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A6NC05

- YD286_HUMAN

UniProt

A6NC05 - YD286_HUMAN

Protein

Glutaredoxin-like protein C5orf63

Gene

C5orf63

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Biological processi

    1. oxidation-reduction process Source: UniProtKB-KW

    Keywords - Biological processi

    Electron transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutaredoxin-like protein C5orf63
    Gene namesi
    Name:C5orf63
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:40051. C5orf63.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 138138Glutaredoxin-like protein C5orf63PRO_0000328756Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi41 ↔ 44Redox-activeBy similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiA6NC05.
    PRIDEiA6NC05.

    Expressioni

    Gene expression databases

    BgeeiA6NC05.
    GenevestigatoriA6NC05.

    Organism-specific databases

    HPAiHPA043240.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NC05.
    SMRiA6NC05. Positions 30-57.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutaredoxin family. YDR286C subfamily.Curated

    Phylogenomic databases

    eggNOGiNOG42959.
    HOVERGENiHBG108701.
    InParanoidiA6NC05.
    OMAiKPYKNRF.
    OrthoDBiEOG7TF7CD.
    PhylomeDBiA6NC05.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR008554. Glutaredoxin-like.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF05768. DUF836. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A6NC05-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLWFQGNSMQ LARSSFGLFL RNCSASKTTL PVLTLFTKDP CPLCDEAKEV    50
    LKPYENRQPY KDQKLPGTRR RRSPSSPSHP HMASQSGKRY NLTLNQVLSF 100
    DYDMGLDAPK TISSDCGAFY CLRMFKSPDM TCCFYPKQ 138
    Length:138
    Mass (Da):15,764
    Last modified:February 6, 2013 - v3
    Checksum:i20D0DF3CBEEDACEB
    GO
    Isoform 2 (identifier: A6NC05-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         58-138: QPYKDQKLPG...DMTCCFYPKQ → FILQEVNITL...LKLEQQSTGG

    Note: No experimental confirmation available.

    Show »
    Length:115
    Mass (Da):13,390
    Checksum:i719AC94D655B620C
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei58 – 13881QPYKD…FYPKQ → FILQEVNITLPENSVWYERY KFDIPVFHLNGQFLMMHRVN TSKLEKQLLKLEQQSTGG in isoform 2. CuratedVSP_044904Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BQ269742 mRNA. No translation available.
    AC004507 Genomic DNA. No translation available.
    AC005915 Genomic DNA. No translation available.
    CCDSiCCDS54895.1. [A6NC05-1]
    CCDS54896.1. [A6NC05-2]
    RefSeqiNP_001157950.1. NM_001164478.1. [A6NC05-2]
    NP_001157951.1. NM_001164479.1. [A6NC05-1]
    UniGeneiHs.49573.

    Genome annotation databases

    EnsembliENST00000296662; ENSP00000453964; ENSG00000164241. [A6NC05-2]
    ENST00000535381; ENSP00000454153; ENSG00000164241. [A6NC05-1]
    ENST00000606937; ENSP00000475810; ENSG00000164241. [A6NC05-1]
    GeneIDi401207.
    KEGGihsa:401207.
    UCSCiuc021ydc.1. human. [A6NC05-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BQ269742 mRNA. No translation available.
    AC004507 Genomic DNA. No translation available.
    AC005915 Genomic DNA. No translation available.
    CCDSi CCDS54895.1. [A6NC05-1 ]
    CCDS54896.1. [A6NC05-2 ]
    RefSeqi NP_001157950.1. NM_001164478.1. [A6NC05-2 ]
    NP_001157951.1. NM_001164479.1. [A6NC05-1 ]
    UniGenei Hs.49573.

    3D structure databases

    ProteinModelPortali A6NC05.
    SMRi A6NC05. Positions 30-57.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi A6NC05.
    PRIDEi A6NC05.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296662 ; ENSP00000453964 ; ENSG00000164241 . [A6NC05-2 ]
    ENST00000535381 ; ENSP00000454153 ; ENSG00000164241 . [A6NC05-1 ]
    ENST00000606937 ; ENSP00000475810 ; ENSG00000164241 . [A6NC05-1 ]
    GeneIDi 401207.
    KEGGi hsa:401207.
    UCSCi uc021ydc.1. human. [A6NC05-1 ]

    Organism-specific databases

    CTDi 401207.
    GeneCardsi GC05M126379.
    HGNCi HGNC:40051. C5orf63.
    HPAi HPA043240.
    neXtProti NX_A6NC05.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42959.
    HOVERGENi HBG108701.
    InParanoidi A6NC05.
    OMAi KPYKNRF.
    OrthoDBi EOG7TF7CD.
    PhylomeDBi A6NC05.

    Miscellaneous databases

    GenomeRNAii 401207.
    NextBioi 106602.

    Gene expression databases

    Bgeei A6NC05.
    Genevestigatori A6NC05.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR008554. Glutaredoxin-like.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF05768. DUF836. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Pancreatic islet.
    2. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiYD286_HUMAN
    AccessioniPrimary (citable) accession number: A6NC05
    Secondary accession number(s): G3V557
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: February 6, 2013
    Last modified: October 1, 2014
    This is version 51 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3