CCDC88B

Functionⁱ

Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4⁺ and the CD8⁺ compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099).By similarity2 Publications

GO - Molecular functionⁱ

dynein light intermediate chain binding Source: GO_Central
microtubule binding Source: GO_Central

Complete GO annotation...

GO - Biological processⁱ

cytoplasmic microtubule organization Source: GO_Central
cytoskeleton-dependent intracellular transport Source: GO_Central
defense response to protozoan Source: Ensembl
positive regulation of cytokine production Source: UniProtKB
positive regulation of T cell activation Source: UniProtKB
positive regulation of T cell proliferation Source: UniProtKB

Complete GO annotation...

Keywordsⁱ

Biological process	Stress response

Biological process

Stress response

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Coiled-coil domain-containing protein 88B Alternative name(s): Brain leucine zipper domain-containing protein Gipie1 Publication Hook-related protein 31 Publication Short name: HkRP3
Gene namesⁱ	Name:CCDC88B Synonyms:BRLZ
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26757. CCDC88B.

HGNCⁱ

HGNC:26757. CCDC88B.

Subcellular locationⁱ

GO - Cellular componentⁱ

centrosome Source: GO_Central
cytoplasm Source: GO_Central
endoplasmic reticulum Source: UniProtKB-SubCell
Golgi apparatus Source: UniProtKB-SubCell
membrane
Source: UniProtKB
Inferred from direct assayⁱ
- 19946888

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	283234.
Open Targets More...OpenTargetsⁱ	ENSG00000168071.
PharmGKBⁱ	PA162381820.

Polymorphism and mutation databases

BioMutaⁱ	CCDC88B.

BioMutaⁱ

CCDC88B.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000317454	1 – 1476	Coiled-coil domain-containing protein 88BAdd BLAST		1476

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	436	PhosphoserineCombined sources	1
Modified residueⁱ	596	PhosphoserineCombined sources	1
Modified residueⁱ	1348	PhosphoserineBy similarity	1
Modified residueⁱ	1379	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	A6NC98.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A6NC98.
PaxDbⁱ	A6NC98.
PRIDEⁱ	A6NC98.

PTM databases

iPTMnetⁱ	A6NC98.
PhosphoSitePlusⁱ	A6NC98.

Expressionⁱ

Tissue specificityⁱ

Expressed in endothelium (at protein level) (PubMed:21289099). Expressed in NK cells (at protein level) (PubMed:25762780).2 Publications

Inductionⁱ

By endoplasmic reticulum stress.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000168071.
CleanExⁱ	HS_CCDC88B.
ExpressionAtlasⁱ	A6NC98. baseline and differential.
Genevisibleⁱ	A6NC98. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA026652.

HPAⁱ

HPA026652.

Interactionⁱ

Subunit structureⁱ

Homodimer (PubMed:25762780). Interacts with DOCK8 (PubMed:25762780). Interacts (via C-terminus) with intact microtubules (PubMed:25762780). Interacts with dynein-dynactin motor complex (PubMed:25762780). Interacts (via C-terminus) with HSPA5 (PubMed:21289099).By similarity2 Publications

GO - Molecular functionⁱ

dynein light intermediate chain binding Source: GO_Central
microtubule binding Source: GO_Central

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	129505. 3 interactors.
IntActⁱ	A6NC98. 41 interactors.
STRINGⁱ	9606.ENSP00000349238.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A6NC98.
SMRⁱ	A6NC98.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	253 – 481	Sequence analysisAdd BLAST		229
Coiled coilⁱ	720 – 1303	Sequence analysisAdd BLAST		584

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	35 – 44	Poly-Glu		10

Sequence similaritiesⁱ

Belongs to the CCDC88 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG1265. Eukaryota. KOG3595. Eukaryota. KOG4643. Eukaryota. ENOG410YFRJ. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00690000101702.
HOVERGENⁱ	HBG104809.
InParanoidⁱ	A6NC98.
OMAⁱ	HGGPRLG.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01AJ.
PhylomeDBⁱ	A6NC98.
TreeFamⁱ	TF320231.

Family and domain databases

InterProⁱ	View protein in InterPro IPR008636. Hook-related_fam.
PANTHERⁱ	PTHR18947. PTHR18947. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05622. HOOK. 1 hit.

