A6NCC3 (GOG8O_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Golgin subfamily A member 8O

Alternative name(s):
Golgin subfamily A member 6-like protein 11

Gene names

Name:

GOLGA8O

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	632 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Post-translational modification	Isoform 2 is phosphorylated on Ser-251.
Sequence similarities	Belongs to the GOLGA6 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A6NCC3-2)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: A6NCC3-1)

The sequence of this isoform differs from the canonical sequence as follows:
     104-262: Missing.
     401-456: EHLEAASQQN...PEDPESREAM → VKETETSTPS...VLRLFLASCL
     457-632: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 632	632	Golgin subfamily A member 8O		PRO_0000342409
Regions
	Coiled coil	85 – 150	66	Potential
	Coiled coil	209 – 421	213	Potential
Natural variations
	Alternative sequence	104 – 262	159	Missing in isoform 2.		VSP_044760
	Alternative sequence	401 – 456	56	EHLEA…SREAM → VKETETSTPSKKGWEAGSSL LGGEVPGQRQLPAWGLVTTA PRRAVLRLFLASCL in isoform 2.		VSP_044761
	Alternative sequence	457 – 632	176	Missing in isoform 2.		VSP_044762

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 9, 2013. Version 3. Checksum: D47C8F62C7FC0B4A	FASTA	632	71,536
	10 20 30 40 50 60 MAEETQHNKL AAAKKKLKEY WQKNRPRVPA GVNRNRKTNG SIPETATSGG CQPPGDSATG 70 80 90 100 110 120 FHREGPTSSA TLKDLESPCQ ERAVVLDSTS VKISRLKNTI KSLKQQKKQV EHQLEEEKKA 130 140 150 160 170 180 NNERQKAERE LEVQIQTLII QKEELNTDLY HMERSLRYFE EESKDLAVRL QHSLQCKGEL 190 200 210 220 230 240 ESALSAVIAT EKKKANQLSS CSKAHTEWEL EQSLQDQALL KAQLTQLKES FQQLQLERDE 250 260 270 280 290 300 CAEHIEGERA RWHQRMSKMS QEICTLKKEK QQDMRRVEEL ERSLSKLKNQ MAEPLPPEPP 310 320 330 340 350 360 AVPSEVELQH LRKELERVAG ELQSQVKNNQ HISLLNRRQE ERIREQEERL RKQEERLQEQ 370 380 390 400 410 420 HEKLRQLAKP QSVFEELNNE NKSTLQLEQQ VKELQEKLGE EHLEAASQQN QQLTAQLSLM 430 440 450 460 470 480 ALPGEGHGGE HLDSEGEEAP RPMPSVPEDP ESREAMSSFM DHLKEKADLS ELVKKQELRF 490 500 510 520 530 540 IQYWQERCHQ KIHHLLSEPG GRAKDAALGG GHHQAGAQGG DEGEAAGAAA DGIAAYSNYN 550 560 570 580 590 600 NGHRKFLAAA HNSADEPGPG APAPQELGAA DKHGDLREVT LTSSAQGEAR EDPLLDKPTA 610 620 630 QPIVQDHQEH PGLGSNCCVP LFCWAWLPRR RR
	Isoform 2 [UniParc]. Checksum: D9A033A49C9FA7C9	FASTA	295	33,450
	10 20 30 40 50 60 MAEETQHNKL AAAKKKLKEY WQKNRPRVPA GVNRNRKTNG SIPETATSGG CQPPGDSATG 70 80 90 100 110 120 FHREGPTSSA TLKDLESPCQ ERAVVLDSTS VKISRLKNTI KSLICTLKKE KQQDMRRVEE 130 140 150 160 170 180 LERSLSKLKN QMAEPLPPEP PAVPSEVELQ HLRKELERVA GELQSQVKNN QHISLLNRRQ 190 200 210 220 230 240 EERIREQEER LRKQEERLQE QHEKLRQLAK PQSVFEELNN ENKSTLQLEQ QVKELQEKLG 250 260 270 280 290 EVKETETSTP SKKGWEAGSS LLGGEVPGQR QLPAWGLVTT APRRAVLRLF LASCL

References

[1]

"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC123768 Genomic DNA. No translation available. AC135983 Genomic DNA. No translation available.
IPI	IPI00479557. IPI00966593.
RefSeq	NP_001264237.1. NM_001277308.1. XP_001126912.1. XM_001126912.3.
3D structure databases
ProteinModelPortal	A6NCC3.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-58933N.
PTM databases
PhosphoSite	A6NCC3.
Proteomic databases
PaxDb	A6NCC3.
PRIDE	A6NCC3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000414865; ENSP00000403486; ENSG00000206127. ENST00000509311; ENSP00000423159; ENSG00000206127.
GeneID	728047.
KEGG	hsa:728047.
UCSC	uc010ubv.2. human.
Organism-specific databases
CTD	728047.
GeneCards	GC15M032735. GC15P030844. GC15P032885.
HGNC	HGNC:44406. GOLGA8O.
neXtProt	NX_A6NCC3.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG268041.
HOGENOM	HOG000218631.
HOVERGEN	HBG107946.
InParanoid	A6NCC3.
OrthoDB	EOG4KKZ47.
Gene expression databases
ArrayExpress	A6NCC3.
Bgee	A6NCC3.
Genevestigator	A6NCC3.
Family and domain databases
InterPro	IPR024858. Golgin_A. [Graphical view]
PANTHER	PTHR10881. PTHR10881. 1 hit.
ProtoNet	Search...
Other
NextBio	125955.

Entry information

Entry name

GOG8O_HUMAN

Accession

Primary (citable) accession number: A6NCC3
Secondary accession number(s): A6NHZ1, E7ENU5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	January 9, 2013
Last modified:	May 29, 2013
This is version 43 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.