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Protein

Coiled-coil domain-containing protein 88B

Gene

CCDC88B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4+ and the CD8+ compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099).By similarity2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 88B
Alternative name(s):
Brain leucine zipper domain-containing protein
Gipie1 Publication
Hook-related protein 31 Publication
Short name:
HkRP3
Gene namesi
Name:CCDC88B
Synonyms:BRLZ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:26757. CCDC88B.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi283234.
OpenTargetsiENSG00000168071.
PharmGKBiPA162381820.

Polymorphism and mutation databases

BioMutaiCCDC88B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003174541 – 1476Coiled-coil domain-containing protein 88BAdd BLAST1476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei436PhosphoserineCombined sources1
Modified residuei596PhosphoserineCombined sources1
Modified residuei1348PhosphoserineBy similarity1
Modified residuei1379PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA6NC98.
PaxDbiA6NC98.
PRIDEiA6NC98.

PTM databases

iPTMnetiA6NC98.
PhosphoSitePlusiA6NC98.

Expressioni

Tissue specificityi

Expressed in endothelium (at protein level) (PubMed:21289099). Expressed in NK cells (at protein level) (PubMed:25762780).2 Publications

Inductioni

By endoplasmic reticulum stress.1 Publication

Gene expression databases

BgeeiENSG00000168071.
CleanExiHS_CCDC88B.
ExpressionAtlasiA6NC98. baseline and differential.
GenevisibleiA6NC98. HS.

Organism-specific databases

HPAiHPA026652.

Interactioni

Subunit structurei

Homodimer (PubMed:25762780). Interacts with DOCK8 (PubMed:25762780). Interacts (via C-terminus) with intact microtubules (PubMed:25762780). Interacts with dynein-dynactin motor complex (PubMed:25762780). Interacts (via C-terminus) with HSPA5 (PubMed:21289099).By similarity2 Publications

Protein-protein interaction databases

BioGridi129505. 2 interactors.
IntActiA6NC98. 37 interactors.
STRINGi9606.ENSP00000349238.

Structurei

3D structure databases

ProteinModelPortaliA6NC98.
SMRiA6NC98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili253 – 481Sequence analysisAdd BLAST229
Coiled coili720 – 1303Sequence analysisAdd BLAST584

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 44Poly-Glu10

Sequence similaritiesi

Belongs to the CCDC88 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1265. Eukaryota.
KOG3595. Eukaryota.
KOG4643. Eukaryota.
ENOG410YFRJ. LUCA.
GeneTreeiENSGT00690000101702.
HOVERGENiHBG104809.
InParanoidiA6NC98.
OMAiEFQHQRY.
OrthoDBiEOG091G01AJ.
PhylomeDBiA6NC98.
TreeFamiTF320231.

