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Protein

Developmental pluripotency-associated 5 protein

Gene

DPPA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the maintenance of embryonic stem (ES) cell pluripotency. Dispensable for self-renewal of pluripotent ES cells and establishment of germ cells. Associates with specific target mRNAs (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Developmental pluripotency-associated 5 protein
Short name:
hDPPA5
Alternative name(s):
Embryonal stem cell-specific gene 1 protein
Short name:
ESG-1
Gene namesi
Name:DPPA5
Synonyms:ESG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:19201. DPPA5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134964500.

Polymorphism and mutation databases

BioMutaiDPPA5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 116116Developmental pluripotency-associated 5 proteinPRO_0000311975Add
BLAST

Proteomic databases

EPDiA6NC42.
PaxDbiA6NC42.
PRIDEiA6NC42.

PTM databases

PhosphoSiteiA6NC42.

Expressioni

Developmental stagei

Expressed in primordial germ (PGC), embryonic germ (EGC) and embryonic stem (ESC) cells. Not detected in embryonic carcinoma (ECC) cells.1 Publication

Inductioni

Down-regulated in differentiated embryonic stem (ESC) cells, compared with strong expression in undifferentiated ESC cells.1 Publication

Gene expression databases

BgeeiA6NC42.
CleanExiHS_DPPA5.
GenevisibleiA6NC42. HS.

Organism-specific databases

HPAiHPA064505.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000359396.

Structurei

3D structure databases

ProteinModelPortaliA6NC42.
SMRiA6NC42. Positions 10-94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 8462KH; atypicalAdd
BLAST

Sequence similaritiesi

Belongs to the KHDC1 family.Curated
Contains 1 KH domain.Curated

Phylogenomic databases

eggNOGiENOG410IZIS. Eukaryota.
ENOG4111AYN. LUCA.
GeneTreeiENSGT00390000011646.
HOGENOMiHOG000081506.
HOVERGENiHBG107820.
InParanoidiA6NC42.
OMAiYGNYLYK.
OrthoDBiEOG7B5WZ3.
PhylomeDBiA6NC42.
TreeFamiTF338690.

Family and domain databases

InterProiIPR004088. KH_dom_type_1.
IPR031952. MOEP19_KH-like.
[Graphical view]
PfamiPF16005. MOEP19. 1 hit.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NC42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTLPARRHI PPWVKVPEDL KDPEVFQVQT RLLKAIFGPD GSRIPYIEQV
60 70 80 90 100
SKAMLELKAL ESSDLTEVVV YGSYLYKLRT KWMLQSMAEW HRQRQERGML
110
KLAEAMNALE LGPWMK
Length:116
Mass (Da):13,498
Last modified:July 24, 2007 - v1
Checksum:iB143BAA8DC68D1BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC019205 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW48774.1.
BC137549 mRNA. Translation: AAI37550.1.
BC137558 mRNA. Translation: AAI37559.1.
CCDSiCCDS34483.1.
RefSeqiNP_001020461.1. NM_001025290.2.
UniGeneiHs.125331.

Genome annotation databases

EnsembliENST00000370370; ENSP00000359396; ENSG00000203909.
GeneIDi340168.
KEGGihsa:340168.
UCSCiuc003pgs.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC019205 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW48774.1.
BC137549 mRNA. Translation: AAI37550.1.
BC137558 mRNA. Translation: AAI37559.1.
CCDSiCCDS34483.1.
RefSeqiNP_001020461.1. NM_001025290.2.
UniGeneiHs.125331.

3D structure databases

ProteinModelPortaliA6NC42.
SMRiA6NC42. Positions 10-94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000359396.

PTM databases

PhosphoSiteiA6NC42.

Polymorphism and mutation databases

BioMutaiDPPA5.

Proteomic databases

EPDiA6NC42.
PaxDbiA6NC42.
PRIDEiA6NC42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370370; ENSP00000359396; ENSG00000203909.
GeneIDi340168.
KEGGihsa:340168.
UCSCiuc003pgs.3. human.

Organism-specific databases

CTDi340168.
GeneCardsiDPPA5.
H-InvDBHIX0026031.
HIX0057776.
HGNCiHGNC:19201. DPPA5.
HPAiHPA064505.
MIMi611111. gene.
neXtProtiNX_A6NC42.
PharmGKBiPA134964500.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZIS. Eukaryota.
ENOG4111AYN. LUCA.
GeneTreeiENSGT00390000011646.
HOGENOMiHOG000081506.
HOVERGENiHBG107820.
InParanoidiA6NC42.
OMAiYGNYLYK.
OrthoDBiEOG7B5WZ3.
PhylomeDBiA6NC42.
TreeFamiTF338690.

Miscellaneous databases

GenomeRNAii340168.
PROiA6NC42.
SOURCEiSearch...

Gene expression databases

BgeeiA6NC42.
CleanExiHS_DPPA5.
GenevisibleiA6NC42. HS.

Family and domain databases

InterProiIPR004088. KH_dom_type_1.
IPR031952. MOEP19_KH-like.
[Graphical view]
PfamiPF16005. MOEP19. 1 hit.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Identification of developmental pluripotency associated 5 expression in human pluripotent stem cells."
    Kim S.-K., Suh M.R., Yoon H.S., Lee J.B., Oh S.K., Moon S.-Y., Moon S.H., Lee J.Y., Hwang J.H., Cho W.J., Kim K.-S.
    Stem Cells 23:458-462(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, DEVELOPMENTAL STAGE.
  5. "Atypical structure and phylogenomic evolution of the new eutherian oocyte-and embryo-expressed KHDC1/DPPA5/ECAT1/OOEP gene family."
    Pierre A., Gautier M., Callebaut I., Bontoux M., Jeanpierre E., Pontarotti P., Monget P.
    Genomics 90:583-594(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiDPPA5_HUMAN
AccessioniPrimary (citable) accession number: A6NC42
Secondary accession number(s): B2RPQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 24, 2007
Last modified: July 6, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.