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Protein

Developmental pluripotency-associated 5 protein

Gene

DPPA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the maintenance of embryonic stem (ES) cell pluripotency. Dispensable for self-renewal of pluripotent ES cells and establishment of germ cells. Associates with specific target mRNAs (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Developmental pluripotency-associated 5 protein
Short name:
hDPPA5
Alternative name(s):
Embryonal stem cell-specific gene 1 protein
Short name:
ESG-1
Gene namesi
Name:DPPA5
Synonyms:ESG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000203909.3
HGNCiHGNC:19201 DPPA5
MIMi611111 gene
neXtProtiNX_A6NC42

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000203909
PharmGKBiPA134964500

Polymorphism and mutation databases

BioMutaiDPPA5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003119751 – 116Developmental pluripotency-associated 5 proteinAdd BLAST116

Proteomic databases

PaxDbiA6NC42
PRIDEiA6NC42
ProteomicsDBi798

PTM databases

PhosphoSitePlusiA6NC42

Expressioni

Developmental stagei

Expressed in primordial germ (PGC), embryonic germ (EGC) and embryonic stem (ESC) cells. Not detected in embryonic carcinoma (ECC) cells.1 Publication

Inductioni

Down-regulated in differentiated embryonic stem (ESC) cells, compared with strong expression in undifferentiated ESC cells.1 Publication

Gene expression databases

BgeeiENSG00000203909
CleanExiHS_DPPA5
GenevisibleiA6NC42 HS

Organism-specific databases

HPAiHPA064505

Interactioni

Protein-protein interaction databases

BioGridi131006, 1 interactor
STRINGi9606.ENSP00000359396

Structurei

3D structure databases

ProteinModelPortaliA6NC42
SMRiA6NC42
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 84KH; atypicalAdd BLAST62

Sequence similaritiesi

Belongs to the KHDC1 family.Curated

Phylogenomic databases

eggNOGiENOG410IZIS Eukaryota
ENOG4111AYN LUCA
GeneTreeiENSGT00390000011646
HOGENOMiHOG000081506
HOVERGENiHBG107820
InParanoidiA6NC42
OMAiIPPWVKP
OrthoDBiEOG091G0VPR
PhylomeDBiA6NC42
TreeFamiTF338690

Family and domain databases

CDDicd12795 FILIA_N_like, 1 hit
Gene3Di3.30.1370.10, 1 hit
InterProiView protein in InterPro
IPR036612 KH_dom_type_1_sf
IPR031952 MOEP19_KH-like
PfamiView protein in Pfam
PF16005 MOEP19, 1 hit
SUPFAMiSSF54791 SSF54791, 1 hit

Sequencei

Sequence statusi: Complete.

A6NC42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTLPARRHI PPWVKVPEDL KDPEVFQVQT RLLKAIFGPD GSRIPYIEQV
60 70 80 90 100
SKAMLELKAL ESSDLTEVVV YGSYLYKLRT KWMLQSMAEW HRQRQERGML
110
KLAEAMNALE LGPWMK
Length:116
Mass (Da):13,498
Last modified:July 24, 2007 - v1
Checksum:iB143BAA8DC68D1BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC019205 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48774.1
BC137549 mRNA Translation: AAI37550.1
BC137558 mRNA Translation: AAI37559.1
CCDSiCCDS34483.1
RefSeqiNP_001020461.1, NM_001025290.2
UniGeneiHs.125331

Genome annotation databases

EnsembliENST00000370370; ENSP00000359396; ENSG00000203909
GeneIDi340168
KEGGihsa:340168
UCSCiuc003pgs.3 human

Similar proteinsi

Entry informationi

Entry nameiDPPA5_HUMAN
AccessioniPrimary (citable) accession number: A6NC42
Secondary accession number(s): B2RPQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 24, 2007
Last modified: June 20, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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