Family and domain databases

InterProiIPR008636. Hook-related_fam.
[Graphical view]
PANTHERiPTHR18947. PTHR18947. 1 hit.
PfamiPF05622. HOOK. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NC98-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGGKGPRLR DFLSGSLATW ALGLAGLVGE AEDSEGEEEE EEEEPPLWLE
60 70 80 90 100
KRFLRLSDGA LLLRVLGIIA PSSRGGPRML RGLDGPAAWR VWNLNHLWGR
110 120 130 140 150
LRDFYQEELQ LLILSPPPDL QTLGFDPLSE EAVEQLEGVL RLLLGASVQC
160 170 180 190 200
EHRELFIRHI QGLSLEVQSE LAAAIQEVTQ PGAGVVLALS GPDPGELAPA
210 220 230 240 250
ELEMLSRSLM GTLSKLARER DLGAQRLAEL LLEREPLCLR PEAPSRAPAE
260 270 280 290 300
GPSHHLALQL ANAKAQLRRL RQELEEKAEL LLDSQAEVQG LEAEIRRLRQ
310 320 330 340 350
EAQALSGQAK RAELYREEAE ALRERAGRLP RLQEELRRCR ERLQAAEAYK
360 370 380 390 400
SQLEEERVLS GVLEASKALL EEQLEAARER CARLHETQRE NLLLRTRLGE
410 420 430 440 450
AHAELDSLRH QVDQLAEENV ELELELQRSL EPPPGSPGEA PLAGAAPSLQ
460 470 480 490 500
DEVREAEAGR LRTLERENRE LRGLLQVLQG QPGGQHPLLE APREDPVLPV
510 520 530 540 550
LEEAPQTPVA FDHSPQGLVQ KARDGGPQAL DLAPPALDSV LEASAECPQA
560 570 580 590 600
PDSDPQEAES PLQAAAMDPQ ASDWSPQESG SPVETQESPE KAGRRSSLQS
610 620 630 640 650
PASVAPPQGP GTKIQAPQLL GGETEGREAP QGELVPEAWG LRQEGPEHKP
660 670 680 690 700
GPSEPSSVQL EEQEGPNQGL DLATGQAEAR EHDQRLEGTV RDPAWQKPQQ
710 720 730 740 750
KSEGALEVQV WEGPIPGESL ASGVAEQEAL REEVAQLRRK AEALGDELEA
760 770 780 790 800
QARKLEAQNT EAARLSKELA QARRAEAEAH REAEAQAWEQ ARLREAVEAA
810 820 830 840 850
GQELESASQE REALVEALAA AGRERRQWER EGSRLRAQSE AAEERMQVLE
860 870 880 890 900
SEGRQHLEEA ERERREKEAL QAELEKAVVR GKELGDRLEH LQRELEQAAL
910 920 930 940 950
ERQEFLREKE SQHQRYQGLE QRLEAELQAA ATSKEEALME LKTRALQLEE
960 970 980 990 1000
ELFQLRQGPA GLGPKKRAEP QLVETQNVRL IEVERSNAML VAEKAALQGQ
1010 1020 1030 1040 1050
LQHLEGQLGS LQGRAQELLL QSQRAQEHSS RLQAEKSVLE IQGQELHRKL
1060 1070 1080 1090 1100
EVLEEEVRAA RQSQEETRGQ QQALLRDHKA LAQLQRRQEA ELEGLLVRHR
1110 1120 1130 1140 1150
DLKANMRALE LAHRELQGRH EQLQAQRASV EAQEVALLAE RERLMQDGHR
1160 1170 1180 1190 1200
QRGLEEELRR LQSEHDRAQM LLAELSRERG ELQGERGELR GRLARLELER
1210 1220 1230 1240 1250
AQLEMQSQQL RESNQQLDLS ACRLTTQCEL LTQLRSAQEE ENRQLLAEVQ
1260 1270 1280 1290 1300
ALSRENRELL ERSLESRDHL HREQREYLDQ LNALRREKQK LVEKIMDQYR
1310 1320 1330 1340 1350
VLEPVPLPRT KKGSWLADKV KRLMRPRREG GPPGGLRLGA DGAGSTESLG
1360 1370 1380 1390 1400
GPPETELPEG READGTGSPS PAPMRRAQSS LCLRDETLAG GQRRKLSSRF
1410 1420 1430 1440 1450
PVGRSSESFS PGDTPRQRFR QRHPGPLGAP VSHSKGPGVG WENSAETLQE
1460 1470
HETDANREGP EVQEPEKRPL TPSLSQ
Length:1,476
Mass (Da):164,809
Last modified:July 24, 2007 - v1
Checksum:i4DB82F199F224EFC
GO
Isoform 2 (identifier: A6NC98-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     987-1034: NAMLVAEKAA...AQEHSSRLQA → VSVGPQWALG...WARGWGCPMQ
     1035-1476: Missing.

