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A6N3Q4

- CC14C_HYLSY

UniProt

A6N3Q4 - CC14C_HYLSY

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Protein

Dual specificity protein phosphatase CDC14C

Gene

CDC14C

Organism
Hylobates syndactylus (Siamang) (Symphalangus syndactylus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases By similarity.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. protein tyrosine/serine/threonine phosphatase activity Source: InterPro
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase CDC14C (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
CDC14 cell division cycle 14 homolog C
Gene namesi
Name:CDC14C
Synonyms:CDC14B2
OrganismiHylobates syndactylus (Siamang) (Symphalangus syndactylus)
Taxonomic identifieri9590 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHylobatidaeSymphalangus

Subcellular locationi

Membrane Curated; Single-pass membrane protein Curated. Nucleusnucleolus
Note: Nucleolar during interphase.By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Dual specificity protein phosphatase CDC14CPRO_0000315823Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA6N3Q4.
SMRiA6N3Q4. Positions 41-378.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei444 – 46623HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni43 – 197155ABy similarityAdd
BLAST
Regioni198 – 21114LinkerBy similarityAdd
BLAST
Regioni212 – 378167BBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1 – 5353Nucleolar localization signalBy similarityAdd
BLAST

Domaini

Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG050818.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiIPR029260. DSPn.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
PF14671. DSPn. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6N3Q4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKRKSEGRSS WAAATCSPCC SLTSPSVKKI RSPTQQDPRH RDPQDDVYLD
60 70 80 90 100
ITDRLRLAIL YSRPKSASNV HYFSIDNELE YENFSEDFGP LNLAMVYRYC
110 120 130 140 150
CKINKKLKSI TMLRKKIVHF TGSDQRKQAN AAFLVGCYMV IYLGRTPEEA
160 170 180 190 200
YRTLIFGDTS YIPFRDAAYG SCNFYITLLD CFHAVKKAMQ YGFLNFNSFN
210 220 230 240 250
LDEYEHYEKA ENGDLNWIIP DRFIAFCGPH SRARLESGYH QHSPETYIQY
260 270 280 290 300
FKNRNVTTII RLNKKMYDAK CFTDAGFDHH DLFFADGSSP TDAIVKGFLD
310 320 330 340 350
ICENAEGAIA VHCKAGLGRT GTLIACYIMK HYRMTAAETI AWVRICRPGL
360 370 380 390 400
VIGPQQQFLV MKQTSLWLEG DYFCQKLKGQ ENGQHRAAFP KLHSGVDDIS
410 420 430 440 450
INGVENQDQQ EPEPYSDDDE INGGTQGDRL RALKSRRQSK TNAILLTCPL
460 470 480
AVLTSALCSV VIWWIVCDYI LPILLFCLDG FGT
Length:483
Mass (Da):54,961
Last modified:July 24, 2007 - v1
Checksum:i8895A87FEBA3E5F1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF606887 Genomic DNA. Translation: ABR10606.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF606887 Genomic DNA. Translation: ABR10606.1 .

3D structure databases

ProteinModelPortali A6N3Q4.
SMRi A6N3Q4. Positions 41-378.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG050818.

Family and domain databases

Gene3Di 3.90.190.10. 2 hits.
InterProi IPR029260. DSPn.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
Pfami PF00782. DSPc. 1 hit.
PF14671. DSPn. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 2 hits.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Subcellular adaptation of a hominoid cell cycle protein expressed in the brain."
    Rosso L., Marques A.C., Kaessmann H.
    Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCC14C_HYLSY
AccessioniPrimary (citable) accession number: A6N3Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

May act as an autosomal functional substitute.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3