A6NC86 (PINLY_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein

Gene names

Name:

PINLYP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the CNF-like-inhibitor family. Contains 1 UPAR/Ly6 domain.
Sequence caution	The sequence AAC99796.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Signal
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	phospholipase inhibitor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A6NC86-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A6NC86-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MWVQTHPSSASYKSWGPGTADTHTM

Note: No experimental confirmation available.

Isoform 3 (identifier: A6NC86-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MWVQTHPSSASYKSWGPGTADTHTM
     63-204: KGKELVHTYK...LHHIECTHSP → SKRMWPGTWW...KTIMRWREQK

Note: No experimental confirmation available.

Isoform 4 (identifier: A6NC86-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 204	178	phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein		PRO_0000332737
Regions
	Domain	27 – 117	91	UPAR/Ly6
Amino acid modifications
	Disulfide bond	29 ↔ 53		By similarity
	Disulfide bond	32 ↔ 39		By similarity
	Disulfide bond	46 ↔ 74		By similarity
	Disulfide bond	80 ↔ 101		By similarity
	Disulfide bond	102 ↔ 107		By similarity
	Disulfide bond	126 ↔ 151		By similarity
	Disulfide bond	144 ↔ 172		By similarity
Natural variations
	Alternative sequence	1 – 88	88	Missing in isoform 4.		VSP_044188
	Alternative sequence	1	1	M → MWVQTHPSSASYKSWGPGTA DTHTM in isoform 2 and isoform 3.		VSP_044189
	Alternative sequence	63 – 204	142	KGKEL…CTHSP → SKRMWPGTWWGGGVYLQGGR DYHAEGGSSRFSRRERGKKS VESRKEGKTIMRWREQK in isoform 3.		VSP_044190
Experimental info
Isoform 3:
	Sequence conflict	6	1	H → R in BAH12443. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 29, 2008. Version 3. Checksum: 9F49DFAF0AFB9868	FASTA	204	21,926
	10 20 30 40 50 60 MRLSRRPETF LLAFVLLCTL LGLGCPLHCE ICTAAGSRCH GQMKTCSSDK DTCVLLVGKA 70 80 90 100 110 120 TSKGKELVHT YKGCIRSQDC YSGVISTTMG PKDHMVTSSF CCQSDGCNSA FLSVPLTNLT 130 140 150 160 170 180 ENGLMCPACT ASFRDKCMGP MTHCTGKENH CVSLSGHVQA GIFKPRFAMR GCATESMCFT 190 200 KPGAEVPTGT NVLFLHHIEC THSP
	Isoform 2 [UniParc]. Checksum: 82895DEA7AAE8DB9	FASTA	228	24,540
	10 20 30 40 50 60 MWVQTHPSSA SYKSWGPGTA DTHTMRLSRR PETFLLAFVL LCTLLGLGCP LHCEICTAAG 70 80 90 100 110 120 SRCHGQMKTC SSDKDTCVLL VGKATSKGKE LVHTYKGCIR SQDCYSGVIS TTMGPKDHMV 130 140 150 160 170 180 TSSFCCQSDG CNSAFLSVPL TNLTENGLMC PACTASFRDK CMGPMTHCTG KENHCVSLSG 190 200 210 220 HVQAGIFKPR FAMRGCATES MCFTKPGAEV PTGTNVLFLH HIECTHSP
	Isoform 3 [UniParc]. Checksum: 11F7FCFB4FCF1654	FASTA	143	15,970
	10 20 30 40 50 60 MWVQTHPSSA SYKSWGPGTA DTHTMRLSRR PETFLLAFVL LCTLLGLGCP LHCEICTAAG 70 80 90 100 110 120 SRCHGQMKTC SSDKDTCVLL VGKATSSKRM WPGTWWGGGV YLQGGRDYHA EGGSSRFSRR 130 140 ERGKKSVESR KEGKTIMRWR EQK
	Isoform 4 [UniParc]. Checksum: CD43B93395A3E824	FASTA	116	12,429
	10 20 30 40 50 60 MGPKDHMVTS SFCCQSDGCN SAFLSVPLTN LTENGLMCPA CTASFRDKCM GPMTHCTGKE 70 80 90 100 110 NHCVSLSGHV QAGIFKPRFA MRGCATESMC FTKPGAEVPT GTNVLFLHHI ECTHSP

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Tongue.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK296854 mRNA. Translation: BAH12443.1. AC006276 Genomic DNA. Translation: AAC99796.1. Sequence problems. L34079 Genomic DNA. No translation available. BC071811 mRNA. No translation available.
IPI	IPI00983701.
RefSeq	NP_001180550.1. NM_001193621.1. NP_001180551.1. NM_001193622.1.
UniGene	Hs.22049.
3D structure databases
ProteinModelPortal	A6NC86.
SMR	A6NC86. Positions 22-186.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000244321.
Proteomic databases
PaxDb	A6NC86.
PRIDE	A6NC86.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000562255; ENSP00000457623; ENSG00000234465. ENST00000562365; ENSP00000456310; ENSG00000234465. ENST00000569031; ENSP00000457369; ENSG00000234465. ENST00000599207; ENSP00000469886; ENSG00000234465.
GeneID	390940.
KEGG	hsa:390940.
UCSC	uc002owu.2. human.
Organism-specific databases
CTD	390940.
GeneCards	GC19P044080.
HGNC	HGNC:44206. PINLYP.
neXtProt	NX_A6NC86.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG42561.
HOGENOM	HOG000060192.
HOVERGEN	HBG108748.
OrthoDB	EOG4Q2DGF.
Gene expression databases
ArrayExpress	A6NC86.
Bgee	A6NC86.
Genevestigator	A6NC86.
Family and domain databases
InterPro	IPR016054. LY6_UPA_recep-like. IPR001526. LY6_UPAR. IPR004126. PLipase_A2_inh. [Graphical view]
Pfam	PF02988. PLA2_inh. 1 hit. PF00021. UPAR_LY6. 1 hit. [Graphical view]
SMART	SM00134. LU. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	390940.
NextBio	104176.

Entry information

Entry name

PINLY_HUMAN

Accession

Primary (citable) accession number: A6NC86
Secondary accession number(s): B7Z457, O95053

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	May 1, 2013
This is version 44 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.