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A6MFL0

- OXLA_DEMVE

UniProt

A6MFL0 - OXLA_DEMVE

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Protein
L-amino-acid oxidase
Gene
N/A
Organism
Demansia vestigiata (Lesser black whip snake) (Demansia atra)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, apoptosis of vascular endothelial cells or tumor cell lines, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation. Its effect on platelets is controversial, since it either induces aggregation or inhibits agonist-induced aggregation. These different effects are probably due to different experimental conditions By similarity.

Catalytic activityi

An L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2.

Cofactori

FAD By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei90 – 901FAD By similarity
Binding sitei109 – 1091Substrate By similarity
Binding sitei280 – 2801FAD; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei391 – 3911Substrate By similarity
Binding sitei476 – 4761FAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 632FAD By similarity
Nucleotide bindingi82 – 832FAD By similarity
Nucleotide bindingi106 – 1094FAD By similarity
Nucleotide bindingi483 – 4886FAD By similarity
Nucleotide bindingi483 – 4842Substrate By similarity

GO - Molecular functioni

  1. L-amino-acid oxidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. defense response to bacterium Source: UniProtKB-KW
  3. hemolysis in other organism Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Hemostasis impairing toxin, Oxidoreductase, Toxin

Keywords - Biological processi

Apoptosis, Cytolysis, Hemolysis

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
L-amino-acid oxidase (EC:1.4.3.2)
Short name:
LAAO
Short name:
LAO
OrganismiDemansia vestigiata (Lesser black whip snake) (Demansia atra)
Taxonomic identifieri412038 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeNotechinaeDemansia

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 517499L-amino-acid oxidase
PRO_5000254114Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 192 By similarity
Glycosylationi191 – 1911N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi350 ↔ 431 By similarity

Post-translational modificationi

N-glycosylated By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Homodimer; non-covalently linked By similarity.

Structurei

3D structure databases

ProteinModelPortaliA6MFL0.
SMRiA6MFL0. Positions 23-505.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG005729.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6MFL0-1 [UniParc]FASTAAdd to Basket

« Hide

MNVFFMFSLL FLAALESCAD DRRNPLGECF READYEEFVD IATNGLKQTS    50
NPKRVVVVGA GMAGLSAAYV LAGAGHNVML LEASERVGGR VNTYRNEQEG 100
WYVNLGPMRL PERHRIVREY IKKFGLQLNQ FFQEDEDAWY FIKNIRKKVR 150
EVKENPSIFP YPVKPSEKGK SAPQLYRDSL QKIIEEYGRS NCSYILNKYD 200
TYSTKDYLIK EGNLSPGAVD MIGDLLNEGS SYYLSFIESL KSDDIFSYEN 250
RFDEIVGGFD LLPKAMYKAI EEKVHLNARV IQIQQNAEGV RVTYQTPAKN 300
LSYVTADYVI VCSTSRAARR IYFEPPLPPE KAHALQSIHY RSATKIFLTC 350
TKKFWEDDGI HGGKSITDRP SRLIHYPNHN FPNGIGVLVI YTIADDADFF 400
LALDNKTIAD IVIHDLSLIH QLPKEKIRDL CYVSMIKKWS LDKYSMGSIT 450
TFAPYQFQEY FETVAAPVGR IYFAGEYTAR AHGWIDSTIK SGLKAARDVN 500
RASQKPSRIQ LSNDNEL 517
Length:517
Mass (Da):58,920
Last modified:July 24, 2007 - v1
Checksum:i474BB53222E72C22
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ917521 mRNA. Translation: ABK63550.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ917521 mRNA. Translation: ABK63550.1 .

3D structure databases

ProteinModelPortali A6MFL0.
SMRi A6MFL0. Positions 23-505.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG005729.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01593. Amino_oxidase. 1 hit.
[Graphical view ]
PRINTSi PR00757. AMINEOXDASEF.
ProtoNeti Search...

Publicationsi

  1. "Diversity of toxic components from the venom of the evolutionarily distinct black whip snake, Demansia vestigiata."
    St Pierre L., Birrell G.W., Earl S.T.H., Wallis T.P., Gorman J.J., de Jersey J., Masci P.P., Lavin M.F.
    J. Proteome Res. 6:3093-3107(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Venom gland.

Entry informationi

Entry nameiOXLA_DEMVE
AccessioniPrimary (citable) accession number: A6MFL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 24, 2007
Last modified: February 19, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi