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A6NC05 (YD286_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutaredoxin-like protein C5orf63
Gene names
Name:C5orf63
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length138 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the glutaredoxin family. YDR286C subfamily.

Ontologies

Keywords
   Biological processElectron transport
Transport
   Coding sequence diversityAlternative splicing
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processoxidation-reduction process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A6NC05-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A6NC05-2)

The sequence of this isoform differs from the canonical sequence as follows:
     58-138: QPYKDQKLPG...DMTCCFYPKQ → FILQEVNITL...LKLEQQSTGG
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 138138Glutaredoxin-like protein C5orf63
PRO_0000328756

Amino acid modifications

Disulfide bond41 ↔ 44Redox-active By similarity

Natural variations

Alternative sequence58 – 13881QPYKD…FYPKQ → FILQEVNITLPENSVWYERY KFDIPVFHLNGQFLMMHRVN TSKLEKQLLKLEQQSTGG in isoform 2.
VSP_044904

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 6, 2013. Version 3.
Checksum: 20D0DF3CBEEDACEB

FASTA13815,764
        10         20         30         40         50         60 
MLWFQGNSMQ LARSSFGLFL RNCSASKTTL PVLTLFTKDP CPLCDEAKEV LKPYENRQPY 

        70         80         90        100        110        120 
KDQKLPGTRR RRSPSSPSHP HMASQSGKRY NLTLNQVLSF DYDMGLDAPK TISSDCGAFY 

       130 
CLRMFKSPDM TCCFYPKQ 

« Hide

Isoform 2 [UniParc].

Checksum: 719AC94D655B620C
Show »

FASTA11513,390

References

« Hide 'large scale' references
[1]"Endocrine pancreas consortium."
Melton D., Brown J., Kenty G., Permutt A., Lee C., Kaestner K., Lemishka I., Scearce M., Brestelli J., Gradwohl G., Clifton S., Hillier L., Marra M., Pape D., Wylie T., Martin J., Blistain A., Schmitt A. expand/collapse author list , Theising B., Ritter E., Ronko I., Bennett J., Cardenas M., Gibbons M., McCann R., Cole R., Tsagareishvili R., Williams T., Jackson Y., Bowers Y.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Pancreatic islet.
[2]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BQ269742 mRNA. No translation available.
AC004507 Genomic DNA. No translation available.
AC005915 Genomic DNA. No translation available.
RefSeqNP_001157950.1. NM_001164478.1.
NP_001157951.1. NM_001164479.1.
UniGeneHs.49573.

3D structure databases

ProteinModelPortalA6NC05.
SMRA6NC05. Positions 30-57.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbA6NC05.
PRIDEA6NC05.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000296662; ENSP00000453964; ENSG00000164241. [A6NC05-2]
ENST00000535381; ENSP00000454153; ENSG00000164241. [A6NC05-1]
ENST00000606937; ENSP00000475810; ENSG00000164241. [A6NC05-1]
GeneID401207.
KEGGhsa:401207.
UCSCuc021ydc.1. human. [A6NC05-1]

Organism-specific databases

CTD401207.
GeneCardsGC05M126379.
HGNCHGNC:40051. C5orf63.
HPAHPA043240.
neXtProtNX_A6NC05.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42959.
HOVERGENHBG108701.
InParanoidA6NC05.
OMAKNRFILQ.
OrthoDBEOG7TF7CD.

Gene expression databases

BgeeA6NC05.
GenevestigatorA6NC05.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR008554. Glutaredoxin-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF05768. DUF836. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi401207.
NextBio106602.

Entry information

Entry nameYD286_HUMAN
AccessionPrimary (citable) accession number: A6NC05
Secondary accession number(s): G3V557
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: February 6, 2013
Last modified: March 19, 2014
This is version 48 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM