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A6NC86

- PINLY_HUMAN

UniProt

A6NC86 - PINLY_HUMAN

Protein

phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein

Gene

PINLYP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 3 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. phospholipase inhibitor activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein
    Gene namesi
    Name:PINLYP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:44206. PINLYP.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 204178phospholipase A2 inhibitor and Ly6/PLAUR domain-containing proteinPRO_0000332737Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi29 ↔ 53By similarity
    Disulfide bondi32 ↔ 39By similarity
    Disulfide bondi46 ↔ 74By similarity
    Disulfide bondi80 ↔ 101By similarity
    Disulfide bondi102 ↔ 107By similarity
    Disulfide bondi126 ↔ 151By similarity
    Disulfide bondi144 ↔ 172By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiA6NC86.
    PRIDEiA6NC86.

    Expressioni

    Gene expression databases

    BgeeiA6NC86.
    GenevestigatoriA6NC86.

    Organism-specific databases

    HPAiHPA061218.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000244321.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NC86.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 11791UPAR/Ly6Add
    BLAST

    Sequence similaritiesi

    Belongs to the CNF-like-inhibitor family.Curated
    Contains 1 UPAR/Ly6 domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42561.
    HOGENOMiHOG000060192.
    HOVERGENiHBG108748.
    OMAiACIAPFQ.
    OrthoDBiEOG771285.
    PhylomeDBiA6NC86.

    Family and domain databases

    InterProiIPR016054. LY6_UPA_recep-like.
    IPR001526. LY6_UPAR.
    IPR004126. PLipase_A2_inh.
    [Graphical view]
    PfamiPF02988. PLA2_inh. 1 hit.
    PF00021. UPAR_LY6. 1 hit.
    [Graphical view]
    SMARTiSM00134. LU. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A6NC86-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRLSRRPETF LLAFVLLCTL LGLGCPLHCE ICTAAGSRCH GQMKTCSSDK    50
    DTCVLLVGKA TSKGKELVHT YKGCIRSQDC YSGVISTTMG PKDHMVTSSF 100
    CCQSDGCNSA FLSVPLTNLT ENGLMCPACT ASFRDKCMGP MTHCTGKENH 150
    CVSLSGHVQA GIFKPRFAMR GCATESMCFT KPGAEVPTGT NVLFLHHIEC 200
    THSP 204
    Length:204
    Mass (Da):21,926
    Last modified:April 29, 2008 - v3
    Checksum:i9F49DFAF0AFB9868
    GO
    Isoform 2 (identifier: A6NC86-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MWVQTHPSSASYKSWGPGTADTHTM

    Note: No experimental confirmation available.

    Show »
    Length:228
    Mass (Da):24,540
    Checksum:i82895DEA7AAE8DB9
    GO
    Isoform 3 (identifier: A6NC86-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MWVQTHPSSASYKSWGPGTADTHTM
         63-204: KGKELVHTYK...LHHIECTHSP → SKRMWPGTWW...KTIMRWREQK

    Note: No experimental confirmation available.Curated

    Show »
    Length:143
    Mass (Da):15,970
    Checksum:i11F7FCFB4FCF1654
    GO
    Isoform 4 (identifier: A6NC86-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-88: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:116
    Mass (Da):12,429
    Checksum:iCD43B93395A3E824
    GO

