ID   PINLY_HUMAN             Reviewed;         204 AA.
AC   A6NC86; B7Z457; O95053;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 3.
DT   27-MAR-2024, entry version 108.
DE   RecName: Full=phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein;
DE   Flags: Precursor;
GN   Name=PINLYP;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Tongue;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=A6NC86-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A6NC86-2; Sequence=VSP_044189;
CC       Name=3;
CC         IsoId=A6NC86-3; Sequence=VSP_044189, VSP_044190;
CC       Name=4;
CC         IsoId=A6NC86-4; Sequence=VSP_044188;
CC   -!- SIMILARITY: Belongs to the CNF-like-inhibitor family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC99796.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AK296854; BAH12443.1; -; mRNA.
DR   EMBL; AC006276; AAC99796.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; L34079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC071811; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS58667.1; -. [A6NC86-4]
DR   CCDS; CCDS74385.2; -. [A6NC86-1]
DR   RefSeq; NP_001180550.1; NM_001193621.1. [A6NC86-1]
DR   RefSeq; NP_001180551.1; NM_001193622.1. [A6NC86-4]
DR   RefSeq; NP_001308053.1; NM_001321124.1. [A6NC86-4]
DR   RefSeq; XP_011525272.1; XM_011526970.2.
DR   RefSeq; XP_011525273.1; XM_011526971.2. [A6NC86-4]
DR   AlphaFoldDB; A6NC86; -.
DR   SMR; A6NC86; -.
DR   STRING; 9606.ENSP00000479240; -.
DR   GlyCosmos; A6NC86; 1 site, 1 glycan.
DR   GlyGen; A6NC86; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; A6NC86; -.
DR   PhosphoSitePlus; A6NC86; -.
DR   BioMuta; PINLYP; -.
DR   MassIVE; A6NC86; -.
DR   PaxDb; 9606-ENSP00000479240; -.
DR   PeptideAtlas; A6NC86; -.
DR   Antibodypedia; 70850; 5 antibodies from 5 providers.
DR   DNASU; 390940; -.
DR   Ensembl; ENST00000562255.5; ENSP00000457623.1; ENSG00000234465.11. [A6NC86-4]
DR   Ensembl; ENST00000562365.2; ENSP00000456310.1; ENSG00000234465.11. [A6NC86-4]
DR   Ensembl; ENST00000569031.6; ENSP00000457369.1; ENSG00000234465.11. [A6NC86-4]
DR   Ensembl; ENST00000599207.6; ENSP00000469886.1; ENSG00000234465.11. [A6NC86-1]
DR   Ensembl; ENST00000612042.4; ENSP00000479240.1; ENSG00000234465.11. [A6NC86-2]
DR   GeneID; 390940; -.
DR   KEGG; hsa:390940; -.
DR   MANE-Select; ENST00000599207.6; ENSP00000469886.1; NM_001193621.3; NP_001180550.2.
DR   UCSC; uc002owu.3; human. [A6NC86-1]
DR   AGR; HGNC:44206; -.
DR   CTD; 390940; -.
DR   DisGeNET; 390940; -.
DR   GeneCards; PINLYP; -.
DR   HGNC; HGNC:44206; PINLYP.
DR   HPA; ENSG00000234465; Low tissue specificity.
DR   neXtProt; NX_A6NC86; -.
DR   OpenTargets; ENSG00000234465; -.
DR   VEuPathDB; HostDB:ENSG00000234465; -.
DR   eggNOG; ENOG502SRI1; Eukaryota.
DR   GeneTree; ENSGT00730000111229; -.
DR   HOGENOM; CLU_094248_0_0_1; -.
DR   InParanoid; A6NC86; -.
DR   OMA; SYKSWGL; -.
DR   OrthoDB; 4297151at2759; -.
DR   PhylomeDB; A6NC86; -.
DR   PathwayCommons; A6NC86; -.
DR   BioGRID-ORCS; 390940; 18 hits in 1141 CRISPR screens.
DR   ChiTaRS; PINLYP; human.
DR   GenomeRNAi; 390940; -.
DR   Pharos; A6NC86; Tdark.
DR   PRO; PR:A6NC86; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; A6NC86; Protein.
DR   Bgee; ENSG00000234465; Expressed in ventricular zone and 131 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004859; F:phospholipase inhibitor activity; IEA:InterPro.
DR   Gene3D; 2.10.60.10; CD59; 2.
DR   InterPro; IPR016054; LY6_UPA_recep-like.
DR   InterPro; IPR004126; PLipase_A2_inh_N.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   PANTHER; PTHR20914; LY6/PLAUR DOMAIN-CONTAINING PROTEIN 8; 1.
DR   PANTHER; PTHR20914:SF25; PHOSPHOLIPASE A2 INHIBITOR AND LY6_PLAUR DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF02988; PLA2_inh; 1.
DR   Pfam; PF00021; UPAR_LY6; 1.
DR   SUPFAM; SSF57302; Snake toxin-like; 2.
DR   Genevisible; A6NC86; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..204
FT                   /note="phospholipase A2 inhibitor and Ly6/PLAUR domain-
FT                   containing protein"
FT                   /id="PRO_0000332737"
FT   DOMAIN          27..117
FT                   /note="UPAR/Ly6"
FT   DISULFID        29..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        32..39
FT                   /evidence="ECO:0000250"
FT   DISULFID        46..74
FT                   /evidence="ECO:0000250"
FT   DISULFID        80..101
FT                   /evidence="ECO:0000250"
FT   DISULFID        102..107
FT                   /evidence="ECO:0000250"
FT   DISULFID        126..151
FT                   /evidence="ECO:0000250"
FT   DISULFID        144..172
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         1..88
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_044188"
FT   VAR_SEQ         1
FT                   /note="M -> MWVQTHPSSASYKSWGPGTADTHTM (in isoform 2 and
FT                   isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_044189"
FT   VAR_SEQ         63..204
FT                   /note="KGKELVHTYKGCIRSQDCYSGVISTTMGPKDHMVTSSFCCQSDGCNSAFLSV
FT                   PLTNLTENGLMCPACTASFRDKCMGPMTHCTGKENHCVSLSGHVQAGIFKPRFAMRGCA
FT                   TESMCFTKPGAEVPTGTNVLFLHHIECTHSP -> SKRMWPGTWWGGGVYLQGGRDYHA
FT                   EGGSSRFSRRERGKKSVESRKEGKTIMRWREQK (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_044190"
FT   CONFLICT        A6NC86-3:6
FT                   /note="H -> R (in Ref. 1; BAH12443)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   204 AA;  21926 MW;  9F49DFAF0AFB9868 CRC64;
     MRLSRRPETF LLAFVLLCTL LGLGCPLHCE ICTAAGSRCH GQMKTCSSDK DTCVLLVGKA
     TSKGKELVHT YKGCIRSQDC YSGVISTTMG PKDHMVTSSF CCQSDGCNSA FLSVPLTNLT
     ENGLMCPACT ASFRDKCMGP MTHCTGKENH CVSLSGHVQA GIFKPRFAMR GCATESMCFT
     KPGAEVPTGT NVLFLHHIEC THSP
//