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A6NC05

- YD286_HUMAN

UniProt

A6NC05 - YD286_HUMAN

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Protein

Glutaredoxin-like protein C5orf63

Gene

C5orf63

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. oxidation-reduction process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaredoxin-like protein C5orf63
Gene namesi
Name:C5orf63
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:40051. C5orf63.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 138138Glutaredoxin-like protein C5orf63PRO_0000328756Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 44Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiA6NC05.
PRIDEiA6NC05.

Expressioni

Gene expression databases

BgeeiA6NC05.
ExpressionAtlasiA6NC05. baseline and differential.
GenevestigatoriA6NC05.

Organism-specific databases

HPAiHPA043240.

Structurei

3D structure databases

ProteinModelPortaliA6NC05.
SMRiA6NC05. Positions 30-57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaredoxin family. YDR286C subfamily.Curated

Phylogenomic databases

eggNOGiNOG42959.
GeneTreeiENSGT00390000014940.
HOVERGENiHBG108701.
OMAiKPYKNRF.
OrthoDBiEOG7TF7CD.
PhylomeDBiA6NC05.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR008554. Glutaredoxin-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF05768. DUF836. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A6NC05-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLWFQGNSMQ LARSSFGLFL RNCSASKTTL PVLTLFTKDP CPLCDEAKEV
60 70 80 90 100
LKPYENRQPY KDQKLPGTRR RRSPSSPSHP HMASQSGKRY NLTLNQVLSF
110 120 130
DYDMGLDAPK TISSDCGAFY CLRMFKSPDM TCCFYPKQ
Length:138
Mass (Da):15,764
Last modified:February 6, 2013 - v3
Checksum:i20D0DF3CBEEDACEB
GO
Isoform 2 (identifier: A6NC05-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-138: QPYKDQKLPG...DMTCCFYPKQ → FILQEVNITL...LKLEQQSTGG

Note: No experimental confirmation available.

Show »
Length:115
Mass (Da):13,390
Checksum:i719AC94D655B620C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei58 – 13881QPYKD…FYPKQ → FILQEVNITLPENSVWYERY KFDIPVFHLNGQFLMMHRVN TSKLEKQLLKLEQQSTGG in isoform 2. CuratedVSP_044904Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BQ269742 mRNA. No translation available.
AC004507 Genomic DNA. No translation available.
AC005915 Genomic DNA. No translation available.
CCDSiCCDS54895.1. [A6NC05-1]
CCDS54896.1. [A6NC05-2]
RefSeqiNP_001157950.1. NM_001164478.1. [A6NC05-2]
NP_001157951.1. NM_001164479.1. [A6NC05-1]
UniGeneiHs.49573.

Genome annotation databases

EnsembliENST00000296662; ENSP00000453964; ENSG00000164241. [A6NC05-2]
ENST00000535381; ENSP00000454153; ENSG00000164241. [A6NC05-1]
ENST00000606937; ENSP00000475810; ENSG00000164241. [A6NC05-1]
GeneIDi401207.
KEGGihsa:401207.
UCSCiuc021ydc.1. human. [A6NC05-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BQ269742 mRNA. No translation available.
AC004507 Genomic DNA. No translation available.
AC005915 Genomic DNA. No translation available.
CCDSi CCDS54895.1. [A6NC05-1 ]
CCDS54896.1. [A6NC05-2 ]
RefSeqi NP_001157950.1. NM_001164478.1. [A6NC05-2 ]
NP_001157951.1. NM_001164479.1. [A6NC05-1 ]
UniGenei Hs.49573.

3D structure databases

ProteinModelPortali A6NC05.
SMRi A6NC05. Positions 30-57.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi A6NC05.
PRIDEi A6NC05.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296662 ; ENSP00000453964 ; ENSG00000164241 . [A6NC05-2 ]
ENST00000535381 ; ENSP00000454153 ; ENSG00000164241 . [A6NC05-1 ]
ENST00000606937 ; ENSP00000475810 ; ENSG00000164241 . [A6NC05-1 ]
GeneIDi 401207.
KEGGi hsa:401207.
UCSCi uc021ydc.1. human. [A6NC05-1 ]

Organism-specific databases

CTDi 401207.
GeneCardsi GC05M126379.
HGNCi HGNC:40051. C5orf63.
HPAi HPA043240.
neXtProti NX_A6NC05.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42959.
GeneTreei ENSGT00390000014940.
HOVERGENi HBG108701.
OMAi KPYKNRF.
OrthoDBi EOG7TF7CD.
PhylomeDBi A6NC05.

Miscellaneous databases

GenomeRNAii 401207.
NextBioi 106602.

Gene expression databases

Bgeei A6NC05.
ExpressionAtlasi A6NC05. baseline and differential.
Genevestigatori A6NC05.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR008554. Glutaredoxin-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF05768. DUF836. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Pancreatic islet.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiYD286_HUMAN
AccessioniPrimary (citable) accession number: A6NC05
Secondary accession number(s): G3V557
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: February 6, 2013
Last modified: October 29, 2014
This is version 52 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3