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A6N3Q4

- CC14C_HYLSY

UniProt

A6N3Q4 - CC14C_HYLSY

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Protein
Dual specificity protein phosphatase CDC14C
Gene
CDC14C, CDC14B2
Organism
Hylobates syndactylus (Siamang) (Symphalangus syndactylus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
  2. protein tyrosine/serine/threonine phosphatase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase CDC14C (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
CDC14 cell division cycle 14 homolog C
Gene namesi
Name:CDC14C
Synonyms:CDC14B2
OrganismiHylobates syndactylus (Siamang) (Symphalangus syndactylus)
Taxonomic identifieri9590 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHylobatidaeSymphalangus

Subcellular locationi

Membrane; Single-pass membrane protein Reviewed prediction. Nucleusnucleolus
Note: Nucleolar during interphase By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei444 – 46623Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Dual specificity protein phosphatase CDC14C
PRO_0000315823Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA6N3Q4.
SMRiA6N3Q4. Positions 41-378.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni43 – 197155A By similarity
Add
BLAST
Regioni198 – 21114Linker By similarity
Add
BLAST
Regioni212 – 378167B By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1 – 5353Nucleolar localization signal By similarity
Add
BLAST

Domaini

Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG050818.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiIPR029260. DSPn.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
PF14671. DSPn. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6N3Q4-1 [UniParc]FASTAAdd to Basket

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MKRKSEGRSS WAAATCSPCC SLTSPSVKKI RSPTQQDPRH RDPQDDVYLD    50
ITDRLRLAIL YSRPKSASNV HYFSIDNELE YENFSEDFGP LNLAMVYRYC 100
CKINKKLKSI TMLRKKIVHF TGSDQRKQAN AAFLVGCYMV IYLGRTPEEA 150
YRTLIFGDTS YIPFRDAAYG SCNFYITLLD CFHAVKKAMQ YGFLNFNSFN 200
LDEYEHYEKA ENGDLNWIIP DRFIAFCGPH SRARLESGYH QHSPETYIQY 250
FKNRNVTTII RLNKKMYDAK CFTDAGFDHH DLFFADGSSP TDAIVKGFLD 300
ICENAEGAIA VHCKAGLGRT GTLIACYIMK HYRMTAAETI AWVRICRPGL 350
VIGPQQQFLV MKQTSLWLEG DYFCQKLKGQ ENGQHRAAFP KLHSGVDDIS 400
INGVENQDQQ EPEPYSDDDE INGGTQGDRL RALKSRRQSK TNAILLTCPL 450
AVLTSALCSV VIWWIVCDYI LPILLFCLDG FGT 483
Length:483
Mass (Da):54,961
Last modified:July 24, 2007 - v1
Checksum:i8895A87FEBA3E5F1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF606887 Genomic DNA. Translation: ABR10606.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF606887 Genomic DNA. Translation: ABR10606.1 .

3D structure databases

ProteinModelPortali A6N3Q4.
SMRi A6N3Q4. Positions 41-378.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG050818.

Family and domain databases

Gene3Di 3.90.190.10. 2 hits.
InterProi IPR029260. DSPn.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
Pfami PF00782. DSPc. 1 hit.
PF14671. DSPn. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 2 hits.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Subcellular adaptation of a hominoid cell cycle protein expressed in the brain."
    Rosso L., Marques A.C., Kaessmann H.
    Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCC14C_HYLSY
AccessioniPrimary (citable) accession number: A6N3Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 24, 2007
Last modified: June 11, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

May act as an autosomal functional substitute.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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