A6N3Q4 (CC14C_HYLSY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dual specificity protein phosphatase CDC14C
EC=3.1.3.16
EC=3.1.3.48

Alternative name(s):
CDC14 cell division cycle 14 homolog C

Gene names

Name:	CDC14C
Synonyms:	CDC14B2

Organism

Hylobates syndactylus (Siamang) (Symphalangus syndactylus)

Taxonomic identifier

9590 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hylobatidae › Symphalangus

Protein attributes

Sequence length	483 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Subcellular location	Membrane; Single-pass membrane protein Potential. Nucleus › nucleolus. Note: Nucleolar during interphase By similarity.
Domain	Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.
Miscellaneous	May act as an autosomal functional substitute.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

Ontologies

Keywords
Cellular component	Membrane Nucleus
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase Protein phosphatase
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 483	483	Dual specificity protein phosphatase CDC14C		PRO_0000315823
Regions
	Transmembrane	444 – 466	23	Helical; Potential
	Region	43 – 197	155	A By similarity
	Region	198 – 211	14	Linker By similarity
	Region	212 – 378	167	B By similarity
	Motif	1 – 53	53	Nucleolar localization signal By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6N3Q4 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 8895A87FEBA3E5F1	FASTA	483	54,961
	10 20 30 40 50 60 MKRKSEGRSS WAAATCSPCC SLTSPSVKKI RSPTQQDPRH RDPQDDVYLD ITDRLRLAIL 70 80 90 100 110 120 YSRPKSASNV HYFSIDNELE YENFSEDFGP LNLAMVYRYC CKINKKLKSI TMLRKKIVHF 130 140 150 160 170 180 TGSDQRKQAN AAFLVGCYMV IYLGRTPEEA YRTLIFGDTS YIPFRDAAYG SCNFYITLLD 190 200 210 220 230 240 CFHAVKKAMQ YGFLNFNSFN LDEYEHYEKA ENGDLNWIIP DRFIAFCGPH SRARLESGYH 250 260 270 280 290 300 QHSPETYIQY FKNRNVTTII RLNKKMYDAK CFTDAGFDHH DLFFADGSSP TDAIVKGFLD 310 320 330 340 350 360 ICENAEGAIA VHCKAGLGRT GTLIACYIMK HYRMTAAETI AWVRICRPGL VIGPQQQFLV 370 380 390 400 410 420 MKQTSLWLEG DYFCQKLKGQ ENGQHRAAFP KLHSGVDDIS INGVENQDQQ EPEPYSDDDE 430 440 450 460 470 480 INGGTQGDRL RALKSRRQSK TNAILLTCPL AVLTSALCSV VIWWIVCDYI LPILLFCLDG FGT

References

[1]	"Subcellular adaptation of a hominoid cell cycle protein expressed in the brain." Rosso L., Marques A.C., Kaessmann H. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	EF606887 Genomic DNA. Translation: ABR10606.1.
3D structure databases
ProteinModelPortal	A6N3Q4.
SMR	A6N3Q4. Positions 41-378.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG050818.
Family and domain databases
InterPro	IPR000340. Dual-sp_phosphatase_cat-dom. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR026068. Dual_Pase_CDC14. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. [Graphical view]
PANTHER	PTHR23339:SF27. PTHR23339:SF27. 1 hit.
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CC14C_HYLSY

Accession

Primary (citable) accession number: A6N3Q4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 24, 2007
Last modified:	March 6, 2013
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program