Sequences (6)ⁱ

Sequence statusⁱ: Complete.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: A6NC98-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGGKGPRLR DFLSGSLATW ALGLAGLVGE AEDSEGEEEE EEEEPPLWLE 
        60         70         80         90        100
KRFLRLSDGA LLLRVLGIIA PSSRGGPRML RGLDGPAAWR VWNLNHLWGR 
       110        120        130        140        150
LRDFYQEELQ LLILSPPPDL QTLGFDPLSE EAVEQLEGVL RLLLGASVQC 
       160        170        180        190        200
EHRELFIRHI QGLSLEVQSE LAAAIQEVTQ PGAGVVLALS GPDPGELAPA 
       210        220        230        240        250
ELEMLSRSLM GTLSKLARER DLGAQRLAEL LLEREPLCLR PEAPSRAPAE 
       260        270        280        290        300
GPSHHLALQL ANAKAQLRRL RQELEEKAEL LLDSQAEVQG LEAEIRRLRQ 
       310        320        330        340        350
EAQALSGQAK RAELYREEAE ALRERAGRLP RLQEELRRCR ERLQAAEAYK 
       360        370        380        390        400
SQLEEERVLS GVLEASKALL EEQLEAARER CARLHETQRE NLLLRTRLGE 
       410        420        430        440        450
AHAELDSLRH QVDQLAEENV ELELELQRSL EPPPGSPGEA PLAGAAPSLQ 
       460        470        480        490        500
DEVREAEAGR LRTLERENRE LRGLLQVLQG QPGGQHPLLE APREDPVLPV 
       510        520        530        540        550
LEEAPQTPVA FDHSPQGLVQ KARDGGPQAL DLAPPALDSV LEASAECPQA 
       560        570        580        590        600
PDSDPQEAES PLQAAAMDPQ ASDWSPQESG SPVETQESPE KAGRRSSLQS 
       610        620        630        640        650
PASVAPPQGP GTKIQAPQLL GGETEGREAP QGELVPEAWG LRQEGPEHKP 
       660        670        680        690        700
GPSEPSSVQL EEQEGPNQGL DLATGQAEAR EHDQRLEGTV RDPAWQKPQQ 
       710        720        730        740        750
KSEGALEVQV WEGPIPGESL ASGVAEQEAL REEVAQLRRK AEALGDELEA 
       760        770        780        790        800
QARKLEAQNT EAARLSKELA QARRAEAEAH REAEAQAWEQ ARLREAVEAA 
       810        820        830        840        850
GQELESASQE REALVEALAA AGRERRQWER EGSRLRAQSE AAEERMQVLE 
       860        870        880        890        900
SEGRQHLEEA ERERREKEAL QAELEKAVVR GKELGDRLEH LQRELEQAAL 
       910        920        930        940        950
ERQEFLREKE SQHQRYQGLE QRLEAELQAA ATSKEEALME LKTRALQLEE 
       960        970        980        990       1000
ELFQLRQGPA GLGPKKRAEP QLVETQNVRL IEVERSNAML VAEKAALQGQ 
      1010       1020       1030       1040       1050
LQHLEGQLGS LQGRAQELLL QSQRAQEHSS RLQAEKSVLE IQGQELHRKL 
      1060       1070       1080       1090       1100
EVLEEEVRAA RQSQEETRGQ QQALLRDHKA LAQLQRRQEA ELEGLLVRHR 
      1110       1120       1130       1140       1150
DLKANMRALE LAHRELQGRH EQLQAQRASV EAQEVALLAE RERLMQDGHR 
      1160       1170       1180       1190       1200
QRGLEEELRR LQSEHDRAQM LLAELSRERG ELQGERGELR GRLARLELER 
      1210       1220       1230       1240       1250
AQLEMQSQQL RESNQQLDLS ACRLTTQCEL LTQLRSAQEE ENRQLLAEVQ 
      1260       1270       1280       1290       1300
ALSRENRELL ERSLESRDHL HREQREYLDQ LNALRREKQK LVEKIMDQYR 
      1310       1320       1330       1340       1350
VLEPVPLPRT KKGSWLADKV KRLMRPRREG GPPGGLRLGA DGAGSTESLG 
      1360       1370       1380       1390       1400
GPPETELPEG READGTGSPS PAPMRRAQSS LCLRDETLAG GQRRKLSSRF 
      1410       1420       1430       1440       1450
PVGRSSESFS PGDTPRQRFR QRHPGPLGAP VSHSKGPGVG WENSAETLQE 
      1460       1470 
HETDANREGP EVQEPEKRPL TPSLSQ

