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UniProtKB - A6NC98 (CC88B_HUMAN)

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Protein

Coiled-coil domain-containing protein 88B

Gene

CCDC88B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4+ and the CD8+ compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099).By similarity2 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 88B
Alternative name(s):
Brain leucine zipper domain-containing protein
Gipie1 Publication
Hook-related protein 31 Publication
Short name:
HkRP3
Gene namesi
Name:CCDC88B
Synonyms:BRLZ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000168071.21.
HGNCiHGNC:26757. CCDC88B.
MIMi611205. gene.
neXtProtiNX_A6NC98.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi283234.
OpenTargetsiENSG00000168071.
PharmGKBiPA162381820.

Polymorphism and mutation databases

BioMutaiCCDC88B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003174541 – 1476Coiled-coil domain-containing protein 88BAdd BLAST1476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei436PhosphoserineCombined sources1
Modified residuei596PhosphoserineCombined sources1
Modified residuei1348PhosphoserineBy similarity1
Modified residuei1379PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA6NC98.
PaxDbiA6NC98.
PRIDEiA6NC98.

PTM databases

iPTMnetiA6NC98.
PhosphoSitePlusiA6NC98.

Expressioni

Tissue specificityi

Expressed in endothelium (at protein level) (PubMed:21289099). Expressed in NK cells (at protein level) (PubMed:25762780).2 Publications

Inductioni

By endoplasmic reticulum stress.1 Publication

Gene expression databases

BgeeiENSG00000168071.
CleanExiHS_CCDC88B.
ExpressionAtlasiA6NC98. baseline and differential.
GenevisibleiA6NC98. HS.

Organism-specific databases

HPAiHPA026652.

Interactioni

Subunit structurei

Homodimer (PubMed:25762780). Interacts with DOCK8 (PubMed:25762780). Interacts (via C-terminus) with intact microtubules (PubMed:25762780). Interacts with dynein-dynactin motor complex (PubMed:25762780). Interacts (via C-terminus) with HSPA5 (PubMed:21289099).By similarity2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi129505. 3 interactors.
IntActiA6NC98. 41 interactors.
STRINGi9606.ENSP00000349238.

Structurei

3D structure databases

ProteinModelPortaliA6NC98.
SMRiA6NC98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili253 – 481Sequence analysisAdd BLAST229
Coiled coili720 – 1303Sequence analysisAdd BLAST584

