UniProtKB - A6NC98 (CC88B_HUMAN)
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Protein
Coiled-coil domain-containing protein 88B
Gene
CCDC88B
Organism
Homo sapiens (Human)
Status
Functioni
Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4+ and the CD8+ compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099).By similarity2 Publications
GO - Molecular functioni
- dynein light intermediate chain binding Source: GO_Central
- microtubule binding Source: GO_Central
GO - Biological processi
- cytoplasmic microtubule organization Source: GO_Central
- cytoskeleton-dependent intracellular transport Source: GO_Central
- defense response to protozoan Source: Ensembl
- positive regulation of cytokine production Source: UniProtKB
- positive regulation of T cell activation Source: UniProtKB
- positive regulation of T cell proliferation Source: UniProtKB
Keywordsi
Biological process | Stress response |
Names & Taxonomyi
Protein namesi | Recommended name: Coiled-coil domain-containing protein 88BAlternative name(s): Brain leucine zipper domain-containing protein Gipie1 Publication Hook-related protein 31 Publication Short name: HkRP3 |
Gene namesi | Name:CCDC88B Synonyms:BRLZ |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000168071.21. |
HGNCi | HGNC:26757. CCDC88B. |
MIMi | 611205. gene. |
neXtProti | NX_A6NC98. |
Subcellular locationi
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 283234. |
OpenTargetsi | ENSG00000168071. |
PharmGKBi | PA162381820. |
Polymorphism and mutation databases
BioMutai | CCDC88B. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000317454 | 1 – 1476 | Coiled-coil domain-containing protein 88BAdd BLAST | 1476 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 436 | PhosphoserineCombined sources | 1 | |
Modified residuei | 596 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1348 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1379 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | A6NC98. |
PaxDbi | A6NC98. |
PRIDEi | A6NC98. |
PTM databases
iPTMneti | A6NC98. |
PhosphoSitePlusi | A6NC98. |
Expressioni
Tissue specificityi
Expressed in endothelium (at protein level) (PubMed:21289099). Expressed in NK cells (at protein level) (PubMed:25762780).2 Publications
Inductioni
By endoplasmic reticulum stress.1 Publication
Gene expression databases
Bgeei | ENSG00000168071. |
CleanExi | HS_CCDC88B. |
ExpressionAtlasi | A6NC98. baseline and differential. |
Genevisiblei | A6NC98. HS. |
Organism-specific databases
HPAi | HPA026652. |
Interactioni
Subunit structurei
Homodimer (PubMed:25762780). Interacts with DOCK8 (PubMed:25762780). Interacts (via C-terminus) with intact microtubules (PubMed:25762780). Interacts with dynein-dynactin motor complex (PubMed:25762780). Interacts (via C-terminus) with HSPA5 (PubMed:21289099).By similarity2 Publications
Binary interactionsi
GO - Molecular functioni
- dynein light intermediate chain binding Source: GO_Central
- microtubule binding Source: GO_Central
Protein-protein interaction databases
BioGridi | 129505. 3 interactors. |
IntActi | A6NC98. 41 interactors. |
STRINGi | 9606.ENSP00000349238. |
Structurei
3D structure databases
ProteinModelPortali | A6NC98. |
SMRi | A6NC98. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 253 – 481 | Sequence analysisAdd BLAST | 229 | |
