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Protein

phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein

Gene

PINLYP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein
Gene namesi
Name:PINLYP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000234465.10
HGNCiHGNC:44206 PINLYP
neXtProtiNX_A6NC86

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000234465

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000033273727 – 204phospholipase A2 inhibitor and Ly6/PLAUR domain-containing proteinAdd BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 53By similarity
Disulfide bondi32 ↔ 39By similarity
Disulfide bondi46 ↔ 74By similarity
Disulfide bondi80 ↔ 101By similarity
Disulfide bondi102 ↔ 107By similarity
Disulfide bondi126 ↔ 151By similarity
Disulfide bondi144 ↔ 172By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiA6NC86
PRIDEiA6NC86

PTM databases

iPTMnetiA6NC86
PhosphoSitePlusiA6NC86

Expressioni

Gene expression databases

BgeeiENSG00000234465
GenevisibleiA6NC86 HS

Organism-specific databases

HPAiHPA061218

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000469886

Structurei

3D structure databases

ProteinModelPortaliA6NC86
SMRiA6NC86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 117UPAR/Ly6Add BLAST91

Sequence similaritiesi

Belongs to the CNF-like-inhibitor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IG64 Eukaryota
ENOG410Y3IY LUCA
GeneTreeiENSGT00730000111229
HOGENOMiHOG000060192
HOVERGENiHBG108748
InParanoidiA6NC86
OMAiKFATRGC
OrthoDBiEOG091G0MU9
PhylomeDBiA6NC86

Family and domain databases

InterProiView protein in InterPro
IPR016054 LY6_UPA_recep-like
IPR004126 PLipase_A2_inh
PfamiView protein in Pfam
PF02988 PLA2_inh, 1 hit
PF00021 UPAR_LY6, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NC86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLSRRPETF LLAFVLLCTL LGLGCPLHCE ICTAAGSRCH GQMKTCSSDK
60 70 80 90 100
DTCVLLVGKA TSKGKELVHT YKGCIRSQDC YSGVISTTMG PKDHMVTSSF
110 120 130 140 150
CCQSDGCNSA FLSVPLTNLT ENGLMCPACT ASFRDKCMGP MTHCTGKENH
160 170 180 190 200
CVSLSGHVQA GIFKPRFAMR GCATESMCFT KPGAEVPTGT NVLFLHHIEC

THSP
Length:204
Mass (Da):21,926
Last modified:April 29, 2008 - v3
Checksum:i9F49DFAF0AFB9868
GO
Isoform 2 (identifier: A6NC86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MWVQTHPSSASYKSWGPGTADTHTM

Note: No experimental confirmation available.
Show »
Length:228
Mass (Da):24,540
Checksum:i82895DEA7AAE8DB9
GO
Isoform 3 (identifier: A6NC86-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MWVQTHPSSASYKSWGPGTADTHTM
     63-204: KGKELVHTYK...LHHIECTHSP → SKRMWPGTWW...KTIMRWREQK

Note: No experimental confirmation available.Curated
Show »
Length:143
Mass (Da):15,970
Checksum:i11F7FCFB4FCF1654
GO
Isoform 4 (identifier: A6NC86-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.

Note: No experimental confirmation available.
Show »
Length:116
Mass (Da):12,429
Checksum:iCD43B93395A3E824
GO

Sequence cautioni

The sequence AAC99796 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 3 (identifier: A6NC86-3)
Sequence conflicti6H → R in BAH12443 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0441881 – 88Missing in isoform 4. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_0441891M → MWVQTHPSSASYKSWGPGTA DTHTM in isoform 2 and isoform 3. 1 Publication1
Alternative sequenceiVSP_04419063 – 204KGKEL…CTHSP → SKRMWPGTWWGGGVYLQGGR DYHAEGGSSRFSRRERGKKS VESRKEGKTIMRWREQK in isoform 3. 1 PublicationAdd BLAST142

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296854 mRNA Translation: BAH12443.1
AC006276 Genomic DNA Translation: AAC99796.1 Sequence problems.
L34079 Genomic DNA No translation available.
BC071811 mRNA No translation available.
CCDSiCCDS58667.1 [A6NC86-4]
CCDS74385.1 [A6NC86-2]
RefSeqiNP_001180550.1, NM_001193621.1 [A6NC86-2]
NP_001180551.1, NM_001193622.1 [A6NC86-4]
NP_001308053.1, NM_001321124.1 [A6NC86-4]
XP_011525272.1, XM_011526970.2 [A6NC86-2]
XP_011525273.1, XM_011526971.2 [A6NC86-4]
UniGeneiHs.22049

Genome annotation databases

EnsembliENST00000562255; ENSP00000457623; ENSG00000234465 [A6NC86-4]
ENST00000562365; ENSP00000456310; ENSG00000234465 [A6NC86-4]
ENST00000569031; ENSP00000457369; ENSG00000234465 [A6NC86-4]
ENST00000599207; ENSP00000469886; ENSG00000234465 [A6NC86-1]
ENST00000612042; ENSP00000479240; ENSG00000234465 [A6NC86-2]
GeneIDi390940
KEGGihsa:390940
UCSCiuc002owu.3 human [A6NC86-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPINLY_HUMAN
AccessioniPrimary (citable) accession number: A6NC86
Secondary accession number(s): B7Z457, O95053
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: March 28, 2018
This is version 77 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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