ID YD286_HUMAN Reviewed; 138 AA. AC A6NC05; G3V557; DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot. DT 06-FEB-2013, sequence version 3. DT 27-MAR-2024, entry version 100. DE RecName: Full=Glutaredoxin-like protein C5orf63; GN Name=C5orf63; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RC TISSUE=Pancreatic islet; RA Melton D., Brown J., Kenty G., Permutt A., Lee C., Kaestner K., RA Lemishka I., Scearce M., Brestelli J., Gradwohl G., Clifton S., Hillier L., RA Marra M., Pape D., Wylie T., Martin J., Blistain A., Schmitt A., RA Theising B., Ritter E., Ronko I., Bennett J., Cardenas M., Gibbons M., RA McCann R., Cole R., Tsagareishvili R., Williams T., Jackson Y., Bowers Y.; RT "Endocrine pancreas consortium."; RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15372022; DOI=10.1038/nature02919; RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.; RT "The DNA sequence and comparative analysis of human chromosome 5."; RL Nature 431:268-274(2004). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=A6NC05-1; Sequence=Displayed; CC Name=2; CC IsoId=A6NC05-2; Sequence=VSP_044904; CC -!- SIMILARITY: Belongs to the glutaredoxin family. YDR286C subfamily. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BQ269742; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; AC004507; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC005915; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR CCDS; CCDS54895.1; -. [A6NC05-1] DR CCDS; CCDS54896.1; -. [A6NC05-2] DR RefSeq; NP_001157950.1; NM_001164478.1. [A6NC05-2] DR RefSeq; NP_001157951.1; NM_001164479.1. [A6NC05-1] DR AlphaFoldDB; A6NC05; -. DR SMR; A6NC05; -. DR BioGRID; 134974; 1. DR STRING; 9606.ENSP00000454153; -. DR iPTMnet; A6NC05; -. DR PhosphoSitePlus; A6NC05; -. DR BioMuta; C5orf63; -. DR MassIVE; A6NC05; -. DR PaxDb; 9606-ENSP00000454153; -. DR PeptideAtlas; A6NC05; -. DR ProteomicsDB; 33428; -. DR ProteomicsDB; 794; -. [A6NC05-1] DR Antibodypedia; 76266; 5 antibodies from 5 providers. DR DNASU; 401207; -. DR Ensembl; ENST00000296662.10; ENSP00000453964.1; ENSG00000164241.14. [A6NC05-2] DR Ensembl; ENST00000535381.6; ENSP00000454153.1; ENSG00000164241.14. [A6NC05-1] DR GeneID; 401207; -. DR KEGG; hsa:401207; -. DR MANE-Select; ENST00000296662.10; ENSP00000453964.1; NM_001164478.2; NP_001157950.1. [A6NC05-2] DR UCSC; uc021ydb.1; human. [A6NC05-1] DR AGR; HGNC:40051; -. DR CTD; 401207; -. DR DisGeNET; 401207; -. DR GeneCards; C5orf63; -. DR HGNC; HGNC:40051; C5orf63. DR HPA; ENSG00000164241; Low tissue specificity. DR neXtProt; NX_A6NC05; -. DR OpenTargets; ENSG00000164241; -. DR VEuPathDB; HostDB:ENSG00000164241; -. DR eggNOG; ENOG502S4BD; Eukaryota. DR GeneTree; ENSGT00390000014940; -. DR HOGENOM; CLU_1854541_0_0_1; -. DR InParanoid; A6NC05; -. DR OMA; FWFQGNS; -. DR OrthoDB; 3108502at2759; -. DR PhylomeDB; A6NC05; -. DR PathwayCommons; A6NC05; -. DR BioGRID-ORCS; 401207; 9 hits in 1107 CRISPR screens. DR ChiTaRS; C5orf63; human. DR GenomeRNAi; 401207; -. DR Pharos; A6NC05; Tdark. DR PRO; PR:A6NC05; -. DR Proteomes; UP000005640; Chromosome 5. DR RNAct; A6NC05; Protein. DR Bgee; ENSG00000164241; Expressed in tendon of biceps brachii and 160 other cell types or tissues. DR ExpressionAtlas; A6NC05; baseline and differential. DR Gene3D; 3.40.30.10; Glutaredoxin; 1. DR InterPro; IPR008554; Glutaredoxin-like. DR InterPro; IPR036249; Thioredoxin-like_sf. DR PANTHER; PTHR33558:SF2; GLUTAREDOXIN-LIKE PROTEIN C5ORF63; 1. DR PANTHER; PTHR33558; GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG; 1. DR Pfam; PF05768; Glrx-like; 1. DR SUPFAM; SSF52833; Thioredoxin-like; 1. DR Genevisible; A6NC05; HS. PE 2: Evidence at transcript level; KW Alternative splicing; Disulfide bond; Electron transport; KW Reference proteome; Transport. FT CHAIN 1..138 FT /note="Glutaredoxin-like protein C5orf63" FT /id="PRO_0000328756" FT REGION 55..88 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 55..69 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 70..88 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT DISULFID 41..44 FT /note="Redox-active" FT /evidence="ECO:0000250" FT VAR_SEQ 58..138 FT /note="QPYKDQKLPGTRRRRSPSSPSHPHMASQSGKRYNLTLNQVLSFDYDMGLDAP FT KTISSDCGAFYCLRMFKSPDMTCCFYPKQ -> FILQEVNITLPENSVWYERYKFDIPV FT FHLNGQFLMMHRVNTSKLEKQLLKLEQQSTGG (in isoform 2)" FT /evidence="ECO:0000305" FT /id="VSP_044904" SQ SEQUENCE 138 AA; 15764 MW; 20D0DF3CBEEDACEB CRC64; MLWFQGNSMQ LARSSFGLFL RNCSASKTTL PVLTLFTKDP CPLCDEAKEV LKPYENRQPY KDQKLPGTRR RRSPSSPSHP HMASQSGKRY NLTLNQVLSF DYDMGLDAPK TISSDCGAFY CLRMFKSPDM TCCFYPKQ //