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Protein

Dual specificity protein phosphatase CDC14C

Gene

CDC14C

Organism
Symphalangus syndactylus (Siamang) (Hylobates syndactylus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases (By similarity).By similarity

Miscellaneous

May act as an autosomal functional substitute.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase CDC14CBy similarity (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
CDC14 cell division cycle 14 homolog C
Gene namesi
Name:CDC14CBy similarity
Synonyms:CDC14Bretro1 Publication
OrganismiSymphalangus syndactylus (Siamang) (Hylobates syndactylus)
Taxonomic identifieri9590 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHylobatidaeSymphalangus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei444 – 466HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003158231 – 483Dual specificity protein phosphatase CDC14CAdd BLAST483

Structurei

3D structure databases

ProteinModelPortaliA6N3Q4
SMRiA6N3Q4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni43 – 197ABy similarityAdd BLAST155
Regioni198 – 211LinkerBy similarityAdd BLAST14
Regioni212 – 378BBy similarityAdd BLAST167

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1 – 53Nucleolar localization signalBy similarityAdd BLAST53

Domaini

Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG050818

Family and domain databases

Gene3Di3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR029260 DSPn
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF14671 DSPn, 1 hit
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequencei

Sequence statusi: Complete.

A6N3Q4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRKSEGRSS WAAATCSPCC SLTSPSVKKI RSPTQQDPRH RDPQDDVYLD
60 70 80 90 100
ITDRLRLAIL YSRPKSASNV HYFSIDNELE YENFSEDFGP LNLAMVYRYC
110 120 130 140 150
CKINKKLKSI TMLRKKIVHF TGSDQRKQAN AAFLVGCYMV IYLGRTPEEA
160 170 180 190 200
YRTLIFGDTS YIPFRDAAYG SCNFYITLLD CFHAVKKAMQ YGFLNFNSFN
210 220 230 240 250
LDEYEHYEKA ENGDLNWIIP DRFIAFCGPH SRARLESGYH QHSPETYIQY
260 270 280 290 300
FKNRNVTTII RLNKKMYDAK CFTDAGFDHH DLFFADGSSP TDAIVKGFLD
310 320 330 340 350
ICENAEGAIA VHCKAGLGRT GTLIACYIMK HYRMTAAETI AWVRICRPGL
360 370 380 390 400
VIGPQQQFLV MKQTSLWLEG DYFCQKLKGQ ENGQHRAAFP KLHSGVDDIS
410 420 430 440 450
INGVENQDQQ EPEPYSDDDE INGGTQGDRL RALKSRRQSK TNAILLTCPL
460 470 480
AVLTSALCSV VIWWIVCDYI LPILLFCLDG FGT
Length:483
Mass (Da):54,961
Last modified:July 24, 2007 - v1
Checksum:i8895A87FEBA3E5F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF606887 Genomic DNA Translation: ABR10606.1

Similar proteinsi

Entry informationi

Entry nameiCC14C_SYMSY
AccessioniPrimary (citable) accession number: A6N3Q4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 24, 2007
Last modified: April 25, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health