A6M3I8 (A6M3I8_CLOB8) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase HAMAP-Rule MF_00111
EC=2.5.1.7 HAMAP-Rule MF_00111

Alternative name(s):
Enoylpyruvate transferase HAMAP-Rule MF_00111
UDP-N-acetylglucosamine enolpyruvyl transferase HAMAP-Rule MF_00111

Gene names

Name:	murA HAMAP-Rule MF_00111
Ordered Locus Names:	Cbei_5062 EMBL ABR37168.1

Organism

Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum) [Complete proteome] [HAMAP] EMBL ABR37168.1

Taxonomic identifier

290402 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium › Clostridium beijerinckii

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity. HAMAP-Rule MF_00111 SAAS SAAS005750
Catalytic activity	Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine. HAMAP-Rule MF_00111 SAAS SAAS005750
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00111 SAAS SAAS005750
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00111.
Sequence similarities	Belongs to the EPSP synthase family. MurA subfamily. HAMAP-Rule MF_00111

Ontologies

Keywords
Biological process	Cell cycle Cell division HAMAP-Rule MF_00111 SAAS SAAS005750 Cell shape Cell wall biogenesis/degradation SAAS SAAS005750 HAMAP-Rule MF_00111 Peptidoglycan synthesis HAMAP-Rule MF_00111 SAAS SAAS005750
Cellular component	Cytoplasm HAMAP-Rule MF_00111 SAAS SAAS005750
Molecular function	Transferase SAAS SAAS005750 HAMAP-Rule MF_00111 EMBL ABR37168.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	UDP-N-acetylgalactosamine biosynthetic process Inferred from electronic annotation. Source: InterPro cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	118	1	Proton donor By similarity HAMAP-Rule MF_00111
Amino acid modifications
	Modified residue	118	1	2-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarity HAMAP-Rule MF_00111

Sequences

	Sequence		Length	Mass (Da)
	A6M3I8 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 8DA827AFACA09596	FASTA	421	45,042
	10 20 30 40 50 60 MERLVINGGN LLEGTVDING AKNAAVAILP AAIMASDGKC IIDNIPDIED VHCLERILRS 70 80 90 100 110 120 LGCDIIKIDN NTLEIDSSNV NNFDACTDDV RRMRASYYFI GALLARFKKA RVVLPGGCSI 130 140 150 160 170 180 GVRPIDQHIK GFEALGADVF IEHGAVNVKA DKLVGANIFF DVVSVGATIN VMIAATLAEG 190 200 210 220 230 240 VTVLENVAKE PHVVDVANFL NSMGADIRGA GTDVIRIKGV ESLKGCSYSV IPDQIEAGTF 250 260 270 280 290 300 MIAAVATGGD VYIRNVIPKH LESITAKLTE MGAVIEEGDD CIRVTVKSPL KGVNIKTTPY 310 320 330 340 350 360 PGFPTDIQQP MSTLLSIVPG RSLITESIWE NRHKHIDELK KMGANIKVEG RVAIIDGAQK 370 380 390 400 410 420 LTGAVVKATD LRAGAAMVIA GLVAEGTTEI TSIEHIDRGY PHIENKFRAL GADIKRIEVD E

References

[1]

"Complete sequence of Clostridium beijerinckii NCIMB 8052." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Tapia R., Brainard J., Schmutz J., Larimer F. , Land M., Hauser L., Kyrpides N., Mikhailova N., Bennet G., Cann I., Chen J.-S., Contreras A.L., Jones D., Kashket E., Mitchell W., Stoddard S., Schwarz W., Qureshi N., Young M., Shi Z., Ezeji T., White B., Blaschek H., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51743 / NCIMB 8052.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000721 Genomic DNA. Translation: ABR37168.1.
RefSeq	YP_001312124.1. NC_009617.1.
3D structure databases
ProteinModelPortal	A6M3I8.
ModBase	Search...
Protein-protein interaction databases
STRING	290402.Cbei_5062.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABR37168; ABR37168; Cbei_5062.
GeneID	5296214.
KEGG	cbe:Cbei_5062.
PATRIC	19354536. VBICloBei69853_5258.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0766.
HOGENOM	HOG000075602.
KO	K00790.
OMA	AGACLMI.
ProtClustDB	PRK12830.
Enzyme and pathway databases
BioCyc	CBEI290402:GHL5-5201-MONOMER.
UniPathway	UPA00219.
Family and domain databases
Gene3D	3.65.10.10. 2 hits.
HAMAP	MF_00111. MurA.
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. IPR005750. UDP_GlcNAc_COvinyl_MurA. [Graphical view]
PANTHER	PTHR21090:SF4. PTHR21090:SF4. 1 hit.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01072. murA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A6M3I8_CLOB8

Accession

Primary (citable) accession number: A6M3I8

Entry history

Integrated into UniProtKB/TrEMBL:	July 24, 2007
Last sequence update:	July 24, 2007
Last modified:	May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)