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A6N3Q4 (CC14C_HYLSY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dual specificity protein phosphatase CDC14C

EC=3.1.3.16
EC=3.1.3.48
Alternative name(s):
CDC14 cell division cycle 14 homolog C
Gene names
Name:CDC14C
Synonyms:CDC14B2
OrganismHylobates syndactylus (Siamang) (Symphalangus syndactylus)
Taxonomic identifier9590 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHylobatidaeSymphalangus

Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subcellular location

Membrane; Single-pass membrane protein Potential. Nucleusnucleolus. Note: Nucleolar during interphase By similarity.

Domain

Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.

Miscellaneous

May act as an autosomal functional substitute.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 483483Dual specificity protein phosphatase CDC14C
PRO_0000315823

Regions

Transmembrane444 – 46623Helical; Potential
Region43 – 197155A By similarity
Region198 – 21114Linker By similarity
Region212 – 378167B By similarity
Motif1 – 5353Nucleolar localization signal By similarity

Sequences

Sequence LengthMass (Da)Tools
A6N3Q4 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 8895A87FEBA3E5F1

FASTA48354,961
        10         20         30         40         50         60 
MKRKSEGRSS WAAATCSPCC SLTSPSVKKI RSPTQQDPRH RDPQDDVYLD ITDRLRLAIL 

        70         80         90        100        110        120 
YSRPKSASNV HYFSIDNELE YENFSEDFGP LNLAMVYRYC CKINKKLKSI TMLRKKIVHF 

       130        140        150        160        170        180 
TGSDQRKQAN AAFLVGCYMV IYLGRTPEEA YRTLIFGDTS YIPFRDAAYG SCNFYITLLD 

       190        200        210        220        230        240 
CFHAVKKAMQ YGFLNFNSFN LDEYEHYEKA ENGDLNWIIP DRFIAFCGPH SRARLESGYH 

       250        260        270        280        290        300 
QHSPETYIQY FKNRNVTTII RLNKKMYDAK CFTDAGFDHH DLFFADGSSP TDAIVKGFLD 

       310        320        330        340        350        360 
ICENAEGAIA VHCKAGLGRT GTLIACYIMK HYRMTAAETI AWVRICRPGL VIGPQQQFLV 

       370        380        390        400        410        420 
MKQTSLWLEG DYFCQKLKGQ ENGQHRAAFP KLHSGVDDIS INGVENQDQQ EPEPYSDDDE 

       430        440        450        460        470        480 
INGGTQGDRL RALKSRRQSK TNAILLTCPL AVLTSALCSV VIWWIVCDYI LPILLFCLDG 


FGT 

« Hide

References

[1]"Subcellular adaptation of a hominoid cell cycle protein expressed in the brain."
Rosso L., Marques A.C., Kaessmann H.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF606887 Genomic DNA. Translation: ABR10606.1.

3D structure databases

ProteinModelPortalA6N3Q4.
SMRA6N3Q4. Positions 41-378.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG050818.

Family and domain databases

InterProIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR026068. Dual_Pase_CDC14.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERPTHR23339:SF27. PTHR23339:SF27. 1 hit.
PfamPF00782. DSPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCC14C_HYLSY
AccessionPrimary (citable) accession number: A6N3Q4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families