Show »
Length:1,034
Mass (Da):114,101
Checksum:i4AC0150AD38D33D6
GO
Isoform 3 (identifier: A6NC98-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-351: Missing.
     352-403: QLEEERVLSG...LRTRLGEAHA → MGGAGALGGA...NPAGRGPCGK
     955-972: LRQGPAGLGPKKRAEPQL → VMPARLGAGGHATLPSIP
     973-1476: Missing.

Note: No experimental confirmation available.
Show »
Length:621
Mass (Da):67,018
Checksum:i60AF1EBA3536FC8D
GO
Isoform 4 (identifier: A6NC98-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1019-1136: Missing.

Note: No experimental confirmation available.
Show »
Length:1,358
Mass (Da):151,121
Checksum:iE01A73698162233C
GO
Isoform 5 (identifier: A6NC98-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-864: Missing.
     865-872: REKEALQA → MKNRGLRE
     1320-1476: VKRLMRPRRE...KRPLTPSLSQ → GPLPRHPCAG...GTVAWADLEP

Note: No experimental confirmation available.
Show »
Length:696
Mass (Da):79,003
Checksum:i5F432467BDA55721
GO
Isoform 6 (identifier: A6NC98-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1337: Missing.
     1338-1367: LGADGAGSTESLGGPPETELPEGREADGTG → MPCAARSRSSWRRSWTNTACWSLCPCPGPR

Show »
Length:139
Mass (Da):15,345
Checksum:i4B20F3982CB8BAB3
GO

Sequence cautioni

The sequence BAC03417 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti291L → W in BAC03417 (PubMed:11230166).Curated1
Sequence conflicti943T → I in AAI41867 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038523193D → E.Corresponds to variant rs647152dbSNPEnsembl.1
Natural variantiVAR_038524639W → R.Corresponds to variant rs685870dbSNPEnsembl.1
Natural variantiVAR_038525886D → A.3 PublicationsCorresponds to variant rs1318165dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0354051 – 1337Missing in isoform 6. 1 PublicationAdd BLAST1337
Alternative sequenceiVSP_0309561 – 864Missing in isoform 5. 1 PublicationAdd BLAST864
Alternative sequenceiVSP_0309571 – 351Missing in isoform 3. 1 PublicationAdd BLAST351
Alternative sequenceiVSP_030958352 – 403QLEEE…GEAHA → MGGAGALGGAGGVQGAAGRA AGGCPRALRPAARDPAREPA AANPAGRGPCGK in isoform 3. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_030959865 – 872REKEALQA → MKNRGLRE in isoform 5. 1 Publication8
Alternative sequenceiVSP_030960955 – 972LRQGP…AEPQL → VMPARLGAGGHATLPSIP in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_030961973 – 1476Missing in isoform 3. 1 PublicationAdd BLAST504
Alternative sequenceiVSP_030962987 – 1034NAMLV…SRLQA → VSVGPQWALGRCPVQCECGS TVDPGLGGIPCSVSVDSQWA RGWGCPMQ in isoform 2. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_0309631019 – 1136Missing in isoform 4. 1 PublicationAdd BLAST118
Alternative sequenceiVSP_0309641035 – 1476Missing in isoform 2. 1 PublicationAdd BLAST442
Alternative sequenceiVSP_0309651320 – 1476VKRLM…PSLSQ → GPLPRHPCAGPRAPSACGMR PWQAGSGGNSAQGSRWGEAL SHSALGTPLGNDSDSAIQAP WGRPSPTAKDLVWDGRTPLR PCRNTKQMPTERALRYRNRR NVPSPHPSASDTVGTAGLGV QPSRHWSVSGGPRQPKSSGS QGPQGESLDKEAWALRSSTV SAGARRWSWDECVDRGDGWP PRAAPGWSSGSSRWLPLRQR SLGDPPAEGGWQELAREPPA LSRWEAESQCWGTVAWADLE P in isoform 5. 1 PublicationAdd BLAST157
Alternative sequenceiVSP_0354061338 – 1367LGADG…ADGTG → MPCAARSRSSWRRSWTNTAC WSLCPCPGPR in isoform 6. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136799 mRNA. Translation: CAB66733.2.
AK090436 mRNA. Translation: BAC03417.1. Different initiation.
AK095289 mRNA. No translation available.
AP003774 Genomic DNA. No translation available.
BC040232 mRNA. Translation: AAH40232.1.
BC141866 mRNA. Translation: AAI41867.1.
AY491401 mRNA. Translation: AAR83719.1.
CCDSiCCDS8072.2. [A6NC98-1]
RefSeqiNP_115627.6. NM_032251.5. [A6NC98-1]
UniGeneiHs.98564.

Genome annotation databases

EnsembliENST00000301897; ENSP00000301897; ENSG00000168071. [A6NC98-6]
ENST00000356786; ENSP00000349238; ENSG00000168071. [A6NC98-1]
GeneIDi283234.
KEGGihsa:283234.
UCSCiuc001nzy.4. human. [A6NC98-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136799 mRNA. Translation: CAB66733.2.
AK090436 mRNA. Translation: BAC03417.1. Different initiation.
AK095289 mRNA. No translation available.
AP003774 Genomic DNA. No translation available.
BC040232 mRNA. Translation: AAH40232.1.
BC141866 mRNA. Translation: AAI41867.1.
AY491401 mRNA. Translation: AAR83719.1.
CCDSiCCDS8072.2. [A6NC98-1]
RefSeqiNP_115627.6. NM_032251.5. [A6NC98-1]
UniGeneiHs.98564.

3D structure databases

ProteinModelPortaliA6NC98.
SMRiA6NC98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129505. 2 interactors.
IntActiA6NC98. 37 interactors.
STRINGi9606.ENSP00000349238.

PTM databases

iPTMnetiA6NC98.
PhosphoSitePlusiA6NC98.

Polymorphism and mutation databases

BioMutaiCCDC88B.

Proteomic databases

MaxQBiA6NC98.
PaxDbiA6NC98.
PRIDEiA6NC98.

Protocols and materials databases

DNASUi283234.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301897; ENSP00000301897; ENSG00000168071. [A6NC98-6]
ENST00000356786; ENSP00000349238; ENSG00000168071. [A6NC98-1]
GeneIDi283234.
KEGGihsa:283234.
UCSCiuc001nzy.4. human. [A6NC98-1]

Organism-specific databases

CTDi283234.
DisGeNETi283234.
GeneCardsiCCDC88B.
H-InvDBHIX0201630.
HGNCiHGNC:26757. CCDC88B.
HPAiHPA026652.
MIMi611205. gene.
neXtProtiNX_A6NC98.
OpenTargetsiENSG00000168071.
PharmGKBiPA162381820.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1265. Eukaryota.
KOG3595. Eukaryota.
KOG4643. Eukaryota.
ENOG410YFRJ. LUCA.
GeneTreeiENSGT00690000101702.
HOVERGENiHBG104809.
InParanoidiA6NC98.
OMAiEFQHQRY.
OrthoDBiEOG091G01AJ.
PhylomeDBiA6NC98.
TreeFamiTF320231.

Miscellaneous databases

ChiTaRSiCCDC88B. human.
GenomeRNAii283234.
PROiA6NC98.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168071.
CleanExiHS_CCDC88B.
ExpressionAtlasiA6NC98. baseline and differential.
GenevisibleiA6NC98. HS.

Family and domain databases

InterProiIPR008636. Hook-related_fam.
[Graphical view]
PANTHERiPTHR18947. PTHR18947. 1 hit.
PfamiPF05622. HOOK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCC88B_HUMAN
AccessioniPrimary (citable) accession number: A6NC98
Secondary accession number(s): A5D8Y5
, B5MDM2, Q05BL2, Q6RUV3, Q8N1Q6, Q8NF44, Q9H0H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 24, 2007
Last modified: November 30, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.