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Protein

Ankyrin repeat domain-containing protein 62

Gene

ANKRD62

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 62
Gene namesi
Name:ANKRD62
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:35241. ANKRD62.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 917917Ankyrin repeat domain-containing protein 62PRO_0000328818Add
BLAST

Proteomic databases

EPDiA6NC57.
PaxDbiA6NC57.
PRIDEiA6NC57.

PTM databases

iPTMnetiA6NC57.
PhosphoSiteiA6NC57.

Expressioni

Gene expression databases

BgeeiENSG00000181626.

Organism-specific databases

HPAiHPA059835.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000326572.

Structurei

3D structure databases

ProteinModelPortaliA6NC57.
SMRiA6NC57. Positions 42-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati71 – 10030ANK 1Add
BLAST
Repeati104 – 13330ANK 2Add
BLAST
Repeati137 – 16630ANK 3Add
BLAST
Repeati170 – 19930ANK 4Add
BLAST
Repeati203 – 23230ANK 5Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili439 – 669231Sequence analysisAdd
BLAST
Coiled coili778 – 906129Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 5 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000033957.
InParanoidiA6NC57.
OMAiEQDLEMT.
OrthoDBiEOG091G077A.
PhylomeDBiA6NC57.
TreeFamiTF333496.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF13606. Ank_3. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NC57-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVRGSFLAA CRRRMATWRK NRDKDGFSNP GYRVRQKDLG MIHKAAIAGD
60 70 80 90 100
VNKVMESILL RLNDLNDRDK KNRTALLLAC AHGRPGVVAD LVARKCQLNL
110 120 130 140 150
TDSENRTALI KAVQCQEEVC ASILLEHGAN PNVRDMYGNT ALHYAIDNEN
160 170 180 190 200
ISMARKLLAY GADIEARSQD GHTSLLLAVN RKKEQMVAFL LKKKPDLTAI
210 220 230 240 250
DNFGRTALIL AARNGSTSVV YQLLQHNIDV FCQDISGWTA EDYAVASKFQ
260 270 280 290 300
AIRGMISEYK ANKRCKSLQN SNSEQDLEMT SEGEQERLEG CESSQPQVEE
310 320 330 340 350
KMKKCRNKKM EVSRNVHADD SDNYNDDVDE LIHKIKNRKP DNHQSPGKEN
360 370 380 390 400
GEFDRLARKT SNEKSKVKSQ IYFTDDLNDI SGSSEKTSED DELPYSDDEN
410 420 430 440 450
FMLLIEQSGM ECKDFVSLSK SKNATAACGR SIEDQKCYCE RLKVKFQKMK
460 470 480 490 500
NNISVLQKVL SETDKTKSQS EHQNLQGKKK LCNLRFILQQ QEEERIKAEE
510 520 530 540 550
LYEKDIEELK IMEEQYRTQT EVKKQSKLTL KSLEVELKTV RSNSNQNFHT
560 570 580 590 600
HERERDLWQE NHLMRDEIAR LRLEIDTIKH QNQETENKYF KDIEIIKENN
610 620 630 640 650
EDLEKTLKRN EEALTKTITR YSKELNVLMD ENTMLNSELQ KEKQSMSRLE
660 670 680 690 700
TEMESYRCRL AAALCDHDQR QSSKRDLQLA FQSTVNEWCH LQEDTNSHIQ
710 720 730 740 750
ILSQQLSKAE STSSGLETEL HYEREALKEK TLHIEHMQGV LSRTQRRLED
760 770 780 790 800
IEHMYQNDQP ILEKYVRKQQ SVEDGLFQLQ SQNLLYQQQC NDARKKADNQ
810 820 830 840 850
EKTIINIQVK CEDTVEKLQA ECRKLEENNK GLMKECTLLK ERQCQYEKEK
860 870 880 890 900
EEREVVRRQL QREVDDALNK QLLLEAMLEI SSERRINLED EAQSLKKKLG
910
QMRSQVCMKL SMSTVTL
Length:917
Mass (Da):106,446
Last modified:August 10, 2010 - v4
Checksum:i9D595F409A828860
GO
Isoform 2 (identifier: A6NC57-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-278: Missing.

Note: No experimental confirmation available.
Show »
Length:639
Mass (Da):75,410
Checksum:iFC551184EC6CCF65
GO

Sequence cautioni

The sequence BX649021 differs from that shown. Reason: Erroneous termination at position 558. Translated as Trp.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti291 – 2911C → R in BX649021 (PubMed:17974005).Curated
Sequence conflicti383 – 3831S → P in BX649021 (PubMed:17974005).Curated
Sequence conflicti434 – 4341D → G in BX649021 (PubMed:17974005).Curated
Sequence conflicti481 – 4811L → H in BX649021 (PubMed:17974005).Curated
Sequence conflicti599 – 5991N → S in BX649021 (PubMed:17974005).Curated
Sequence conflicti666 – 6661D → G in BX649021 (PubMed:17974005).Curated
Sequence conflicti829 – 8291N → D in BX649021 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti188 – 1881A → S.
Corresponds to variant rs1986751 [ dbSNP | Ensembl ].
VAR_042527
Natural varianti265 – 2651C → R.
Corresponds to variant rs6505715 [ dbSNP | Ensembl ].
VAR_042528
Natural varianti406 – 4061E → K.1 Publication
Corresponds to variant rs4519391 [ dbSNP | Ensembl ].
VAR_042529
Natural varianti613 – 6131A → T.1 Publication
Corresponds to variant rs7243248 [ dbSNP | Ensembl ].
VAR_042530

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 278278Missing in isoform 2. 1 PublicationVSP_032799Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX649021 mRNA. No translation available.
AP002414 Genomic DNA. No translation available.
CCDSiCCDS67439.1. [A6NC57-1]
RefSeqiNP_001264262.1. NM_001277333.1. [A6NC57-1]
UniGeneiHs.448906.

Genome annotation databases

EnsembliENST00000587848; ENSP00000467740; ENSG00000181626. [A6NC57-1]
GeneIDi342850.
KEGGihsa:342850.
UCSCiuc031rhk.2. human. [A6NC57-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX649021 mRNA. No translation available.
AP002414 Genomic DNA. No translation available.
CCDSiCCDS67439.1. [A6NC57-1]
RefSeqiNP_001264262.1. NM_001277333.1. [A6NC57-1]
UniGeneiHs.448906.

3D structure databases

ProteinModelPortaliA6NC57.
SMRiA6NC57. Positions 42-288.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000326572.

PTM databases

iPTMnetiA6NC57.
PhosphoSiteiA6NC57.

Proteomic databases

EPDiA6NC57.
PaxDbiA6NC57.
PRIDEiA6NC57.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000587848; ENSP00000467740; ENSG00000181626. [A6NC57-1]
GeneIDi342850.
KEGGihsa:342850.
UCSCiuc031rhk.2. human. [A6NC57-1]

Organism-specific databases

CTDi342850.
GeneCardsiANKRD62.
H-InvDBHIX0027376.
HGNCiHGNC:35241. ANKRD62.
HPAiHPA059835.
neXtProtiNX_A6NC57.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000033957.
InParanoidiA6NC57.
OMAiEQDLEMT.
OrthoDBiEOG091G077A.
PhylomeDBiA6NC57.
TreeFamiTF333496.

Miscellaneous databases

GenomeRNAii342850.
PROiA6NC57.

Gene expression databases

BgeeiENSG00000181626.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF13606. Ank_3. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANR62_HUMAN
AccessioniPrimary (citable) accession number: A6NC57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: August 10, 2010
Last modified: September 7, 2016
This is version 83 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.