Length:1,476

Mass (Da):164,809

Last modified:July 24, 2007 - v1

Checksum:ⁱ4DB82F199F224EFC

GO

Isoform 2 (identifier: A6NC98-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
987-1034: NAMLVAEKAA...AQEHSSRLQA → VSVGPQWALG...WARGWGCPMQ
1035-1476: Missing.

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        10         20         30         40         50
MEGGKGPRLR DFLSGSLATW ALGLAGLVGE AEDSEGEEEE EEEEPPLWLE 
        60         70         80         90        100
KRFLRLSDGA LLLRVLGIIA PSSRGGPRML RGLDGPAAWR VWNLNHLWGR 
       110        120        130        140        150
LRDFYQEELQ LLILSPPPDL QTLGFDPLSE EAVEQLEGVL RLLLGASVQC 
       160        170        180        190        200
EHRELFIRHI QGLSLEVQSE LAAAIQEVTQ PGAGVVLALS GPDPGELAPA 
       210        220        230        240        250
ELEMLSRSLM GTLSKLARER DLGAQRLAEL LLEREPLCLR PEAPSRAPAE 
       260        270        280        290        300
GPSHHLALQL ANAKAQLRRL RQELEEKAEL LLDSQAEVQG LEAEIRRLRQ 
       310        320        330        340        350
EAQALSGQAK RAELYREEAE ALRERAGRLP RLQEELRRCR ERLQAAEAYK 
       360        370        380        390        400
SQLEEERVLS GVLEASKALL EEQLEAARER CARLHETQRE NLLLRTRLGE 
       410        420        430        440        450
AHAELDSLRH QVDQLAEENV ELELELQRSL EPPPGSPGEA PLAGAAPSLQ 
       460        470        480        490        500
DEVREAEAGR LRTLERENRE LRGLLQVLQG QPGGQHPLLE APREDPVLPV 
       510        520        530        540        550
LEEAPQTPVA FDHSPQGLVQ KARDGGPQAL DLAPPALDSV LEASAECPQA 
       560        570        580        590        600
PDSDPQEAES PLQAAAMDPQ ASDWSPQESG SPVETQESPE KAGRRSSLQS 
       610        620        630        640        650
PASVAPPQGP GTKIQAPQLL GGETEGREAP QGELVPEAWG LRQEGPEHKP 
       660        670        680        690        700
GPSEPSSVQL EEQEGPNQGL DLATGQAEAR EHDQRLEGTV RDPAWQKPQQ 
       710        720        730        740        750
KSEGALEVQV WEGPIPGESL ASGVAEQEAL REEVAQLRRK AEALGDELEA 
       760        770        780        790        800
QARKLEAQNT EAARLSKELA QARRAEAEAH REAEAQAWEQ ARLREAVEAA 
       810        820        830        840        850
GQELESASQE REALVEALAA AGRERRQWER EGSRLRAQSE AAEERMQVLE 
       860        870        880        890        900
SEGRQHLEEA ERERREKEAL QAELEKAVVR GKELGDRLEH LQRELEQAAL 
       910        920        930        940        950
ERQEFLREKE SQHQRYQGLE QRLEAELQAA ATSKEEALME LKTRALQLEE 
       960        970        980        990       1000
ELFQLRQGPA GLGPKKRAEP QLVETQNVRL IEVERSVSVG PQWALGRCPV 
      1010       1020       1030 
QCECGSTVDP GLGGIPCSVS VDSQWARGWG CPMQ

Show »

Length:1,034

Mass (Da):114,101

Checksum:ⁱ4AC0150AD38D33D6

GO

Isoform 3 (identifier: A6NC98-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-351: Missing.
     352-403: QLEEERVLSG...LRTRLGEAHA → MGGAGALGGA...NPAGRGPCGK
     955-972: LRQGPAGLGPKKRAEPQL → VMPARLGAGGHATLPSIP
     973-1476: Missing.