    Sequence cautioni

    The sequence AAC99796.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Isoform 3 (identifier: A6NC86-3)
    Sequence conflicti6 – 61H → R in BAH12443. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8888Missing in isoform 4. 1 PublicationVSP_044188Add
    BLAST
    Alternative sequencei1 – 11M → MWVQTHPSSASYKSWGPGTA DTHTM in isoform 2 and isoform 3. 1 PublicationVSP_044189
    Alternative sequencei63 – 204142KGKEL…CTHSP → SKRMWPGTWWGGGVYLQGGR DYHAEGGSSRFSRRERGKKS VESRKEGKTIMRWREQK in isoform 3. 1 PublicationVSP_044190Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK296854 mRNA. Translation: BAH12443.1.
    AC006276 Genomic DNA. Translation: AAC99796.1. Sequence problems.
    L34079 Genomic DNA. No translation available.
    BC071811 mRNA. No translation available.
    CCDSiCCDS58667.1. [A6NC86-4]
    RefSeqiNP_001180550.1. NM_001193621.1. [A6NC86-2]
    NP_001180551.1. NM_001193622.1. [A6NC86-4]
    XP_005258988.1. XM_005258931.1. [A6NC86-4]
    UniGeneiHs.22049.

    Genome annotation databases

    EnsembliENST00000562255; ENSP00000457623; ENSG00000234465. [A6NC86-4]
    ENST00000562365; ENSP00000456310; ENSG00000234465. [A6NC86-4]
    ENST00000569031; ENSP00000457369; ENSG00000234465. [A6NC86-4]
    ENST00000599207; ENSP00000469886; ENSG00000234465. [A6NC86-1]
    GeneIDi390940.
    KEGGihsa:390940.
    UCSCiuc002owu.2. human. [A6NC86-1]
    uc021uvg.1. human. [A6NC86-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK296854 mRNA. Translation: BAH12443.1 .
    AC006276 Genomic DNA. Translation: AAC99796.1 . Sequence problems.
    L34079 Genomic DNA. No translation available.
    BC071811 mRNA. No translation available.
    CCDSi CCDS58667.1. [A6NC86-4 ]
    RefSeqi NP_001180550.1. NM_001193621.1. [A6NC86-2 ]
    NP_001180551.1. NM_001193622.1. [A6NC86-4 ]
    XP_005258988.1. XM_005258931.1. [A6NC86-4 ]
    UniGenei Hs.22049.

    3D structure databases

    ProteinModelPortali A6NC86.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000244321.

    Proteomic databases

    PaxDbi A6NC86.
    PRIDEi A6NC86.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000562255 ; ENSP00000457623 ; ENSG00000234465 . [A6NC86-4 ]
    ENST00000562365 ; ENSP00000456310 ; ENSG00000234465 . [A6NC86-4 ]
    ENST00000569031 ; ENSP00000457369 ; ENSG00000234465 . [A6NC86-4 ]
    ENST00000599207 ; ENSP00000469886 ; ENSG00000234465 . [A6NC86-1 ]
    GeneIDi 390940.
    KEGGi hsa:390940.
    UCSCi uc002owu.2. human. [A6NC86-1 ]
    uc021uvg.1. human. [A6NC86-2 ]

    Organism-specific databases

    CTDi 390940.
    GeneCardsi GC19P044083.
    HGNCi HGNC:44206. PINLYP.
    HPAi HPA061218.
    neXtProti NX_A6NC86.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42561.
    HOGENOMi HOG000060192.
    HOVERGENi HBG108748.
    OMAi ACIAPFQ.
    OrthoDBi EOG771285.
    PhylomeDBi A6NC86.

    Miscellaneous databases

    GenomeRNAii 390940.
    NextBioi 104176.
    PROi A6NC86.

    Gene expression databases

    Bgeei A6NC86.
    Genevestigatori A6NC86.

    Family and domain databases

    InterProi IPR016054. LY6_UPA_recep-like.
    IPR001526. LY6_UPAR.
    IPR004126. PLipase_A2_inh.
    [Graphical view ]
    Pfami PF02988. PLA2_inh. 1 hit.
    PF00021. UPAR_LY6. 1 hit.
    [Graphical view ]
    SMARTi SM00134. LU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Tongue.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).

    Entry informationi

    Entry nameiPINLY_HUMAN
    AccessioniPrimary (citable) accession number: A6NC86
    Secondary accession number(s): B7Z457, O95053
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 57 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3