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Protein

Glutaredoxin-like protein C5orf63

Gene

C5orf63

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaredoxin-like protein C5orf63
Gene namesi
Name:C5orf63
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164241.13.
HGNCiHGNC:40051. C5orf63.

Pathology & Biotechi

Organism-specific databases

DisGeNETi401207.
OpenTargetsiENSG00000164241.

Polymorphism and mutation databases

BioMutaiC5orf63.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003287561 – 138Glutaredoxin-like protein C5orf63Add BLAST138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 44Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiA6NC05.
PRIDEiA6NC05.

PTM databases

iPTMnetiA6NC05.
PhosphoSitePlusiA6NC05.

Expressioni

Gene expression databases

BgeeiENSG00000164241.
ExpressionAtlasiA6NC05. baseline and differential.
GenevisibleiA6NC05. HS.

Organism-specific databases

HPAiHPA043240.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000454153.

Structurei

3D structure databases

ProteinModelPortaliA6NC05.
SMRiA6NC05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaredoxin family. YDR286C subfamily.Curated

Phylogenomic databases

eggNOGiENOG410IYHR. Eukaryota.
ENOG41120UF. LUCA.
GeneTreeiENSGT00390000014940.
HOVERGENiHBG108701.
OMAiKPYKNRF.
OrthoDBiEOG091G08JC.
PhylomeDBiA6NC05.

Family and domain databases

InterProiView protein in InterPro
IPR008554. Glutaredoxin-like.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF05768. DUF836. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NC05-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLWFQGNSMQ LARSSFGLFL RNCSASKTTL PVLTLFTKDP CPLCDEAKEV
60 70 80 90 100
LKPYENRQPY KDQKLPGTRR RRSPSSPSHP HMASQSGKRY NLTLNQVLSF
110 120 130
DYDMGLDAPK TISSDCGAFY CLRMFKSPDM TCCFYPKQ
Length:138
Mass (Da):15,764
Last modified:February 6, 2013 - v3
Checksum:i20D0DF3CBEEDACEB
GO
Isoform 2 (identifier: A6NC05-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-138: QPYKDQKLPG...DMTCCFYPKQ → FILQEVNITL...LKLEQQSTGG

Note: No experimental confirmation available.
Show »
Length:115
Mass (Da):13,390
Checksum:i719AC94D655B620C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04490458 – 138QPYKD…FYPKQ → FILQEVNITLPENSVWYERY KFDIPVFHLNGQFLMMHRVN TSKLEKQLLKLEQQSTGG in isoform 2. CuratedAdd BLAST81

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BQ269742 mRNA. No translation available.
AC004507 Genomic DNA. No translation available.
AC005915 Genomic DNA. No translation available.
CCDSiCCDS54895.1. [A6NC05-1]
CCDS54896.1. [A6NC05-2]
RefSeqiNP_001157950.1. NM_001164478.1. [A6NC05-2]
NP_001157951.1. NM_001164479.1. [A6NC05-1]
UniGeneiHs.49573.

Genome annotation databases

EnsembliENST00000296662; ENSP00000453964; ENSG00000164241. [A6NC05-2]
ENST00000535381; ENSP00000454153; ENSG00000164241. [A6NC05-1]
ENST00000606937; ENSP00000475810; ENSG00000164241. [A6NC05-1]
GeneIDi401207.
KEGGihsa:401207.
UCSCiuc021ydb.1. human. [A6NC05-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiYD286_HUMAN
AccessioniPrimary (citable) accession number: A6NC05
Secondary accession number(s): G3V557
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: February 6, 2013
Last modified: September 27, 2017
This is version 70 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families