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        10         20         30         40         50
MGGAGALGGA GGVQGAAGRA AGGCPRALRP AARDPAREPA AANPAGRGPC 
        60         70         80         90        100
GKELDSLRHQ VDQLAEENVE LELELQRSLE PPPGSPGEAP LAGAAPSLQD 
       110        120        130        140        150
EVREAEAGRL RTLERENREL RGLLQVLQGQ PGGQHPLLEA PREDPVLPVL 
       160        170        180        190        200
EEAPQTPVAF DHSPQGLVQK ARDGGPQALD LAPPALDSVL EASAECPQAP 
       210        220        230        240        250
DSDPQEAESP LQAAAMDPQA SDWSPQESGS PVETQESPEK AGRRSSLQSP 
       260        270        280        290        300
ASVAPPQGPG TKIQAPQLLG GETEGREAPQ GELVPEAWGL RQEGPEHKPG 
       310        320        330        340        350
PSEPSSVQLE EQEGPNQGLD LATGQAEARE HDQRLEGTVR DPAWQKPQQK 
       360        370        380        390        400
SEGALEVQVW EGPIPGESLA SGVAEQEALR EEVAQLRRKA EALGDELEAQ 
       410        420        430        440        450
ARKLEAQNTE AARLSKELAQ ARRAEAEAHR EAEAQAWEQA RLREAVEAAG 
       460        470        480        490        500
QELESASQER EALVEALAAA GRERRQWERE GSRLRAQSEA AEERMQVLES 
       510        520        530        540        550
EGRQHLEEAE RERREKEALQ AELEKAVVRG KELGDRLEHL QRELEQAALE 
       560        570        580        590        600
RQEFLREKES QHQRYQGLEQ RLEAELQAAA TSKEEALMEL KTRALQLEEE 
       610        620 
LFQVMPARLG AGGHATLPSI P

Note: No experimental confirmation available.

Show »

Length:621

Mass (Da):67,018

Checksum:ⁱ60AF1EBA3536FC8D

GO

Isoform 4 (identifier: A6NC98-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1019-1136: Missing.

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        10         20         30         40         50
MEGGKGPRLR DFLSGSLATW ALGLAGLVGE AEDSEGEEEE EEEEPPLWLE 
        60         70         80         90        100
KRFLRLSDGA LLLRVLGIIA PSSRGGPRML RGLDGPAAWR VWNLNHLWGR 
       110        120        130        140        150
LRDFYQEELQ LLILSPPPDL QTLGFDPLSE EAVEQLEGVL RLLLGASVQC 
       160        170        180        190        200
EHRELFIRHI QGLSLEVQSE LAAAIQEVTQ PGAGVVLALS GPDPGELAPA 
       210        220        230        240        250
ELEMLSRSLM GTLSKLARER DLGAQRLAEL LLEREPLCLR PEAPSRAPAE 
       260        270        280        290        300
GPSHHLALQL ANAKAQLRRL RQELEEKAEL LLDSQAEVQG LEAEIRRLRQ 
       310        320        330        340        350
EAQALSGQAK RAELYREEAE ALRERAGRLP RLQEELRRCR ERLQAAEAYK 
       360        370        380        390        400
SQLEEERVLS GVLEASKALL EEQLEAARER CARLHETQRE NLLLRTRLGE 
       410        420        430        440        450
AHAELDSLRH QVDQLAEENV ELELELQRSL EPPPGSPGEA PLAGAAPSLQ 
       460        470        480        490        500
DEVREAEAGR LRTLERENRE LRGLLQVLQG QPGGQHPLLE APREDPVLPV 
       510        520        530        540        550
LEEAPQTPVA FDHSPQGLVQ KARDGGPQAL DLAPPALDSV LEASAECPQA 
       560        570        580        590        600
PDSDPQEAES PLQAAAMDPQ ASDWSPQESG SPVETQESPE KAGRRSSLQS 
       610        620        630        640        650
PASVAPPQGP GTKIQAPQLL GGETEGREAP QGELVPEAWG LRQEGPEHKP 
       660        670        680        690        700
GPSEPSSVQL EEQEGPNQGL DLATGQAEAR EHDQRLEGTV RDPAWQKPQQ 
       710        720        730        740        750
KSEGALEVQV WEGPIPGESL ASGVAEQEAL REEVAQLRRK AEALGDELEA 
       760        770        780        790        800
QARKLEAQNT EAARLSKELA QARRAEAEAH REAEAQAWEQ ARLREAVEAA 
       810        820        830        840        850
GQELESASQE REALVEALAA AGRERRQWER EGSRLRAQSE AAEERMQVLE 
       860        870        880        890        900
SEGRQHLEEA ERERREKEAL QAELEKAVVR GKELGDRLEH LQRELEQAAL 
       910        920        930        940        950
ERQEFLREKE SQHQRYQGLE QRLEAELQAA ATSKEEALME LKTRALQLEE 
       960        970        980        990       1000
ELFQLRQGPA GLGPKKRAEP QLVETQNVRL IEVERSNAML VAEKAALQGQ 
      1010       1020       1030       1040       1050
LQHLEGQLGS LQGRAQELLL AERERLMQDG HRQRGLEEEL RRLQSEHDRA 
      1060       1070       1080       1090       1100
QMLLAELSRE RGELQGERGE LRGRLARLEL ERAQLEMQSQ QLRESNQQLD 
      1110       1120       1130       1140       1150
LSACRLTTQC ELLTQLRSAQ EEENRQLLAE VQALSRENRE LLERSLESRD 
      1160       1170       1180       1190       1200
HLHREQREYL DQLNALRREK QKLVEKIMDQ YRVLEPVPLP RTKKGSWLAD 
      1210       1220       1230       1240       1250
KVKRLMRPRR EGGPPGGLRL GADGAGSTES LGGPPETELP EGREADGTGS 
      1260       1270       1280       1290       1300
PSPAPMRRAQ SSLCLRDETL AGGQRRKLSS RFPVGRSSES FSPGDTPRQR 
      1310       1320       1330       1340       1350
FRQRHPGPLG APVSHSKGPG VGWENSAETL QEHETDANRE GPEVQEPEKR 

