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Protein

WD repeat-containing protein 35

Gene

Wdr35

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-RNO-5610787. Hedgehog 'off' state.
R-RNO-5620924. Intraflagellar transport.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 35
Alternative name(s):
Naofen
Gene namesi
Name:Wdr35
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1564116. Wdr35.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004054061 – 1170WD repeat-containing protein 35Add BLAST1170

Proteomic databases

PaxDbiA6N6J5.
PeptideAtlasiA6N6J5.
PRIDEiA6N6J5.

Expressioni

Tissue specificityi

Expressed at high levels in testis and at lower levels in the brain (at protein level). Also present in other tissues, including heart, uterus, spinal cord, ovary, liver, kidney, lung, pancreas and stomach.1 Publication

Gene expression databases

BgeeiENSRNOG00000028783.
GenevisibleiA6N6J5. RN.

Interactioni

Subunit structurei

Component of the IFT complex A (IFT-A). Interacts with IFT43 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042019.

Structurei

3D structure databases

ProteinModelPortaliA6N6J5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati12 – 51WD 1Add BLAST40
Repeati69 – 108WD 2Add BLAST40
Repeati113 – 152WD 3Add BLAST40
Repeati154 – 193WD 4Add BLAST40
Repeati491 – 528WD 5Add BLAST38

Sequence similaritiesi

Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2041. Eukaryota.
ENOG410XNSQ. LUCA.
GeneTreeiENSGT00610000085970.
HOGENOMiHOG000255527.
HOVERGENiHBG079343.
InParanoidiA6N6J5.
KOiK19674.
OMAiLINFEIR.
OrthoDBiEOG091G014X.
PhylomeDBiA6N6J5.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR024977. Apc4_WD40_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
IPR017233. WD_repeat_p35.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 1 hit.
[Graphical view]
PIRSFiPIRSF037536. WD_repeat_p35. 1 hit.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6N6J5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFFYLSKKIA VPNNVKLKCI SWNKDQGFIA CGGEDGLLKV LRLETQTDDS
60 70 80 90 100
KLRGLAAPSN LSMNQNLEGH SGAVQVVTWN EQYQKLTTSD QNGLIIVWML
110 120 130 140 150
YKGSWYEEMI NNRNKSVVRS MSWNADGQKI CIVYEDGAVI VGSVDGNRIW
160 170 180 190 200
GKDLKGIQLC HVTWSADSKI LLFGMANGEI HIYDNQGNFI MKMKLNCLVN
210 220 230 240 250
VTGAISIAGI HWYHGTEGYV EPDCPCLAIC FDNGRCQIMR HENDQNPVLI
260 270 280 290 300
DTGMYVVGIQ WNHIGSVLAV AGSQKVVTQD KDVNIVQFYT PFGEHLGTLK
310 320 330 340 350
VPGKQMCSLS WEGGGLKIAL AVDSFIYFAN IRPDYKWGYC SNTVVYAYTR
360 370 380 390 400
PDRPEYCVVF WDTKNNEKYV KYVKSLISIT TCGDFCILAT KADENHPQFV
410 420 430 440 450
LVLCNSIGTP LDPKYIDLVP LFVAMTKTHV IAASKEALYT WQYRVAKKLT
460 470 480 490 500
ALEINQITRS RKEGRERIYH VDDVPSGSVD GVFDYSKAIQ GTRDPICAIT
510 520 530 540 550
ASDKTLIVGR ESGVIQRYSF PNVALIQKYS LDCRACQLSL NCNSSRLAII
560 570 580 590 600
DIAGVLTFFD LDTRVTDSTG QQVVGELLKL ERKDVWDMKW AKDNPDLFAM
610 620 630 640 650
MEKTRMYVFR NLDPEEPIQT SGYICNFEDL EIKSVLLDEI LKNPEHPSKD
660 670 680 690 700
YIMNFEIRSL RDSRALIEKV GIEDASQFIE DNPHPRLWRL LAEAALQKLD
710 720 730 740 750
LYTAQQAFVR CKDYQGIKFV KRLGNLQSES MKQAEVIAYF GRFEEAERMY
760 770 780 790 800
LDMDRRDLAI GLRLKLGDWF RVLQLLKTGS GDADDSLLEQ AHNAIGDYFA
810 820 830 840 850
DRQKWMNAVQ YYVKGRNQER LAECYYMLED YEGLENLANS LPENHKLLPE
860 870 880 890 900
IAQMFVRVGM CEQAVSAFLK CNQPKAAVDT CVHLNQWNKA VELAKSHSMK
910 920 930 940 950
EIGSLLARYA SHLLEKNKTL DAIELYRKAS YFFDAAKLMY KIADEEAKKR
960 970 980 990 1000
TKPLRVKKLY VLSALLIEQY HEQMKNAQRG KVKGKNSEAT SALAGLLEEE
1010 1020 1030 1040 1050
VLSTTSRFTD NAWRGAEAYH FFILAQRQLY EGYVDTALKT ALHLRDYEDI
1060 1070 1080 1090 1100
IPSVEIYSLL ALCACASRAF GTCSKAFIKL ESLETLSAEQ KQQYEDLALE
1110 1120 1130 1140 1150
IFTKHTPKDN RKSELNSLLE GGEGKLPTCI ATGSPIIEYQ FWVCKVCKHY
1160 1170
VLAQEISNYN FCPLCHSSVE
Length:1,170
Mass (Da):132,779
Last modified:July 24, 2007 - v1
Checksum:i70792ECD36111DEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF613262 mRNA. Translation: ABR22620.1.
CH473947 Genomic DNA. Translation: EDM03084.1.
RefSeqiNP_001092810.1. NM_001099340.1.
UniGeneiRn.14574.

Genome annotation databases

EnsembliENSRNOT00000051970; ENSRNOP00000042019; ENSRNOG00000028783.
GeneIDi503018.
KEGGirno:503018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF613262 mRNA. Translation: ABR22620.1.
CH473947 Genomic DNA. Translation: EDM03084.1.
RefSeqiNP_001092810.1. NM_001099340.1.
UniGeneiRn.14574.

3D structure databases

ProteinModelPortaliA6N6J5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042019.

Proteomic databases

PaxDbiA6N6J5.
PeptideAtlasiA6N6J5.
PRIDEiA6N6J5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000051970; ENSRNOP00000042019; ENSRNOG00000028783.
GeneIDi503018.
KEGGirno:503018.

Organism-specific databases

CTDi57539.
RGDi1564116. Wdr35.

Phylogenomic databases

eggNOGiKOG2041. Eukaryota.
ENOG410XNSQ. LUCA.
GeneTreeiENSGT00610000085970.
HOGENOMiHOG000255527.
HOVERGENiHBG079343.
InParanoidiA6N6J5.
KOiK19674.
OMAiLINFEIR.
OrthoDBiEOG091G014X.
PhylomeDBiA6N6J5.

Enzyme and pathway databases

ReactomeiR-RNO-5610787. Hedgehog 'off' state.
R-RNO-5620924. Intraflagellar transport.

Miscellaneous databases

PROiA6N6J5.

Gene expression databases

BgeeiENSRNOG00000028783.
GenevisibleiA6N6J5. RN.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR024977. Apc4_WD40_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
IPR017233. WD_repeat_p35.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 1 hit.
[Graphical view]
PIRSFiPIRSF037536. WD_repeat_p35. 1 hit.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDR35_RAT
AccessioniPrimary (citable) accession number: A6N6J5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: July 24, 2007
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.