Coiled coili | 720 – 1303 | Sequence analysisAdd BLAST | 584 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 35 – 44 | Poly-Glu | 10 |
Sequence similaritiesi
Belongs to the CCDC88 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG1265. Eukaryota. KOG3595. Eukaryota. KOG4643. Eukaryota. ENOG410YFRJ. LUCA. |
GeneTreei | ENSGT00690000101702. |
HOVERGENi | HBG104809. |
InParanoidi | A6NC98. |
OMAi | HGGPRLG. |
OrthoDBi | EOG091G01AJ. |
PhylomeDBi | A6NC98. |
TreeFami | TF320231. |
Family and domain databases
Gene3Di | 1.10.418.10. 1 hit. |
InterProi | View protein in InterPro IPR036872. CH_dom_sf. IPR008636. Hook-like_fam. |
PANTHERi | PTHR18947. PTHR18947. 1 hit. |
Pfami | View protein in Pfam PF05622. HOOK. 1 hit. |
s (6)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: A6NC98-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MEGGKGPRLR DFLSGSLATW ALGLAGLVGE AEDSEGEEEE EEEEPPLWLE
60 70 80 90 100
KRFLRLSDGA LLLRVLGIIA PSSRGGPRML RGLDGPAAWR VWNLNHLWGR
110 120 130 140 150
LRDFYQEELQ LLILSPPPDL QTLGFDPLSE EAVEQLEGVL RLLLGASVQC
160 170 180 190 200
EHRELFIRHI QGLSLEVQSE LAAAIQEVTQ PGAGVVLALS GPDPGELAPA
210 220 230 240 250
ELEMLSRSLM GTLSKLARER DLGAQRLAEL LLEREPLCLR PEAPSRAPAE
260 270 280 290 300
GPSHHLALQL ANAKAQLRRL RQELEEKAEL LLDSQAEVQG LEAEIRRLRQ
310 320 330 340 350
EAQALSGQAK RAELYREEAE ALRERAGRLP RLQEELRRCR ERLQAAEAYK
360 370 380 390 400
SQLEEERVLS GVLEASKALL EEQLEAARER CARLHETQRE NLLLRTRLGE
410 420 430 440 450
AHAELDSLRH QVDQLAEENV ELELELQRSL EPPPGSPGEA PLAGAAPSLQ
460 470 480 490 500
DEVREAEAGR LRTLERENRE LRGLLQVLQG QPGGQHPLLE APREDPVLPV
510 520 530 540 550
LEEAPQTPVA FDHSPQGLVQ KARDGGPQAL DLAPPALDSV LEASAECPQA
560 570 580 590 600
PDSDPQEAES PLQAAAMDPQ ASDWSPQESG SPVETQESPE KAGRRSSLQS
610 620 630 640 650
PASVAPPQGP GTKIQAPQLL GGETEGREAP QGELVPEAWG LRQEGPEHKP
660 670 680 690 700
GPSEPSSVQL EEQEGPNQGL DLATGQAEAR EHDQRLEGTV RDPAWQKPQQ
710 720 730 740 750
KSEGALEVQV WEGPIPGESL ASGVAEQEAL REEVAQLRRK AEALGDELEA
760 770 780 790 800
QARKLEAQNT EAARLSKELA QARRAEAEAH REAEAQAWEQ ARLREAVEAA
810 820 830 840 850
GQELESASQE REALVEALAA AGRERRQWER EGSRLRAQSE AAEERMQVLE
860 870 880 890 900
SEGRQHLEEA ERERREKEAL QAELEKAVVR GKELGDRLEH LQRELEQAAL
910 920 930 940 950
ERQEFLREKE SQHQRYQGLE QRLEAELQAA ATSKEEALME LKTRALQLEE
960 970 980 990 1000
ELFQLRQGPA GLGPKKRAEP QLVETQNVRL IEVERSNAML VAEKAALQGQ
1010 1020 1030 1040 1050
LQHLEGQLGS LQGRAQELLL QSQRAQEHSS RLQAEKSVLE IQGQELHRKL
1060 1070 1080 1090 1100
EVLEEEVRAA RQSQEETRGQ QQALLRDHKA LAQLQRRQEA ELEGLLVRHR
1110 1120 1130 1140 1150
DLKANMRALE LAHRELQGRH EQLQAQRASV EAQEVALLAE RERLMQDGHR
1160 1170 1180 1190 1200
QRGLEEELRR LQSEHDRAQM LLAELSRERG ELQGERGELR GRLARLELER
1210 1220 1230 1240 1250
AQLEMQSQQL RESNQQLDLS ACRLTTQCEL LTQLRSAQEE ENRQLLAEVQ
1260 1270 1280 1290 1300
ALSRENRELL ERSLESRDHL HREQREYLDQ LNALRREKQK LVEKIMDQYR
1310 1320 1330 1340 1350
VLEPVPLPRT KKGSWLADKV KRLMRPRREG GPPGGLRLGA DGAGSTESLG
1360 1370 1380 1390 1400
GPPETELPEG READGTGSPS PAPMRRAQSS LCLRDETLAG GQRRKLSSRF
1410 1420 1430 1440 1450
PVGRSSESFS PGDTPRQRFR QRHPGPLGAP VSHSKGPGVG WENSAETLQE
1460 1470
HETDANREGP EVQEPEKRPL TPSLSQ
Isoform 3 (identifier: A6NC98-3) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
1-351: Missing.
352-403: QLEEERVLSG...LRTRLGEAHA → MGGAGALGGA...NPAGRGPCGK
955-972: LRQGPAGLGPKKRAEPQL → VMPARLGAGGHATLPSIP
973-1476: Missing.