PLTPSLSQ

Note: No experimental confirmation available.

Show »

Length:1,358

Mass (Da):151,121

Checksum:ⁱE01A73698162233C

GO

Isoform 5 (identifier: A6NC98-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-864: Missing.
     865-872: REKEALQA → MKNRGLRE
     1320-1476: VKRLMRPRRE...KRPLTPSLSQ → GPLPRHPCAG...GTVAWADLEP

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        10         20         30         40         50
MKNRGLREEL EKAVVRGKEL GDRLEHLQRE LEQAALERQE FLREKESQHQ 
        60         70         80         90        100
RYQGLEQRLE AELQAAATSK EEALMELKTR ALQLEEELFQ LRQGPAGLGP 
       110        120        130        140        150
KKRAEPQLVE TQNVRLIEVE RSNAMLVAEK AALQGQLQHL EGQLGSLQGR 
       160        170        180        190        200
AQELLLQSQR AQEHSSRLQA EKSVLEIQGQ ELHRKLEVLE EEVRAARQSQ 
       210        220        230        240        250
EETRGQQQAL LRDHKALAQL QRRQEAELEG LLVRHRDLKA NMRALELAHR 
       260        270        280        290        300
ELQGRHEQLQ AQRASVEAQE VALLAERERL MQDGHRQRGL EEELRRLQSE 
       310        320        330        340        350
HDRAQMLLAE LSRERGELQG ERGELRGRLA RLELERAQLE MQSQQLRESN 
       360        370        380        390        400
QQLDLSACRL TTQCELLTQL RSAQEEENRQ LLAEVQALSR ENRELLERSL 
       410        420        430        440        450
ESRDHLHREQ REYLDQLNAL RREKQKLVEK IMDQYRVLEP VPLPRTKKGS 
       460        470        480        490        500
WLADKGPLPR HPCAGPRAPS ACGMRPWQAG SGGNSAQGSR WGEALSHSAL 
       510        520        530        540        550
GTPLGNDSDS AIQAPWGRPS PTAKDLVWDG RTPLRPCRNT KQMPTERALR 
       560        570        580        590        600
YRNRRNVPSP HPSASDTVGT AGLGVQPSRH WSVSGGPRQP KSSGSQGPQG 
       610        620        630        640        650
ESLDKEAWAL RSSTVSAGAR RWSWDECVDR GDGWPPRAAP GWSSGSSRWL 
       660        670        680        690 
PLRQRSLGDP PAEGGWQELA REPPALSRWE AESQCWGTVA WADLEP

Note: No experimental confirmation available.