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 44Poly-Glu10

Sequence similaritiesi

Belongs to the CCDC88 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1265. Eukaryota.
KOG3595. Eukaryota.
KOG4643. Eukaryota.
ENOG410YFRJ. LUCA.
GeneTreeiENSGT00690000101702.
HOVERGENiHBG104809.
InParanoidiA6NC98.
OMAiHGGPRLG.
OrthoDBiEOG091G01AJ.
PhylomeDBiA6NC98.
TreeFamiTF320231.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiView protein in InterPro
IPR036872. CH_dom_sf.
IPR008636. Hook-like_fam.
PANTHERiPTHR18947. PTHR18947. 1 hit.
PfamiView protein in Pfam
PF05622. HOOK. 1 hit.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NC98-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGGKGPRLR DFLSGSLATW ALGLAGLVGE AEDSEGEEEE EEEEPPLWLE 
        60         70         80         90        100
KRFLRLSDGA LLLRVLGIIA PSSRGGPRML RGLDGPAAWR VWNLNHLWGR 
       110        120        130        140        150
LRDFYQEELQ LLILSPPPDL QTLGFDPLSE EAVEQLEGVL RLLLGASVQC 
       160        170        180        190        200
EHRELFIRHI QGLSLEVQSE LAAAIQEVTQ PGAGVVLALS GPDPGELAPA 
       210        220        230        240        250
ELEMLSRSLM GTLSKLARER DLGAQRLAEL LLEREPLCLR PEAPSRAPAE 
       260        270        280        290        300
GPSHHLALQL ANAKAQLRRL RQELEEKAEL LLDSQAEVQG LEAEIRRLRQ 
       310        320        330        340        350
EAQALSGQAK RAELYREEAE ALRERAGRLP RLQEELRRCR ERLQAAEAYK 
       360        370        380        390        400
SQLEEERVLS GVLEASKALL EEQLEAARER CARLHETQRE NLLLRTRLGE 
       410        420        430        440        450
AHAELDSLRH QVDQLAEENV ELELELQRSL EPPPGSPGEA PLAGAAPSLQ 
       460        470        480        490        500
DEVREAEAGR LRTLERENRE LRGLLQVLQG QPGGQHPLLE APREDPVLPV 
       510        520        530        540        550
LEEAPQTPVA FDHSPQGLVQ KARDGGPQAL DLAPPALDSV LEASAECPQA 
       560        570        580        590        600
PDSDPQEAES PLQAAAMDPQ ASDWSPQESG SPVETQESPE KAGRRSSLQS 
       610        620        630        640        650
PASVAPPQGP GTKIQAPQLL GGETEGREAP QGELVPEAWG LRQEGPEHKP 
       660        670        680        690        700
GPSEPSSVQL EEQEGPNQGL DLATGQAEAR EHDQRLEGTV RDPAWQKPQQ 
       710        720        730        740        750
KSEGALEVQV WEGPIPGESL ASGVAEQEAL REEVAQLRRK AEALGDELEA 
       760        770        780        790        800
QARKLEAQNT EAARLSKELA QARRAEAEAH REAEAQAWEQ ARLREAVEAA 
       810        820        830        840        850
GQELESASQE REALVEALAA AGRERRQWER EGSRLRAQSE AAEERMQVLE 
       860        870        880        890        900
SEGRQHLEEA ERERREKEAL QAELEKAVVR GKELGDRLEH LQRELEQAAL 
       910        920        930        940        950
ERQEFLREKE SQHQRYQGLE QRLEAELQAA ATSKEEALME LKTRALQLEE 
       960        970        980        990       1000
ELFQLRQGPA GLGPKKRAEP QLVETQNVRL IEVERSNAML VAEKAALQGQ 
      1010       1020       1030       1040       1050
LQHLEGQLGS LQGRAQELLL QSQRAQEHSS RLQAEKSVLE IQGQELHRKL 
      1060       1070       1080       1090       1100
EVLEEEVRAA RQSQEETRGQ QQALLRDHKA LAQLQRRQEA ELEGLLVRHR 
      1110       1120       1130       1140       1150
DLKANMRALE LAHRELQGRH EQLQAQRASV EAQEVALLAE RERLMQDGHR 
      1160       1170       1180       1190       1200
QRGLEEELRR LQSEHDRAQM LLAELSRERG ELQGERGELR GRLARLELER 
      1210       1220       1230       1240       1250
AQLEMQSQQL RESNQQLDLS ACRLTTQCEL LTQLRSAQEE ENRQLLAEVQ 
      1260       1270       1280       1290       1300
ALSRENRELL ERSLESRDHL HREQREYLDQ LNALRREKQK LVEKIMDQYR 
      1310       1320       1330       1340       1350
VLEPVPLPRT KKGSWLADKV KRLMRPRREG GPPGGLRLGA DGAGSTESLG 
      1360       1370       1380       1390       1400
GPPETELPEG READGTGSPS PAPMRRAQSS LCLRDETLAG GQRRKLSSRF 
      1410       1420       1430       1440       1450
PVGRSSESFS PGDTPRQRFR QRHPGPLGAP VSHSKGPGVG WENSAETLQE 
      1460       1470 
HETDANREGP EVQEPEKRPL TPSLSQ
Length:1,476
Mass (Da):164,809
Last modified:July 24, 2007 - v1
Checksum:i4DB82F199F224EFC
GO
Isoform 2 (identifier: A6NC98-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     987-1034: NAMLVAEKAA...AQEHSSRLQA → VSVGPQWALG...WARGWGCPMQ
     1035-1476: Missing.

Show »
Length:1,034
Mass (Da):114,101
Checksum:i4AC0150AD38D33D6
GO
Isoform 3 (identifier: A6NC98-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-351: Missing.
     352-403: QLEEERVLSG...LRTRLGEAHA → MGGAGALGGA...NPAGRGPCGK
     955-972: LRQGPAGLGPKKRAEPQL → VMPARLGAGGHATLPSIP
     973-1476: Missing.

Note: No experimental confirmation available.
Show »
Length:621
Mass (Da):67,018
Checksum:i60AF1EBA3536FC8D
GO
Isoform 4 (identifier: A6NC98-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1019-1136: Missing.

