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Protein

Alpha-conotoxin-like Mr1.2

Gene
N/A
Organism
Conus marmoreus (Marble cone)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin-like Mr1.2
OrganismiConus marmoreus (Marble cone)
Taxonomic identifieri42752 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri127. Mr1.2 precursor.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000037066122 – 48By similarityAdd BLAST27
PeptideiPRO_000037066249 – 65Alpha-conotoxin-like Mr1.2Add BLAST17

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 56By similarity
Disulfide bondi51 ↔ 64By similarity
Modified residuei65Asparagine amideBy similarity1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

ProteinModelPortaliA6M934.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is I (CC-C-C). Alpha4/7 pattern.

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR009958. Conotoxin_a-typ.
PfamiView protein in Pfam
PF07365. Toxin_8. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6M934-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMRMMFTVF LLVVLATTVV SFTSDRGSDG RNAAAKDKAS DLVALTVKGC
60
CSNPPCYANN QAYCNGRR
Length:68
Mass (Da):7,296
Last modified:July 24, 2007 - v1
Checksum:i31C166F007FC1439
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ359140 mRNA. Translation: ABD48791.1.

Similar proteinsi

Entry informationi

Entry nameiCA12_CONMR
AccessioniPrimary (citable) accession number: A6M934
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: July 24, 2007
Last modified: November 22, 2017
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families