Show »

Length:696

Mass (Da):79,003

Checksum:ⁱ5F432467BDA55721

GO

Isoform 6 (identifier: A6NC98-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1337: Missing.
1338-1367: LGADGAGSTESLGGPPETELPEGREADGTG → MPCAARSRSSWRRSWTNTACWSLCPCPGPR

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        10         20         30         40         50
MPCAARSRSS WRRSWTNTAC WSLCPCPGPR SPSPAPMRRA QSSLCLRDET 
        60         70         80         90        100
LAGGQRRKLS SRFPVGRSSE SFSPGDTPRQ RFRQRHPGPL GAPVSHSKGP 
       110        120        130 
GVGWENSAET LQEHETDANR EGPEVQEPEK RPLTPSLSQ

Show »

Length:139

Mass (Da):15,345

Checksum:ⁱ4B20F3982CB8BAB3

GO

Sequence cautionⁱ

The sequence BAC03417 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	291	L → W in BAC03417 (PubMed:11230166).Curated		1
Sequence conflictⁱ	943	T → I in AAI41867 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_038523	193	D → E. Corresponds to variant dbSNP:rs647152Ensembl.	1
Natural variantⁱVAR_038524	639	W → R. Corresponds to variant dbSNP:rs685870Ensembl.	1
Natural variantⁱVAR_038525	886	D → A3 PublicationsCorresponds to variant dbSNP:rs1318165Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_035405	1 – 1337	Missing in isoform 6. 1 PublicationAdd BLAST	1337
Alternative sequenceⁱVSP_030956	1 – 864	Missing in isoform 5. 1 PublicationAdd BLAST	864
Alternative sequenceⁱVSP_030957	1 – 351	Missing in isoform 3. 1 PublicationAdd BLAST	351
Alternative sequenceⁱVSP_030958	352 – 403	QLEEE…GEAHA → MGGAGALGGAGGVQGAAGRA AGGCPRALRPAARDPAREPA AANPAGRGPCGK in isoform 3. 1 PublicationAdd BLAST	52
Alternative sequenceⁱVSP_030959	865 – 872	REKEALQA → MKNRGLRE in isoform 5. 1 Publication	8
Alternative sequenceⁱVSP_030960	955 – 972	LRQGP…AEPQL → VMPARLGAGGHATLPSIP in isoform 3. 1 PublicationAdd BLAST	18
Alternative sequenceⁱVSP_030961	973 – 1476	Missing in isoform 3. 1 PublicationAdd BLAST	504
Alternative sequenceⁱVSP_030962	987 – 1034	NAMLV…SRLQA → VSVGPQWALGRCPVQCECGS TVDPGLGGIPCSVSVDSQWA RGWGCPMQ in isoform 2. 1 PublicationAdd BLAST	48
Alternative sequenceⁱVSP_030963	1019 – 1136	Missing in isoform 4. 1 PublicationAdd BLAST	118
Alternative sequenceⁱVSP_030964	1035 – 1476	Missing in isoform 2. 1 PublicationAdd BLAST	442
Alternative sequenceⁱVSP_030965	1320 – 1476	VKRLM…PSLSQ → GPLPRHPCAGPRAPSACGMR PWQAGSGGNSAQGSRWGEAL SHSALGTPLGNDSDSAIQAP WGRPSPTAKDLVWDGRTPLR PCRNTKQMPTERALRYRNRR NVPSPHPSASDTVGTAGLGV QPSRHWSVSGGPRQPKSSGS QGPQGESLDKEAWALRSSTV SAGARRWSWDECVDRGDGWP PRAAPGWSSGSSRWLPLRQR SLGDPPAEGGWQELAREPPA LSRWEAESQCWGTVAWADLE P in isoform 5. 1 PublicationAdd BLAST	157
Alternative sequenceⁱVSP_035406	1338 – 1367	LGADG…ADGTG → MPCAARSRSSWRRSWTNTAC WSLCPCPGPR in isoform 6. 1 PublicationAdd BLAST	30

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL136799 mRNA. Translation: CAB66733.2. AK090436 mRNA. Translation: BAC03417.1. Different initiation. AK095289 mRNA. No translation available. AP003774 Genomic DNA. No translation available. BC040232 mRNA. Translation: AAH40232.1. BC141866 mRNA. Translation: AAI41867.1. AY491401 mRNA. Translation: AAR83719.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8072.2. [A6NC98-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_115627.6. NM_032251.5. [A6NC98-1]
UniGeneⁱ	Hs.98564.

