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A6NC86 (PINLY_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein
Gene names
Name:PINLYP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length204 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the CNF-like-inhibitor family.

Contains 1 UPAR/Ly6 domain.

Sequence caution

The sequence AAC99796.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DomainSignal
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphospholipase inhibitor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A6NC86-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A6NC86-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MWVQTHPSSASYKSWGPGTADTHTM
Note: No experimental confirmation available.
Isoform 3 (identifier: A6NC86-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MWVQTHPSSASYKSWGPGTADTHTM
     63-204: KGKELVHTYK...LHHIECTHSP → SKRMWPGTWW...KTIMRWREQK
Note: No experimental confirmation available.
Isoform 4 (identifier: A6NC86-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 204178phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein
PRO_0000332737

Regions

Domain27 – 11791UPAR/Ly6

Amino acid modifications

Disulfide bond29 ↔ 53 By similarity
Disulfide bond32 ↔ 39 By similarity
Disulfide bond46 ↔ 74 By similarity
Disulfide bond80 ↔ 101 By similarity
Disulfide bond102 ↔ 107 By similarity
Disulfide bond126 ↔ 151 By similarity
Disulfide bond144 ↔ 172 By similarity

Natural variations

Alternative sequence1 – 8888Missing in isoform 4.
VSP_044188
Alternative sequence11M → MWVQTHPSSASYKSWGPGTA DTHTM in isoform 2 and isoform 3.
VSP_044189
Alternative sequence63 – 204142KGKEL…CTHSP → SKRMWPGTWWGGGVYLQGGR DYHAEGGSSRFSRRERGKKS VESRKEGKTIMRWREQK in isoform 3.
VSP_044190

Experimental info

Isoform 3:
Sequence conflict61H → R in BAH12443. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 29, 2008. Version 3.
Checksum: 9F49DFAF0AFB9868

FASTA20421,926
        10         20         30         40         50         60 
MRLSRRPETF LLAFVLLCTL LGLGCPLHCE ICTAAGSRCH GQMKTCSSDK DTCVLLVGKA 

        70         80         90        100        110        120 
TSKGKELVHT YKGCIRSQDC YSGVISTTMG PKDHMVTSSF CCQSDGCNSA FLSVPLTNLT 

       130        140        150        160        170        180 
ENGLMCPACT ASFRDKCMGP MTHCTGKENH CVSLSGHVQA GIFKPRFAMR GCATESMCFT 

       190        200 
KPGAEVPTGT NVLFLHHIEC THSP 

« Hide

Isoform 2 [UniParc].

Checksum: 82895DEA7AAE8DB9
Show »

FASTA22824,540
Isoform 3 [UniParc].

Checksum: 11F7FCFB4FCF1654
Show »

FASTA14315,970
Isoform 4 [UniParc].

Checksum: CD43B93395A3E824
Show »

FASTA11612,429

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Tongue.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK296854 mRNA. Translation: BAH12443.1.
AC006276 Genomic DNA. Translation: AAC99796.1. Sequence problems.
L34079 Genomic DNA. No translation available.
BC071811 mRNA. No translation available.
CCDSCCDS58667.1. [A6NC86-4]
RefSeqNP_001180550.1. NM_001193621.1. [A6NC86-2]
NP_001180551.1. NM_001193622.1. [A6NC86-4]
XP_005258988.1. XM_005258931.1. [A6NC86-4]
UniGeneHs.22049.

3D structure databases

ProteinModelPortalA6NC86.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000244321.

Proteomic databases

PaxDbA6NC86.
PRIDEA6NC86.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000562255; ENSP00000457623; ENSG00000234465. [A6NC86-4]
ENST00000562365; ENSP00000456310; ENSG00000234465. [A6NC86-4]
ENST00000569031; ENSP00000457369; ENSG00000234465. [A6NC86-4]
ENST00000599207; ENSP00000469886; ENSG00000234465. [A6NC86-1]
GeneID390940.
KEGGhsa:390940.
UCSCuc002owu.2. human. [A6NC86-1]
uc021uvg.1. human. [A6NC86-2]

Organism-specific databases

CTD390940.
GeneCardsGC19P044083.
HGNCHGNC:44206. PINLYP.
HPAHPA061218.
neXtProtNX_A6NC86.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42561.
HOGENOMHOG000060192.
HOVERGENHBG108748.
OMAACIAPFQ.
OrthoDBEOG771285.
PhylomeDBA6NC86.

Gene expression databases

BgeeA6NC86.
GenevestigatorA6NC86.

Family and domain databases

InterProIPR016054. LY6_UPA_recep-like.
IPR001526. LY6_UPAR.
IPR004126. PLipase_A2_inh.
[Graphical view]
PfamPF02988. PLA2_inh. 1 hit.
PF00021. UPAR_LY6. 1 hit.
[Graphical view]
SMARTSM00134. LU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi390940.
NextBio104176.
PROA6NC86.

Entry information

Entry namePINLY_HUMAN
AccessionPrimary (citable) accession number: A6NC86
Secondary accession number(s): B7Z457, O95053
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: July 9, 2014
This is version 56 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM