LTSSAQGEAR EDPLLDKPTA
610 620 630
QPIVQDHQEH PGLGSNCCVP LFCWAWLPRR RR

Note: No experimental confirmation available.

Length:632
Mass (Da):71,536
Last modified:January 9, 2013 - v3
Checksum:iD47C8F62C7FC0B4A
GO
Isoform 2 (identifier: A6NCC3-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-262: Missing.
     401-456: EHLEAASQQN...PEDPESREAM → VKETETSTPS...VLRLFLASCL
     457-632: Missing.

Show »
Length:295
Mass (Da):33,450
Checksum:iD9A033A49C9FA7C9
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei104 – 262159Missing in isoform 2. CuratedVSP_044760Add
BLAST
Alternative sequencei401 – 45656EHLEA…SREAM → VKETETSTPSKKGWEAGSSL LGGEVPGQRQLPAWGLVTTA PRRAVLRLFLASCL in isoform 2. CuratedVSP_044761Add
BLAST
Alternative sequencei457 – 632176Missing in isoform 2. CuratedVSP_044762Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123768 Genomic DNA. No translation available.
AC135983 Genomic DNA. No translation available.
CCDSiCCDS59252.1. [A6NCC3-2]
RefSeqiNP_001264237.1. NM_001277308.1. [A6NCC3-2]
UniGeneiHs.525905.
Hs.672754.

Genome annotation databases

EnsembliENST00000509311; ENSP00000423159; ENSG00000206127. [A6NCC3-2]
GeneIDi728047.
KEGGihsa:728047.
UCSCiuc010ubv.2. human. [A6NCC3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123768 Genomic DNA. No translation available.
AC135983 Genomic DNA. No translation available.
CCDSi CCDS59252.1. [A6NCC3-2 ]
RefSeqi NP_001264237.1. NM_001277308.1. [A6NCC3-2 ]
UniGenei Hs.525905.
Hs.672754.

3D structure databases

ProteinModelPortali A6NCC3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-58933N.
IntActi A6NCC3. 1 interaction.

PTM databases

PhosphoSitei A6NCC3.

Proteomic databases

PaxDbi A6NCC3.
PRIDEi A6NCC3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000509311 ; ENSP00000423159 ; ENSG00000206127 . [A6NCC3-2 ]
GeneIDi 728047.
KEGGi hsa:728047.
UCSCi uc010ubv.2. human. [A6NCC3-2 ]

Organism-specific databases

CTDi 728047.
GeneCardsi GC15M032752.
HGNCi HGNC:44406. GOLGA8O.
neXtProti NX_A6NCC3.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG268041.
GeneTreei ENSGT00530000062932.
HOGENOMi HOG000218631.
HOVERGENi HBG107946.
InParanoidi A6NCC3.
OMAi TMEEYRT.
PhylomeDBi A6NCC3.

Miscellaneous databases

GenomeRNAii 728047.
NextBioi 125955.

Gene expression databases

Bgeei A6NCC3.
ExpressionAtlasi A6NCC3. baseline.
Genevestigatori A6NCC3.

Family and domain databases

InterProi IPR024858. Golgin_A.
[Graphical view ]
PANTHERi PTHR10881. PTHR10881. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiGOG8O_HUMAN
AccessioniPrimary (citable) accession number: A6NCC3
Secondary accession number(s): A6NHZ1, E7ENU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: January 9, 2013
Last modified: October 29, 2014
This is version 55 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3