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A6NC86

- PINLY_HUMAN

UniProt

A6NC86 - PINLY_HUMAN

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Protein

phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein

Gene

PINLYP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. phospholipase inhibitor activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein
Gene namesi
Name:PINLYP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:44206. PINLYP.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 204178phospholipase A2 inhibitor and Ly6/PLAUR domain-containing proteinPRO_0000332737Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 53By similarity
Disulfide bondi32 ↔ 39By similarity
Disulfide bondi46 ↔ 74By similarity
Disulfide bondi80 ↔ 101By similarity
Disulfide bondi102 ↔ 107By similarity
Disulfide bondi126 ↔ 151By similarity
Disulfide bondi144 ↔ 172By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiA6NC86.
PRIDEiA6NC86.

Expressioni

Gene expression databases

BgeeiA6NC86.
GenevestigatoriA6NC86.

Organism-specific databases

HPAiHPA061218.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000244321.

Structurei

3D structure databases

ProteinModelPortaliA6NC86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 11791UPAR/Ly6Add
BLAST

Sequence similaritiesi

Belongs to the CNF-like-inhibitor family.Curated
Contains 1 UPAR/Ly6 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42561.
GeneTreeiENSGT00730000111229.
HOGENOMiHOG000060192.
HOVERGENiHBG108748.
InParanoidiA6NC86.
OMAiACIAPFQ.
OrthoDBiEOG771285.
PhylomeDBiA6NC86.

Family and domain databases

InterProiIPR016054. LY6_UPA_recep-like.
IPR001526. LY6_UPAR.
IPR004126. PLipase_A2_inh.
[Graphical view]
PfamiPF02988. PLA2_inh. 1 hit.
PF00021. UPAR_LY6. 1 hit.
[Graphical view]
SMARTiSM00134. LU. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A6NC86-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLSRRPETF LLAFVLLCTL LGLGCPLHCE ICTAAGSRCH GQMKTCSSDK
60 70 80 90 100
DTCVLLVGKA TSKGKELVHT YKGCIRSQDC YSGVISTTMG PKDHMVTSSF
110 120 130 140 150
CCQSDGCNSA FLSVPLTNLT ENGLMCPACT ASFRDKCMGP MTHCTGKENH
160 170 180 190 200
CVSLSGHVQA GIFKPRFAMR GCATESMCFT KPGAEVPTGT NVLFLHHIEC

THSP
Length:204
Mass (Da):21,926
Last modified:April 29, 2008 - v3
Checksum:i9F49DFAF0AFB9868
GO
Isoform 2 (identifier: A6NC86-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MWVQTHPSSASYKSWGPGTADTHTM

Note: No experimental confirmation available.

Show »
Length:228
Mass (Da):24,540
Checksum:i82895DEA7AAE8DB9
GO
Isoform 3 (identifier: A6NC86-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MWVQTHPSSASYKSWGPGTADTHTM
     63-204: KGKELVHTYK...LHHIECTHSP → SKRMWPGTWW...KTIMRWREQK

Note: No experimental confirmation available.Curated

Show »
Length:143
Mass (Da):15,970
Checksum:i11F7FCFB4FCF1654
GO
Isoform 4 (identifier: A6NC86-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.

Note: No experimental confirmation available.

Show »
Length:116
Mass (Da):12,429
Checksum:iCD43B93395A3E824
GO

Sequence cautioni

The sequence AAC99796.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform 3 (identifier: A6NC86-3)
Sequence conflicti6 – 61H → R in BAH12443. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8888Missing in isoform 4. 1 PublicationVSP_044188Add
BLAST
Alternative sequencei1 – 11M → MWVQTHPSSASYKSWGPGTA DTHTM in isoform 2 and isoform 3. 1 PublicationVSP_044189
Alternative sequencei63 – 204142KGKEL…CTHSP → SKRMWPGTWWGGGVYLQGGR DYHAEGGSSRFSRRERGKKS VESRKEGKTIMRWREQK in isoform 3. 1 PublicationVSP_044190Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK296854 mRNA. Translation: BAH12443.1.
AC006276 Genomic DNA. Translation: AAC99796.1. Sequence problems.
L34079 Genomic DNA. No translation available.
BC071811 mRNA. No translation available.
CCDSiCCDS58667.1. [A6NC86-4]
CCDS74385.1. [A6NC86-2]
RefSeqiNP_001180550.1. NM_001193621.1. [A6NC86-2]
NP_001180551.1. NM_001193622.1. [A6NC86-4]
XP_005258988.1. XM_005258931.1. [A6NC86-4]
UniGeneiHs.22049.

Genome annotation databases

EnsembliENST00000562255; ENSP00000457623; ENSG00000234465. [A6NC86-4]
ENST00000562365; ENSP00000456310; ENSG00000234465. [A6NC86-4]
ENST00000569031; ENSP00000457369; ENSG00000234465. [A6NC86-4]
ENST00000599207; ENSP00000469886; ENSG00000234465. [A6NC86-1]
ENST00000612042; ENSP00000479240; ENSG00000234465. [A6NC86-2]
GeneIDi390940.
KEGGihsa:390940.
UCSCiuc002owu.2. human. [A6NC86-1]
uc021uvg.1. human. [A6NC86-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK296854 mRNA. Translation: BAH12443.1 .
AC006276 Genomic DNA. Translation: AAC99796.1 . Sequence problems.
L34079 Genomic DNA. No translation available.
BC071811 mRNA. No translation available.
CCDSi CCDS58667.1. [A6NC86-4 ]
CCDS74385.1. [A6NC86-2 ]
RefSeqi NP_001180550.1. NM_001193621.1. [A6NC86-2 ]
NP_001180551.1. NM_001193622.1. [A6NC86-4 ]
XP_005258988.1. XM_005258931.1. [A6NC86-4 ]
UniGenei Hs.22049.

3D structure databases

ProteinModelPortali A6NC86.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000244321.

Proteomic databases

PaxDbi A6NC86.
PRIDEi A6NC86.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000562255 ; ENSP00000457623 ; ENSG00000234465 . [A6NC86-4 ]
ENST00000562365 ; ENSP00000456310 ; ENSG00000234465 . [A6NC86-4 ]
ENST00000569031 ; ENSP00000457369 ; ENSG00000234465 . [A6NC86-4 ]
ENST00000599207 ; ENSP00000469886 ; ENSG00000234465 . [A6NC86-1 ]
ENST00000612042 ; ENSP00000479240 ; ENSG00000234465 . [A6NC86-2 ]
GeneIDi 390940.
KEGGi hsa:390940.
UCSCi uc002owu.2. human. [A6NC86-1 ]
uc021uvg.1. human. [A6NC86-2 ]

Organism-specific databases

CTDi 390940.
GeneCardsi GC19P044083.
HGNCi HGNC:44206. PINLYP.
HPAi HPA061218.
neXtProti NX_A6NC86.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42561.
GeneTreei ENSGT00730000111229.
HOGENOMi HOG000060192.
HOVERGENi HBG108748.
InParanoidi A6NC86.
OMAi ACIAPFQ.
OrthoDBi EOG771285.
PhylomeDBi A6NC86.

Miscellaneous databases

GenomeRNAii 390940.
NextBioi 104176.
PROi A6NC86.

Gene expression databases

Bgeei A6NC86.
Genevestigatori A6NC86.

Family and domain databases

InterProi IPR016054. LY6_UPA_recep-like.
IPR001526. LY6_UPAR.
IPR004126. PLipase_A2_inh.
[Graphical view ]
Pfami PF02988. PLA2_inh. 1 hit.
PF00021. UPAR_LY6. 1 hit.
[Graphical view ]
SMARTi SM00134. LU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Tongue.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).

Entry informationi

Entry nameiPINLY_HUMAN
AccessioniPrimary (citable) accession number: A6NC86
Secondary accession number(s): B7Z457, O95053
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: October 29, 2014
This is version 58 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3