Note: No experimental confirmation available.
Show »Sequence cautioni
The sequence BAC03417 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 291 | L → W in BAC03417 (PubMed:11230166).Curated | 1 | |
Sequence conflicti | 943 | T → I in AAI41867 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038523 | 193 | D → E. Corresponds to variant dbSNP:rs647152Ensembl. | 1 | |
Natural variantiVAR_038524 | 639 | W → R. Corresponds to variant dbSNP:rs685870Ensembl. | 1 | |
Natural variantiVAR_038525 | 886 | D → A3 PublicationsCorresponds to variant dbSNP:rs1318165Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035405 | 1 – 1337 | Missing in isoform 6. 1 PublicationAdd BLAST | 1337 | |
Alternative sequenceiVSP_030956 | 1 – 864 | Missing in isoform 5. 1 PublicationAdd BLAST | 864 | |
Alternative sequenceiVSP_030957 | 1 – 351 | Missing in isoform 3. 1 PublicationAdd BLAST | 351 | |
Alternative sequenceiVSP_030958 | 352 – 403 | QLEEE…GEAHA → MGGAGALGGAGGVQGAAGRA AGGCPRALRPAARDPAREPA AANPAGRGPCGK in isoform 3. 1 PublicationAdd BLAST | 52 | |
Alternative sequenceiVSP_030959 | 865 – 872 | REKEALQA → MKNRGLRE in isoform 5. 1 Publication | 8 | |
Alternative sequenceiVSP_030960 | 955 – 972 | LRQGP…AEPQL → VMPARLGAGGHATLPSIP in isoform 3. 1 PublicationAdd BLAST | 18 | |
Alternative sequenceiVSP_030961 | 973 – 1476 | Missing in isoform 3. 1 PublicationAdd BLAST | 504 | |
Alternative sequenceiVSP_030962 | 987 – 1034 | NAMLV…SRLQA → VSVGPQWALGRCPVQCECGS TVDPGLGGIPCSVSVDSQWA RGWGCPMQ in isoform 2. 1 PublicationAdd BLAST | 48 | |
Alternative sequenceiVSP_030963 | 1019 – 1136 | Missing in isoform 4. 1 PublicationAdd BLAST | 118 | |
Alternative sequenceiVSP_030964 | 1035 – 1476 | Missing in isoform 2. 1 PublicationAdd BLAST | 442 | |
Alternative sequenceiVSP_030965 | 1320 – 1476 | VKRLM…PSLSQ → GPLPRHPCAGPRAPSACGMR PWQAGSGGNSAQGSRWGEAL SHSALGTPLGNDSDSAIQAP WGRPSPTAKDLVWDGRTPLR PCRNTKQMPTERALRYRNRR NVPSPHPSASDTVGTAGLGV QPSRHWSVSGGPRQPKSSGS QGPQGESLDKEAWALRSSTV SAGARRWSWDECVDRGDGWP PRAAPGWSSGSSRWLPLRQR SLGDPPAEGGWQELAREPPA LSRWEAESQCWGTVAWADLE P in isoform 5. 1 PublicationAdd BLAST | 157 | |
Alternative sequenceiVSP_035406 | 1338 – 1367 | LGADG…ADGTG → MPCAARSRSSWRRSWTNTAC WSLCPCPGPR in isoform 6. 1 PublicationAdd BLAST | 30 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136799 mRNA. Translation: CAB66733.2. AK090436 mRNA. Translation: BAC03417.1. Different initiation. AK095289 mRNA. No translation available. AP003774 Genomic DNA. No translation available. BC040232 mRNA. Translation: AAH40232.1. BC141866 mRNA. Translation: AAI41867.1. AY491401 mRNA. Translation: AAR83719.1. |
CCDSi | CCDS8072.2. [A6NC98-1] |
RefSeqi | NP_115627.6. NM_032251.5. [A6NC98-1] |
UniGenei | Hs.98564. |
Genome annotation databases
Ensembli | ENST00000301897; ENSP00000301897; ENSG00000168071. [A6NC98-6] ENST00000356786; ENSP00000349238; ENSG00000168071. [A6NC98-1] |
GeneIDi | 283234. |
KEGGi | hsa:283234. |
UCSCi | uc001nzy.4. human. [A6NC98-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | CC88B_HUMAN | |
Accessioni | A6NC98Primary (citable) accession number: A6NC98 Secondary accession number(s): A5D8Y5 Q9H0H1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | July 24, 2007 | |
Last modified: | February 28, 2018 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |