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Protein
Submitted name:

Neuregulin 1 type IV fetal C beta 1a

Gene

NRG1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Neuregulin 1 type IV fetal C beta 1aImported
Gene namesi
Name:NRG1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei210 – 23223HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31776.

PTM / Processingi

Proteomic databases

PeptideAtlasiA6MW56.
PRIDEiA6MW56.

Expressioni

Gene expression databases

GenevisibleiA6MW56. HS.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 10792Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini140 – 18445EGF-likeInterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOGENOMiHOG000273863.
HOVERGENiHBG006531.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR002154. Neuregulin_C.
IPR018250. NRG1.
[Graphical view]
PANTHERiPTHR11100:SF7. PTHR11100:SF7. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF02158. Neuregulin. 1 hit.
[Graphical view]
PRINTSiPR01089. NEUREGULIN.
SMARTiSM00181. EGF. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

A6MW56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKGRAGRVG TTALPPRLKE MKSQESAAGS KLVLRCETSS EYSSLRFKWF
60 70 80 90 100
KNGNELNRKN KPQNIKIQKK PGKSELRINK ASLADSGEYM CKVISKLGND
110 120 130 140 150
SASANITIVE SNEIITGMPA STEGAYVSSA ASTSTTGTSH LVKCAEKEKT
160 170 180 190 200
FCVNGGECFM VKDLSNPSRY LCKCPNEFTG DRCQNYVMAS FYKHLGIEFM
210 220 230 240 250
EAEELYQKRV LTITGICIAL LVVGIMCVVA YCKTKKQRKK LHDRLRQSPR
260 270 280 290 300
SERNNTMNIA NGPHHPNPPP ENVQLVNQYV SKNVISSEHI VEREAETSFP
310 320 330 340 350
TSHYTSTAHH STTVTQTPSH SWSNGHTESI LSESHSVIVM SSVENSRHSS
360 370 380 390 400
PTGGPRGRLN GTGGPRECNS YLRHARETPD SYRDSPHSER YVSVMTTPAR
410 420 430 440 450
MSPVDFHTPS SPKSPPSEMS PPVSSMTVSM PSMAVSPFME EERPLLLVTP
460 470 480
PRLREKKFDH HPQQFSSFHH NPAHDSNSLP A
Length:481
Mass (Da):53,253
Last modified:July 24, 2007 - v1
Checksum:i0E5B8B7386B8A340
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei481 – 4811Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF517297 mRNA. Translation: ABR13844.1.
RefSeqiNP_001153467.1. NM_001159995.2.
UniGeneiHs.453951.
Hs.668810.

Genome annotation databases

GeneIDi3084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF517297 mRNA. Translation: ABR13844.1.
RefSeqiNP_001153467.1. NM_001159995.2.
UniGeneiHs.453951.
Hs.668810.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiA6MW56.
PRIDEiA6MW56.

Protocols and materials databases

DNASUi3084.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3084.

Organism-specific databases

CTDi3084.
PharmGKBiPA31776.

Phylogenomic databases

HOGENOMiHOG000273863.
HOVERGENiHBG006531.

Miscellaneous databases

ChiTaRSiNRG1. human.
GenomeRNAii3084.

Gene expression databases

GenevisibleiA6MW56. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR002154. Neuregulin_C.
IPR018250. NRG1.
[Graphical view]
PANTHERiPTHR11100:SF7. PTHR11100:SF7. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF02158. Neuregulin. 1 hit.
[Graphical view]
PRINTSiPR01089. NEUREGULIN.
SMARTiSM00181. EGF. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA6MW56_HUMAN
AccessioniPrimary (citable) accession number: A6MW56
Entry historyi
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: September 7, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.