Genome annotation databases

Ensemblⁱ	ENST00000301897; ENSP00000301897; ENSG00000168071. [A6NC98-6] ENST00000356786; ENSP00000349238; ENSG00000168071. [A6NC98-1]
GeneIDⁱ	283234.
KEGGⁱ	hsa:283234.
UCSC genome browser More...UCSCⁱ	uc001nzy.4. human. [A6NC98-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL136799 mRNA. Translation: CAB66733.2. AK090436 mRNA. Translation: BAC03417.1. Different initiation. AK095289 mRNA. No translation available. AP003774 Genomic DNA. No translation available. BC040232 mRNA. Translation: AAH40232.1. BC141866 mRNA. Translation: AAI41867.1. AY491401 mRNA. Translation: AAR83719.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8072.2. [A6NC98-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_115627.6. NM_032251.5. [A6NC98-1]
UniGeneⁱ	Hs.98564.

3D structure databases

ProteinModelPortalⁱ	A6NC98.
SMRⁱ	A6NC98.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	129505. 3 interactors.
IntActⁱ	A6NC98. 41 interactors.
STRINGⁱ	9606.ENSP00000349238.

PTM databases

iPTMnetⁱ	A6NC98.
PhosphoSitePlusⁱ	A6NC98.

Polymorphism and mutation databases

BioMutaⁱ	CCDC88B.

BioMutaⁱ

CCDC88B.

Proteomic databases

EPDⁱ	A6NC98.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A6NC98.
PaxDbⁱ	A6NC98.
PRIDEⁱ	A6NC98.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	283234.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000301897; ENSP00000301897; ENSG00000168071. [A6NC98-6] ENST00000356786; ENSP00000349238; ENSG00000168071. [A6NC98-1]
GeneIDⁱ	283234.
KEGGⁱ	hsa:283234.
UCSC genome browser More...UCSCⁱ	uc001nzy.4. human. [A6NC98-1]

Organism-specific databases

CTDⁱ	283234.
DisGeNET More...DisGeNETⁱ	283234.
GeneCardsⁱ	CCDC88B.
H-InvDBⁱ	HIX0201630.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26757. CCDC88B.
Human Protein Atlas More...HPAⁱ	HPA026652.
MIMⁱ	611205. gene.
neXtProtⁱ	NX_A6NC98.
Open Targets More...OpenTargetsⁱ	ENSG00000168071.
PharmGKBⁱ	PA162381820.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1265. Eukaryota. KOG3595. Eukaryota. KOG4643. Eukaryota. ENOG410YFRJ. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00690000101702.
HOVERGENⁱ	HBG104809.
InParanoidⁱ	A6NC98.
OMAⁱ	HGGPRLG.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01AJ.
PhylomeDBⁱ	A6NC98.
TreeFamⁱ	TF320231.

Miscellaneous databases

ChiTaRSⁱ	CCDC88B. human.
GenomeRNAiⁱ	283234.
Protein Ontology More...PROⁱ	PR:A6NC98.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000168071.
CleanExⁱ	HS_CCDC88B.
ExpressionAtlasⁱ	A6NC98. baseline and differential.
Genevisibleⁱ	A6NC98. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR008636. Hook-related_fam.
PANTHERⁱ	PTHR18947. PTHR18947. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05622. HOOK. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CC88B_HUMAN
Accessionⁱ	A6NC98Primary (citable) accession number: A6NC98 Secondary accession number(s): A5D8Y5 Q9H0H1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
	Last sequence update:	July 24, 2007
	Last modified:	June 7, 2017
	This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - A6NC98 (CC88B_HUMAN)

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Coiled-coil domain-containing protein 88B

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6)i

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (6)ⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