Note: No experimental confirmation available.
Show »
Length:1,358
Mass (Da):151,121
Checksum:iE01A73698162233C
GO
Isoform 5 (identifier: A6NC98-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-864: Missing.
     865-872: REKEALQA → MKNRGLRE
     1320-1476: VKRLMRPRRE...KRPLTPSLSQ → GPLPRHPCAG...GTVAWADLEP

Note: No experimental confirmation available.
Show »
Length:696
Mass (Da):79,003
Checksum:i5F432467BDA55721
GO
Isoform 6 (identifier: A6NC98-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1337: Missing.
     1338-1367: LGADGAGSTESLGGPPETELPEGREADGTG → MPCAARSRSSWRRSWTNTACWSLCPCPGPR

Show »
Length:139
Mass (Da):15,345
Checksum:i4B20F3982CB8BAB3
GO

Sequence cautioni

The sequence BAC03417 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti291L → W in BAC03417 (PubMed:11230166).Curated1
Sequence conflicti943T → I in AAI41867 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038523193D → E. Corresponds to variant dbSNP:rs647152Ensembl.1
Natural variantiVAR_038524639W → R. Corresponds to variant dbSNP:rs685870Ensembl.1
Natural variantiVAR_038525886D → A3 PublicationsCorresponds to variant dbSNP:rs1318165Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0354051 – 1337Missing in isoform 6. 1 PublicationAdd BLAST1337
Alternative sequenceiVSP_0309561 – 864Missing in isoform 5. 1 PublicationAdd BLAST864
Alternative sequenceiVSP_0309571 – 351Missing in isoform 3. 1 PublicationAdd BLAST351
Alternative sequenceiVSP_030958352 – 403QLEEE…GEAHA → MGGAGALGGAGGVQGAAGRA AGGCPRALRPAARDPAREPA AANPAGRGPCGK in isoform 3. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_030959865 – 872REKEALQA → MKNRGLRE in isoform 5. 1 Publication8
Alternative sequenceiVSP_030960955 – 972LRQGP…AEPQL → VMPARLGAGGHATLPSIP in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_030961973 – 1476Missing in isoform 3. 1 PublicationAdd BLAST504
Alternative sequenceiVSP_030962987 – 1034NAMLV…SRLQA → VSVGPQWALGRCPVQCECGS TVDPGLGGIPCSVSVDSQWA RGWGCPMQ in isoform 2. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_0309631019 – 1136Missing in isoform 4. 1 PublicationAdd BLAST118
Alternative sequenceiVSP_0309641035 – 1476Missing in isoform 2. 1 PublicationAdd BLAST442
Alternative sequenceiVSP_0309651320 – 1476VKRLM…PSLSQ → GPLPRHPCAGPRAPSACGMR PWQAGSGGNSAQGSRWGEAL SHSALGTPLGNDSDSAIQAP WGRPSPTAKDLVWDGRTPLR PCRNTKQMPTERALRYRNRR NVPSPHPSASDTVGTAGLGV QPSRHWSVSGGPRQPKSSGS QGPQGESLDKEAWALRSSTV SAGARRWSWDECVDRGDGWP PRAAPGWSSGSSRWLPLRQR SLGDPPAEGGWQELAREPPA LSRWEAESQCWGTVAWADLE P in isoform 5. 1 PublicationAdd BLAST157
Alternative sequenceiVSP_0354061338 – 1367LGADG…ADGTG → MPCAARSRSSWRRSWTNTAC WSLCPCPGPR in isoform 6. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136799 mRNA. Translation: CAB66733.2.
AK090436 mRNA. Translation: BAC03417.1. Different initiation.
AK095289 mRNA. No translation available.
AP003774 Genomic DNA. No translation available.
BC040232 mRNA. Translation: AAH40232.1.
BC141866 mRNA. Translation: AAI41867.1.
AY491401 mRNA. Translation: AAR83719.1.
CCDSiCCDS8072.2. [A6NC98-1]
RefSeqiNP_115627.6. NM_032251.5. [A6NC98-1]
UniGeneiHs.98564.

Genome annotation databases

EnsembliENST00000301897; ENSP00000301897; ENSG00000168071. [A6NC98-6]
ENST00000356786; ENSP00000349238; ENSG00000168071. [A6NC98-1]
GeneIDi283234.
KEGGihsa:283234.
UCSCiuc001nzy.4. human. [A6NC98-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCC88B_HUMAN
AccessioniPrimary (citable) accession number: A6NC98
Secondary accession number(s): A5D8Y5
, B5MDM2, Q05BL2, Q6RUV3, Q8N1Q6, Q8NF44, Q9H0H1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 24, 2007
Last modified: February 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome