A6NC05 (YD286_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutaredoxin-like protein C5orf63

Gene names

Name:

C5orf63

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	138 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the glutaredoxin family. YDR286C subfamily.

Ontologies

Keywords
Biological process	Electron transport Transport
Coding sequence diversity	Alternative splicing
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A6NC05-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A6NC05-2)

The sequence of this isoform differs from the canonical sequence as follows:
     58-138: QPYKDQKLPG...DMTCCFYPKQ → FILQEVNITL...LKLEQQSTGG

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 138	138	Glutaredoxin-like protein C5orf63		PRO_0000328756
Amino acid modifications
	Disulfide bond	41 ↔ 44		Redox-active By similarity
Natural variations
	Alternative sequence	58 – 138	81	QPYKD…FYPKQ → FILQEVNITLPENSVWYERY KFDIPVFHLNGQFLMMHRVN TSKLEKQLLKLEQQSTGG in isoform 2.		VSP_044904

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 6, 2013. Version 3. Checksum: 20D0DF3CBEEDACEB	FASTA	138	15,764
	10 20 30 40 50 60 MLWFQGNSMQ LARSSFGLFL RNCSASKTTL PVLTLFTKDP CPLCDEAKEV LKPYENRQPY 70 80 90 100 110 120 KDQKLPGTRR RRSPSSPSHP HMASQSGKRY NLTLNQVLSF DYDMGLDAPK TISSDCGAFY 130 CLRMFKSPDM TCCFYPKQ
	Isoform 2 [UniParc]. Checksum: 719AC94D655B620C	FASTA	115	13,390
	10 20 30 40 50 60 MLWFQGNSMQ LARSSFGLFL RNCSASKTTL PVLTLFTKDP CPLCDEAKEV LKPYENRFIL 70 80 90 100 110 QEVNITLPEN SVWYERYKFD IPVFHLNGQF LMMHRVNTSK LEKQLLKLEQ QSTGG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Endocrine pancreas consortium." Melton D., Brown J., Kenty G., Permutt A., Lee C., Kaestner K., Lemishka I., Scearce M., Brestelli J., Gradwohl G., Clifton S., Hillier L., Marra M., Pape D., Wylie T., Martin J., Blistain A., Schmitt A. , Theising B., Ritter E., Ronko I., Bennett J., Cardenas M., Gibbons M., McCann R., Cole R., Tsagareishvili R., Williams T., Jackson Y., Bowers Y. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Pancreatic islet.
[2]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BQ269742 mRNA. No translation available. AC004507 Genomic DNA. No translation available. AC005915 Genomic DNA. No translation available.
IPI	IPI00455619.
RefSeq	NP_001157950.1. NM_001164478.1. NP_001157951.1. NM_001164479.1.
UniGene	Hs.49573.
3D structure databases
ProteinModelPortal	A6NC05.
SMR	A6NC05. Positions 30-57.
ModBase	Search...
Proteomic databases
PaxDb	A6NC05.
PRIDE	A6NC05.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000296662; ENSP00000453964; ENSG00000164241. ENST00000535381; ENSP00000454153; ENSG00000164241.
GeneID	401207.
KEGG	hsa:401207.
UCSC	uc021ydc.1. human.
Organism-specific databases
CTD	401207.
GeneCards	GC05M126379.
HGNC	HGNC:40051. C5orf63.
HPA	HPA043240.
neXtProt	NX_A6NC05.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG42959.
HOVERGEN	HBG108701.
InParanoid	A6NC05.
OMA	PENSAWY.
Gene expression databases
ArrayExpress	A6NC05.
Bgee	A6NC05.
Genevestigator	A6NC05.
Family and domain databases
Gene3D	3.40.30.10. 1 hit.
InterPro	IPR008554. Glutaredoxin-like. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF05768. DUF836. 1 hit. [Graphical view]
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	401207.
NextBio	106602.

Entry information

Entry name

YD286_HUMAN

Accession

Primary (citable) accession number: A6NC05
Secondary accession number(s): G3V557

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	February 6, 2013
Last modified:	May 1, 2013
This is version 42 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.